Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | amine GPCR | Dopamine D2 receptor | 444 aa | 424 aa | 32.3 % |
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D2 receptor | 444 aa | 479 aa | 22.8 % |
Echinococcus multilocularis | serotonin receptor | Dopamine D2 receptor | 444 aa | 446 aa | 31.8 % |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Dopamine D2 receptor | 444 aa | 489 aa | 24.5 % |
Echinococcus multilocularis | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 465 aa | 21.7 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine D2 receptor | 444 aa | 438 aa | 29.9 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D2 receptor | 444 aa | 432 aa | 30.6 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Dopamine D2 receptor | 444 aa | 386 aa | 19.9 % |
Echinococcus granulosus | alpha 1A adrenergic receptor | Dopamine D2 receptor | 444 aa | 466 aa | 20.2 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D2 receptor | 444 aa | 464 aa | 29.3 % |
Echinococcus granulosus | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 457 aa | 21.7 % |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 417 aa | 23.3 % | |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 464 aa | 27.4 % | |
Schistosoma mansoni | biogenic amine receptor | Dopamine D2 receptor | 444 aa | 455 aa | 29.5 % |
Schistosoma mansoni | biogenic amine (dopamine) receptor | Dopamine D2 receptor | 444 aa | 493 aa | 26.8 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Dopamine D2 receptor | 444 aa | 430 aa | 30.5 % |
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D2 receptor | 444 aa | 456 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | squalene monooxygenase, putative | 0.2708 | 0.5 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.2708 | 0.5 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.2708 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = 91 % | Percent change in serum prolactin in adult male Dawley rats after intraperitoneal administration. | ChEMBL. | 8096548 |
EDmin (functional) | = 20 mg kg-1 | Conditioned avoidance response in rats after oral administration | ChEMBL. | 8096548 |
EDmin (functional) | = 80 mg kg-1 | Compound was tested for the presence of catalepsy (CAT) in rats after oral administration | ChEMBL. | 8096548 |
EDmin (functional) | > 100 mg kg-1 | Tested for the apomorphine climbing behavior in mice after oral administration | ChEMBL. | 8096548 |
EDmin (functional) | > 100 mg kg-1 | Tested for the apomorphine climbing behavior in mice after oral administration | ChEMBL. | 8096548 |
IC50 (binding) | = 3.4 uM | Competition in vitro with the dopamine receptor D2 anatagonist [3H]-spiperone, for binding sites on calf caudate membranes. | ChEMBL. | 8096548 |
IC50 (binding) | = 3.4 uM | Competition in vitro with the dopamine receptor D2 anatagonist [3H]-spiperone, for binding sites on calf caudate membranes. | ChEMBL. | 8096548 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.