TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 287.269 | Formula: C11H17N3O6
H donors: 4 H acceptors: 5 LogP: -2.39 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OCC1OC([C@H]([C@@H]1O)O)c1nn(c(c1OC)C(=O)N)C
InChi: 1S/C11H17N3O6/c1-14-6(11(12)18)9(19-2)5(13-14)10-8(17)7(16)4(3-15)20-10/h4,7-8,10,15-17H,3H2,1-2H3,(H2,12,18)/t4?,7?,8-,10?/m0/s1
InChiKey: SVOWVYKXWQPIDD-JJYWOCIQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	phosphoglycerate kinase	0.0099	0.0936	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0025	0.0116	0.0197
Brugia malayi	Dopamine receptor protein 2	0.0025	0.0116	0.0197
Brugia malayi	hypothetical protein	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus granulosus	tar DNA binding protein	0.0074	0.0655	0.1113
Brugia malayi	RE15519p	0.0025	0.0116	0.0197
Echinococcus granulosus	serotonin transporter	0.0088	0.0812	0.138
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Trypanosoma brucei	DNA polymerase IV, putative	0.0045	0.0334	0.2048
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0334	0.2048
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0074	0.0655	0.1113
Loa Loa (eye worm)	TTK protein kinase	0.0543	0.5881	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0025	0.0116	0.0197
Onchocerca volvulus		0.0025	0.0116	0.0197
Echinococcus multilocularis	g-protein coupled receptor	0.0025	0.0116	0.0116
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0025	0.0116	0.0197
Schistosoma mansoni	hypothetical protein	0.0018	0.0038	0.0065
Schistosoma mansoni	sodium/chloride dependent transporter	0.0018	0.0039	0.0066
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0334	0.2048
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Brugia malayi	ImpB/MucB/SamB family protein	0.0075	0.0664	0.1129
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0655	0.1113
Schistosoma mansoni	hypothetical protein	0.0197	0.2029	0.345
Brugia malayi	ImpB/MucB/SamB family protein	0.0045	0.0334	0.0568
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0655	0.1113
Echinococcus granulosus	neuropeptide receptor A26	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0116	0.0197
Schistosoma mansoni	hypothetical protein	0.004	0.0275	0.0468
Onchocerca volvulus	Dual specificity protein kinase TTK homolog	0.0543	0.5881	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0038	0.0065
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0038	0.0065
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0334	0.2048
Onchocerca volvulus		0.0025	0.0116	0.0197
Echinococcus granulosus	allatostatin A receptor	0.0025	0.0116	0.0197
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0116	0.0197
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0025	0.0116	0.0197
Onchocerca volvulus		0.0025	0.0116	0.0197
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0038	0.0038
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0116	0.0197
Brugia malayi	Dopamine receptor protein 1	0.0025	0.0116	0.0197
Schistosoma mansoni	hypothetical protein	0.0018	0.0038	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Brugia malayi	G protein-coupled receptor	0.0025	0.0116	0.0197
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0116	0.0116
Mycobacterium leprae	Probable phosphoglycerate kinase Pgk	0.0099	0.0936	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0427	0.0427
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0025	0.0116	0.0197
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0045	0.0334	0.0568
Echinococcus granulosus	7TM GPCR rhodopsin	0.0025	0.0116	0.0197
Brugia malayi	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0116	0.0197
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0334	0.2048
Mycobacterium tuberculosis	Probable phosphoglycerate kinase Pgk	0.0099	0.0936	1
Brugia malayi	hypothetical protein	0.0025	0.0116	0.0197
Trypanosoma brucei	phosphoglycerate kinase	0.0099	0.0936	1
Wolbachia endosymbiont of Brugia malayi	phosphoglycerate kinase	0.0099	0.0936	0.5
Onchocerca volvulus		0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0812	0.138
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0116	0.0116
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0427	0.0725
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0116	0.0197
Schistosoma mansoni	opsin-like receptor	0.0025	0.0116	0.0197
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0025	0.0116	0.0116
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0038	0.0065
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0025	0.0116	0.0197
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0427	0.0725
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0334	0.2048
Schistosoma mansoni	growth hormone secretagogue receptor	0.0025	0.0116	0.0197
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0275	0.0468
Trichomonas vaginalis	CAMK family protein kinase	0.0543	0.5881	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0116	0.0197
Trypanosoma brucei	DNA polymerase IV, putative	0.0045	0.0334	0.2048
Echinococcus multilocularis	allatostatin A receptor	0.0025	0.0116	0.0116
Onchocerca volvulus		0.0025	0.0116	0.0197
Brugia malayi	Phosphoglycerate kinase	0.0036	0.0239	0.0406
Echinococcus multilocularis	tar DNA binding protein	0.0074	0.0655	0.0655
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0116	0.0197
Schistosoma mansoni	opsin-like receptor	0.0025	0.0116	0.0197
Onchocerca volvulus		0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus multilocularis	orexin receptor type 2	0.0025	0.0116	0.0116
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0116	0.0116
Brugia malayi	sulfakinin receptor protein	0.0025	0.0116	0.0197
Loa Loa (eye worm)	melatonin receptor type 1A	0.0025	0.0116	0.0197
