TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 391.955 | Formula: C22H32ClN2O2-
H donors: 2 H acceptors: 0 LogP: 4.96 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCCNC(C(c1ccc(cc1)OC)NCCC)c1ccc(cc1)OC.[Cl-]
InChi: 1S/C22H32N2O2.ClH/c1-5-15-23-21(17-7-11-19(25-3)12-8-17)22(24-16-6-2)18-9-13-20(26-4)14-10-18;/h7-14,21-24H,5-6,15-16H2,1-4H3;1H/p-1
InChiKey: RPPYPISEUSZHOD-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0028	0.0082	0.0217
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0026	0.0075	0.5802
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.0661	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Brugia malayi	hypothetical protein	0.0015	0.003	0.0045
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0015	0.003	0.008
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.0661	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.001	0.0012	0.0012
Echinococcus granulosus	GPCR family 2	0.001	0.0012	0.0012
Brugia malayi	isocitrate dehydrogenase	0.001	0.0012	0.0017
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0015	0.003	0.003
Schistosoma mansoni	hypothetical protein	0.001	0.0012	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0082	0.0121
Brugia malayi	neuropeptide F receptor	0.0015	0.003	0.0045
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.003	0.008
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.002	0.0051	0.0076
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.003	0.003
Onchocerca volvulus		0.0015	0.003	0.0048
Schistosoma mansoni	hypothetical protein	0.0015	0.003	0.008
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0065	0.0231	0.0612
Echinococcus multilocularis	g-protein coupled receptor	0.0015	0.003	0.003
Schistosoma mansoni	hypothetical protein	0.0027	0.0078	0.0208
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.0661	1
Echinococcus multilocularis	snurportin 1	0.0196	0.0761	0.0761
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Echinococcus granulosus	neuropeptide s receptor	0.0015	0.003	0.003
Trypanosoma cruzi	transcription factor btf3, putative	0.0023	0.0063	0.4723
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.003	0.003
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.003	0.003
Echinococcus multilocularis	isocitrate dehydrogenase	0.001	0.0012	0.0012
Onchocerca volvulus		0.0015	0.003	0.0048
Schistosoma mansoni	intermediate filament proteins	0.002	0.0051	0.0136
Mycobacterium leprae	PROBABLE HYDROLASE	0.0807	0.3235	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0103	0.0153
Trichomonas vaginalis	glucosylceramidase, putative	0.0112	0.0423	0.6266
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.001	0.0012	0.0012
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.248	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.003	0.003
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.003	0.008
Echinococcus multilocularis	neuropeptide receptor	0.0015	0.003	0.003
Echinococcus multilocularis	Niemann Pick C1 protein	0.0065	0.0233	0.0233
Brugia malayi	Serotonin receptor	0.0015	0.003	0.0045
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.003	0.003
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0028	0.0082	0.0122
Loa Loa (eye worm)	TYRA-2 protein	0.0015	0.003	0.0045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.003	0.008
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0015	0.003	0.003
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0065	0.0231	0.0231
Brugia malayi	Hemopexin family protein	0.094	0.3771	0.5599
Echinococcus granulosus	snurportin 1	0.0196	0.0761	0.0761
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0019	0.0046	0.0069
Loa Loa (eye worm)	matrix metalloproteinase	0.0663	0.265	0.3935
Echinococcus multilocularis	neuropeptide receptor	0.0015	0.003	0.003
Schistosoma mansoni	amine GPCR	0.0015	0.003	0.008
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0028	0.0082	0.0082
Schistosoma mansoni	histamine h1 receptor	0.0015	0.003	0.008
Loa Loa (eye worm)	hypothetical protein	0.002	0.0051	0.0076
Brugia malayi	Isocitrate dehydrogenase	0.001	0.0012	0.0017
Schistosoma mansoni	biogenic amine receptor	0.0015	0.003	0.008
Echinococcus multilocularis	fmrfamide receptor	0.0015	0.003	0.003
Schistosoma mansoni	hypothetical protein	0.0015	0.003	0.008
Echinococcus multilocularis	neuropeptide s receptor	0.0015	0.003	0.003
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0015	0.003	0.008
Loa Loa (eye worm)	hypothetical protein	0.002	0.005	0.0074
