Detailed information for compound 314270

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 473.567 | Formula: C27H31N5O3
  • H donors: 1 H acceptors: 3 LogP: 4.52 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC1CCCC1)Cn1cnc(c2c1nc(n2)[C@H](COc1ccccc1)C)N
  • InChi: 1S/C27H31N5O3/c1-18(16-34-20-8-4-3-5-9-20)26-30-24-25(28)29-17-32(27(24)31-26)15-19-12-13-22(33-2)23(14-19)35-21-10-6-7-11-21/h3-5,8-9,12-14,17-18,21H,6-7,10-11,15-16,28H2,1-2H3/t18-/m0/s1
  • InChiKey: VPOFCSWPOLRVTI-SFHVURJKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 4B, cAMP-specific Starlite/ChEMBL References
Homo sapiens phosphodiesterase 4C, cAMP-specific References
Homo sapiens phosphodiesterase 4D, cAMP-specific Starlite/ChEMBL References
Homo sapiens phosphodiesterase 4A, cAMP-specific Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) aminopeptidase N 0.0111 0.0732 0.2174
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0111 0.0732 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Onchocerca volvulus 0.0039 0.0168 0.0595
Loa Loa (eye worm) hypothetical protein 0.0072 0.0426 0.1265
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.2386
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0054 0.0289 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0054 0.0289 0.0981
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0039 0.0168 0.0498
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Loa Loa (eye worm) hypothetical protein 0.0072 0.0426 0.1265
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0289 0.2386
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0111 0.0732 0.0732
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0039 0.0168 0.1015
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Mycobacterium ulcerans thymidine phosphorylase 0.1291 1 1
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1245 0.9645 1
Brugia malayi latrophilin 2 splice variant baaae 0.002 0.002 0.0067
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0054 0.0289 0.0981
Brugia malayi Peptidase family M1 containing protein 0.0111 0.0732 0.2489
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0054 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0058
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0111 0.0732 0.0732
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0054 0.0289 0.214
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0054 0.0289 0.214
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0054 0.0289 0.214
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0289 0.2386
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0447 0.3369 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0054 0.0289 0.214
Loa Loa (eye worm) hypothetical protein 0.0054 0.0289 0.0857
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0054 0.0289 0.0857
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0029 0.0093 0.0275
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Leishmania major cAMP-specific phosphodiesterase, putative 0.0054 0.0289 0.214
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.0498
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0054 0.0289 0.214
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0111 0.0732 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0027 0.0074 0.0076
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0072 0.0426 0.0426
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1291 1 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0056 0.0299 0.2332
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0289 0.214
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Brugia malayi Calcitonin receptor-like protein seb-1 0.0029 0.0093 0.0315
Trypanosoma brucei hypothetical protein, conserved 0.0054 0.0289 0.214
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0111 0.0732 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0056 0.0299 0.2332
Leishmania major hypothetical protein, conserved 0.0054 0.0289 0.214
Echinococcus multilocularis muscleblind protein 1 0.0088 0.0554 0.0554
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0027 0.0074 0.0074
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Entamoeba histolytica aminopeptidase, putative 0.0111 0.0732 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.2386
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0054 0.0289 0.0289
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0054 0.0289 0.2386
Brugia malayi Peptidase family M1 containing protein 0.0377 0.282 0.9583
Echinococcus multilocularis muscleblind protein 0.0088 0.0554 0.0554
Plasmodium falciparum phosphodiesterase delta, putative 0.0054 0.0289 1
Loa Loa (eye worm) hypothetical protein 0.0266 0.1949 0.5785
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0289 0.214
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0111 0.0732 0.0732
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0054 0.0289 0.0299
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0056 0.0299 0.0889
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0054 0.0289 0.0289
Echinococcus granulosus leukotriene A 4 hydrolase 0.0039 0.0168 0.0168
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0111 0.0732 0.7423
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0289 0.214
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0054 0.0289 0.214
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0289 0.214
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.2386
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0027 0.0074 0.0219
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0054 0.0289 0.0299
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0054 0.0289 0.0289
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0054 0.0289 0.0299
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0054 0.0289 0.0981
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.2386
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0275
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0029 0.0093 0.0315
