TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 276.331 | Formula: C15H20N2O3
H donors: 2 H acceptors: 1 LogP: 1.7 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: NCC(c1c[nH]c2c1cc(OC)cc2)C(=O)OC(C)C
InChi: 1S/C15H20N2O3/c1-9(2)20-15(18)12(7-16)13-8-17-14-5-4-10(19-3)6-11(13)14/h4-6,8-9,12,17H,7,16H2,1-3H3
InChiKey: QDJFBGGPDVCELG-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cyclin B	0.0109	0.0281	0.0577
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.005	0.0013	0.0001
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0033	0.0039
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.005	0.0013	0.0002
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Loa Loa (eye worm)	protein tyrosine phosphatase	0.005	0.0013	0.0012
Echinococcus multilocularis	hypothetical protein	0.005	0.0013	0.0001
Echinococcus granulosus	cyclins	0.0081	0.0151	0.0299
Onchocerca volvulus		0.005	0.0013	0.0001
Brugia malayi	RNase H family protein	0.0593	0.2506	0.3372
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0057	0.0044	0.0068
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.005	0.0013	0.0001
Onchocerca volvulus		0.0109	0.0281	0.0363
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.005	0.0013	0.0001
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0013	0.0012
Trypanosoma brucei	ingi protein (ORF1)	0.0643	0.2738	0.2728
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0057	0.0044	0.0032
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Trichomonas vaginalis	reverse transcriptase [C. elegans], putative	0.005	0.0013	0.005
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.005	0.0013	0.0012
Onchocerca volvulus		0.005	0.0013	0.0001
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Brugia malayi	hypothetical protein	0.005	0.0013	0.0001
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.005	0.0013	0.0001
Onchocerca volvulus		0.005	0.0013	0.0001
Onchocerca volvulus		0.005	0.0013	0.0001
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Trichomonas vaginalis	NeSL-1_NeSL reverse transcriptases, putative	0.005	0.0013	0.005
Echinococcus multilocularis	cyclins	0.0081	0.0151	0.0299
Echinococcus multilocularis	cyclin b3	0.0081	0.0151	0.0299
Onchocerca volvulus		0.005	0.0013	0.0001
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Onchocerca volvulus	Ribonuclease H1 homolog	0.0593	0.2506	0.3372
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.005	0.0013	0.0001
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.005	0.0013	0.0001
Brugia malayi	hypothetical protein	0.005	0.0013	0.0001
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.005	0.0013	0.0001
Trichomonas vaginalis	cyclin B, putative	0.0081	0.0151	0.0604
Schistosoma mansoni	phosphoglucomutase	0.0593	0.2506	0.2497
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0057	0.0044	0.0032
Onchocerca volvulus		0.005	0.0013	0.0001
Trichomonas vaginalis	cyclin B3, putative	0.0081	0.0151	0.0604
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0151	0.0604
Echinococcus granulosus	calpain A	0.0057	0.0044	0.0068
Schistosoma mansoni	phosphoglucomutase	0.0593	0.2506	0.2497
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.005	0.0013	0.0001
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.005	0.0013	0.0001
Onchocerca volvulus		0.005	0.0013	0.0001
Trichomonas vaginalis	cyclins, putative	0.0109	0.0281	0.1121
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.005	0.0013	0.0001
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0109	0.0281	0.1076
Echinococcus granulosus	ribonuclease H1	0.0593	0.2506	0.5367
Entamoeba histolytica	cyclin, putative	0.0109	0.0281	1
Echinococcus multilocularis	cyclins	0.0081	0.0151	0.0299
Mycobacterium tuberculosis	Possible maturase	0.005	0.0013	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.005	0.0013	0.0001
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0109	0.0281	0.0363
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0207	0.0732	0.0972
Trichomonas vaginalis	reverse transcriptases, putative	0.005	0.0013	0.005
Giardia lamblia	Ribonuclease H	0.0593	0.2506	1
Brugia malayi	Protein-tyrosine phosphatase	0.005	0.0013	0.0001
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0013	0.0012
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0013	0.0012
Trichomonas vaginalis	cyclin B, putative	0.0109	0.0281	0.1121
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.005	0.0013	0.0001
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.005	0.0013	0.0001
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.005	0.0013	0.0001
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Echinococcus multilocularis	cyclins	0.0081	0.0151	0.0299
Toxoplasma gondii	ribonuclease HI protein	0.0593	0.2506	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0109	0.0281	0.0363
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0013	0.0012
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0013	0.0012
Echinococcus multilocularis	cyclin B3 1	0.0081	0.0151	0.0299
Trypanosoma cruzi	cyclin, putative	0.0109	0.0281	0.1076
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.005	0.0013	0.0012
Onchocerca volvulus		0.005	0.0013	0.0001