Echinococcus multilocularis	allatostatin A receptor	0.0015	0.003	0.003
Trichomonas vaginalis	glucosylceramidase, putative	0.0112	0.0423	0.6266
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0015	0.003	0.003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.003	0.003
Loa Loa (eye worm)	neuropeptide F receptor	0.0015	0.003	0.0045
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0033	0.0103	0.0153
Echinococcus multilocularis	neuropeptide receptor A26	0.0015	0.003	0.003
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0015	0.003	0.008
Schistosoma mansoni	amine GPCR	0.0015	0.003	0.008
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0011	0.0013	0.002
Onchocerca volvulus		0.0015	0.003	0.0048
Onchocerca volvulus		0.0015	0.003	0.0048
Onchocerca volvulus		0.0015	0.003	0.0048
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0013	0.0024	0.1134
Trypanosoma brucei	transcription factor BTF3, putative	0.0023	0.0063	0.4723
Brugia malayi	GnHR receptor homolog	0.0015	0.003	0.0045
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0013	0.0024	0.1134
Brugia malayi	Melatonin receptor type 1A	0.0015	0.003	0.0045
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0015	0.003	0.003
Echinococcus granulosus	sterol regulatory element binding protein	0.0028	0.0082	0.0082
Onchocerca volvulus		0.0015	0.003	0.0048
Schistosoma mansoni	hypothetical protein	0.0015	0.003	0.008
Echinococcus multilocularis	serotonin receptor	0.0015	0.003	0.003
Brugia malayi	AKH receptor	0.0015	0.003	0.0045
Trichomonas vaginalis	glucosylceramidase, putative	0.0112	0.0423	0.6266
Brugia malayi	G-protein coupled receptor	0.0015	0.003	0.0045
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0028	0.0082	0.2764
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0015	0.003	0.003
Plasmodium vivax	basic transcription factor 3b, putative	0.0023	0.0063	0.4723
Trichomonas vaginalis	glucosylceramidase, putative	0.0112	0.0423	0.6266
Loa Loa (eye worm)	hypothetical protein	0.0037	0.012	0.0178
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0028	0.0082	0.0082
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0015	0.003	0.003
Echinococcus multilocularis	neuropeptides capa receptor	0.0015	0.003	0.003
Echinococcus multilocularis	neuropeptide Y receptor	0.0015	0.003	0.003
Echinococcus granulosus	7tm_1 domain containing protein	0.0015	0.003	0.003
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0015	0.003	0.003
Echinococcus granulosus	g-protein coupled receptor	0.0015	0.003	0.003
Onchocerca volvulus		0.0015	0.003	0.0048
Echinococcus multilocularis	orexin receptor type 2	0.0015	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Echinococcus granulosus	importin subunit beta 1	0.0018	0.0043	0.0043
Echinococcus multilocularis	Niemann Pick C1 protein	0.0093	0.0346	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0015	0.003	0.008
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0015	0.003	0.0048
Echinococcus granulosus	cpg binding protein	0.002	0.0051	0.0051
Schistosoma mansoni	cpg binding protein	0.002	0.0051	0.0134
Schistosoma mansoni	hypothetical protein	0.0271	0.1064	0.2822
Entamoeba histolytica	hypothetical protein	0.0023	0.0063	0.1866
Schistosoma mansoni	growth hormone secretagogue receptor	0.0015	0.003	0.008
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Echinococcus granulosus	lamin dm0	0.002	0.0051	0.0051
Echinococcus granulosus	Niemann Pick C1 protein	0.0093	0.0346	0.0346
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0015	0.003	0.0045
Schistosoma mansoni	hypothetical protein	0.0015	0.003	0.008
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Echinococcus granulosus	sodium channel protein	0.0026	0.0075	0.0075
Brugia malayi	G protein-coupled receptor F59B2.13	0.0015	0.003	0.0045
Echinococcus granulosus	somatostatin receptor	0.0015	0.003	0.003
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0015	0.003	0.008
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Entamoeba histolytica	hypothetical protein	0.0024	0.0066	0.1996
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Loa Loa (eye worm)	ICD-1 protein	0.0023	0.0063	0.0093
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0511	0.2035	0.5396
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0028	0.0082	0.0082
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0015	0.003	0.008
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0015	0.003	0.008