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0027 0.0074 0.0076
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Trypanosoma cruzi aminopeptidase, putative 0.0111 0.0732 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.214
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0054 0.0289 0.0289
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0054 0.0289 0.2386
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0054 0.0289 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0111 0.0732 0.0732
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0039 0.0168 0.0174
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0299 0.2509
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0111 0.0732 0.7423
Trypanosoma brucei Aminopeptidase M1, putative 0.0111 0.0732 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0111 0.0732 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 1
Mycobacterium ulcerans aminopeptidase N PepN 0.0111 0.0732 0.0574
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0027 0.0074 0.0074
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0392 0.2942 0.2942
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0111 0.0732 0.0732
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0299 0.2509
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0168 0.0168
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0039 0.0168 0.0168
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.2386
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0054 0.0289 0.0981
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0299 0.2509
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Loa Loa (eye worm) hypothetical protein 0.0054 0.0289 0.0857
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.2386
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0289 0.2386
Loa Loa (eye worm) hypothetical protein 0.0054 0.0289 0.0857
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0299 0.031
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0056 0.0299 0.0299
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0054 0.0289 0.0289
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0299 0.2509
Echinococcus multilocularis thymidine phosphorylase 0.1291 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0289 0.214
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0054 0.0289 0.0289
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0027 0.0074 0.0074
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.2386
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0054 0.0289 0.0289
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0392 0.2942 0.8733
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Echinococcus granulosus muscleblind protein 0.0088 0.0554 0.0554
Loa Loa (eye worm) hypothetical protein 0.0447 0.3369 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0027 0.0074 0.025
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.0498
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0111 0.0732 0.0759
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0054 0.0289 0.214
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0054 0.0289 0.0299
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0111 0.0732 0.0759
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0478 0.362 0.362
Leishmania major hypothetical protein, conserved 0.0054 0.0289 0.214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0027 0.0074 0.0076
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.0498
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0364 0.2723 0.5
Brugia malayi serine/threonine-protein kinase plk-2 0.0056 0.0299 0.1018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0123 0.0826 0.2452
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0447 0.3369 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0111 0.0732 0.0732
Giardia lamblia Kinase, PLK 0.0056 0.0299 0.0035
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0054 0.0289 0.214
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0111 0.0732 0.0732
Loa Loa (eye worm) hypothetical protein 0.0088 0.0554 0.1644
Loa Loa (eye worm) peptidase family M1 containing protein 0.0305 0.2255 0.6693
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.2386
Toxoplasma gondii aminopeptidase N, putative 0.0039 0.0168 0.0498
Plasmodium vivax phosphodiesterase gamma, putative 0.0054 0.0289 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0056 0.0299 0.0299
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0054 0.0289 0.214
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0447 0.3369 0.3369
Onchocerca volvulus 0.014 0.096 0.3403
Loa Loa (eye worm) TATA binding protein associated factor 0.0039 0.0168 0.0498
Plasmodium falciparum phosphodiesterase gamma, putative 0.0054 0.0289 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0054 0.0289 0.214
Echinococcus granulosus aminopeptidase N 0.0377 0.282 0.282
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0111 0.0732 0.0732
Brugia malayi Muscleblind-like protein 0.0088 0.0554 0.1883
Trypanosoma cruzi polo-like protein kinase, putative 0.0056 0.0299 0.2332
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0054 0.0289 0.0289
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0111 0.0732 0.0732
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0054 0.0289 0.0289
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.2386
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0039 0.0168 0.0174
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0447 0.3369 0.3369
Schistosoma mansoni kinase 0.0028 0.0084 0.0087
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0299 0.2509
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0054 0.0289 0.0289
Brugia malayi Pre-SET motif family protein 0.0123 0.0826 0.2808
Trypanosoma brucei Aminopeptidase M1, putative 0.0111 0.0732 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0226 0.164 0.1701
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0027 0.0074 0.0074
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0054 0.0289 0.0981
