TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 240.261 | Formula: C13H12N4O
H donors: 2 H acceptors: 3 LogP: 0.89 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Nc1nc2CC(=Nc2c(n1)O)Cc1ccccc1
InChi: 1S/C13H12N4O/c14-13-16-10-7-9(15-11(10)12(18)17-13)6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H3,14,16,17,18)
InChiKey: DWYNGUFXKBGCLA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	purine nucleoside phosphorylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma japonicum	Purine nucleoside phosphorylase, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma mansoni	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Candida albicans	similar to human purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma japonicum	ko:K03783 purine-nucleoside phosphorylase, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma mansoni	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium ulcerans	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128114	All targets in OG5_128114
Candida albicans	similar to human purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	Get druggable targets OG5_128114	All targets in OG5_128114

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	purine nucleoside phosphorylase	289 aa	255 aa	23.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	G protein-coupled receptor	0.0171	0.1587	0.1313
Echinococcus granulosus	g protein coupled receptor	0.0171	0.1587	0.1147
Schistosoma mansoni	hypothetical protein	0.0171	0.1587	0.0909
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.1587	0.1147
Echinococcus granulosus	7TM GPCR rhodopsin	0.0171	0.1587	0.1147
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0171	0.1587	0.0909
Onchocerca volvulus		0.0171	0.1587	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0171	0.1587	0.0909
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.1587	0.1147
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	0.0154	0.1285	0.5
Schistosoma mansoni	opsin-like receptor	0.0171	0.1587	0.0909
Brugia malayi	hypothetical protein	0.0171	0.1587	0.1313
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0171	0.1587	0.1313
Brugia malayi	putative neuropeptide receptor	0.0171	0.1587	0.1313
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.1587	0.1147
Echinococcus multilocularis	g protein coupled receptor	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Schistosoma mansoni	amine GPCR	0.0171	0.1587	0.0909
Echinococcus granulosus	serotonin receptor	0.0171	0.1587	0.1147
Echinococcus multilocularis	neuropeptide receptor	0.065	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0123	0.0747	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.1587	0.1147
Schistosoma mansoni	hypothetical protein	0.0171	0.1587	0.0909
Echinococcus granulosus	g-protein coupled receptor	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.0488	0.7152	0.7003
Echinococcus granulosus	tm gpcr rhodopsin	0.0171	0.1587	0.1147
Echinococcus multilocularis	orexin receptor type 2	0.0171	0.1587	0.1147
Brugia malayi	ORL1-like opioid receptor	0.0171	0.1587	0.1313
Onchocerca volvulus		0.0171	0.1587	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.1285	0.0829
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.1285	0.0829
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0171	0.1587	0.1313
Echinococcus granulosus	biogenic amine 5HT receptor	0.0171	0.1587	0.1147
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0171	0.1587	0.1147
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Schistosoma mansoni	hypothetical protein	0.0171	0.1587	0.0909
Brugia malayi	hypothetical protein	0.0171	0.1587	0.1313
Schistosoma mansoni	hypothetical protein	0.0171	0.1587	0.0909
Brugia malayi	hypothetical protein	0.0171	0.1587	0.1313
Brugia malayi	hypothetical protein	0.0171	0.1587	0.1313
Echinococcus granulosus	g protein coupled receptor	0.0171	0.1587	0.1147
Echinococcus granulosus	allatostatin A receptor	0.0171	0.1587	0.1147
Onchocerca volvulus		0.0171	0.1587	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0171	0.1587	0.0909
Echinococcus granulosus	orexin receptor type 2	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Echinococcus multilocularis	g protein coupled receptor	0.0171	0.1587	0.1147
Echinococcus granulosus	neuropeptide FF receptor 2	0.0171	0.1587	0.1147
Echinococcus multilocularis	somatostatin receptor	0.0171	0.1587	0.1147
Brugia malayi	Serotonin receptor	0.0171	0.1587	0.1313
Schistosoma mansoni	biogenic amine receptor	0.0171	0.1587	0.0909
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0171	0.1587	0.0909
