Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Enterococcus faecalis (strain ATCC 700802 / V583) | Beta-ketoacyl-ACP synthase III | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K01641 hydroxymethylglutaryl-CoA synthase [EC2.3.3.10], putative | Beta-ketoacyl-ACP synthase III | 321 aa | 271 aa | 22.1 % |
Mycobacterium tuberculosis | Conserved hypothetical protein | Beta-ketoacyl-ACP synthase III | 321 aa | 310 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0052 | 0.006 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0052 | 0.006 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0052 | 0.006 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0052 | 0.006 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0052 | 0.006 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0052 | 0.006 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0052 | 0.006 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0383 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0383 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0052 | 0.006 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0052 | 0.006 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0383 | 1 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0383 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.495 | Inhibition of Enterococcus faecalis FabH by FabD/FabH coupled assay | ChEMBL. | 17707951 |
IC50 (binding) | = 3.2 uM | Inhibitory concentration against Enterococcus faecalis beta-Ketoacyl-acyl carrier protein synthase III | ChEMBL. | 15743201 |
IC50 (binding) | = 3.2 uM | Inhibitory concentration against Enterococcus faecalis beta-Ketoacyl-acyl carrier protein synthase III | ChEMBL. | 15743201 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.