Detailed information for compound 31182

Basic information

Technical information
  • TDR Targets ID: 31182
  • Name: 2,4-diethyl-3-sulfanylidene-1,2,4-thiadiazoli din-5-one
  • MW: 190.286 | Formula: C6H10N2OS2
  • H donors: 0 H acceptors: 1 LogP: 1.36 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1sc(=O)n(c1=S)CC
  • InChi: 1S/C6H10N2OS2/c1-3-7-5(10)8(4-2)11-6(7)9/h3-4H2,1-2H3
  • InChiKey: LDHHNMNHSWWSNP-UHFFFAOYSA-N  

Network

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Synonyms

  • 2,4-diethyl-3-thioxo-1,2,4-thiadiazolidin-5-one
  • Thiadiazolidinone (TDZD) deriv. 21

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni synaptic glycoprotein sc2 related 0.1703 0.5236 1
Echinococcus multilocularis synaptic glycoprotein sc2 0.1703 0.5236 1
Schistosoma mansoni synaptic glycoprotein sc2 related 0.1703 0.5236 1
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1703 0.5236 0.5
Loa Loa (eye worm) hypothetical protein 0.3005 1 1
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.3005 1 0.5
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.3005 1 1
Onchocerca volvulus 0.1703 0.5236 0.5
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.3005 1 1
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.1703 0.5236 1
Echinococcus granulosus synaptic glycoprotein sc2 0.1703 0.5236 1
Plasmodium vivax polyprenol reductase, putative 0.1703 0.5236 0.5
Mycobacterium ulcerans hypothetical protein 0.3005 1 0.5
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.3005 1 1
Entamoeba histolytica steroid 5-alpha reductase, putative 0.3005 1 1
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.3005 1 1
Loa Loa (eye worm) hypothetical protein 0.1703 0.5236 0.5236
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1703 0.5236 0.5
Plasmodium falciparum polyprenol reductase, putative 0.1703 0.5236 0.5
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.3005 1 1
Giardia lamblia Synaptic glycoprotein SC2 0.1703 0.5236 0.5
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.1703 0.5236 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.3005 1 1
Loa Loa (eye worm) hypothetical protein 0.1703 0.5236 0.5236
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.3005 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 20 uM Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta ChEMBL. 11881998
IC50 (binding) = 20 uM Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta ChEMBL. 11881998

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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