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.001	0.0012	0.0012
Trypanosoma brucei	importin beta-1 subunit, putative	0.0018	0.0043	0.2937
Schistosoma mansoni	importin beta-1	0.0018	0.0043	0.0115
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0015	0.003	0.008
Loa Loa (eye worm)	hypothetical protein	0.001	0.0009	0.0013
Echinococcus multilocularis	sterol regulatory element binding protein	0.0028	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.003	0.003
Brugia malayi	neuropeptide F receptor	0.0015	0.003	0.0045
Echinococcus granulosus	lamin	0.002	0.0051	0.0051
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0015	0.003	0.003
Echinococcus granulosus	orexin receptor type 2	0.0015	0.003	0.003
Schistosoma mansoni	cpg binding protein	0.0019	0.0046	0.0122
Brugia malayi	CXXC zinc finger family protein	0.0019	0.0046	0.0069
Brugia malayi	Matrixin family protein	0.0663	0.265	0.3935
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0015	0.003	0.003
Echinococcus granulosus	serotonin receptor	0.0015	0.003	0.003
Onchocerca volvulus		0.002	0.0051	0.0083
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0065	0.0231	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Schistosoma mansoni	hypothetical protein	0.001	0.0012	0.0031
Echinococcus multilocularis	G protein coupled receptor 139	0.0015	0.003	0.003
Toxoplasma gondii	NAC domain-containing protein	0.0023	0.0063	0.4723
Schistosoma mansoni	amine GPCR	0.0015	0.003	0.008
Brugia malayi	hypothetical protein	0.0015	0.003	0.0045
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0063	0.0612
Brugia malayi	CHE-14 protein	0.0028	0.0082	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Schistosoma mansoni	hypothetical protein	0.0027	0.0078	0.0208
Trypanosoma brucei	PAB1-binding protein , putative	0.0037	0.012	1
Echinococcus multilocularis	lamin	0.002	0.0051	0.0051
Echinococcus granulosus	neuropeptides capa receptor	0.0015	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0108	0.016
Onchocerca volvulus		0.002	0.0051	0.0083
Brugia malayi	cytoplasmic intermediate filament protein	0.0011	0.0013	0.002
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0043	0.0065
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.001	0.0009	0.0009
Onchocerca volvulus		0.0015	0.003	0.0048
Echinococcus multilocularis	protein patched	0.0028	0.0082	0.0082
Echinococcus granulosus	transcription factor btf3	0.0023	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Brugia malayi	Latrophilin receptor protein 2	0.001	0.0012	0.0017
Toxoplasma gondii	LsmAD domain-containing protein	0.0037	0.012	1
Trichomonas vaginalis	importin beta-1, putative	0.0015	0.0029	0.0087
Schistosoma mansoni	hypothetical protein	0.0024	0.0066	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Brugia malayi	hypothetical protein	0.0024	0.0066	0.0097
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0015	0.003	0.003
Onchocerca volvulus		0.094	0.3771	0.6083
Brugia malayi	hypothetical protein	0.0037	0.012	0.0178
Loa Loa (eye worm)	matrixin family protein	0.1672	0.6735	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.003	0.008
Brugia malayi	hypothetical protein	0.0015	0.003	0.0045
Schistosoma mansoni	lamin	0.002	0.0051	0.0136
Schistosoma mansoni	hypothetical protein	0.094	0.3771	1
Echinococcus multilocularis	protein dispatched 1	0.0032	0.0098	0.0098
Mycobacterium ulcerans	hydrolase	0.0807	0.3235	0.5
Brugia malayi	ORL1-like opioid receptor	0.0015	0.003	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0028	0.0082	0.0082
Brugia malayi	hypothetical protein	0.0015	0.003	0.0045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.003	0.008
Trichomonas vaginalis	glucosylceramidase, putative	0.0112	0.0423	0.6266
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.003	0.008
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Schistosoma mansoni	patched 1	0.0028	0.0082	0.0218
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.003	0.008
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0807	0.3235	1
Plasmodium falciparum	basic transcription factor 3b, putative	0.0023	0.0063	0.4723
Onchocerca volvulus		0.0015	0.003	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0807	0.3235	0.4803
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.0661	1
Echinococcus multilocularis	musashi	0.002	0.0051	0.0051
Echinococcus granulosus	expressed conserved protein	0.0061	0.0217	0.0217
Brugia malayi	Intermediate filament tail domain containing protein	0.002	0.0051	0.0076