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0054 0.0289 0.0981
Toxoplasma gondii aminopeptidase N protein 0.0039 0.0168 0.0498
Toxoplasma gondii aminopeptidase n, putative 0.0039 0.0168 0.0498
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0072 0.0426 0.0442
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0039 0.0168 0.5814
Brugia malayi hypothetical protein 0.0111 0.0732 0.2489
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0111 0.0732 0.0732
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0054 0.0289 0.214
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0168 0.0168
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0039 0.0168 0.5814
Schistosoma mansoni aminopeptidase A (M01 family) 0.0039 0.0168 0.0174
Trypanosoma brucei polo-like protein kinase 0.0056 0.0299 0.2332
Loa Loa (eye worm) hypothetical protein 0.0338 0.2514 0.746
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.214
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0072 0.0426 0.4578
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0111 0.0732 1
Echinococcus multilocularis aminopeptidase N 0.0377 0.282 0.282
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.2386
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0289 0.0857
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0054 0.0289 0.2386
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Onchocerca volvulus 0.0111 0.0732 0.2597
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0392 0.2942 0.2942
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0054 0.0289 0.0299
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0447 0.3369 0.3369
Brugia malayi TATA binding protein associated factor 0.0039 0.0168 0.057
Onchocerca volvulus Serine\/threonine kinase homolog 0.0056 0.0299 0.1062
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0299 0.2509
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0447 0.3369 0.3493
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0054 0.0289 0.214
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0054 0.0289 0.0289
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0447 0.3369 0.3369
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0054 0.0289 0.0299
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.2386
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.2386
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.2386
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0289 0.214
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 0.2386
Brugia malayi Peptidase family M1 containing protein 0.0039 0.0168 0.057
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0054 0.0289 0.214
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0054 0.0289 0.0299
Loa Loa (eye worm) PDE1B protein 0.0054 0.0289 0.0857
Schistosoma mansoni hypothetical protein 0.002 0.002 0.002
Onchocerca volvulus 0.0377 0.282 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0054 0.0289 0.0299
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Brugia malayi hypothetical protein 0.0039 0.0168 0.057
Loa Loa (eye worm) hypothetical protein 0.0088 0.0554 0.1644
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0054 0.0289 0.0299
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0392 0.2942 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0054 0.0289 0.0299
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0054 0.0289 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0299 0.2509
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0289 0.2386
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0364 0.2723 0.2599
Trichomonas vaginalis set domain proteins, putative 0.014 0.096 1

Activities

Activity type Activity value Assay description Source Reference
Effect (binding) Inhibition of [3H]-cAMP binding to human phosphodiesterase 3 at 30 uM; Inactive ChEMBL. 15715490
Effect (binding) Inhibition of [3H]-cGMP binding to human Phosphodiesterase 5 at 30 uM; Inactive ChEMBL. 15715490
Effect (binding) 0 Inhibition of [3H]-cGMP binding to human Phosphodiesterase 5 at 30 uM; Inactive ChEMBL. 15715490
Effect (binding) 0 Inhibition of [3H]-cAMP binding to human phosphodiesterase 3 at 30 uM; Inactive ChEMBL. 15715490
Ki (binding) = 533 nM Inhibition of [3H]-cAMP binding to recombinant human Phosphodiesterase 4BL (PDE4BL) in baculovirus expression system ChEMBL. 15715490
Ki (binding) = 533 nM Inhibition of [3H]-cAMP binding to recombinant human Phosphodiesterase 4BL (PDE4BL) in baculovirus expression system ChEMBL. 15715490
Ki (binding) = 590 nM Inhibition of [3H]-cAMP binding to recombinant human Phosphodiesterase 4D5 (PDE4D5) in baculovirus expression system ChEMBL. 15715490
Ki (binding) = 590 nM Inhibition of [3H]-cAMP binding to recombinant human Phosphodiesterase 4D5 (PDE4D5) in baculovirus expression system ChEMBL. 15715490
Ki (binding) = 640 nM Inhibition of [3H]-cAMP binding to recombinant human Phosphodiesterase 4D3 (PDE4D3) in baculovirus expression system ChEMBL. 15715490
Ki (binding) = 640 nM Inhibition of [3H]-cAMP binding to recombinant human Phosphodiesterase 4D3 (PDE4D3) in baculovirus expression system ChEMBL. 15715490
Ki (binding) = 1210 nM Inhibition of [3H]-cAMP binding to human lung Phosphodiesterase 4 ChEMBL. 15715490
Ki (binding) = 1210 nM Inhibition of [3H]-cAMP binding to human lung Phosphodiesterase 4 ChEMBL. 15715490
Ki (binding) = 4450 nM Inhibition of [3H]-cAMP binding to recombinant human Phosphodiesterase 4DE (PDE4DE) in baculovirus expression system ChEMBL. 15715490
Ki (binding) = 4450 nM Inhibition of [3H]-cAMP binding to recombinant human Phosphodiesterase 4DE (PDE4DE) in baculovirus expression system ChEMBL. 15715490
Ki (binding) = 15200 nM Inhibition of [3H]-cAMP binding to recombinant human Phosphodiesterase 4AL (PDE4AL) in baculovirus expression system ChEMBL. 15715490
Ki (binding) = 15200 nM Inhibition of [3H]-cAMP binding to recombinant human Phosphodiesterase 4AL (PDE4AL) in baculovirus expression system ChEMBL. 15715490

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.