Detailed information for compound 291287

Basic information

Technical information
  • TDR Targets ID: 291287
  • Name: 4-(benzenesulfonamido)-2-[(4-tert-butylbenzoy l)amino]-N-(4-methoxyphenyl)benzamide
  • MW: 557.66 | Formula: C31H31N3O5S
  • H donors: 3 H acceptors: 4 LogP: 6.31 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)NC(=O)c1ccc(cc1NC(=O)c1ccc(cc1)C(C)(C)C)NS(=O)(=O)c1ccccc1
  • InChi: 1S/C31H31N3O5S/c1-31(2,3)22-12-10-21(11-13-22)29(35)33-28-20-24(34-40(37,38)26-8-6-5-7-9-26)16-19-27(28)30(36)32-23-14-17-25(39-4)18-15-23/h5-20,34H,1-4H3,(H,32,36)(H,33,35)
  • InChiKey: UTWGURDRIAPSSN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(benzenesulfonamido)-2-[[(4-tert-butylphenyl)-oxomethyl]amino]-N-(4-methoxyphenyl)benzamide
  • 2-[(4-tert-butylphenyl)carbonylamino]-N-(4-methoxyphenyl)-4-(phenylsulfonylamino)benzamide
  • 2-[(4-tert-butylbenzoyl)amino]-N-(4-methoxyphenyl)-4-(phenylsulfonylamino)benzamide
  • 2-[[(4-tert-butylphenyl)-oxomethyl]amino]-N-(4-methoxyphenyl)-4-(phenylsulfonylamino)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0957 0.1145
Loa Loa (eye worm) hypothetical protein 0.0024 0.0283 0.0343
Echinococcus granulosus General substrate transporter 0.0085 0.1779 0.2141
Brugia malayi GH02984p 0.0348 0.8264 1
Toxoplasma gondii protein kinase, putative 0.0279 0.6554 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0957 0.1145
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0444 0.0643
Plasmodium vivax lysine--tRNA ligase, putative 0.0022 0.0233 0.0201
Echinococcus granulosus high affinity choline transporter 1 0.0348 0.8264 1
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0637 0.0926
Loa Loa (eye worm) sugar transporter 0.0099 0.212 0.2566
Toxoplasma gondii lysine-tRNA ligase 0.0022 0.0233 0.0308
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0022 0.0233 0.395
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0099 0.212 0.2555
Echinococcus granulosus intermediate filament protein 0.0027 0.0356 0.0417
Schistosoma mansoni hypothetical protein 0.0099 0.212 0.2536
Brugia malayi glutaminase DH11.1 0.0274 0.6433 0.7776
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0637 0.0757
Schistosoma mansoni glutaminase 0.0274 0.6433 0.7776
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.016 0.3616 0.5495
Onchocerca volvulus Huntingtin homolog 0.0123 0.2713 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.042 0.0494
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.003 0.0435 0.0512
Echinococcus multilocularis solute carrier family 22 0.0014 0.0033 0.0025
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.042 0.047
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0152 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.003 0.0435 0.0404
Brugia malayi Sugar transporter family protein 0.0099 0.212 0.2536
Schistosoma mansoni protein kinase 0.003 0.0435 0.0489
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0356 0.0393
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0435 0.0628
Brugia malayi Latrophilin receptor protein 2 0.0016 0.008 0.0058
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0444 0.8107
Mycobacterium ulcerans glutaminase 0.0274 0.6433 1
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0637 0.0757
Plasmodium falciparum mitogen-activated protein kinase 2 0.016 0.3616 0.3595
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0019 0.0167 0.0209
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.004
Leishmania major protein kinase, putative 0.003 0.0435 0.7919
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0435 0.0489
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.004
Trypanosoma brucei glucose transporter 2A 0.0031 0.0444 0.8107
Schistosoma mansoni inositol transporter 0.0038 0.0637 0.0734
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.003 0.0435 0.0512
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.004
Schistosoma mansoni lysyl-tRNA synthetase 0.0022 0.0233 0.0244
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0637 0.0757
Brugia malayi hypothetical protein 0.0036 0.0578 0.0663
Onchocerca volvulus 0.0027 0.0356 0.1207
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.003 0.0435 0.0512
Loa Loa (eye worm) hypothetical protein 0.0204 0.4703 0.5691
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0022 0.0233 0.0313
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0444 0.8107
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.003 0.0435 0.0404
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.004
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0033 0.004
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.042 0.0494
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.004
Echinococcus multilocularis GPCR, family 2 0.0016 0.008 0.0082
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.042 0.047
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0099 0.212 0.2555
Entamoeba histolytica hypothetical protein 0.0036 0.0578 1
Onchocerca volvulus 0.0038 0.0637 0.2254
Trichomonas vaginalis glutaminase, putative 0.0274 0.6433 1
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0541 0.051
Echinococcus multilocularis solute carrier family 5 0.0038 0.0637 0.0757
Loa Loa (eye worm) hypothetical protein 0.0348 0.8264 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.003 0.0435 0.0512
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0444 0.0643
Plasmodium falciparum protein kinase 7 0.0279 0.6554 0.6542
Echinococcus multilocularis General substrate transporter 0.0085 0.1779 0.2141
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.017 0.3862 0.4666
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0578 0.0686
Echinococcus granulosus solute carrier family 22 0.0014 0.0033 0.0025
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0033 0.004
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0356 0.0431