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Onchocerca volvulus		0.005	0.0013	0.0001
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Trypanosoma cruzi	cyclin, putative	0.0109	0.0281	0.1076
Brugia malayi	Protein-tyrosine phosphatase 1	0.005	0.0013	0.0001
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0593	0.2506	0.5
Onchocerca volvulus		0.005	0.0013	0.0001
Brugia malayi	RNase H family protein	0.0593	0.2506	0.3372
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0013	0.0012
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0013	0.0012
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Echinococcus multilocularis	cyclin B	0.0109	0.0281	0.0577
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0207	0.0732	0.1547
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.005	0.0013	0.0001
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1061	0.4659	0.4652
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Onchocerca volvulus		0.005	0.0013	0.0001
Leishmania major	cyclin	0.0109	0.0281	0.1074
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0643	0.2738	0.2728
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.005	0.0013	0.0001
Echinococcus multilocularis	cyclins	0.0081	0.0151	0.0299
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.005	0.0013	0.0001
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Entamoeba histolytica	cyclin, putative	0.0081	0.0151	0.5165
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1061	0.4659	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.005	0.0013	0.0001
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.005	0.0013	0.0001
Brugia malayi	calpain family protein 1	0.0055	0.0033	0.0027
Echinococcus multilocularis	ribonuclease H1	0.0593	0.2506	0.5367
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.005	0.0013	0.0001
Trichomonas vaginalis	cyclin A, putative	0.0109	0.0281	0.1121
Brugia malayi	Protein-tyrosine phosphatase	0.005	0.0013	0.0001
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Echinococcus granulosus	cyclins	0.0081	0.0151	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0281	0.0374
Echinococcus granulosus	cyclins	0.0081	0.0151	0.0299
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Onchocerca volvulus		0.005	0.0013	0.0001
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.005	0.0013	0.0001
Onchocerca volvulus		0.005	0.0013	0.0001
Trypanosoma cruzi	ribonuclease H1, putative	0.0593	0.2506	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1061	0.4659	0.6287
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.005	0.0013	0.0001
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0013	0.0012
Onchocerca volvulus		0.005	0.0013	0.0001
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0013	0.0012
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.005	0.0013	0.0001
Schistosoma mansoni	phosphoglucomutase	0.0593	0.2506	0.2497
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0055	0.0033	0.002
Brugia malayi	hypothetical protein	0.005	0.0013	0.0001
Trichomonas vaginalis	cyclins, putative	0.0109	0.0281	0.1121
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Trypanosoma brucei	mitotic cyclin 6	0.0109	0.0281	0.0269
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.005	0.0013	0.0012
Trypanosoma brucei	hypothetical protein, conserved	0.0643	0.2738	0.2728
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0013	0.0012
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.005	0.0013	0.0001
Trichomonas vaginalis	cyclins, putative	0.0081	0.0151	0.0604
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.005	0.0013	0.0001
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.005	0.0013	0.0001
Onchocerca volvulus		0.005	0.0013	0.0001
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Onchocerca volvulus		0.005	0.0013	0.0001
Treponema pallidum	ribonuclease H (rnhA)	0.0593	0.2506	0.5
Echinococcus multilocularis	calpain A	0.0057	0.0044	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Plasmodium falciparum	cyclin	0.0081	0.0151	0.5
Giardia lamblia	G2/mitotic-specific cyclin B	0.0109	0.0281	0.1076
Trypanosoma cruzi	ribonuclease H1, putative	0.0593	0.2506	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Schistosoma mansoni	cyclins	0.0081	0.0151	0.0139
Leishmania major	ribonuclease H1, putative	0.0593	0.2506	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Giardia lamblia	Hypothetical protein	0.0081	0.0151	0.0557
Giardia lamblia	Cyclin A	0.0081	0.0151	0.0557
Trypanosoma brucei	RNA helicase, putative	0.2223	1	1
Echinococcus multilocularis	cyclins	0.0081	0.0151	0.0299
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.005	0.0013	0.0002
Trichomonas vaginalis	cyclin B, putative	0.0109	0.0281	0.1121
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Trichomonas vaginalis	cyclin B, putative	0.0109	0.0281	0.1121
Onchocerca volvulus		0.005	0.0013	0.0001
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Trypanosoma cruzi	cyclin 6, putative	0.0109	0.0281	0.1076
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.005	0.0013	0.0001
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0207	0.0732	0.1547
Trichomonas vaginalis	reverse transcriptases, putative	0.005	0.0013	0.005