Brugia malayi	Serotonin receptor	0.0025	0.0116	0.0197
Onchocerca volvulus		0.0025	0.0116	0.0197
Brugia malayi	G-protein coupled receptor	0.0025	0.0116	0.0197
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0116	0.0197
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0936	0.1592
Echinococcus multilocularis	dro:myosuppressin receptor	0.0025	0.0116	0.0116
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0334	0.1366
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.004	0.0275	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Schistosoma mansoni	sodium/chloride dependent transporter	0.0088	0.0812	0.138
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0025	0.0116	0.0116
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0116	0.0197
Onchocerca volvulus		0.0025	0.0116	0.0197
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0427	0.0725
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0038	0.0038
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0116	0.0197
Plasmodium vivax	phosphoglycerate kinase, putative	0.0099	0.0936	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Trypanosoma brucei	phosphoglycerate kinase	0.0099	0.0936	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0045	0.0334	0.0568
Brugia malayi	hypothetical protein	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0116	0.0116
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0334	0.1366
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0116	0.0197
Loa Loa (eye worm)	TAR-binding protein	0.0074	0.0655	0.1113
Brugia malayi	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0116	0.0116
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0427	0.0725
Giardia lamblia	Phosphoglycerate kinase	0.0099	0.0936	0.1086
Echinococcus granulosus	dna polymerase kappa	0.0045	0.0334	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0334	0.2048
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0812	0.138
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0116	0.0197
Schistosoma mansoni	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus granulosus	geminin	0.0197	0.2029	0.345
Brugia malayi	larval opioid receptor	0.0025	0.0116	0.0197
Brugia malayi	neuropeptide F receptor	0.0025	0.0116	0.0197
Echinococcus granulosus	somatostatin receptor	0.0025	0.0116	0.0197
Brugia malayi	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0025	0.0116	0.0116
Onchocerca volvulus		0.0025	0.0116	0.0197
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0025	0.0116	0.0197
Brugia malayi	neuropeptide F receptor	0.0025	0.0116	0.0197
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0045	0.0334	0.0334
Brugia malayi	Protein kinase domain containing protein	0.0543	0.5881	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0025	0.0116	0.0116
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0116	0.0197
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0025	0.0116	0.0197
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0099	0.0936	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0025	0.0116	0.0197
Chlamydia trachomatis	phosphoglycerate kinase	0.0099	0.0936	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0116	0.0116
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0655	0.1113
Brugia malayi	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0116	0.0197
Echinococcus multilocularis	serotonin receptor	0.0025	0.0116	0.0116
Schistosoma mansoni	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.0116	0.0116
Brugia malayi	Melatonin receptor type 1A	0.0025	0.0116	0.0197
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0045	0.0334	0.0568
Schistosoma mansoni	amine GPCR	0.0025	0.0116	0.0197
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0025	0.0116	0.0197
Echinococcus multilocularis	G protein coupled receptor 139	0.0025	0.0116	0.0116
Brugia malayi	Serotonin receptor	0.0025	0.0116	0.0197
Loa Loa (eye worm)	norepinephrine transporter	0.0088	0.0812	0.138
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0116	0.0116
Mycobacterium ulcerans	phosphoglycerate kinase	0.0099	0.0936	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0025	0.0116	0.0197
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0116	0.0197
Schistosoma mansoni	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus granulosus	hypothetical protein	0.0025	0.0116	0.0197
Onchocerca volvulus		0.0025	0.0116	0.0197
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0025	0.0116	0.0197
Brugia malayi	G-protein coupled receptor	0.0025	0.0116	0.0197
Onchocerca volvulus		0.0025	0.0116	0.0197
Schistosoma mansoni	adenoreceptor	0.0025	0.0116	0.0197
Onchocerca volvulus		0.0025	0.0116	0.0197
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0025	0.0116	0.0197
Trypanosoma brucei	unspecified product	0.0045	0.0334	0.2048
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0334	0.2048
Echinococcus granulosus	GPCR family 2	0.0018	0.0038	0.0065
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0116	0.0197
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0116	0.0197
Schistosoma mansoni	myosin xvIII	0.0025	0.0116	0.0197
Brugia malayi	ORL1-like opioid receptor	0.0025	0.0116	0.0197
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0025	0.0116	0.0197
Echinococcus granulosus	neuropeptide FF receptor 2	0.0025	0.0116	0.0197
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0038	0.0065
Echinococcus multilocularis	neuropeptide receptor A26	0.0025	0.0116	0.0116
Echinococcus multilocularis	somatostatin receptor	0.0025	0.0116	0.0116
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0088	0.0812	0.138
Brugia malayi	putative neuropeptide receptor NPR1	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Brugia malayi	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0116	0.0116