Schistosoma mansoni intermediate filament proteins 0.0027 0.0356 0.0393
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0033 0.5
Entamoeba histolytica hypothetical protein 0.0036 0.0578 1
Echinococcus multilocularis lamin 0.0027 0.0356 0.0417
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.003 0.0435 0.0489
Leishmania major glucose transporter, lmgt2 0.0031 0.0444 0.8107
Plasmodium falciparum calcium-dependent protein kinase 5 0.003 0.0435 0.0404
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.003 0.0435 0.0404
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0957 0.1123
Trypanosoma cruzi hexose transporter 0.0031 0.0444 0.8107
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0541 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0099 0.212 0.2555
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0957 0.1123
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.008 0.0082
Schistosoma mansoni high-affinity choline transporter 0.0348 0.8264 1
Onchocerca volvulus Huntingtin homolog 0.0123 0.2713 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.016 0.3616 0.3595
Schistosoma mansoni hypothetical protein 0.0034 0.0532 0.0606
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.042 0.5405
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0541 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.008 0.0058
Loa Loa (eye worm) hypothetical protein 0.0038 0.0637 0.077
Entamoeba histolytica protein kinase, putative 0.003 0.0435 0.5841
Loa Loa (eye worm) hypothetical protein 0.0123 0.2713 0.3283
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0099 0.212 0.2555
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0344 0.0416
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.003 0.0435 0.0512
Schistosoma mansoni hypothetical protein 0.0016 0.008 0.0058
Schistosoma mansoni glucose transport protein 0.0099 0.212 0.2536
Loa Loa (eye worm) hypothetical protein 0.0034 0.0532 0.0643
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.003 0.0435 0.0617
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0637 0.0757
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0444 0.8107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0099 0.212 0.2555
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0444 0.8107
Entamoeba histolytica hypothetical protein 0.0036 0.0578 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0444 0.0643
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.042 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0099 0.212 0.2555
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0444 0.0643
Trypanosoma brucei glucose transporter, putative 0.0031 0.0444 0.8107
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0099 0.212 0.2555
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0444 0.8107
Echinococcus granulosus solute carrier family 5 0.0038 0.0637 0.0757
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0033 0.0025
Loa Loa (eye worm) glutaminase 2 0.0274 0.6433 0.7785
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.212 0.3261
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0033 0.0025
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0103 0.1383
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0047 0.0018
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.042 0.047
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.042 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.003 0.0435 0.0404
Trypanosoma brucei glucose transporter, putative 0.0031 0.0444 0.8107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.004
Loa Loa (eye worm) sugar transporter 0.0014 0.0033 0.004
Loa Loa (eye worm) glutaminase 0.0274 0.6433 0.7785
Leishmania major lysyl-tRNA synthetase, putative 0.0022 0.0233 0.395
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0637 0.0757
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0637 0.0757
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0356 0.0431
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0444 0.8107
Plasmodium vivax CDK-related protein kinase 6, putative 0.0419 1 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0152 1
Schistosoma mansoni glucose transport protein 0.0099 0.212 0.2536
Loa Loa (eye worm) hypothetical protein 0.0016 0.008 0.0097
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.004
Trypanosoma brucei glucose transporter 1E 0.0031 0.0444 0.8107
Schistosoma mansoni glucose transport protein 0.0099 0.212 0.2536
Schistosoma mansoni lysyl-tRNA synthetase 0.0022 0.0233 0.0244
Loa Loa (eye worm) hypothetical protein 0.0123 0.2713 0.3283
Echinococcus granulosus lysyl tRNA synthetase 0.0022 0.0233 0.0268
Giardia lamblia Lysyl-tRNA synthetase 0.0022 0.0233 0.5182
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0921 0.1114
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.004
Leishmania major glucose transporter, lmgt1 0.0031 0.0444 0.8107
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0957 0.1158
Schistosoma mansoni hypothetical protein 0.0036 0.0578 0.0663
Echinococcus granulosus lamin dm0 0.0027 0.0356 0.0417
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0957 0.1123
Schistosoma mansoni protein kinase 0.003 0.0435 0.0489
Schistosoma mansoni inositol transporter 0.0038 0.0637 0.0734
Echinococcus granulosus solute carrier family 22 0.0014 0.0033 0.0025
Brugia malayi hypothetical protein 0.0123 0.2713 0.3256
Trypanosoma brucei glucose transporter, putative 0.0031 0.0444 0.8107
Plasmodium falciparum hexose transporter 0.0099 0.212 0.2094
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0578 0.0686
Loa Loa (eye worm) hypothetical protein 0.003 0.042 0.0508
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.4703 0.5674
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.003 0.0435 0.0404
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0578 0.0663
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0033 0.0025
