Detailed information for compound 310436

Basic information

Technical information
  • TDR Targets ID: 310436
  • Name: N-[2-(4-hydroxyphenyl)-2,3-dihydro-1H-inden-1 -yl]-2,2-diphenylacetamide
  • MW: 419.514 | Formula: C29H25NO2
  • H donors: 2 H acceptors: 2 LogP: 5.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)C1Cc2c(C1NC(=O)C(c1ccccc1)c1ccccc1)cccc2
  • InChi: 1S/C29H25NO2/c31-24-17-15-20(16-18-24)26-19-23-13-7-8-14-25(23)28(26)30-29(32)27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-18,26-28,31H,19H2,(H,30,32)
  • InChiKey: ZPORBGGQIAIHNC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-hydroxyphenyl)indan-1-yl]-2,2-diphenyl-acetamide
  • N-[2-(4-hydroxyphenyl)-1-indanyl]-2,2-diphenylacetamide
  • N-[2-(4-hydroxyphenyl)-2,3-dihydro-1H-inden-1-yl]-2,2-diphenyl-ethanamide
  • N-[2-(4-hydroxyphenyl)-2,3-dihydro-1H-inden-1-yl]-2,2-di(phenyl)acetamide
  • N-[2-(4-hydroxyphenyl)indan-1-yl]-2,2-di(phenyl)acetamide
  • N-[2-(4-hydroxyphenyl)-1-indanyl]-2,2-di(phenyl)acetamide
  • N-[2-(4-hydroxyphenyl)-2,3-dihydro-1H-inden-1-yl]-2,2-di(phenyl)ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Acyl coenzyme A:cholesterol acyltransferase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma japonicum ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus granulosus sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus multilocularis sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma mansoni sterol O-acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum sterol O-acyltransferase, putative Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 21.2 %
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 24.1 %
Dictyostelium discoideum diacylglycerol O-acyltransferase 1 Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 547 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0102 0.0551 0.1066
Onchocerca volvulus 0.0102 0.0551 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0052 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0102 0.0551 0.1066
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0102 0.0551 0.1066
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0973 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0102 0.0551 0.0683
Echinococcus multilocularis g-protein coupled receptor 0.0102 0.0551 0.0683
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Schistosoma mansoni hypothetical protein 0.0102 0.0551 0.1066
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0794 0.8063 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0102 0.0551 0.0683
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0551 0.0683
Echinococcus multilocularis serotonin receptor 0.0102 0.0551 0.0683
Brugia malayi hypothetical protein 0.0102 0.0551 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Entamoeba histolytica fatty acid elongase, putative 0.0126 0.0812 1
Onchocerca volvulus 0.0102 0.0551 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0102 0.0551 0.1066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0052 0 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0102 0.0551 0.1066
Brugia malayi putative neuropeptide receptor NPR1 0.0102 0.0551 1
Echinococcus multilocularis orexin receptor type 2 0.0102 0.0551 0.0683
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus granulosus G protein coupled receptor 139 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0476 0.4609 0.8918
Loa Loa (eye worm) G-protein coupled receptor 0.0102 0.0551 0.1066
Echinococcus granulosus neuropeptide receptor 0.0102 0.0551 0.1066
Leishmania major glycerol uptake protein, putative 0.0052 0 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0102 0.0551 0.1066
Schistosoma mansoni amine GPCR 0.0102 0.0551 0.1066
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0973 1 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0102 0.0551 0.1066
Brugia malayi hypothetical protein 0.0102 0.0551 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0102 0.0551 0.1066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0551 0.1066
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.0551 0.1066
Echinococcus multilocularis neuropeptide receptor 0.0102 0.0551 0.0683
Brugia malayi follicle stimulating hormone receptor 0.0102 0.0551 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0052 0 0.5
Onchocerca volvulus 0.0102 0.0551 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Schistosoma mansoni hypothetical protein 0.0102 0.0551 0.1066
Echinococcus granulosus neuropeptide receptor A26 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Brugia malayi GnHR receptor homolog 0.0102 0.0551 1
Onchocerca volvulus 0.0102 0.0551 1
Schistosoma mansoni biogenic amine receptor 0.0102 0.0551 0.1066
Echinococcus granulosus neuropeptides capa receptor 0.0102 0.0551 0.1066
