Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus subsp. aureus MW2 | Methionyl-tRNA synthetase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | methionine-tRNA ligase | Methionyl-tRNA synthetase | 657 aa | 698 aa | 25.6 % |
Onchocerca volvulus | Methionyl-tRNA synthetase | 657 aa | 662 aa | 23.4 % | |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | Methionyl-tRNA synthetase | 657 aa | 699 aa | 26.5 % |
Brugia malayi | methionyl-tRNA synthetase | Methionyl-tRNA synthetase | 657 aa | 665 aa | 22.6 % |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | Methionyl-tRNA synthetase | 657 aa | 560 aa | 25.2 % |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | Methionyl-tRNA synthetase | 657 aa | 561 aa | 25.1 % |
Treponema pallidum | methionyl-tRNA synthetase | Methionyl-tRNA synthetase | 657 aa | 755 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase | 0.0713 | 0.4403 | 0.4398 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0713 | 0.4403 | 0.4398 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0884 | 0.5508 | 0.9285 |
Loa Loa (eye worm) | hypothetical protein | 0.0713 | 0.4403 | 0.4398 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0759 | 0.4703 | 0.7926 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1579 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0713 | 0.4403 | 1 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0033 | 0.0009 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0713 | 0.4403 | 0.4398 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0713 | 0.4403 | 0.4398 |
Echinococcus granulosus | carbonic anhydrase | 0.0713 | 0.4403 | 0.4398 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1579 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0713 | 0.4403 | 0.4398 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.023 | 0.1283 | 0.1428 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1413 | 0.8928 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0713 | 0.4403 | 0.4398 |
Schistosoma mansoni | hypothetical protein | 0.0713 | 0.4403 | 0.4398 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1579 | 1 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0199 | 0.1083 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0713 | 0.4403 | 0.4398 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.023 | 0.1283 | 0.2151 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1579 | 1 | 1 |
Chlamydia trachomatis | sulfate transporter | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0713 | 0.4403 | 0.4398 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0713 | 0.4403 | 0.4398 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1413 | 0.8928 | 1 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0033 | 0.0009 | 0.0009 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1478 | 0.9352 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1413 | 0.8928 | 0.8927 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1579 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1579 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1579 | 1 | 1 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0033 | 0.0009 | 0.0021 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1579 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.1579 | 1 | 1 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0033 | 0.0009 | 0.001 |
Onchocerca volvulus | 0.0199 | 0.1083 | 0.5 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0713 | 0.4403 | 0.4398 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1478 | 0.9352 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0713 | 0.4403 | 1 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0033 | 0.0009 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1478 | 0.9352 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0713 | 0.4403 | 0.4398 |
Loa Loa (eye worm) | hypothetical protein | 0.0713 | 0.4403 | 0.4398 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1579 | 1 | 1 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0033 | 0.0009 | 0.0009 |
Echinococcus granulosus | carbonic anhydrase | 0.0713 | 0.4403 | 0.4398 |
Schistosoma mansoni | carbonic anhydrase | 0.1413 | 0.8928 | 0.8927 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0033 | 0.0009 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1413 | 0.8928 | 0.9547 |
Leishmania major | carbonic anhydrase-like protein | 0.1579 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0713 | 0.4403 | 0.4398 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0713 | 0.4403 | 0.4398 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0046 | 0.0094 | 0.0214 |
Echinococcus multilocularis | carbonic anhydrase | 0.0713 | 0.4403 | 0.4398 |
Schistosoma mansoni | carbonic anhydrase | 0.0713 | 0.4403 | 0.4398 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0949 | 0.5931 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 38 nM | Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetase | ChEMBL. | 15225702 |
IC50 (binding) | = 38 nM | Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetase | ChEMBL. | 15225702 |
MIC (functional) | = 32 ug ml-1 | Antibacterial activity against Staphylococcus aureus Oxford | ChEMBL. | 15225702 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.