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0116	0.0116
Echinococcus multilocularis	serotonin receptor	0.0025	0.0116	0.0116
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0116	0.0197
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0116	0.0197
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.0116	0.0197
Brugia malayi	Phosphoglycerate kinase	0.0099	0.0936	0.1592
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0116	0.0116
Echinococcus multilocularis	dna polymerase kappa	0.0045	0.0334	0.0334
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0025	0.0116	0.0197
Brugia malayi	hypothetical protein	0.0025	0.0116	0.0197
Schistosoma mansoni	hypothetical protein	0.0197	0.2029	0.345
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0116	0.0197
Schistosoma mansoni	phosphoglycerate kinase	0.0099	0.0936	0.1592
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0116	0.0116
Brugia malayi	G protein-coupled receptor F59B2.13	0.0025	0.0116	0.0197
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0025	0.0116	0.0116
Trypanosoma brucei	DNA polymerase eta, putative	0.0075	0.0664	0.6404
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0116	0.0197
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0116	0.0116
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0025	0.0116	0.0197
Onchocerca volvulus		0.0025	0.0116	0.0197
Trypanosoma brucei	phosphoglycerate kinase, putative	0.0036	0.0239	0.079
Leishmania major	DNA polymerase eta, putative	0.0075	0.0664	0.6096
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0334	0.2048
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0116	0.0197
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus multilocularis	dna polymerase eta	0.0075	0.0664	0.0664
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0025	0.0116	0.0197
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0116	0.0197
Entamoeba histolytica	phosphoglycerate kinase, putative	0.0099	0.0936	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0116	0.0116
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0116	0.0197
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0025	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Leishmania major	DNA polymerase eta, putative	0.0044	0.0319	0.1154
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0088	0.0812	0.138
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0116	0.0197
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0116	0.0116
Schistosoma mansoni	amine GPCR	0.0025	0.0116	0.0197
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0427	0.0725
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0116	0.0197
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0025	0.0116	0.0197
Loa Loa (eye worm)	TYRA-2 protein	0.0025	0.0116	0.0197
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0025	0.0116	0.0116
Trypanosoma brucei	DNA polymerase IV, putative	0.0045	0.0334	0.2048
Leishmania major	phosphoglycerate kinase B, cytosolic	0.0099	0.0936	1
Echinococcus granulosus	dna polymerase eta	0.0075	0.0664	0.1129
Echinococcus granulosus	dual specificity serine:threonine tyrosine	0.0543	0.5881	1
Onchocerca volvulus		0.0025	0.0116	0.0197
Echinococcus granulosus	g-protein coupled receptor	0.0025	0.0116	0.0197
Brugia malayi	putative neuropeptide receptor	0.0025	0.0116	0.0197
Brugia malayi	AKH receptor	0.0025	0.0116	0.0197
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0116	0.0116
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0088	0.0812	0.138
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0334	0.1366
Trichomonas vaginalis	CAMK family protein kinase	0.0543	0.5881	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0116	0.0116
Onchocerca volvulus		0.0088	0.0812	0.138
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0025	0.0116	0.0197
Trypanosoma brucei	phosphoglycerate kinase	0.0036	0.0239	0.079
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0116	0.0197
Schistosoma mansoni	DNA polymerase eta	0.0075	0.0664	0.1129
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Brugia malayi	GnHR receptor homolog	0.0025	0.0116	0.0197
Trypanosoma cruzi	DNA polymerase eta, putative	0.0044	0.0319	0.1154
Onchocerca volvulus		0.0025	0.0116	0.0197
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0045	0.0334	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0099	0.0936	1
Schistosoma mansoni	phosphoglycerate kinase	0.0099	0.0936	0.1592
Echinococcus multilocularis	neuropeptide s receptor	0.0025	0.0116	0.0116
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0655	0.1113
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0116	0.0197
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0427	0.0427
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.0655	0.1113
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0427	0.0725
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0116	0.0197
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0025	0.0116	0.0197
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0116	0.0197
Echinococcus granulosus	sex peptide receptor	0.0025	0.0116	0.0197
Toxoplasma gondii	phosphoglycerate kinase PGKI	0.0099	0.0936	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0025	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Schistosoma mansoni	dual specificity serine/threonine tyrosine kinase	0.0543	0.5881	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0075	0.0664	0.6096
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus multilocularis	geminin	0.0197	0.2029	0.2029
Leishmania major	DNA polymerase kappa, putative	0.0045	0.0334	0.1366