Echinococcus granulosus sterol O acyltransferase 1 0.0528 0.5168 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0973 1 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0102 0.0551 0.1066
Schistosoma mansoni biogenic amine (5HT) receptor 0.0102 0.0551 0.1066
Brugia malayi hypothetical protein 0.0102 0.0551 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0551 0.0683
Brugia malayi G-protein coupled receptor 0.0102 0.0551 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0102 0.0551 0.0683
Brugia malayi G protein-coupled receptor F59B2.13 0.0102 0.0551 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Brugia malayi Dopamine receptor 0.0102 0.0551 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Schistosoma mansoni opsin-like receptor 0.0102 0.0551 0.1066
Echinococcus granulosus g-protein coupled receptor 0.0102 0.0551 0.1066
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0102 0.0551 0.0683
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0102 0.0551 1
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0052 0 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0102 0.0551 0.0683
Schistosoma mansoni adenoreceptor 0.0102 0.0551 0.1066
Brugia malayi Serotonin receptor 0.0102 0.0551 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0102 0.0551 1
Echinococcus granulosus neuropeptide Y receptor 0.0102 0.0551 0.1066
Schistosoma mansoni alpha-1 adrenergic receptor 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus granulosus orexin receptor type 2 0.0102 0.0551 0.1066
Echinococcus granulosus tm gpcr rhodopsin 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0102 0.0551 0.1066
Schistosoma mansoni myosin xvIII 0.0102 0.0551 0.1066
Schistosoma mansoni neuropeptide receptor 0.0102 0.0551 0.1066
Brugia malayi Dopamine receptor protein 1 0.0102 0.0551 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus multilocularis neuropeptide FF receptor 2 0.0102 0.0551 0.0683
Leishmania major glycerol uptake protein, putative 0.0052 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0102 0.0551 0.1066
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.0551 0.1066
Echinococcus granulosus somatostatin receptor 0.0102 0.0551 0.1066
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0102 0.0551 0.0683
Echinococcus multilocularis fmrfamide receptor 0.0102 0.0551 0.0683
Echinococcus multilocularis fmrfamide receptor 0.0102 0.0551 0.0683
Schistosoma mansoni neuropeptide f receptor 76f 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Trypanosoma cruzi GUP1, putative 0.0052 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Loa Loa (eye worm) TYRA-2 protein 0.0102 0.0551 0.1066
Schistosoma mansoni sterol O-acyltransferase 1 0.0528 0.5168 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus multilocularis sex peptide receptor 0.0102 0.0551 0.0683
Leishmania major hypothetical protein, conserved 0.0052 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0551 0.0683
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.0551 0.1066
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.0551 0.1066
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0973 1 0.5
Leishmania major glycerol uptake protein, putative 0.0052 0 0.5
Entamoeba histolytica fatty acid elongase, putative 0.0126 0.0812 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Onchocerca volvulus 0.0102 0.0551 1
Echinococcus multilocularis neuropeptide receptor 0.0102 0.0551 0.0683
Trichomonas vaginalis conserved hypothetical protein 0.0052 0 0.5
Onchocerca volvulus 0.0102 0.0551 1
Echinococcus multilocularis neuropeptides capa receptor 0.0102 0.0551 0.0683
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0102 0.0551 0.0683
Brugia malayi G protein-coupled receptor 0.0102 0.0551 1
Echinococcus multilocularis somatostatin receptor 0.0102 0.0551 0.0683
Loa Loa (eye worm) hypothetical protein 0.0528 0.5168 1
Brugia malayi hypothetical protein 0.0102 0.0551 1
Schistosoma mansoni hypothetical protein 0.0102 0.0551 0.1066
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0102 0.0551 1
Brugia malayi hypothetical protein 0.0102 0.0551 1
Brugia malayi RE15519p 0.0102 0.0551 1
Trichomonas vaginalis transmembrane protein nessy, putative 0.0052 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0551 0.0683
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0102 0.0551 0.1066
Onchocerca volvulus 0.0102 0.0551 1
Brugia malayi larval opioid receptor 0.0102 0.0551 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus granulosus biogenic amine 5HT receptor 0.0102 0.0551 0.1066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0551 0.0683
Brugia malayi hypothetical protein 0.0102 0.0551 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0102 0.0551 0.1066
Schistosoma mansoni opsin-like receptor 0.0102 0.0551 0.1066
