Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calpain 1, (mu/I) large subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | calpain A | calpain 1, (mu/I) large subunit | 714 aa | 753 aa | 31.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | calpain family protein 1 | 0.0097 | 0.009 | 0.009 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0138 | 0.0336 | 0.0811 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0205 | 0.0745 | 0.0458 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0132 | 0.03 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.009 | 0.009 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0294 | 0.128 | 0.2186 |
Echinococcus multilocularis | calpain A | 0.0138 | 0.0336 | 0.0452 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0138 | 0.0336 | 0.0811 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0997 | 0.5535 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0294 | 0.128 | 0.1011 |
Schistosoma mansoni | choline o-acyltransferase | 0.0205 | 0.0745 | 1 |
Onchocerca volvulus | 0.0205 | 0.0745 | 1 | |
Onchocerca volvulus | 0.0205 | 0.0745 | 1 | |
Echinococcus multilocularis | choline O acetyltransferase | 0.0205 | 0.0745 | 0.1202 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.0745 | 0.0745 |
Onchocerca volvulus | 0.0205 | 0.0745 | 1 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0997 | 0.5535 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0294 | 0.128 | 0.128 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0997 | 0.5535 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0997 | 0.5535 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0205 | 0.0745 | 0.0458 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0294 | 0.128 | 0.1118 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0294 | 0.128 | 0.1816 |
Onchocerca volvulus | 0.0205 | 0.0745 | 1 | |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0138 | 0.0336 | 0.0452 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0205 | 0.0745 | 0.0745 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.021 | 0.021 |
Echinococcus granulosus | choline O acetyltransferase | 0.0205 | 0.0745 | 0.0786 |
Schistosoma mansoni | choline o-acyltransferase | 0.0205 | 0.0745 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.03 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.1735 | 1 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0294 | 0.128 | 0.1118 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0205 | 0.0745 | 0.0745 |
Brugia malayi | Choline O-acetyltransferase | 0.0205 | 0.0745 | 0.0458 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0294 | 0.128 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0997 | 0.5535 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.