Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.3005 | 1 | 0.5 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1703 | 0.5236 | 0.5 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1703 | 0.5236 | 0.5 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.1703 | 0.5236 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.3005 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.3005 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1703 | 0.5236 | 0.5236 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.1703 | 0.5236 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.3005 | 1 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.3005 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.3005 | 1 | 0.5 |
Onchocerca volvulus | 0.1703 | 0.5236 | 0.5 | |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.1703 | 0.5236 | 1 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.3005 | 1 | 1 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.1703 | 0.5236 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1703 | 0.5236 | 0.5236 |
Plasmodium vivax | polyprenol reductase, putative | 0.1703 | 0.5236 | 0.5 |
Plasmodium falciparum | polyprenol reductase, putative | 0.1703 | 0.5236 | 0.5 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.1703 | 0.5236 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.3005 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.3005 | 1 | 1 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.1703 | 0.5236 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3005 | 1 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.1703 | 0.5236 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.3005 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 20 uM | Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta | ChEMBL. | 11881998 |
IC50 (binding) | = 20 uM | Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta | ChEMBL. | 11881998 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.