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0102 0.0551 0.0683
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus granulosus neuropeptides capa receptor 0.0102 0.0551 0.1066
Loa Loa (eye worm) neuropeptide F receptor 0.0102 0.0551 0.1066
Onchocerca volvulus 0.0102 0.0551 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Onchocerca volvulus 0.0102 0.0551 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0102 0.0551 1
Brugia malayi Dopamine receptor protein 2 0.0102 0.0551 1
Entamoeba histolytica fatty acid elongase, putative 0.0126 0.0812 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0551 0.1066
Schistosoma mansoni neuropeptide receptor 0.0102 0.0551 0.1066
Brugia malayi G-protein coupled receptor 0.0102 0.0551 1
Schistosoma mansoni hypothetical protein 0.0102 0.0551 0.1066
Onchocerca volvulus 0.0102 0.0551 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus granulosus fmrfamide receptor 0.0102 0.0551 0.1066
Echinococcus multilocularis neuropeptide s receptor 0.0102 0.0551 0.0683
Brugia malayi hypothetical protein 0.0102 0.0551 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Schistosoma mansoni opsin-like receptor 0.0102 0.0551 0.1066
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0973 1 0.5
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0973 1 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0102 0.0551 0.1066
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.0551 0.1066
Echinococcus granulosus neuropeptide receptor 0.0102 0.0551 0.1066
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0102 0.0551 1
Echinococcus granulosus hypothetical protein 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus granulosus g protein coupled receptor 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0551 0.1066
Onchocerca volvulus 0.0102 0.0551 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Schistosoma mansoni amine GPCR 0.0102 0.0551 0.1066
Schistosoma mansoni amine GPCR 0.0102 0.0551 0.1066
Schistosoma mansoni biogenic amine receptor 0.0102 0.0551 0.1066
Brugia malayi hypothetical protein 0.0102 0.0551 1
Brugia malayi sulfakinin receptor protein 0.0102 0.0551 1
Toxoplasma gondii hypothetical protein 0.0052 0 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0102 0.0551 0.0683
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0102 0.0551 0.1066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0551 0.1066
Echinococcus multilocularis serotonin receptor 0.0102 0.0551 0.0683
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0102 0.0551 0.0683
Schistosoma mansoni neuropeptide receptor 0.0102 0.0551 0.1066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0551 0.0683
Brugia malayi neuropeptide F receptor 0.0102 0.0551 1
Echinococcus multilocularis sterol O acyltransferase 1 0.0528 0.5168 0.641
Trypanosoma brucei glycerol uptake protein, putative 0.0052 0 0.5
Leishmania major glycerol uptake protein, putative 0.0052 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0102 0.0551 0.0683
Echinococcus granulosus neuropeptide Y receptor 0.0102 0.0551 0.1066
Brugia malayi Serotonin receptor 0.0102 0.0551 1
Echinococcus granulosus tm gpcr rhodopsin 0.0102 0.0551 0.1066
Trichomonas vaginalis conserved hypothetical protein 0.0052 0 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0102 0.0551 0.1066
Trypanosoma cruzi GUP1, putative 0.0052 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.0551 0.1066
Echinococcus granulosus 7TM GPCR rhodopsin 0.0102 0.0551 0.1066
Onchocerca volvulus 0.0102 0.0551 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0102 0.0551 0.1066
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0102 0.0551 0.1066
Echinococcus multilocularis neuropeptide receptor A26 0.0102 0.0551 0.0683
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0973 1 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Brugia malayi Melatonin receptor type 1A 0.0102 0.0551 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0102 0.0551 0.1066
Onchocerca volvulus Neuropeptide F receptor homolog 0.0102 0.0551 1
Trypanosoma brucei glycerol uptake protein, putative 0.0052 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Brugia malayi ORL1-like opioid receptor 0.0102 0.0551 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus multilocularis neuropeptide Y receptor 0.0102 0.0551 0.0683
Entamoeba histolytica fatty acid elongase, putative 0.0126 0.0812 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0102 0.0551 0.0683
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0102 0.0551 0.0683
Echinococcus granulosus alpha 1A adrenergic receptor 0.0102 0.0551 0.1066
Schistosoma mansoni biogenic amine (5HT) receptor 0.0102 0.0551 0.1066
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0102 0.0551 0.1066
