Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.1703 | 0.5236 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.3005 | 1 | 1 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.3005 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1703 | 0.5236 | 0.5236 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1703 | 0.5236 | 0.5 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.1703 | 0.5236 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.3005 | 1 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.3005 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.3005 | 1 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.1703 | 0.5236 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.3005 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.3005 | 1 | 1 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.1703 | 0.5236 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.1703 | 0.5236 | 1 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1703 | 0.5236 | 0.5 |
Plasmodium falciparum | polyprenol reductase, putative | 0.1703 | 0.5236 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.3005 | 1 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.3005 | 1 | 1 |
Onchocerca volvulus | 0.1703 | 0.5236 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.3005 | 1 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.1703 | 0.5236 | 0.5 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.1703 | 0.5236 | 1 |
Plasmodium vivax | polyprenol reductase, putative | 0.1703 | 0.5236 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1703 | 0.5236 | 0.5236 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.3005 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 20 uM | Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta | ChEMBL. | 11881998 |
IC50 (binding) | = 20 uM | Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta | ChEMBL. | 11881998 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.