TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 274.32 | Formula: C17H14N4
H donors: 1 H acceptors: 3 LogP: 2.51 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Nc1nc(c2ccccn2)c2c(n1)c1cc(C)ccc1C2
InChi: 1S/C17H14N4/c1-10-5-6-11-9-13-15(12(11)8-10)20-17(18)21-16(13)14-4-2-3-7-19-14/h2-8H,9H2,1H3,(H2,18,20,21)
InChiKey: FTBBRVLBUQCRRS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0283	0.1015	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0169	0.052	0.0496
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0169	0.052	0.0496
Brugia malayi	putative neuropeptide receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Brugia malayi	hypothetical protein	0.006	0.0046	0.002
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0169	0.052	0.0496
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.052	0.0496
Loa Loa (eye worm)	amidase	0.0283	0.1015	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0169	0.052	0.0496
Onchocerca volvulus		0.144	0.6064	1
Trypanosoma cruzi	amidase, putative	0.0283	0.1015	0.1639
Brugia malayi	sulfakinin receptor protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.002
Brugia malayi	Dopamine receptor protein 2	0.0169	0.052	0.0496
Echinococcus granulosus	neuropeptide receptor	0.0169	0.052	0.0496
Echinococcus granulosus	neuropeptides capa receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.052	0.0496
Loa Loa (eye worm)	neuropeptide F receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.052	0.0496
Trypanosoma cruzi	amidase, putative	0.0283	0.1015	0.1639
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0283	0.1015	0.4854
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.002
Onchocerca volvulus		0.0169	0.052	0.0819
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0283	0.1015	0.0992
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Echinococcus multilocularis	neuropeptide s receptor	0.0169	0.052	0.0496
Brugia malayi	hypothetical protein	0.0169	0.052	0.0496
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0169	0.052	0.0496
Brugia malayi	putative amidase	0.0283	0.1015	0.0992
Onchocerca volvulus		0.006	0.0046	0.0034
Onchocerca volvulus		0.006	0.0046	0.0034
Brugia malayi	G-protein coupled receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	TYRA-2 protein	0.0169	0.052	0.0496
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	carboxylesterase	0.006	0.0046	0.002
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Brugia malayi	Carboxylesterase family protein	0.006	0.0046	0.002
Echinococcus granulosus	carboxylesterase 5A	0.006	0.0046	0.002
Echinococcus granulosus	g protein coupled receptor	0.0169	0.052	0.0496
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Echinococcus multilocularis	g-protein coupled receptor	0.0169	0.052	0.0496
Schistosoma mansoni	histamine h1 receptor	0.0169	0.052	0.0496
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.052	0.0496
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0283	0.1015	0.5
Schistosoma mansoni	neuroligin 3 (S09 family)	0.006	0.0046	0.002
Echinococcus granulosus	neuroligin	0.006	0.0046	0.002
Schistosoma mansoni	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0169	0.052	0.0496
Echinococcus granulosus	fatty acid amide hydrolase 1	0.2342	1	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0169	0.052	0.0496
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0169	0.052	0.0496
Brugia malayi	RE15519p	0.0169	0.052	0.0496
Echinococcus multilocularis	neuropeptide receptor A26	0.0169	0.052	0.0496
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0283	0.1015	0.0992
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0169	0.052	0.0496
Echinococcus granulosus	serotonin transporter	0.0257	0.0904	0.0881
Echinococcus multilocularis	BC026374 protein (S09 family)	0.006	0.0046	0.002
Loa Loa (eye worm)	hypothetical protein	0.2342	1	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Echinococcus multilocularis	g protein coupled receptor	0.0169	0.052	0.0496
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.052	0.0496
Echinococcus multilocularis	neuropeptide Y receptor	0.0169	0.052	0.0496
Trichomonas vaginalis	lipase containing protein, putative	0.144	0.6064	1
