TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 317.467 | Formula: C23H27N
H donors: 0 H acceptors: 0 LogP: 4.73 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(cc1)C1c2cc(CC)ccc2C2=C1CN(C)CC2
InChi: 1S/C23H27N/c1-4-16-6-9-18(10-7-16)23-21-14-17(5-2)8-11-19(21)20-12-13-24(3)15-22(20)23/h6-11,14,23H,4-5,12-13,15H2,1-3H3
InChiKey: BJLBDDZNGBILHF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Protein ultraspiracle homolog	0.007	0.051	0.1592
Echinococcus multilocularis	ras gtpase	0.0293	0.3511	0.3504
Plasmodium falciparum	topoisomerase I	0.0208	0.2372	1
Trichomonas vaginalis	GTP-binding protein rit, putative	0.0293	0.3511	0.8755
Mycobacterium tuberculosis	Probable reductase	0.0097	0.087	0.3997
Schistosoma mansoni	aryl hydrocarbon receptor	0.0055	0.0301	0.029
Onchocerca volvulus		0.007	0.051	0.1592
Echinococcus granulosus	thyroid hormone receptor alpha	0.0033	0.0011	0.0011
Trypanosoma brucei	unspecified product	0.0038	0.0082	0.0124
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.007	0.051	0.05
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0046	0.0181	0.0109
Brugia malayi	Ras protein let-60	0.0293	0.3511	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0048	0.0207	0.0176
Mycobacterium tuberculosis	Probable oxidoreductase	0.0108	0.1016	0.4791
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0048	0.0207	0.0176
Loa Loa (eye worm)	hypothetical protein	0.007	0.051	0.1427
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0097	0.087	0.3997
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0017	0.0006
Loa Loa (eye worm)	thioredoxin reductase	0.0042	0.0137	0.036
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.007	0.051	0.051
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0046	0.0181	0.0109
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Treponema pallidum	fructose-bisphosphate aldolase	0.0328	0.3985	0.5
Plasmodium vivax	thioredoxin reductase, putative	0.0042	0.0137	0.0512
Brugia malayi	Nuclear hormone receptor-like 1	0.007	0.051	0.1427
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0017	0.0006
Onchocerca volvulus		0.004	0.011	0.0314
Echinococcus granulosus	nuclear receptor nhr 48	0.0033	0.0011	0.0011
Echinococcus granulosus	DNA topoisomerase 1	0.0208	0.2372	0.2372
Brugia malayi	PAS domain containing protein	0.0055	0.0301	0.0828
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0082	0.0124
Mycobacterium tuberculosis	Probable dehydrogenase	0.0097	0.087	0.3997
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.007	0.051	0.1427
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0033	0.0011	0.0011
Brugia malayi	Thioredoxin reductase	0.0042	0.0137	0.036
Brugia malayi	hypothetical protein	0.0037	0.0065	0.0153
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0046	0.0181	0.0109
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0017	0.0006
Loa Loa (eye worm)	steroid hormone receptor	0.007	0.051	0.1427
Schistosoma mansoni	thyroid hormone receptor	0.007	0.051	0.05
Schistosoma mansoni	DNA topoisomerase type I	0.0208	0.2372	0.2364
Leishmania major	DNA topoisomerase type IB small subunit	0.0052	0.0271	0.0334
Echinococcus granulosus	ras gtpase	0.0293	0.3511	0.3511
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.007	0.051	0.1427
Loa Loa (eye worm)	hypothetical protein	0.007	0.051	0.1427
Trypanosoma brucei	DNA topoisomerase IB, large subunit	0.0156	0.1667	0.3989
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0328	0.3985	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0328	0.3985	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.016	0.1727	0.4134
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0048	0.0207	0.043
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.007	0.051	0.1427
Schistosoma mansoni	single-minded	0.0055	0.0301	0.029
Trichomonas vaginalis	rheb, putative	0.0293	0.3511	0.8755
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.007	0.051	0.05
Plasmodium vivax	glutathione reductase, putative	0.0042	0.0137	0.0512
Mycobacterium ulcerans	hypothetical protein	0.0178	0.1971	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0065	0.0153
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Echinococcus granulosus	FTZ F1 alpha	0.007	0.051	0.051
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.007	0.051	0.05
Loa Loa (eye worm)	Ras protein let-60	0.0293	0.3511	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.007	0.051	0.05
Brugia malayi	steroid hormone receptor	0.007	0.051	0.1427
Brugia malayi	Pre-SET motif family protein	0.0233	0.2712	0.7718
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0037	0.0065	0.0065
Echinococcus granulosus	dna polymerase kappa	0.0046	0.0181	0.0181
Schistosoma mansoni	RAR-like nuclear receptor	0.007	0.051	0.05
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.007	0.051	0.1427
Trypanosoma brucei	DNA topoisomerase type IB small subunit	0.0052	0.0271	0.0584
Trypanosoma cruzi	DNA topoisomerase IB, large subunit, putative	0.0156	0.1667	0.383
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.007	0.051	0.1427
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.007	0.051	0.05
Echinococcus multilocularis	transfer RNA-Lys	0.004	0.011	0.0099
