Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0238 | 0.0438 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1756 | 0.8707 | 0.8648 |
Leishmania major | delta-6 fatty acid desaturase | 0.0238 | 0.0441 | 0.0004 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0238 | 0.0438 | 0.5 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0238 | 0.0438 | 0.5 |
Schistosoma mansoni | fatty acid desaturase | 0.0418 | 0.142 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0123 | 0.0142 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0238 | 0.0441 | 0.0004 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0238 | 0.0438 | 0.0503 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1756 | 0.8703 | 0.5 |
Leishmania major | delta-5 fatty acid desaturase | 0.0417 | 0.1417 | 0.1024 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0238 | 0.0441 | 0.0004 |
Loa Loa (eye worm) | FAT-3 protein | 0.0417 | 0.1417 | 0.1628 |
Brugia malayi | acyl-CoA desaturase | 0.1756 | 0.8703 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.1417 | 0.1628 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0417 | 0.1417 | 0.1628 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0238 | 0.0438 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1756 | 0.8703 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.1994 | 1 | 1 |
Onchocerca volvulus | 0.1993 | 0.9997 | 1 | |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1756 | 0.8703 | 1 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0238 | 0.0438 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1994 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1994 | 1 | 1 |
Brugia malayi | Fatty acid desaturase family protein | 0.0238 | 0.0438 | 0.0503 |
Mycobacterium ulcerans | hypothetical protein | 0.0238 | 0.0441 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0238 | 0.0438 | 0.5 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0238 | 0.0438 | 0.0503 |
Onchocerca volvulus | 0.1993 | 0.9997 | 1 | |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1756 | 0.8707 | 0.8648 |
Brugia malayi | Fatty acid desaturase family protein | 0.0238 | 0.0438 | 0.0503 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0238 | 0.0441 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | = 50 % | Maximum percentage reduction in mean blood pressure in metacorticoid (DOCA) hypertensive rats at a standard oral dose of 100 mg/kg | ChEMBL. | 3361578 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.