Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.2924 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0288 | 0.0215 |
Schistosoma mansoni | hypothetical protein | 0.046 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0288 | 0.0216 |
Trichomonas vaginalis | beta-galactosidase, putative | 0.0184 | 0.394 | 0.6165 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0288 | 0.0216 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0288 | 0.0215 |
Loa Loa (eye worm) | glycosyl hydrolase family 2 | 0.0065 | 0.1319 | 0.4279 |
Brugia malayi | hypothetical protein | 0.0138 | 0.2924 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0061 | 0.1242 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1028 | 0.0961 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0648 | 0.0648 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0787 | 0.0718 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0184 | 0.394 | 0.6165 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0787 | 0.0718 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0288 | 0.0216 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0288 | 0.0215 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0288 | 0.0216 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1028 | 0.0961 |
Trichomonas vaginalis | glycoside hydrolase, putative | 0.0294 | 0.6355 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.0787 | 0.2392 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.1129 | 0.3612 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0288 | 0.0608 |
Echinococcus granulosus | cpg binding protein | 0.0034 | 0.0648 | 0.0578 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0288 | 0.0215 |
Loa Loa (eye worm) | beta-glucuronidase | 0.006 | 0.1209 | 0.389 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.074 | 0.074 |
Brugia malayi | CXXC zinc finger family protein | 0.0032 | 0.0608 | 0.1754 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0288 | 0.0616 |
Onchocerca volvulus | Huntingtin homolog | 0.0138 | 0.2924 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1028 | 0.1028 |
Trichomonas vaginalis | beta-mannosidase, putative | 0.006 | 0.1209 | 0.1827 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0288 | 0.0618 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0288 | 0.5 |
Schistosoma mansoni | beta-mannosidase | 0.006 | 0.1209 | 0.1209 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1129 | 0.3605 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.2924 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0288 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.1028 | 0.3244 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0118 | 0.0044 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0288 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0288 | 0.0606 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0608 | 0.0608 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.3733 | 0.3733 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0074 | 0.0074 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0068 | 0.1403 | 0.1403 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0288 | 0.0616 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0288 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0288 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0288 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.074 | 0.2217 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0288 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0138 | 0.2924 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.1129 | 0.3612 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0032 | 0.0608 | 0.1746 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0288 | 0.0288 |
Echinococcus multilocularis | cpg binding protein | 0.0034 | 0.0648 | 0.0578 |
Brugia malayi | Beta-glucuronidase precursor | 0.006 | 0.1209 | 0.3896 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0288 | 0.0216 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0787 | 0.0787 |
Echinococcus multilocularis | dnaJ subfamily B | 0.046 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0787 | 0.0787 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0288 | 0.5 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0288 | 0.0288 |
Brugia malayi | manba-prov protein | 0.006 | 0.1209 | 0.3896 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1028 | 0.0961 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.1129 | 0.3605 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0288 | 0.0618 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.074 | 0.2225 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1028 | 0.1028 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0118 | 0.0044 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0288 | 0.0288 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0648 | 0.0648 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0288 | 0.0216 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0288 | 0.0288 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1028 | 0.1028 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0288 | 0.0606 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0288 | 0.0288 |
Brugia malayi | Glycosyl hydrolases family 2, sugar binding domain containing protein | 0.0065 | 0.1319 | 0.4285 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1028 | 0.0961 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0288 | 0.5 |
Entamoeba histolytica | beta-galactosidase, putative | 0.0124 | 0.263 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.1028 | 0.325 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0288 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -24 % | Evaluated for seizure threshold test at a dose 30 mg/kg &MMT is the maximal metrazole threshold to tonic flexion. | ChEMBL. | 6330354 |
Change (functional) | = -24 % | Evaluated for seizure threshold test at a dose 30 mg/kg &MMT is the maximal metrazole threshold to tonic flexion. | ChEMBL. | 6330354 |
Change (functional) | 0 % | Evaluated for seizure threshold test at a dose 30 mg/kg &MST is the metrazole seizure threshold to persistent clonus; I = Inactive | ChEMBL. | 6330354 |
ED50 (functional) | 0 mg kg-1 | Effective dose (ED50) was determined in sc Met (pentylenetetrazol) seizure threshold test; I = Inactive at all doses including 600 mg/kg | ChEMBL. | 6330354 |
IC50 (binding) | uM | Inhibition of binding to GABA-A central benzodiazepine receptor (Inactive) | ChEMBL. | 6330354 |
IC50 (binding) | 0 uM | Inhibition of binding to GABA-A central benzodiazepine receptor (Inactive) | ChEMBL. | 6330354 |
LD50 (ADMET) | = 150 mg kg-1 | Compound was evaluated for median lethal dose | ChEMBL. | 6330354 |
LD50 (ADMET) | = 150 mg kg-1 | Compound was evaluated for median lethal dose | ChEMBL. | 6330354 |
TD50 (ADMET) | = 45 mg kg-1 | Compound was determined in rotorod test and expressed as TD50 | ChEMBL. | 6330354 |
TD50 (ADMET) | = 45 mg kg-1 | Compound was determined in rotorod test and expressed as TD50 | ChEMBL. | 6330354 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.