Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 614 aa | 547 aa | 32.5 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 632 aa | 25.6 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 507 aa | 26.4 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 614 aa | 642 aa | 34.0 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 583 aa | 30.7 % | |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 574 aa | 24.0 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 614 aa | 564 aa | 29.8 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 614 aa | 531 aa | 39.7 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 614 aa | 642 aa | 34.1 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 614 aa | 577 aa | 40.7 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 573 aa | 30.5 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 570 aa | 25.4 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 614 aa | 496 aa | 24.0 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 614 aa | 602 aa | 24.3 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 581 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.4886 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0144 | 0.3803 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.4886 | 0.4886 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.4886 | 0.4886 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.4886 | 0.4886 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.4886 | 1 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0157 | 0.4507 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.4886 | 0.0859 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0238 | 0.8917 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0093 | 0.1083 | 0.1083 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.4886 | 0.4886 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.4886 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0259 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.4886 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0165 | 0.4973 | 0.4973 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0183 | 0.5936 | 0.5936 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0183 | 0.5936 | 0.5936 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.4886 | 0.4886 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.4886 | 1 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0157 | 0.4507 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0165 | 0.4973 | 0.4973 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.4886 | 0.4886 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.4886 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.3 | Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method | ChEMBL. | No reference |
IC50 (binding) | = 0.05 uM | In vitro inhibitory concentration against rat cortex acetylcholinesterase | ChEMBL. | 15993600 |
IC50 (binding) | = 0.05 uM | In vitro inhibitory concentration against rat cortex acetylcholinesterase | ChEMBL. | 15993600 |
IC50 (binding) | = 0.05 uM | Inhibition of AChE | ChEMBL. | 22019465 |
IC50 (binding) | = 84.3 uM | In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate | ChEMBL. | 15993600 |
IC50 (binding) | = 84.3 uM | In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate | ChEMBL. | 15993600 |
IC50 (binding) | = 0.05 umol/L | Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method | ChEMBL. | No reference |
Ki (binding) | = 257.1 nM | Binding affinity to acetylcholinesterase (unknown origin) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.