Mycobacterium leprae	PROBABLE AMIDASE AMIC (AMINOHYDROLASE)	0.0283	0.1015	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.052	0.0496
Echinococcus granulosus	acetylcholinesterase	0.006	0.0046	0.002
Brugia malayi	hypothetical protein	0.0169	0.052	0.0496
Echinococcus granulosus	g protein coupled receptor	0.0169	0.052	0.0496
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.052	0.0496
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0169	0.052	0.0496
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0169	0.052	0.0496
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0169	0.052	0.0496
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0283	0.1015	0.5
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0169	0.052	0.0496
Echinococcus granulosus	serotonin receptor	0.0169	0.052	0.0496
Brugia malayi	G protein-coupled receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Schistosoma mansoni	myosin xvIII	0.0169	0.052	0.0496
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0169	0.052	0.0496
Brugia malayi	Lipase family protein	0.144	0.6064	0.6054
Schistosoma mansoni	growth hormone secretagogue receptor	0.0169	0.052	0.0496
Brugia malayi	hypothetical protein	0.0169	0.052	0.0496
Echinococcus multilocularis	neuropeptide receptor	0.0169	0.052	0.0496
Brugia malayi	neuropeptide F receptor	0.0169	0.052	0.0496
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.052	0.0496
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.002
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.006	0.0046	0.002
Echinococcus multilocularis	acetylcholinesterase	0.006	0.0046	0.002
Brugia malayi	Dopamine receptor protein 1	0.0169	0.052	0.0496
Onchocerca volvulus		0.0169	0.052	0.0819
Brugia malayi	putative neuropeptide receptor NPR1	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0257	0.0904	0.0881
Loa Loa (eye worm)	neuropeptide F receptor	0.0169	0.052	0.0496
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.052	0.0496
Echinococcus multilocularis	neuropeptides capa receptor	0.0169	0.052	0.0496
Onchocerca volvulus		0.0169	0.052	0.0819
Schistosoma mansoni	opsin-like receptor	0.0169	0.052	0.0496
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.2342	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0169	0.052	0.0496
Brugia malayi	Melatonin receptor type 1A	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.192	0.8156	0.8152
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0169	0.052	0.0496
Echinococcus granulosus	7tm_1 domain containing protein	0.0169	0.052	0.0496
Onchocerca volvulus		0.006	0.0046	0.0034
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0169	0.052	0.0496
Trypanosoma cruzi	hypothetical protein, conserved	0.144	0.6064	1
Schistosoma mansoni	biogenic amine receptor	0.0169	0.052	0.0496
Schistosoma mansoni	amine GPCR	0.0169	0.052	0.0496
Brugia malayi	hypothetical protein	0.0169	0.052	0.0496
Onchocerca volvulus		0.0169	0.052	0.0819
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0283	0.1015	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0169	0.052	0.0496
Brugia malayi	hypothetical protein	0.0169	0.052	0.0496
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0169	0.052	0.0496
Brugia malayi	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0169	0.052	0.0819
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Schistosoma mansoni	fatty-acid amide hydrolase	0.0283	0.1015	0.0992
Brugia malayi	Carboxylesterase family protein	0.006	0.0046	0.002
Schistosoma mansoni	hypothetical protein	0.0169	0.052	0.0496
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0169	0.052	0.0496
Onchocerca volvulus		0.0257	0.0904	0.1456
Schistosoma mansoni	neuropeptide receptor	0.0169	0.052	0.0496
Schistosoma mansoni	amine GPCR	0.0169	0.052	0.0496
Echinococcus multilocularis	somatostatin receptor	0.0169	0.052	0.0496
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0283	0.1015	0.1639
Echinococcus granulosus	neuropeptide s receptor	0.0169	0.052	0.0496
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.006	0.0046	0.002
Echinococcus granulosus	biogenic amine 5HT receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	G-protein coupled receptor	0.0169	0.052	0.0496
Onchocerca volvulus		0.0169	0.052	0.0819