Echinococcus granulosus	neuropeptide Y receptor	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Onchocerca volvulus		0.0171	0.1587	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Echinococcus multilocularis	neuropeptide s receptor	0.0171	0.1587	0.1147
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0132	0.0894	0.023
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Echinococcus granulosus	rhodopsin orphan GPCR	0.0171	0.1587	0.1147
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0171	0.1587	0.1313
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.1285	0.0829
Brugia malayi	hypothetical protein	0.0171	0.1587	0.1313
Brugia malayi	G protein-coupled receptor F59B2.13	0.0171	0.1587	0.1313
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0171	0.1587	0.1147
Brugia malayi	neuropeptide F receptor	0.0171	0.1587	0.1313
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0171	0.1587	0.0909
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0171	0.1587	0.134
Echinococcus multilocularis	g-protein coupled receptor	0.0171	0.1587	0.1147
Schistosoma mansoni	integrin beta subunit	0.0188	0.1883	0.1228
Loa Loa (eye worm)	integrin beta-2	0.0319	0.4185	0.5384
Echinococcus multilocularis	neuropeptide Y receptor	0.0171	0.1587	0.1147
Brugia malayi	AKH receptor	0.0171	0.1587	0.1313
Onchocerca volvulus		0.0171	0.1587	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.1587	0.0909
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0123	0.0747	0.0262
Schistosoma mansoni	biogenic amine receptor	0.0171	0.1587	0.0909
Schistosoma mansoni	purine nucleoside phosphorylase	0.0154	0.1285	0.0582
Brugia malayi	putative neuropeptide receptor NPR1	0.0171	0.1587	0.1313
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0259	0.3135	0.3749
Echinococcus granulosus	tm gpcr rhodopsin	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0488	0.7152	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.1587	0.1147
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Brugia malayi	hypothetical protein	0.0171	0.1587	0.1313
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0171	0.1587	0.1313
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0171	0.1587	0.134
Schistosoma mansoni	neuropeptide receptor	0.065	1	1
Schistosoma mansoni	adenoreceptor	0.0171	0.1587	0.0909
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.1285	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	0.0154	0.1285	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0171	0.1587	0.0909
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.1285	0.0829
Loa Loa (eye worm)	melatonin receptor type 1A	0.0171	0.1587	0.134
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0171	0.1587	0.1147
Echinococcus multilocularis	allatostatin A receptor	0.0171	0.1587	0.1147
Onchocerca volvulus		0.0171	0.1587	1
Echinococcus multilocularis	integrin beta 2	0.0236	0.2734	0.2353
Echinococcus multilocularis	g protein coupled receptor	0.0171	0.1587	0.1147
Onchocerca volvulus		0.0171	0.1587	1
Schistosoma mansoni	neuropeptide receptor	0.0171	0.1587	0.0909
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0171	0.1587	0.134
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0171	0.1587	0.1147
Onchocerca volvulus		0.0171	0.1587	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Echinococcus granulosus	7tm_1 domain containing protein	0.0171	0.1587	0.1147
Brugia malayi	hypothetical protein	0.0171	0.1587	0.1313
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0171	0.1587	0.1147
Echinococcus granulosus	neuropeptide receptor A26	0.0171	0.1587	0.1147
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.1285	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Echinococcus multilocularis	G protein coupled receptor 139	0.065	1	1
Brugia malayi	Dopamine receptor	0.0171	0.1587	0.1313
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.1285	0.0829
Schistosoma mansoni	purine nucleoside phosphorylase	0.0154	0.1285	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	0.0154	0.1285	0.6406
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Loa Loa (eye worm)	G-protein coupled receptor	0.0171	0.1587	0.134
Mycobacterium ulcerans	purine nucleoside phosphorylase	0.0154	0.1285	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0171	0.1587	0.1147
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0171	0.1587	0.1147
Brugia malayi	Dopamine receptor protein 1	0.0171	0.1587	0.1313
Echinococcus granulosus	fmrfamide receptor	0.0171	0.1587	0.1147
Echinococcus multilocularis	sex peptide receptor	0.0171	0.1587	0.1147
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.1285	0.0829
