Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0058 | 0.0046 | 0.1215 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 4.1 G protein, putative homolog | 0.0167 | 0.0376 | 0.742 |
Loa Loa (eye worm) | protein tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0167 | 0.0376 | 0.0376 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0167 | 0.0376 | 0.0376 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0175 | 0.0399 | 0.0399 |
Echinococcus granulosus | Receptor type tyrosine protein phosphatase O | 0.0167 | 0.0376 | 0.0376 |
Plasmodium vivax | serine/threonine protein phosphatase 2B catalytic subunit A, putative | 0.0043 | 0 | 0.5 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0213 | 0.0514 | 0.0514 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | protein-tyrosine-phosphatase | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Brugia malayi | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0167 | 0.0376 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Brugia malayi | Rhodanese-like domain containing protein | 0.0058 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Schistosoma mansoni | receptor protein tyrosine phosphatase n (ia2) | 0.0167 | 0.0376 | 0.0376 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0167 | 0.0376 | 0.0376 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.3225 | 0.9637 | 0.9637 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0213 | 0.0514 | 0.0514 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0167 | 0.0376 | 0.0376 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0167 | 0.0376 | 0.0376 |
Schistosoma mansoni | protein-tyrosine phosphatase non-receptor type nt5 | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Brugia malayi | Dual specificity protein phosphatase CDC14B | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | protein-tyrosine phosphatase 1 | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Toxoplasma gondii | protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0175 | 0.0399 | 0.0399 |
Echinococcus granulosus | Receptor type tyrosine protein phosphatase O | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Brugia malayi | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0167 | 0.0376 | 1 |
Trichomonas vaginalis | pten, drome, putative | 0.0167 | 0.0376 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0167 | 0.0376 | 0.0376 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0219 | 0.0533 | 0.0533 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0058 | 0.0046 | 0.1215 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0167 | 0.0376 | 0.0376 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0167 | 0.0376 | 0.0376 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0219 | 0.0533 | 0.0533 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0058 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0008 | 0.0008 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase H | 0.0167 | 0.0376 | 0.0376 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0167 | 0.0376 | 0.0376 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0219 | 0.0533 | 0.0533 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0058 | 0.0046 | 0.0046 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Echinococcus multilocularis | 0.0167 | 0.0376 | 0.0376 | |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0213 | 0.0514 | 0.0514 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0205 | 0.0491 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0175 | 0.0399 | 0.0399 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0058 | 0.0046 | 0.0046 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0058 | 0.0046 | 0.0046 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0004 | 0.0004 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Trypanosoma brucei | protein tyrosine phosphatase 1 | 0.0167 | 0.0376 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.3345 | 1 | 1 |
Leishmania major | tyrosine specific protein phosphatase, putative | 0.0205 | 0.0491 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0167 | 0.0376 | 0.0376 |
Echinococcus granulosus | protein tyrosine phosphatase n9 | 0.0167 | 0.0376 | 0.0376 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0175 | 0.0399 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Echinococcus multilocularis | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.3233 | 0.966 | 0.966 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0213 | 0.0514 | 0.0514 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0219 | 0.0533 | 0.0533 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Leishmania major | protein-tyrosine phosphatase 1-like protein | 0.0167 | 0.0376 | 0.766 |
Schistosoma mansoni | receptor protein tyrosine phosphatase n (ia2) | 0.0167 | 0.0376 | 0.0376 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Giardia lamblia | Protein tyrosine phosphatase | 0.0167 | 0.0376 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.3345 | 1 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | dual specificity protein phosphatase CDC14B | 0.0167 | 0.0376 | 0.0376 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0219 | 0.0533 | 0.0533 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.3345 | 1 | 1 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0058 | 0.0046 | 0.1215 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0167 | 0.0376 | 0.0376 |
Schistosoma mansoni | receptor protein tyrosine phosphatase r (pcptp1) | 0.0167 | 0.0376 | 0.0376 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0167 | 0.0376 | 0.0376 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0205 | 0.0491 | 1 |
Plasmodium falciparum | serine/threonine protein phosphatase 2B catalytic subunit A | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0213 | 0.0514 | 0.0514 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0167 | 0.0376 | 0.0376 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0175 | 0.0399 | 0.0399 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0219 | 0.0533 | 0.0533 |
Brugia malayi | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0167 | 0.0376 | 0.766 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Brugia malayi | protein-tyrosine phosphatase Lar-like precursor, putative | 0.0205 | 0.0491 | 0.0491 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0205 | 0.0491 | 0.0491 |
Onchocerca volvulus | 0.0205 | 0.0491 | 1 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.3345 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Schistosoma mansoni | rgs-gaip interacting protein gipc | 0.0167 | 0.0376 | 0.0376 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0167 | 0.0376 | 1 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0205 | 0.0491 | 0.0491 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0205 | 0.0491 | 0.0491 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0046 | 0.0046 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.3225 | 0.9637 | 0.9637 |
Brugia malayi | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Brugia malayi | Protein-tyrosine phosphatase 1 | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Schistosoma mansoni | protein-tyrosine phosphatase n9 | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0167 | 0.0376 | 0.0376 |
Brugia malayi | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0032 | 0.0032 |
Echinococcus multilocularis | protein tyrosine phosphatase n9 | 0.0167 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0167 | 0.0376 | 0.742 | |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0167 | 0.0376 | 0.0376 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0175 | 0.0399 | 0.0399 |
Schistosoma mansoni | non-receptor protein-tyrosine phosphatase | 0.0167 | 0.0376 | 0.0376 |
Schistosoma mansoni | pcd6 interacting protein-related | 0.0167 | 0.0376 | 0.0376 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AD50 (functional) | = 3.12 mg kg-1 | Narcotic antagonist activity was measured by rat tail flick procedure after the drug was injected intraperitoneally | ChEMBL. | 7120287 |
ED50 (functional) | = 4.9 mg kg-1 | Analgesic activity by mouse writhing test after subcutaneous injection. | ChEMBL. | 7120287 |
ED50 (functional) | = 4.9 mg kg-1 | Analgesic activity by mouse writhing test after subcutaneous injection. | ChEMBL. | 7120287 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.