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0169	0.052	0.0496
Schistosoma mansoni	fatty-acid amide hydrolase	0.2342	1	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Trypanosoma brucei	lipase domain protein, putative	0.144	0.6064	1
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0283	0.1015	0.0992
Echinococcus granulosus	g-protein coupled receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0283	0.1015	0.4854
Echinococcus granulosus	sex peptide receptor	0.0169	0.052	0.0496
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0169	0.052	0.0496
Loa Loa (eye worm)	acetylcholinesterase 1	0.006	0.0046	0.002
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Schistosoma mansoni	neuropeptide receptor	0.0169	0.052	0.0496
Echinococcus multilocularis	sex peptide receptor	0.0169	0.052	0.0496
Echinococcus multilocularis	para nitrobenzyl esterase	0.006	0.0046	0.002
Echinococcus granulosus	BC026374 protein S09 family	0.006	0.0046	0.002
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0169	0.052	0.0496
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.052	0.0496
Schistosoma mansoni	biogenic amine receptor	0.0169	0.052	0.0496
Onchocerca volvulus		0.0169	0.052	0.0819
Loa Loa (eye worm)	hypothetical protein	0.0257	0.0904	0.0881
Echinococcus granulosus	allatostatin A receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0169	0.052	0.0496
Echinococcus granulosus	sn1 specific diacylglycerol lipase beta	0.144	0.6064	0.6054
Echinococcus granulosus	somatostatin receptor	0.0169	0.052	0.0496
Echinococcus multilocularis	serotonin transporter	0.0257	0.0904	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Echinococcus granulosus	para nitrobenzyl esterase	0.006	0.0046	0.002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.052	0.0496
Schistosoma mansoni	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Schistosoma mansoni	adenoreceptor	0.0169	0.052	0.0496
Echinococcus multilocularis	neuroligin	0.006	0.0046	0.002
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0169	0.052	0.0496
Echinococcus multilocularis	g protein coupled receptor	0.0169	0.052	0.0496
Onchocerca volvulus		0.0169	0.052	0.0819
Echinococcus multilocularis	g protein coupled receptor	0.0169	0.052	0.0496
Brugia malayi	Carboxylesterase family protein	0.006	0.0046	0.002
Echinococcus multilocularis	serotonin receptor	0.192	0.8156	0.8152
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0169	0.052	0.0496
Brugia malayi	Amidase family protein	0.0283	0.1015	0.0992
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Leishmania major	hypothetical protein, conserved	0.144	0.6064	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0169	0.052	0.0496
Brugia malayi	ORL1-like opioid receptor	0.0169	0.052	0.0496
Echinococcus granulosus	fatty acid amide hydrolase 1	0.2342	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0169	0.052	0.0496
Echinococcus multilocularis	neuropeptide receptor	0.0169	0.052	0.0496
Echinococcus granulosus	neuropeptide FF receptor 2	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	carboxylesterase	0.006	0.0046	0.002
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0283	0.1015	0.0992
Echinococcus multilocularis	fmrfamide receptor	0.0169	0.052	0.0496
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0169	0.052	0.0496
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.006	0.0046	0.002
Schistosoma mansoni	BC026374 protein (S09 family)	0.006	0.0046	0.002
Schistosoma mansoni	gliotactin	0.006	0.0046	0.002
Echinococcus granulosus	neuropeptides capa receptor	0.0169	0.052	0.0496
Echinococcus granulosus	tm gpcr rhodopsin	0.0169	0.052	0.0496
Echinococcus granulosus	G protein coupled receptor 139	0.0169	0.052	0.0496
Brugia malayi	larval opioid receptor	0.0169	0.052	0.0496
Echinococcus granulosus	rhodopsin orphan GPCR	0.0169	0.052	0.0496
Echinococcus granulosus	rhodopsin orphan GPCR	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Brugia malayi	neuropeptide F receptor	0.0169	0.052	0.0496
Brugia malayi	Serotonin receptor	0.0169	0.052	0.0496
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.052	0.0496
Schistosoma mansoni	biogenic amine receptor	0.0169	0.052	0.0496
Echinococcus granulosus	dro:myosuppressin receptor	0.0169	0.052	0.0496
