Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.0271 | 0.0444 | 0.0444 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1037 | 0.7504 | 0.7389 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0271 | 0.0444 | 0.0444 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0271 | 0.0444 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.0271 | 0.0444 | 0.5 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0271 | 0.0444 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0271 | 0.0444 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.1432 | 0.14 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0271 | 0.0444 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0271 | 0.0444 | 0.5 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.1308 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1037 | 0.7504 | 0.7389 |
Loa Loa (eye worm) | hypothetical protein | 0.1037 | 0.7504 | 1 |
Toxoplasma gondii | phosphorylase family protein | 0.0271 | 0.0444 | 0.5 |
Treponema pallidum | pfs protein (pfs) | 0.0271 | 0.0444 | 0.5 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0271 | 0.0444 | 0.5 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.0529 | 0.0089 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.1037 | 0.7504 | 0.7389 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Leishmania major | nucleoside phosphorylase-like protein | 0.0271 | 0.0444 | 0.5 |
Toxoplasma gondii | phosphorylase family protein | 0.0271 | 0.0444 | 0.5 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.1308 | 1 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.0271 | 0.0444 | 0.0444 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.1308 | 1 | 1 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0271 | 0.0444 | 0.5 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.0529 | 0.0089 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.1308 | 1 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.1308 | 1 | 0.5 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0271 | 0.0444 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0271 | 0.0444 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Chlamydia trachomatis | AMP nucleosidase | 0.0271 | 0.0444 | 0.5 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.1432 | 0.1034 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0271 | 0.0444 | 0.5 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0271 | 0.0444 | 0.0444 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0271 | 0.0444 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0271 | 0.0444 | 0.5 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0271 | 0.0444 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0271 | 0.0444 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Trypanosoma brucei | uridine phosphorylase | 0.0271 | 0.0444 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0271 | 0.0444 | 0.0444 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1308 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0271 | 0.0444 | 0.5 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0271 | 0.0444 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0271 | 0.0444 | 0.5 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0271 | 0.0444 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2340 nM | Inhibition of VCAM (vascular cell adhesion molecule) adhesion to alpha4-beta1 integrin of leukocyte cells | ChEMBL. | 10853676 |
IC50 (functional) | = 2340 nM | Inhibition of VCAM (vascular cell adhesion molecule) adhesion to alpha4-beta1 integrin of leukocyte cells | ChEMBL. | 10853676 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.