Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0111 | 0.0481 | 0.0481 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0274 | 0.1507 | 0.1507 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0274 | 0.1507 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1507 | 0.1507 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0111 | 0.0481 | 0.0481 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0274 | 0.1507 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1621 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0274 | 0.1507 | 0.1169 |
Brugia malayi | Carboxylesterase family protein | 0.1621 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0153 | 0.0744 | 0.0377 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0274 | 0.1507 | 1 |
Onchocerca volvulus | 0.0274 | 0.1507 | 1 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0274 | 0.1507 | 0.5 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.0382 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1507 | 0.1507 |
Schistosoma mansoni | acetylcholinesterase | 0.0274 | 0.1507 | 0.1507 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0274 | 0.1507 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0111 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | carboxylesterase | 0.1621 | 1 | 1 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0095 | 0.0382 | 0.0382 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0111 | 0.0481 | 0.0481 |
Schistosoma mansoni | tyrosinase precursor | 0.0528 | 0.3108 | 0.3108 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0744 | 0.0744 |
Brugia malayi | Carboxylesterase family protein | 0.0274 | 0.1507 | 0.1507 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0111 | 0.0481 | 0.0481 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0111 | 0.0481 | 0.0481 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.0382 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0274 | 0.1507 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0528 | 0.3108 | 0.3108 |
Onchocerca volvulus | 0.0274 | 0.1507 | 1 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0102 | 0.0102 |
Echinococcus granulosus | acetylcholinesterase | 0.1621 | 1 | 1 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.0382 | 0.0382 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0153 | 0.0744 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1507 | 0.1507 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.0382 | 0.1566 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0274 | 0.1507 | 0.1169 |
Brugia malayi | Carboxylesterase family protein | 0.0274 | 0.1507 | 0.1507 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0104 | 0.0436 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0744 | 0.0744 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0104 | 0.0436 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0102 | 0.0102 |
Brugia malayi | Carboxylesterase family protein | 0.0274 | 0.1507 | 0.1507 |
Loa Loa (eye worm) | hypothetical protein | 0.1621 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0274 | 0.1507 | 0.1507 |
Onchocerca volvulus | 0.0274 | 0.1507 | 1 | |
Brugia malayi | ShTK domain containing protein | 0.0111 | 0.0481 | 0.0481 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0274 | 0.1507 | 0.1169 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0102 | 0.0102 |
Echinococcus granulosus | muscleblind protein | 0.0153 | 0.0744 | 0.0377 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0111 | 0.0481 | 0.0481 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0274 | 0.1507 | 0.1507 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0095 | 0.0382 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1621 | 1 | 1 |
Onchocerca volvulus | 0.0274 | 0.1507 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1507 | 0.1507 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0111 | 0.0481 | 0.0481 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1621 | 1 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0153 | 0.0744 | 0.0744 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1621 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1621 | 1 | 1 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0104 | 0.0436 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0274 | 0.1507 | 0.1507 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1507 | 0.1507 |
Echinococcus multilocularis | acetylcholinesterase | 0.1621 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0274 | 0.1507 | 0.1169 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0274 | 0.1507 | 0.1169 |
Onchocerca volvulus | 0.0274 | 0.1507 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.1621 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0274 | 0.1507 | 0.1507 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1507 | 0.1507 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0274 | 0.1507 | 0.1507 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1507 | 0.1507 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0095 | 0.0382 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0481 | 0.0481 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0274 | 0.1507 | 0.1507 |
Schistosoma mansoni | gliotactin | 0.0274 | 0.1507 | 0.1507 |
Brugia malayi | hypothetical protein | 0.0274 | 0.1507 | 0.1507 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0104 | 0.0436 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0274 | 0.1507 | 0.1169 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0274 | 0.1507 | 0.1169 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0095 | 0.0382 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1621 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0274 | 0.1507 | 0.1169 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0095 | 0.0382 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0274 | 0.1507 | 0.1507 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.7 uM | Compound was evaluated for inhibition of tyrosinase enzyme. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.