Echinococcus granulosus serotonin receptor 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Brugia malayi neuropeptide F receptor 0.0102 0.0551 1
Loa Loa (eye worm) neuropeptide F receptor 0.0102 0.0551 0.1066
Schistosoma mansoni amine GPCR 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0102 0.0551 0.1066
Trichomonas vaginalis porcupine, putative 0.0052 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0102 0.0551 0.0683
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0551 0.1066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0551 0.1066
Trypanosoma cruzi glycerol uptake protein, putative 0.0052 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus granulosus 7tm_1 domain containing protein 0.0102 0.0551 0.1066
Echinococcus granulosus allatostatin A receptor 0.0102 0.0551 0.1066
Brugia malayi hypothetical protein 0.0102 0.0551 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0102 0.0551 0.1066
Brugia malayi hypothetical protein 0.0102 0.0551 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0102 0.0551 0.1066
Onchocerca volvulus 0.0102 0.0551 1
Brugia malayi putative neuropeptide receptor 0.0102 0.0551 1
Schistosoma mansoni neuropeptide receptor 0.0102 0.0551 0.1066
Schistosoma mansoni amine GPCR 0.0102 0.0551 0.1066
Echinococcus multilocularis G-protein coupled receptor, putative 0.0102 0.0551 0.0683
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0102 0.0551 0.1066
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0102 0.0551 0.1066
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0102 0.0551 0.1066
Schistosoma mansoni histamine h1 receptor 0.0102 0.0551 0.1066
Echinococcus granulosus biogenic amine 5HT receptor 0.0102 0.0551 0.1066
Onchocerca volvulus 0.0102 0.0551 1
Echinococcus multilocularis G protein coupled receptor 139 0.0102 0.0551 0.0683
Echinococcus multilocularis neuropeptides capa receptor 0.0102 0.0551 0.0683
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Schistosoma mansoni neuropeptide F-like receptor 0.0102 0.0551 0.1066
Echinococcus multilocularis neuropeptide Y receptor 0.0102 0.0551 0.0683
Echinococcus granulosus tm gpcr rhodopsin 0.0102 0.0551 0.1066
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.0551 0.1066
Treponema pallidum alginate O-acetylation protein (algI) 0.0052 0 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0102 0.0551 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0102 0.0551 1
Onchocerca volvulus 0.0102 0.0551 1
Echinococcus multilocularis g protein coupled receptor 0.0102 0.0551 0.0683
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus multilocularis allatostatin A receptor 0.0102 0.0551 0.0683
Echinococcus granulosus tachykinin peptides receptor 99D 0.0102 0.0551 0.1066
Echinococcus granulosus neuropeptide FF receptor 2 0.0102 0.0551 0.1066
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.1066
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0102 0.0551 0.1066
Entamoeba histolytica fatty acid elongase, putative 0.0126 0.0812 1
Loa Loa (eye worm) G-protein coupled receptor 0.0102 0.0551 0.1066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0551 0.1066
Echinococcus granulosus neuropeptide s receptor 0.0102 0.0551 0.1066
Echinococcus multilocularis dro:myosuppressin receptor 0.0102 0.0551 0.0683
Leishmania major glycerol uptake protein, putative 0.0052 0 0.5
Echinococcus granulosus sex peptide receptor 0.0102 0.0551 0.1066
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0102 0.0551 0.1066
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0102 0.0551 0.1066
Echinococcus multilocularis g protein coupled receptor 0.0102 0.0551 0.0683
Onchocerca volvulus 0.0102 0.0551 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0551 0.0683
Onchocerca volvulus 0.0102 0.0551 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0102 0.0551 0.0683
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0551 0.0683
Schistosoma mansoni neuropeptide F-like receptor 0.0102 0.0551 0.1066
Brugia malayi AKH receptor 0.0102 0.0551 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.1 uM In vitro inhibitory activity of the compound against Acyl coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes at 10 microM ChEMBL. 8648610
IC50 (binding) = 0.1 uM In vitro inhibitory activity of the compound against Acyl coenzyme A:cholesterol acyltransferase 1 from rat hepatic microsomes at 10 microM ChEMBL. 8648610
Reduction (functional) = -63 % In vivo activity of the compound to reduce liver cholesterol esters (hamster) at 5 mg/kg/day ChEMBL. 8648610
Reduction (functional) = -27 % In vivo activity of the compound to reduce liver cholesterol esters (hamster) at 1 mg/kg/day ChEMBL. 8648610

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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