Onchocerca volvulus		0.0171	0.1587	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Brugia malayi	GnHR receptor homolog	0.0171	0.1587	0.1313
Onchocerca volvulus		0.0171	0.1587	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0259	0.3135	0.3729
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0171	0.1587	0.1147
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0171	0.1587	0.0909
Echinococcus multilocularis	neuropeptides capa receptor	0.0171	0.1587	0.1147
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.1587	0.1147
Echinococcus multilocularis	fmrfamide receptor	0.0171	0.1587	0.1147
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.1285	0.0829
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.1587	0.0909
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0171	0.1587	0.1147
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.0488	0.7152	0.7003
Echinococcus granulosus	g protein coupled receptor	0.0171	0.1587	0.1147
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0122	0.0726	0.024
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.0488	0.7152	0.6922
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Echinococcus multilocularis	serotonin receptor	0.0171	0.1587	0.1147
Brugia malayi	Integrin beta pat-3 precursor	0.0319	0.4185	0.5369
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Schistosoma mansoni	neuropeptide F-like receptor	0.0171	0.1587	0.0909
Brugia malayi	hypothetical protein	0.0171	0.1587	0.1313
Schistosoma mansoni	opsin-like receptor	0.0171	0.1587	0.0909
Brugia malayi	hypothetical protein	0.0171	0.1587	0.1313
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0171	0.1587	0.1147
Schistosoma mansoni	neuropeptide F-like receptor	0.0171	0.1587	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Onchocerca volvulus		0.0171	0.1587	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.1285	0.0829
Loa Loa (eye worm)	neuropeptide F receptor	0.0171	0.1587	0.134
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0171	0.1587	0.1147
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0171	0.1587	0.1313
Onchocerca volvulus		0.0171	0.1587	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0123	0.0747	0.0032
Schistosoma mansoni	histamine h1 receptor	0.0171	0.1587	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0171	0.1587	0.0909
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.1285	0.0829
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.1285	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.1285	0.0829
Echinococcus granulosus	neuropeptide s receptor	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Schistosoma mansoni	opsin-like receptor	0.0171	0.1587	0.0909
Echinococcus granulosus	integrin beta 2	0.0236	0.2734	0.2353
Schistosoma mansoni	amine GPCR	0.0171	0.1587	0.0909
Brugia malayi	neuropeptide F receptor	0.0171	0.1587	0.1313
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0171	0.1587	1
Brugia malayi	larval opioid receptor	0.0171	0.1587	0.1313
Brugia malayi	Serotonin receptor	0.0171	0.1587	0.1313
Schistosoma mansoni	amine GPCR	0.0171	0.1587	0.0909
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0171	0.1587	0.1147
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.1587	0.0909
Echinococcus granulosus	rhodopsin orphan GPCR	0.0171	0.1587	0.1147
Echinococcus granulosus	neuropeptides capa receptor	0.0171	0.1587	0.1147
Brugia malayi	sulfakinin receptor protein	0.0171	0.1587	0.1313
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.1587	0.0909
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0171	0.1587	0.1147
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.1587	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Echinococcus granulosus	rhodopsin orphan GPCR	0.0171	0.1587	0.1147
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0171	0.1587	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0171	0.1587	0.134
Echinococcus multilocularis	serotonin receptor	0.0171	0.1587	0.1147
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.1587	0.0909
Echinococcus granulosus	rhodopsin orphan GPCR	0.0171	0.1587	0.1147
Echinococcus granulosus	sex peptide receptor	0.0171	0.1587	0.1147
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.1587	0.1147
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0171	0.1587	0.0909
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0171	0.1587	0.0909
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0171	0.1587	0.1147
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	0.0122	0.0726	0.024
Echinococcus multilocularis	neuropeptide receptor A26	0.0171	0.1587	0.1147