Echinococcus multilocularis	dnaJ subfamily B	0.0271	0.1064	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.003	0.003
Echinococcus multilocularis	neuropeptide Y receptor	0.0015	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0061	0.009
Schistosoma mansoni	biogenic amine receptor	0.0015	0.003	0.008
Loa Loa (eye worm)	hypothetical protein	0.001	0.0012	0.0017
Onchocerca volvulus	Matrilysin homolog	0.0663	0.265	0.4276
Brugia malayi	latrophilin 2 splice variant baaae	0.0023	0.0061	0.009
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0733	0.2933	0.7779
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.003	0.008
Loa Loa (eye worm)	intermediate filament protein	0.002	0.0051	0.0076
Brugia malayi	RNA, U transporter 1	0.0052	0.018	0.0268
Brugia malayi	Importin beta-1 subunit	0.0018	0.0043	0.0065
Brugia malayi	Matrixin family protein	0.1672	0.6735	1
Echinococcus multilocularis	lamin dm0	0.002	0.0051	0.0051
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0015	0.003	0.0045
Brugia malayi	sulfakinin receptor protein	0.0015	0.003	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0015	0.003	0.008
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0024	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Brugia malayi	hypothetical protein	0.0015	0.003	0.0045
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0015	0.003	0.003
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0065	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Onchocerca volvulus		0.0015	0.003	0.0048
Brugia malayi	MH2 domain containing protein	0.0079	0.0289	0.0429
Echinococcus granulosus	ubiquitin specific protease 41	0.0028	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0233	0.0346
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0028	0.0082	0.645
Echinococcus multilocularis	somatostatin receptor	0.0015	0.003	0.003
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0015	0.003	0.008
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0013	0.0024	0.0024
Echinococcus granulosus	g protein coupled receptor	0.0015	0.003	0.003
Echinococcus granulosus	biogenic amine 5HT receptor	0.0015	0.003	0.003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.003	0.003
Schistosoma mansoni	hypothetical protein	0.0027	0.0078	0.0208
Schistosoma mansoni	lamin	0.002	0.0051	0.0136
Schistosoma mansoni	neuropeptide F-like receptor	0.0015	0.003	0.008
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0065	0.0231	0.0343
Onchocerca volvulus		0.0663	0.265	0.4276
Brugia malayi	hypothetical protein	0.0015	0.003	0.0045
Echinococcus granulosus	dro:myosuppressin receptor	0.0015	0.003	0.003
Entamoeba histolytica	hypothetical protein	0.0024	0.0066	0.1996
Brugia malayi	Dopamine receptor	0.0015	0.003	0.0045
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0015	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Loa Loa (eye worm)	isocitrate dehydrogenase	0.001	0.0012	0.0017
Echinococcus granulosus	dnaJ subfamily B	0.0271	0.1064	0.1064
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0017	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.003	0.003
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0033	0.0103	0.0153
Schistosoma mansoni	hypothetical protein	0.001	0.0012	0.0031
Brugia malayi	RE15519p	0.0015	0.003	0.0045
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.003	0.003
Loa Loa (eye worm)	matrixin family protein	0.147	0.5916	0.8784
Brugia malayi	Matrixin family protein	0.0663	0.265	0.3935
Brugia malayi	hypothetical protein	0.0015	0.003	0.0045
Schistosoma mansoni	neuropeptide F-like receptor	0.0015	0.003	0.008
Echinococcus granulosus	hypothetical protein	0.0015	0.003	0.003
Onchocerca volvulus	Matrix metalloproteinase homolog	0.147	0.5916	0.9544
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0024	0.0066	0.0066
Schistosoma mansoni	hypothetical protein	0.001	0.0012	0.0031
Echinococcus granulosus	neuropeptide receptor	0.0015	0.003	0.003
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0015	0.003	0.003
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0065	0.0231	0.0343
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.003	0.003
Brugia malayi	Niemann-Pick C1 protein precursor	0.0065	0.0233	0.0346
Echinococcus multilocularis	expressed conserved protein	0.0061	0.0217	0.0217
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.003	0.003
Trichomonas vaginalis	glucosylceramidase, putative	0.0118	0.0447	0.665
Loa Loa (eye worm)	MH2 domain-containing protein	0.0079	0.0289	0.0429
