Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0138 | 0.6136 | 0.6136 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0164 | 0.7952 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0138 | 0.6136 | 0.6136 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0164 | 0.7952 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0138 | 0.6136 | 0.6136 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0193 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0138 | 0.6136 | 0.6136 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0164 | 0.7952 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0138 | 0.6136 | 0.6136 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0193 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.6136 | 0.6136 |
Brugia malayi | Animal haem peroxidase family protein | 0.0138 | 0.6136 | 0.6136 |
Brugia malayi | Animal haem peroxidase family protein | 0.0138 | 0.6136 | 0.6136 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.005 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0138 | 0.6136 | 1 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0193 | 1 | 1 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0193 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0138 | 0.6136 | 0.6136 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0138 | 0.6136 | 0.6136 |
Trichomonas vaginalis | hypothetical protein | 0.0164 | 0.7952 | 0.7952 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.6136 | 0.6136 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0193 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0164 | 0.7952 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0138 | 0.6136 | 0.6136 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0138 | 0.6136 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.6136 | 0.6136 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.6136 | 0.6136 |
Onchocerca volvulus | Peroxidase homolog | 0.0138 | 0.6136 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0138 | 0.6136 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0138 | 0.6136 | 0.6136 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 1 | 1 |
Onchocerca volvulus | 0.0138 | 0.6136 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0138 | 0.6136 | 0.6136 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.6136 | 0.6136 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0138 | 0.6136 | 0.6136 |
Schistosoma mansoni | peroxidasin | 0.0138 | 0.6136 | 0.6136 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.6136 | 0.6136 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.6136 | 0.6136 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0164 | 0.7952 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.6136 | 0.6136 |
Trypanosoma cruzi | Protein prenyltransferase alpha subunit repeat, putative | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0138 | 0.6136 | 0.6136 |
Onchocerca volvulus | 0.0138 | 0.6136 | 1 | |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0193 | 1 | 1 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0193 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.6136 | 0.6136 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.6136 | 0.6136 |
Echinococcus granulosus | peroxidasin | 0.0138 | 0.6136 | 0.6136 |
Leishmania major | protein farnesyltransferase alpha subunit, putative | 0.005 | 0 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0164 | 0.7952 | 0.7952 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.6136 | 0.6136 |
Toxoplasma gondii | hypothetical protein | 0.0143 | 0.65 | 0.8174 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0193 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0164 | 0.7952 | 0.7952 |
Onchocerca volvulus | Peroxidasin homolog | 0.0138 | 0.6136 | 1 |
Trypanosoma brucei | protein farnesyltransferase alpha subunit, putative | 0.005 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.005 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0138 | 0.6136 | 0.6136 |
Onchocerca volvulus | Dual oxidase homolog | 0.0138 | 0.6136 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.6136 | 0.6136 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0164 | 0.7952 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.6136 | 0.6136 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0143 | 0.65 | 0.65 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.6136 | 0.6136 |
Onchocerca volvulus | 0.0138 | 0.6136 | 1 | |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0193 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 18 nM | Inhibition of farnesyltransferase | ChEMBL. | 14741286 |
IC50 (binding) | = 18 nM | Inhibition of farnesyltransferase | ChEMBL. | 14741286 |
IC50 (functional) | = 47 nM | Inhibitory activity of the compound against v-H-Ras gene transfected cell line | ChEMBL. | 14741286 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.