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0169	0.052	0.0496
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.006	0.0046	0.0219
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.052	0.0496
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0169	0.052	0.0496
Brugia malayi	hypothetical protein	0.0169	0.052	0.0496
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.006	0.0046	0.002
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Schistosoma mansoni	neuropeptide receptor	0.0169	0.052	0.0496
Brugia malayi	hypothetical protein	0.0169	0.052	0.0496
Schistosoma mansoni	acetylcholinesterase	0.006	0.0046	0.002
Loa Loa (eye worm)	serotonin transporter b	0.0257	0.0904	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Mycobacterium leprae	PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A)	0.0283	0.1015	0.5
Schistosoma mansoni	sodium/chloride dependent transporter	0.0257	0.0904	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Onchocerca volvulus		0.006	0.0046	0.0034
Echinococcus granulosus	7TM GPCR rhodopsin	0.0169	0.052	0.0496
Echinococcus multilocularis	G protein coupled receptor 139	0.0169	0.052	0.0496
Brugia malayi	follicle stimulating hormone receptor	0.0169	0.052	0.0496
Echinococcus multilocularis	serotonin receptor	0.192	0.8156	0.8152
Echinococcus multilocularis	neuropeptides capa receptor	0.0169	0.052	0.0496
Onchocerca volvulus		0.0169	0.052	0.0819
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0283	0.1015	0.4854
Schistosoma mansoni	opsin-like receptor	0.0169	0.052	0.0496
Echinococcus granulosus	orexin receptor type 2	0.0169	0.052	0.0496
Loa Loa (eye worm)	G-protein coupled receptor	0.0169	0.052	0.0496
Schistosoma mansoni	neuropeptide F-like receptor	0.0169	0.052	0.0496
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0529	0.2091	1
Echinococcus multilocularis	orexin receptor type 2	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Schistosoma mansoni	amine GPCR	0.0169	0.052	0.0496
Brugia malayi	Serotonin receptor	0.0169	0.052	0.0496
Echinococcus granulosus	g protein coupled receptor	0.0169	0.052	0.0496
Echinococcus multilocularis	acetylcholinesterase	0.006	0.0046	0.002
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0283	0.1015	0.5
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0169	0.052	0.0496
Onchocerca volvulus		0.0169	0.052	0.0819
Echinococcus multilocularis	fmrfamide receptor	0.0169	0.052	0.0496
Onchocerca volvulus		0.0169	0.052	0.0819
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0257	0.0904	0.0881
Echinococcus granulosus	acetylcholinesterase	0.006	0.0046	0.002
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0169	0.052	0.0819
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0169	0.052	0.0496
Brugia malayi	Amidase family protein	0.0283	0.1015	0.0992
Brugia malayi	G-protein coupled receptor	0.0169	0.052	0.0496
Echinococcus granulosus	fmrfamide receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	amidase	0.0283	0.1015	0.0992
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0169	0.052	0.0496
Toxoplasma gondii	prolyl endopeptidase	0.0056	0.0025	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0169	0.052	0.0496
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0169	0.052	0.0496
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.2342	1	1
Leishmania major	hypothetical protein, conserved	0.0283	0.1015	0.1639
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.002
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	carboxylesterase	0.006	0.0046	0.002
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Brugia malayi	Dopamine receptor	0.0169	0.052	0.0496
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.052	0.0496
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0283	0.1015	0.0992
Onchocerca volvulus		0.006	0.0046	0.0034
Echinococcus granulosus	tm gpcr rhodopsin	0.0169	0.052	0.0496
Loa Loa (eye worm)	norepinephrine transporter	0.0257	0.0904	0.0881
Loa Loa (eye worm)	melatonin receptor type 1A	0.0169	0.052	0.0496
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0169	0.052	0.0496
Echinococcus multilocularis	dro:myosuppressin receptor	0.0169	0.052	0.0496