Brugia malayi	Nuclear hormone receptor-like 1	0.0037	0.0065	0.0153
Brugia malayi	ecdysteroid receptor	0.007	0.051	0.1427
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0328	0.3985	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.007	0.051	0.051
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.007	0.051	0.1427
Echinococcus multilocularis	microtubule associated protein 2	0.0774	1	1
Brugia malayi	Pre-SET motif family protein	0.0033	0.0017	0.0016
Mycobacterium ulcerans	DNA polymerase IV	0.0046	0.0181	0.0383
Brugia malayi	hypoxia-induced factor 1	0.0169	0.1842	0.5231
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0033	0.0011	0.0011
Leishmania major	mitochondrial DNA polymerase beta	0.0339	0.4132	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0339	0.4132	1
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0169	0.1842	0.5231
Loa Loa (eye worm)	hypothetical protein	0.007	0.051	0.1427
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0017	0.0016
Brugia malayi	glutathione reductase	0.0042	0.0137	0.036
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0328	0.3985	1
Echinococcus multilocularis	DNA topoisomerase 1	0.0208	0.2372	0.2364
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Toxoplasma gondii	DNA topoisomerase I, putative	0.0208	0.2372	1
Trichomonas vaginalis	dexras1, putative	0.0293	0.3511	0.8755
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.007	0.051	0.05
Trichomonas vaginalis	ras-dva small GTPase, putative	0.0293	0.3511	0.8755
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.007	0.051	0.05
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0033	0.0011	0.0011
Schistosoma mansoni	DNA topoisomerase type I	0.0156	0.1667	0.1658
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.007	0.051	0.1427
Echinococcus multilocularis	ecdysone induced protein 78C	0.007	0.051	0.05
Trichomonas vaginalis	ral, putative	0.0293	0.3511	0.8755
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0043	0.0145	0.0134
Schistosoma mansoni	retinoic acid receptor RXR	0.007	0.051	0.05
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0037	0.0065	0.0054
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0011	0.0011
Onchocerca volvulus		0.0033	0.0017	0.0018
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0037	0.0065	0.0054
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.007	0.051	0.05
Brugia malayi	Ras-related protein R-Ras2	0.0293	0.3511	1
Brugia malayi	nuclear hormone receptor	0.007	0.051	0.1427
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0097	0.087	0.3997
Loa Loa (eye worm)	DNA topoisomerase I	0.0208	0.2372	0.6747
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.016	0.1724	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0017	0.0006
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0339	0.4132	1
Brugia malayi	polk-prov protein	0.0035	0.0031	0.0058
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0233	0.2712	0.7718
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0328	0.3985	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0108	0.1016	0.1705
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0058	0.0348	0.0527
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Trypanosoma brucei	DNA polymerase IV, putative	0.0046	0.0181	0.0365
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.007	0.051	0.1427
Onchocerca volvulus		0.0266	0.3147	1
Loa Loa (eye worm)	glutathione reductase	0.0042	0.0137	0.036
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0065	0.0153
Schistosoma mansoni	nuclear hormone receptor	0.007	0.051	0.05
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0339	0.4132	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0017	0.0017
Echinococcus granulosus	ecdysone induced protein 78C	0.007	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.007	0.051	0.1427
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0037	0.0065	0.0054
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.007	0.051	0.1427
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.007	0.051	0.1427
Brugia malayi	nuclear receptor RXR	0.0037	0.0065	0.0153
Loa Loa (eye worm)	hypothetical protein	0.007	0.051	0.1427
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0031	0.0058
Trichomonas vaginalis	rap1 and, putative	0.0293	0.3511	0.8755
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0097	0.087	0.3997
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.007	0.051	0.1427
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.007	0.051	0.1427
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0048	0.0207	0.0176
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.007	0.051	0.1427
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.007	0.051	0.1427
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0046	0.0181	0.0109
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0108	0.1016	0.4791
Echinococcus multilocularis	FTZ F1 alpha	0.007	0.051	0.05
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0097	0.087	0.3997
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0017	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2033	0.5777