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0013	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0066	0.0237	0.0628
Schistosoma mansoni	amine GPCR	0.0015	0.003	0.008
Echinococcus granulosus	intermediate filament protein	0.002	0.0051	0.0051
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0015	0.003	0.0048
Leishmania major	GTP-binding protein, putative	0.0013	0.0024	0.1134
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0063	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0015	0.003	0.0045
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0013	0.0024	0.1134
Leishmania major	basic transcription factor 3a, putative	0.0023	0.0063	0.4723
Brugia malayi	follicle stimulating hormone receptor	0.0015	0.003	0.0045
Echinococcus granulosus	g protein coupled receptor	0.0015	0.003	0.003
Schistosoma mansoni	transcription factor btf3	0.0023	0.0063	0.0167
Echinococcus granulosus	7TM GPCR rhodopsin	0.0015	0.003	0.003
Leishmania major	hypothetical protein, conserved	0.0037	0.012	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0065	0.0233	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0079	0.0289	0.0429
Echinococcus granulosus	allatostatin A receptor	0.0015	0.003	0.003
Onchocerca volvulus		0.0015	0.003	0.0048
Echinococcus granulosus	sex peptide receptor	0.0015	0.003	0.003
Schistosoma mansoni	neuropeptide receptor	0.0015	0.003	0.008
Brugia malayi	Dopamine receptor protein 2	0.0015	0.003	0.0045
Schistosoma mansoni	opsin-like receptor	0.0015	0.003	0.008
Trypanosoma cruzi	PAB1-binding protein , putative	0.0037	0.012	1
Echinococcus multilocularis	fmrfamide receptor	0.0015	0.003	0.003
Echinococcus multilocularis	neuropeptides capa receptor	0.0015	0.003	0.003
Echinococcus granulosus	Niemann Pick C1 protein	0.0065	0.0233	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0015	0.003	0.0045
Echinococcus granulosus	neuropeptide receptor A26	0.0015	0.003	0.003
Schistosoma mansoni	neuropeptide receptor	0.0015	0.003	0.008
Echinococcus granulosus	fmrfamide receptor	0.0015	0.003	0.003
Schistosoma mansoni	opsin-like receptor	0.0015	0.003	0.008
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0015	0.003	0.0045
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.001	0.0012	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0082	0.0122
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0015	0.003	0.003
Onchocerca volvulus		0.0015	0.003	0.0048
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0015	0.003	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0663	0.265	0.3935
Loa Loa (eye worm)	hypothetical protein	0.0733	0.2933	0.4355
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0028	0.0082	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0015	0.003	0.0045
Plasmodium falciparum	ataxin-2 like protein, putative	0.0037	0.012	1
Schistosoma mansoni	adenoreceptor	0.0015	0.003	0.008
Plasmodium falciparum	importin beta, putative	0.0018	0.0043	0.2937
Brugia malayi	Serotonin receptor	0.0015	0.003	0.0045
Loa Loa (eye worm)	melatonin receptor type 1A	0.0015	0.003	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0015	0.003	0.003
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.0661	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0112	0.0423	0.6266
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0007	0.0011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.003	0.008
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0026	0.0075	0.0075
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0028	0.0082	0.0907
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.003	0.008
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0028	0.0082	0.645
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Entamoeba histolytica	hypothetical protein	0.0024	0.0066	0.1996
Echinococcus multilocularis	sex peptide receptor	0.0015	0.003	0.003
Schistosoma mansoni	hypothetical protein	0.0027	0.0078	0.0208
Trypanosoma cruzi	PAB1-binding protein , putative	0.0037	0.012	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0015	0.003	0.008
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0196	0.0761	0.113
Schistosoma mansoni	neuropeptide receptor	0.0015	0.003	0.008
Schistosoma mansoni	transcription factor LCR-F1	0.0024	0.0066	0.0174
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0015	0.003	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0082	0.0907
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0028	0.0082	0.645
