Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thioredoxin reductase | 0.0039 | 0.0669 | 0.0639 |
Mycobacterium tuberculosis | Probable reductase | 0.0088 | 0.2446 | 0.4618 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.1471 | 0.1485 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.3423 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0039 | 0.0669 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0088 | 0.2446 | 0.4618 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.06 | 0.0605 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0298 | 1 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.06 | 0.0605 |
Brugia malayi | Thioredoxin reductase | 0.0039 | 0.0669 | 0.0488 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0146 | 0.4518 | 0.5 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0296 | 0.991 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0098 | 0.28 | 0.5535 |
Loa Loa (eye worm) | glutathione reductase | 0.0039 | 0.0669 | 0.0639 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0088 | 0.2446 | 0.4618 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0296 | 0.991 | 1 |
Brugia malayi | glutathione reductase | 0.0039 | 0.0669 | 0.0488 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0039 | 0.0039 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0088 | 0.2446 | 0.4618 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1876 | 0.1861 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0039 | 0.0669 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0039 | 0.0669 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.1471 | 0.1485 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0109 | 0.011 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0088 | 0.2446 | 0.4618 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0105 | 0.305 | 0.8645 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0098 | 0.28 | 0.1705 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0098 | 0.28 | 0.5535 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0298 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0146 | 0.4518 | 1 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0296 | 0.991 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0039 | 0.0688 | 0.0694 |
Plasmodium falciparum | glutathione reductase | 0.0039 | 0.0669 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0077 | 0.2032 | 0.1891 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0687 | 0.0505 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0296 | 0.991 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0689 | 0.0659 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0776 | 0.0747 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0298 | 1 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0039 | 0.0669 | 0.5 |
Leishmania major | trypanothione reductase | 0.0039 | 0.0669 | 0.5 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.3423 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0088 | 0.2446 | 0.4618 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0146 | 0.4518 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.305 | 0.3078 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0039 | 0.0688 | 0.0694 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0109 | 0.011 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0115 | 0.3423 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.1603 | 0.1617 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0109 | 0.011 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0296 | 0.991 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0098 | 0.28 | 0.5535 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0846 | 0.0818 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 324 nM | Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells | ChEMBL. | 15603957 |
IC50 (functional) | = 324 nM | Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells | ChEMBL. | 15603957 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.