Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Alcohol dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | likely Zinc-binding dehydrogenase, one of two genes similar to S. cerevisiae YAL060W and BDH1 (YAL060W) butanediol dehydrogenase | Alcohol dehydrogenase | 374 aa | 366 aa | 24.6 % |
Toxoplasma gondii | quinone oxidoreductase, putative | Alcohol dehydrogenase | 374 aa | 323 aa | 23.8 % |
Trypanosoma cruzi | oxidoreductase, putative | Alcohol dehydrogenase | 374 aa | 318 aa | 20.1 % |
Onchocerca volvulus | Alcohol dehydrogenase | 374 aa | 376 aa | 48.9 % | |
Mycobacterium tuberculosis | Possible dehydrogenase | Alcohol dehydrogenase | 374 aa | 350 aa | 26.0 % |
Onchocerca volvulus | Putative ATP-dependent RNA helicase DDX52 | Alcohol dehydrogenase | 374 aa | 337 aa | 21.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0088 | 0.0311 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0526 | 0.2071 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0011 | 0 | 0.5 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0088 | 0.0311 | 0.1503 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0526 | 0.2071 | 1 |
Leishmania major | NADP-dependent alcohol dehydrogenase, putative | 0.0011 | 0 | 0.5 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0088 | 0.0311 | 0.0311 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0011 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase, putative | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0526 | 0.2071 | 1 |
Leishmania major | zinc binding dehydrogenase-like protein | 0.0011 | 0 | 0.5 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0011 | 0 | 0.5 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0088 | 0.0311 | 1 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0088 | 0.0311 | 1 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0088 | 0.0311 | 1 |
Leishmania major | quinone oxidoreductase, putative | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | tyrosinase precursor | 0.2501 | 1 | 1 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | 0.0526 | 0.2071 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0526 | 0.2071 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0011 | 0 | 0.5 |
Brugia malayi | ShTK domain containing protein | 0.0526 | 0.2071 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0526 | 0.2071 | 1 |
Onchocerca volvulus | 0.0526 | 0.2071 | 1 | |
Wolbachia endosymbiont of Brugia malayi | NADPH:quinone reductase | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 | 0.0078 | 0.0268 | 0.8612 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0526 | 0.2071 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0526 | 0.2071 | 1 |
Onchocerca volvulus | 0.0526 | 0.2071 | 1 | |
Trypanosoma cruzi | oxidoreductase, putative | 0.0011 | 0 | 0.5 |
Brugia malayi | Alcohol dehydrogenase class III | 0.0088 | 0.0311 | 0.1503 |
Onchocerca volvulus | 0.0526 | 0.2071 | 1 | |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0011 | 0 | 0.5 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0088 | 0.0311 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0011 | 0 | 0.5 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0011 | 0 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0526 | 0.2071 | 1 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0088 | 0.0311 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0011 | 0 | 0.5 |
Leishmania major | oxidoreductase, putative | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0011 | 0 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0526 | 0.2071 | 1 |
Mycobacterium tuberculosis | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0078 | 0.0268 | 0.8612 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0011 | 0 | 0.5 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0088 | 0.0311 | 1 |
Trypanosoma brucei | oxidoreductase, putative | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0088 | 0.0311 | 0.1503 |
Leishmania major | d-xylulose reductase, putative | 0.0011 | 0 | 0.5 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0088 | 0.0311 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0526 | 0.2071 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 15 % | In vivo inhibition of ethanol metabolism following 1 mMol/Kg p.o. | ChEMBL. | 6343601 |
Ki (binding) | = 0.01 mM | In vitro inhibition against horse liver alcohol dehydrogenase | ChEMBL. | 6343601 |
Ki (binding) | = 0.01 mM | In vitro inhibition against horse liver alcohol dehydrogenase | ChEMBL. | 6343601 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.