Echinococcus granulosus	neuropeptide Y receptor	0.0015	0.003	0.003
Echinococcus multilocularis	serotonin receptor	0.0015	0.003	0.003
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0065	0.0231	0.0612
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0028	0.0082	0.0217
Schistosoma mansoni	ran	0.0013	0.0024	0.0063
Brugia malayi	hypothetical protein	0.0015	0.003	0.0045
Plasmodium falciparum	ataxin-2 like protein, putative	0.0037	0.012	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0015	0.003	0.003
Echinococcus multilocularis	ubiquitin specific protease 41	0.0028	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Onchocerca volvulus		0.0015	0.003	0.0048
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0015	0.003	0.008
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0015	0.003	0.003
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.0661	1
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0013	0.0024	0.1134
Brugia malayi	putative neuropeptide receptor NPR1	0.0015	0.003	0.0045
Echinococcus multilocularis	dro:myosuppressin receptor	0.0015	0.003	0.003
Schistosoma mansoni	ran	0.0013	0.0024	0.0063
Leishmania major	importin beta-1 subunit, putative	0.0015	0.0029	0.1645
Echinococcus granulosus	biogenic amine 5HT receptor	0.0015	0.003	0.003
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0013	0.0024	0.0035
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.003	0.008
Echinococcus multilocularis	cpg binding protein	0.002	0.0051	0.0051
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.003	0.003
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0015	0.003	0.003
Toxoplasma gondii	HEAT repeat-containing protein	0.0018	0.0043	0.2937
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0015	0.003	0.0045
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.001	0.0012	0.0012
Plasmodium vivax	importin-beta 2, putative	0.0018	0.0043	0.2937
Loa Loa (eye worm)	neuropeptide F receptor	0.0015	0.003	0.0045
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0807	0.3235	0.4803
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0065	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Brugia malayi	larval opioid receptor	0.0015	0.003	0.0045
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0063	0.0612
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0017	0.0037	0.0037
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0065	0.0231	0.0231
Brugia malayi	Dopamine receptor protein 1	0.0015	0.003	0.0045
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.003	0.003
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0015	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0663	0.265	0.3935
Schistosoma mansoni	cpg binding protein	0.002	0.0051	0.0134
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0537	0.214	0.214
Entamoeba histolytica	hypothetical protein	0.0015	0.0029	0.0266
Brugia malayi	intermediate filament protein	0.002	0.0051	0.0076
Schistosoma mansoni	biogenic amine receptor	0.0015	0.003	0.008
Schistosoma mansoni	myosin xvIII	0.0015	0.003	0.008
Trypanosoma brucei	importin beta-1 subunit, putative	0.0018	0.0043	0.2937
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0015	0.003	0.0045
Onchocerca volvulus		0.0015	0.003	0.0048
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0015	0.003	0.0045
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.003	0.003
Schistosoma mansoni	hypothetical protein	0.0017	0.0037	0.0098
Onchocerca volvulus		0.0015	0.003	0.0048
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0171	0.0661	0.0981
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0015	0.003	0.0045
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0013	0.0024	0.1134
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.003	0.003
Loa Loa (eye worm)	latrophilin receptor protein 2	0.001	0.0012	0.0017
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.001	0.0012	0.0012
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.001	0.0012	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.003	0.003
Entamoeba histolytica	hypothetical protein	0.0024	0.0066	0.1996
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.003	0.008
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0015	0.003	0.003
Brugia malayi	beta-NAC-like protein	0.0023	0.0063	0.0093
Brugia malayi	hypothetical protein	0.0015	0.003	0.0045
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0015	0.003	0.003
Loa Loa (eye worm)	G-protein coupled receptor	0.0015	0.003	0.0045