Brugia malayi	Carboxylesterase family protein	0.006	0.0046	0.002
Brugia malayi	AKH receptor	0.0169	0.052	0.0496
Schistosoma mansoni	opsin-like receptor	0.0169	0.052	0.0496
Brugia malayi	hypothetical protein	0.0169	0.052	0.0496
Brugia malayi	hypothetical protein	0.0169	0.052	0.0496
Brugia malayi	G protein-coupled receptor F59B2.13	0.0169	0.052	0.0496
Loa Loa (eye worm)	lipase	0.144	0.6064	0.6054
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Trichomonas vaginalis	lipase containing protein, putative	0.144	0.6064	1
Echinococcus granulosus	neuropeptide Y receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.002
Schistosoma mansoni	amidase	0.2342	1	1
Echinococcus granulosus	neuropeptide receptor	0.0169	0.052	0.0496
Brugia malayi	Carboxylesterase family protein	0.006	0.0046	0.002
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0169	0.052	0.0496
Echinococcus multilocularis	carboxylesterase 5A	0.006	0.0046	0.002
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0257	0.0904	0.0881
Echinococcus granulosus	biogenic amine 5HT receptor	0.192	0.8156	0.8152
Echinococcus granulosus	neuropeptide receptor A26	0.0169	0.052	0.0496
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.006	0.0046	0.0219
Echinococcus granulosus	rhodopsin orphan GPCR	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Echinococcus granulosus	rhodopsin orphan GPCR	0.0169	0.052	0.0496
Echinococcus granulosus	neuropeptide Y receptor	0.0169	0.052	0.0496
Schistosoma mansoni	neuropeptide f receptor 76f	0.0169	0.052	0.0496
Echinococcus granulosus	tm gpcr rhodopsin	0.0169	0.052	0.0496
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0283	0.1015	0.4854
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0257	0.0904	0.0881
Echinococcus granulosus	rhodopsin orphan GPCR	0.0169	0.052	0.0496
Echinococcus multilocularis	sn1 specific diacylglycerol lipase beta	0.144	0.6064	0.6054
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.002
Schistosoma mansoni	neuropeptide receptor	0.0169	0.052	0.0496
Onchocerca volvulus		0.0169	0.052	0.0819
Onchocerca volvulus		0.0169	0.052	0.0819
Schistosoma mansoni	neuropeptide F-like receptor	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Schistosoma mansoni	amine GPCR	0.0169	0.052	0.0496
Onchocerca volvulus		0.0169	0.052	0.0819
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.006	0.0046	0.002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0169	0.052	0.0496
Onchocerca volvulus		0.0169	0.052	0.0819
Schistosoma mansoni	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Mycobacterium ulcerans	carboxylesterase, LipT	0.0529	0.2091	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Echinococcus granulosus	rhodopsin orphan GPCR	0.0169	0.052	0.0496
Brugia malayi	GnHR receptor homolog	0.0169	0.052	0.0496
Onchocerca volvulus		0.0169	0.052	0.0819
Trypanosoma cruzi	hypothetical protein, conserved	0.144	0.6064	1
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0283	0.1015	0.4854
Trypanosoma brucei	lipase domain protein, putative	0.144	0.6064	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0169	0.052	0.0496
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.006	0.0046	0.002
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.002
Echinococcus granulosus	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.002
Onchocerca volvulus		0.0169	0.052	0.0819
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0169	0.052	0.0496
Brugia malayi	Carboxylesterase family protein	0.006	0.0046	0.002
Loa Loa (eye worm)	hypothetical protein	0.192	0.8156	0.8152
Onchocerca volvulus		0.0169	0.052	0.0819
Schistosoma mansoni	biogenic amine (5HT) receptor	0.192	0.8156	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0169	0.052	0.0496
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0257	0.0904	0.0881
Schistosoma mansoni	amine GPCR	0.0169	0.052	0.0496
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0169	0.052	0.0496

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 154.2 nM	Inhibition constant against Adenosine A2a receptor	ChEMBL.	15713381
Ratio (binding)	= 5.5	Ratio of inhibition constant of A1 to that of A2a adenosine receptor	ChEMBL.	15713381

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 315530