Leishmania major	DNA topoisomerase IB, large subunit	0.0156	0.1667	0.383
Toxoplasma gondii	hypothetical protein	0.0055	0.0302	0.1211
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0328	0.3985	1
Trichomonas vaginalis	set domain proteins, putative	0.0266	0.3147	0.7798
Brugia malayi	hypothetical protein	0.0183	0.2033	0.5777
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.007	0.051	0.05
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0328	0.3985	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.007	0.051	0.1427
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0065	0.0153
Loa Loa (eye worm)	hypothetical protein	0.007	0.051	0.1427
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.007	0.051	0.1427
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.016	0.1727	0.3978
Schistosoma mansoni	steroid hormone receptor ad4bp	0.007	0.051	0.05
Trypanosoma brucei	trypanothione reductase	0.0042	0.0137	0.0258
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0328	0.3985	1
Toxoplasma gondii	thioredoxin reductase	0.0042	0.0137	0.0512
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0017	0.0006
Loa Loa (eye worm)	hypothetical protein	0.007	0.051	0.1427
Trypanosoma cruzi	DNA topoisomerase type IB small subunit, putative	0.0052	0.0271	0.0334
Echinococcus granulosus	thioredoxin glutathione reductase	0.0043	0.0145	0.0145
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.007	0.051	0.1427
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.016	0.1727	0.3978
Plasmodium vivax	topoisomerase I, putative	0.0208	0.2372	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0328	0.3985	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.007	0.051	0.051
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.007	0.051	0.051
Onchocerca volvulus	Bile acid receptor homolog	0.007	0.051	0.1592
Brugia malayi	Steroid receptor seven-up type 2	0.007	0.051	0.1427
Brugia malayi	Nuclear hormone receptor-like 1	0.0037	0.0065	0.0153
Brugia malayi	hypothetical protein	0.0037	0.0065	0.0153
Schistosoma mansoni	coup transcription factor	0.007	0.051	0.05
Echinococcus multilocularis	thyroid hormone receptor alpha	0.007	0.051	0.05
Brugia malayi	DNA topoisomerase I	0.0208	0.2372	0.6747
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.007	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0293	0.3511	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.007	0.051	0.1427
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.007	0.051	0.051
Schistosoma mansoni	microtubule-associated protein tau	0.0774	1	1
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.016	0.1724	0.8675
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.007	0.051	0.1427
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.007	0.051	0.05
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.007	0.051	0.05
Brugia malayi	nuclear receptor NHR-88	0.007	0.051	0.1427
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.007	0.051	0.1427
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0108	0.1016	0.4791
Trypanosoma brucei	DNA polymerase IV, putative	0.0046	0.0181	0.0365
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.007	0.051	0.051
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0065	0.0153
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0037	0.0065	0.0153
Echinococcus multilocularis	dna polymerase kappa	0.0046	0.0181	0.017
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.007	0.051	0.05
Echinococcus granulosus	single minded 2	0.004	0.011	0.011
Giardia lamblia	Fructose-bisphosphate aldolase	0.0328	0.3985	0.5
Loa Loa (eye worm)	hypothetical protein	0.007	0.051	0.1427
Mycobacterium ulcerans	DNA polymerase IV	0.0046	0.0181	0.0383
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.007	0.051	0.1427
Brugia malayi	bHLH-PAS transcription factor	0.004	0.011	0.0282
Schistosoma mansoni	DNA topoisomerase type I	0.0156	0.1667	0.1658
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.016	0.1724	0.8655
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0065	0.0153
Schistosoma mansoni	thyroid hormone receptor	0.007	0.051	0.05
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0328	0.3985	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0178	0.1971	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.007	0.051	0.1592

Activities

Activity type	Activity value	Assay description	Source	Reference
Survival (functional)	= 0 %	In vivo activity of compound at 40 mg/kg in 48/80 challenge expressed as number of mice surviving for more than 240 min; 0/2	ChEMBL.	10866399
Survival (functional)	= 0 %	In vivo activity of compound at 10 mg/kg in 48/80 challenge expressed as number of mice surviving for more than 240 min; 0/2	ChEMBL.	10866399
Survival (functional)	= 0 %	In vivo activity of compound at 40 mg/kg in 48/80 challenge expressed as number of mice surviving for more than 240 min; 0/2	ChEMBL.	10866399
Survival (functional)	= 0 %	In vivo activity of compound at 10 mg/kg in 48/80 challenge expressed as number of mice surviving for more than 240 min; 0/2	ChEMBL.	10866399

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL281853

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 29087