Brugia malayi	hypothetical protein	0.0024	0.0067	0.0099
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.001	0.0012	0.0012
Schistosoma mansoni	neuropeptide receptor	0.0015	0.003	0.008
Onchocerca volvulus		0.0019	0.0046	0.0074
Onchocerca volvulus	Glucosylceramidase homolog	0.0112	0.0423	0.0682
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0015	0.0029	0.1645
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Echinococcus granulosus	g protein coupled receptor	0.0015	0.003	0.003
Schistosoma mansoni	hypothetical protein	0.0023	0.0061	0.016
Echinococcus multilocularis	importin subunit beta 1	0.0018	0.0043	0.0043
Echinococcus granulosus	G protein coupled receptor 139	0.0015	0.003	0.003
Onchocerca volvulus	Matrilysin homolog	0.154	0.6199	1
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.003	0.003
Loa Loa (eye worm)	G-protein coupled receptor	0.0015	0.003	0.0045
Echinococcus multilocularis	GPCR, family 2	0.001	0.0012	0.0012
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.001	0.0012	0.0012
Trichomonas vaginalis	glucosylceramidase, putative	0.0118	0.0447	0.665
Schistosoma mansoni	hypothetical protein	0.0196	0.0761	0.2019
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0015	0.003	0.008
Brugia malayi	hypothetical protein	0.0015	0.003	0.0045
Echinococcus multilocularis	transcription factor btf3	0.0023	0.0063	0.0063
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0013	0.0024	0.1134
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.001	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0007	0.0011
Echinococcus granulosus	neuropeptides capa receptor	0.0015	0.003	0.003
Brugia malayi	G protein-coupled receptor	0.0015	0.003	0.0045
Brugia malayi	G-protein coupled receptor	0.0015	0.003	0.0045
Schistosoma mansoni	opsin-like receptor	0.0015	0.003	0.008
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.003	0.003
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.003	0.003
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0028	0.0082	0.0907
Trypanosoma cruzi	transcription factor btf3, putative	0.0023	0.0063	0.4723
Brugia malayi	Matrixin family protein	0.0663	0.265	0.3935
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.001	0.0012	0.0012
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0015	0.0029	0.0087
Echinococcus multilocularis	sodium channel protein	0.0026	0.0075	0.0075
Schistosoma mansoni	amine GPCR	0.0015	0.003	0.008
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Trichomonas vaginalis	glucosylceramidase, putative	0.0112	0.0423	0.6266
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0015	0.0029	0.0087
Echinococcus granulosus	neuropeptide Y receptor	0.0015	0.003	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0082	0.0919
Schistosoma mansoni	neuropeptide f receptor 76f	0.0015	0.003	0.008
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0036	0.0115	0.9515
Plasmodium vivax	ataxin-2 like protein, putative	0.0037	0.012	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0015	0.003	0.0045
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0028	0.0082	0.0121
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0033	0.0103	0.0153
Brugia malayi	putative neuropeptide receptor	0.0015	0.003	0.0045
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.003	0.003
Entamoeba histolytica	transcription factor BTF3, putative	0.0023	0.0063	0.1866
Brugia malayi	Matrixin family protein	0.0663	0.265	0.3935
Onchocerca volvulus		0.0015	0.003	0.0048
Onchocerca volvulus		0.0015	0.003	0.0048
Echinococcus granulosus	neuropeptide receptor	0.0015	0.003	0.003
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0028	0.0082	0.645
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.004	0.0132	0.0351
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.001	0.0012	0.0012
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0015	0.003	0.003
Echinococcus granulosus	Protein patched homolog 1	0.0028	0.0082	0.0082
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0171	0.0661	0.0981
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.003	0.003
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0013	0.0024	0.0035

Activities

Activity type	Activity value	Assay description	Source	Reference
Ka (binding)	0 M-1	Binding affinity for murine Estrogen receptor; No affinity	ChEMBL.	6809943

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 380111

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 286219