Echinococcus granulosus	G protein coupled receptor 139	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0812	0.138
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.0116	0.0116
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0025	0.0116	0.0197
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0025	0.0116	0.0116
Giardia lamblia	Kinase, TTK	0.0543	0.5881	1
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0099	0.0936	0.1086
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus granulosus	7tm_1 domain containing protein	0.0025	0.0116	0.0197
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0116	0.0197
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0116	0.0197
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Schistosoma mansoni	amine GPCR	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0116	0.0197
Schistosoma mansoni	hypothetical protein	0.0018	0.0038	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Treponema pallidum	phosphoglycerate kinase	0.0099	0.0936	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0025	0.0116	0.0197
Schistosoma mansoni	hypothetical protein	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0058	0.048	0.0816
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0116	0.0197
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0334	0.1366
Echinococcus granulosus	serotonin receptor	0.0025	0.0116	0.0197
Echinococcus multilocularis	phosphoglycerate kinase 1	0.0099	0.0936	0.0936
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0025	0.0116	0.0197
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0038	0.0065
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.048	0.0816
Echinococcus multilocularis	sex peptide receptor	0.0025	0.0116	0.0116
Brugia malayi	RNA recognition motif domain containing protein	0.0074	0.0655	0.1113
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0099	0.0936	0.1086
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.048	0.0816
Toxoplasma gondii	phosphoglycerate kinase PGKII	0.0099	0.0936	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0025	0.0116	0.0197
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0045	0.0334	0.1366
Schistosoma mansoni	amine GPCR	0.0025	0.0116	0.0197
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0116	0.0197
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Brugia malayi	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0038	0.0038
Loa Loa (eye worm)	serotonin transporter b	0.0088	0.0812	0.138
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0116	0.0116
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0116	0.0116
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0025	0.0116	0.0197
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0116	0.0197
Schistosoma mansoni	hypothetical protein	0.0018	0.0038	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Schistosoma mansoni	opsin-like receptor	0.0025	0.0116	0.0197
Loa Loa (eye worm)	RNA binding protein	0.0074	0.0655	0.1113
Brugia malayi	TAR-binding protein	0.0074	0.0655	0.1113
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0116	0.0197
Echinococcus multilocularis	dual specificity serine:threonine tyrosine	0.0543	0.5881	0.5881
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0025	0.0116	0.0197
Onchocerca volvulus		0.0025	0.0116	0.0197
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0116	0.0197
Brugia malayi	follicle stimulating hormone receptor	0.0025	0.0116	0.0197
Brugia malayi	Dopamine receptor	0.0025	0.0116	0.0197
Echinococcus granulosus	orexin receptor type 2	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus granulosus	fmrfamide receptor	0.0025	0.0116	0.0197
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.048	0.0816
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0334	0.2048
Leishmania major	phosphoglycerate kinase C, glycosomal	0.0099	0.0936	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0664	0.1129
Echinococcus granulosus	neuropeptide s receptor	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0044	0.0319	0.3409
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0427	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0334	0.2048
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0116	0.0197
Schistosoma mansoni	histamine h1 receptor	0.0025	0.0116	0.0197
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0116	0.0197
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0116	0.0116
Schistosoma mansoni	amine GPCR	0.0025	0.0116	0.0197
Brugia malayi	RNA binding protein	0.0074	0.0655	0.1113
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0025	0.0116	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0197
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0025	0.0116	0.0197
Echinococcus multilocularis	serotonin transporter	0.0088	0.0812	0.0812
Echinococcus granulosus	phosphoglycerate kinase 1	0.0099	0.0936	0.1592
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0025	0.0116	0.0116
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0038	0.0065
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.0116	0.0197
Onchocerca volvulus		0.0025	0.0116	0.0197
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0116	0.0197

Activities

Activity type	Activity value	Assay description	Source	Reference
Rating (functional)	= 0	Virus rating against rhinovirus type 1A	ChEMBL.	2539476
Rating (functional)	= 0.3	Virus rating of against herpes simplex virus type 2	ChEMBL.	2539476
Rating (functional)	= 1	Virus rating against adenovirus type 2	ChEMBL.	2539476
Rating (functional)	= 1.65	Virus rating against parainfluenza virus type 3	ChEMBL.	2539476

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 373763

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 279434