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Trichomonas vaginalis	cyclins, putative	0.0109	0.0281	0.1121
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1061	0.4659	0.6283
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.005	0.0013	0.0002
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0057	0.0044	0.0068
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.005	0.0013	0.0001
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.005	0.0013	0.0001
Brugia malayi	hypothetical protein	0.005	0.0013	0.0001
Trichomonas vaginalis	pten, drome, putative	0.005	0.0013	0.0052
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Trypanosoma brucei	unspecified product	0.0643	0.2738	0.2728
Onchocerca volvulus		0.005	0.0013	0.0001
Echinococcus multilocularis	cyclins	0.0081	0.0151	0.0299
Echinococcus multilocularis	cyclins	0.0081	0.0151	0.0299
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.005	0.0013	0.0001
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0013	0.0012
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.005	0.0013	0.0001
Onchocerca volvulus		0.005	0.0013	0.0001
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0013	0.0012
Onchocerca volvulus		0.1659	0.7408	1
Entamoeba histolytica	cyclin family protein	0.0081	0.0151	0.5165
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1061	0.4659	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0013	0.0012
Schistosoma mansoni	cyclin B	0.0109	0.0281	0.0269
Onchocerca volvulus		0.005	0.0013	0.0001
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.005	0.0013	0.0012
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.005	0.0013	0.0001
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1659	0.7408	1
Echinococcus granulosus	cyclin b3	0.0081	0.0151	0.0299
Trichomonas vaginalis	cyclin D, putative	0.0081	0.0151	0.0604
Echinococcus granulosus	cyclins	0.0081	0.0151	0.0299
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1659	0.7408	1
Trichomonas vaginalis	cyclin B, putative	0.0109	0.0281	0.1121
Schistosoma mansoni	cyclin B3	0.0207	0.0732	0.072
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.005	0.0013	0.0001
Echinococcus granulosus	cyclins	0.0081	0.0151	0.0299
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.005	0.0013	0.0001
Echinococcus granulosus	cyclin B3 1	0.0081	0.0151	0.0299
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.005	0.0013	0.0001
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.005	0.0013	0.0001
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.005	0.0013	0.0001
Brugia malayi	calpain family protein 1	0.0055	0.0033	0.0027
Echinococcus granulosus	protein tyrosine phosphatase n9	0.005	0.0013	0.0001
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.005	0.0013	0.0001
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Onchocerca volvulus		0.005	0.0013	0.0001
Trichomonas vaginalis	ribonuclease H1, putative	0.0593	0.2506	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Onchocerca volvulus		0.1659	0.7408	1
Echinococcus multilocularis		0.005	0.0013	0.0001
Trichomonas vaginalis	cyclin D, putative	0.0081	0.0151	0.0604
Loa Loa (eye worm)	hypothetical protein	0.005	0.0013	0.0012
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0013	0.0001
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.005	0.0013	0.0001
Brugia malayi	RNase H family protein	0.0593	0.2506	0.3372
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.005	0.0013	0.0001
Trypanosoma brucei	ribonuclease H1	0.0593	0.2506	0.2497
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0109	0.0281	0.1074
Trypanosoma brucei	ingi protein (ORF1)	0.0643	0.2738	0.2728
Entamoeba histolytica	cyclin family protein	0.0081	0.0151	0.5165
Brugia malayi	hypothetical protein	0.005	0.0013	0.0001
Onchocerca volvulus	4.1 G protein, putative homolog	0.005	0.0013	0.0001
Giardia lamblia	Protein tyrosine phosphatase	0.005	0.0013	0.0002
Loa Loa (eye worm)	calpain family protein 1	0.0055	0.0033	0.0039
Trichomonas vaginalis	cyclins, putative	0.0109	0.0281	0.1121
Loa Loa (eye worm)	cyclin domain-containing protein	0.0207	0.0732	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0281	0.0374

Activities

Activity type	Activity value	Assay description	Source	Reference
BP (functional)	= -48 mmHg	Change in blood pressure in normotensive anesthetized cat.	ChEMBL.	7097726
BP (functional)	= -1 mmHg	Antihypertensive activity in renal hypertensive rats 2 hr after oral administration (10 mg/Kg)	ChEMBL.	7097726
BP (functional)	= 7 mmHg	Antihypertensive activity in renal hypertensive rats 1 hr after oral administration (10 mg/Kg)	ChEMBL.	7097726
BP (functional)	= 7 mmHg	Antihypertensive activity in renal hypertensive rats 6 hr after oral administration (10 mg/Kg)	ChEMBL.	7097726
BP (functional)	= 13 mmHg	Antihypertensive activity in renal hypertensive rats 4 hr after oral administration (10 mg/Kg)	ChEMBL.	7097726
BP (functional)	= 13 mmHg	Antihypertensive activity in renal hypertensive rats 8 hr after oral administration (10 mg/Kg)	ChEMBL.	7097726
BP (functional)	= 181 mmHg	Decrease in blood pressure in normotensive anesthetized cat at dose 10 mg/Kg iv	ChEMBL.	7097726

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 278285