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.003 0.0435 0.0512
Schistosoma mansoni lamin 0.0027 0.0356 0.0393
Schistosoma mansoni protein kinase 0.003 0.0435 0.0489
Schistosoma mansoni hypothetical protein 0.0016 0.008 0.0058
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.004
Echinococcus granulosus GPCR family 2 0.0016 0.008 0.0082
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0957 0.1145
Plasmodium falciparum lysine--tRNA ligase 0.0022 0.0233 0.0201
Loa Loa (eye worm) hypothetical protein 0.0027 0.0356 0.0431
Echinococcus granulosus solute carrier family 22 0.0014 0.0033 0.0025
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.003 0.0435 0.0512
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.003 0.0435 0.0617
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.042 0.047
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.008 0.0082
Echinococcus multilocularis high affinity choline transporter 1 0.0348 0.8264 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0033 0.0025
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.003 0.0435 0.0512
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0921 0.1079
Echinococcus granulosus lamin 0.0027 0.0356 0.0417
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0444 0.0643
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0033 0.0025
Echinococcus multilocularis solute carrier family 22 0.0014 0.0033 0.0025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.004
Brugia malayi intermediate filament protein 0.0027 0.0356 0.0393
Echinococcus granulosus calcium dependent protein kinase 0.0028 0.0389 0.0457
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0541 1
Brugia malayi lysyl-tRNA synthetase 0.0022 0.0233 0.0244
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0532 0.0606
Schistosoma mansoni hypothetical protein 0.0016 0.008 0.0058
Toxoplasma gondii facilitative glucose transporter GT1 0.0099 0.212 0.3201
Loa Loa (eye worm) hypothetical protein 0.003 0.0435 0.0526
Brugia malayi Cam kinase protein 1 0.003 0.0435 0.0489
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.042 0.0605
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.003 0.0435 0.0526
Plasmodium vivax hexose transporter 0.0099 0.212 0.2094
Trypanosoma brucei glucose transporter, putative 0.0031 0.0444 0.8107
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.008 0.0097
Trypanosoma brucei glucose transporter, putative 0.0031 0.0444 0.8107
Echinococcus multilocularis lamin dm0 0.0027 0.0356 0.0417
Trypanosoma brucei glucose transporter, putative 0.0031 0.0444 0.8107
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0541 0.0779
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0541 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.0444 0.8107
Trypanosoma brucei glucose transporter, putative 0.0031 0.0444 0.8107
Schistosoma mansoni lamin 0.0027 0.0356 0.0393
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.003 0.0435 0.7919
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0541 0.051
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0541 1
Entamoeba histolytica hypothetical protein 0.0036 0.0578 1
Leishmania major glucose transporter, lmgt3 0.0031 0.0444 0.8107
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.017 0.3862 0.4666
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0047 0.0057
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.003 0.0435 0.0617
Loa Loa (eye worm) hypothetical protein 0.003 0.042 0.0508
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0637 0.0734
Echinococcus multilocularis solute carrier family 22 0.0014 0.0033 0.0025
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.003 0.0435 0.0526
Loa Loa (eye worm) hypothetical protein 0.0022 0.0233 0.0282
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0233 0.0313
Entamoeba histolytica protein kinase, putative 0.003 0.0435 0.5841
Echinococcus multilocularis solute carrier family 22 0.0014 0.0033 0.0025
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0444 0.0643
Echinococcus multilocularis lysyl tRNA synthetase 0.0022 0.0233 0.0268
Echinococcus multilocularis musashi 0.0027 0.0356 0.0417
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0957 0.1123
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0957 0.1145
Onchocerca volvulus 0.0027 0.0356 0.1207
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0444 0.0643
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0022 0.0233 0.0313
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0022 0.0233 0.3046
Schistosoma mansoni hypothetical protein 0.0016 0.008 0.0058
Schistosoma mansoni sodium/solute symporter 0.0038 0.0637 0.0734
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0022 0.0233 0.395
Plasmodium falciparum calcium-dependent protein kinase 4 0.003 0.0435 0.0404
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0099 0.212 0.2555
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0444 0.8107
Echinococcus multilocularis calcium dependent protein kinase 0.0028 0.0389 0.0457
Chlamydia trachomatis lysine--tRNA ligase 0.0022 0.0233 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.004
Plasmodium vivax calcium-dependent protein kinase, putative 0.003 0.0435 0.0404
Plasmodium falciparum calcium-dependent protein kinase 3 0.003 0.0435 0.0404
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0637 0.0757

Activities

Activity type Activity value Assay description Source Reference
K ass (binding) = 620000 l M-1 Binding affinity for coagulation factor X as apparent association constant (Kass) derived from protease inhibition kinetics. ChEMBL. 10715154
K ass (binding) = 620000 l M-1 Binding affinity for coagulation factor X as apparent association constant (Kass) derived from protease inhibition kinetics. ChEMBL. 10715154

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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