Loa Loa (eye worm)	G-protein coupled receptor	0.0171	0.1587	0.134
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0128	0.0826	0.0124
Echinococcus granulosus	somatostatin receptor	0.0171	0.1587	0.1147
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	0.0154	0.1285	0.5
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0171	0.1587	0.1147
Brugia malayi	G-protein coupled receptor	0.0171	0.1587	0.1313
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Onchocerca volvulus		0.0171	0.1587	1
Echinococcus multilocularis	fmrfamide receptor	0.0171	0.1587	0.1147
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0171	0.1587	0.1147
Echinococcus multilocularis	neuropeptide receptor	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Echinococcus multilocularis	neuropeptide Y receptor	0.0171	0.1587	0.1147
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.1285	0.0829
Loa Loa (eye worm)	TYRA-2 protein	0.0171	0.1587	0.134
Schistosoma mansoni	peptidylglycine monooxygenase	0.0259	0.3135	0.2581
Echinococcus granulosus	G protein coupled receptor 139	0.0171	0.1587	0.1147
Echinococcus multilocularis	neuropeptides capa receptor	0.0171	0.1587	0.1147
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	0.0154	0.1285	0.5
Echinococcus granulosus	hypothetical protein	0.0171	0.1587	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0171	0.1587	0.0909
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0171	0.1587	0.0909
Onchocerca volvulus		0.0171	0.1587	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0171	0.1587	1
Brugia malayi	Melatonin receptor type 1A	0.0171	0.1587	0.1313
Echinococcus granulosus	biogenic amine 5HT receptor	0.0171	0.1587	0.1147
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0171	0.1587	0.0909
Schistosoma mansoni	amine GPCR	0.0171	0.1587	0.0909
Brugia malayi	hypothetical protein	0.0171	0.1587	0.1313
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0171	0.1587	0.1147
Schistosoma mansoni	amine GPCR	0.0171	0.1587	0.0909
Echinococcus multilocularis	dro:myosuppressin receptor	0.0171	0.1587	0.1147
Echinococcus granulosus	receptor type guanylyl cyclase	0.0123	0.0747	0.0262
Echinococcus granulosus	neuropeptide receptor	0.0171	0.1587	0.1147
Echinococcus granulosus	neuropeptides capa receptor	0.0171	0.1587	0.1147
Brugia malayi	RE15519p	0.0171	0.1587	0.1313
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.1587	0.0909
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0122	0.0726	0.024
Brugia malayi	follicle stimulating hormone receptor	0.0171	0.1587	0.1313
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0171	0.1587	0.1147
Schistosoma mansoni	dopamine-beta-monooxygenase	0.0259	0.3135	0.2581
Echinococcus granulosus	dro:myosuppressin receptor	0.0171	0.1587	0.1147
Brugia malayi	Dopamine receptor protein 2	0.0171	0.1587	0.1313
Onchocerca volvulus		0.0171	0.1587	1
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0488	0.7152	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.1587	0.0909
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0171	0.1587	0.1147
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0171	0.1587	0.0909
Schistosoma mansoni	myosin xvIII	0.0171	0.1587	0.0909
Brugia malayi	G-protein coupled receptor	0.0171	0.1587	0.1313
Echinococcus granulosus	tm gpcr rhodopsin	0.0171	0.1587	0.1147
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0171	0.1587	0.0909
Schistosoma mansoni	neuropeptide f receptor 76f	0.0171	0.1587	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1587	0.134
Schistosoma mansoni	growth hormone secretagogue receptor	0.0171	0.1587	0.0909
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	0.0154	0.1285	0.0841
Schistosoma mansoni	neuropeptide receptor	0.0171	0.1587	0.0909
Schistosoma mansoni	neuropeptide receptor	0.0171	0.1587	0.0909
Loa Loa (eye worm)	neuropeptide F receptor	0.0171	0.1587	0.134
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.1587	0.0909
Onchocerca volvulus		0.0171	0.1587	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0171	0.1587	0.1313
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0171	0.1587	0.134
Onchocerca volvulus		0.0171	0.1587	1
Echinococcus granulosus	neuropeptide Y receptor	0.0171	0.1587	0.1147
Echinococcus granulosus	rhodopsin orphan GPCR	0.0171	0.1587	0.1147
Schistosoma mansoni	biogenic amine receptor	0.0171	0.1587	0.0909

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.085 nM	Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate	ChEMBL.	8421291
IC50 (binding)	= 0.085 nM	Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate	ChEMBL.	8421291

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 276885