Detailed information for compound 322574

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 318.358 | Formula: C14H17F3N2OS
  • H donors: 1 H acceptors: 1 LogP: 2.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@@H](CC(=O)N1CSCC1)Cc1cccc(c1)C(F)(F)F
  • InChi: 1S/C14H17F3N2OS/c15-14(16,17)11-3-1-2-10(6-11)7-12(18)8-13(20)19-4-5-21-9-19/h1-3,6,12H,4-5,7-9,18H2/t12-/m1/s1
  • InChiKey: UZHNBYQRDWHSCE-GFCCVEGCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0011 0.0009
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.001 0.0044
Schistosoma mansoni peptide (allatostatin)-like receptor 0.002 0.0011 0.0009
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.002 0.0011 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0346 0.2022
Loa Loa (eye worm) follicle stimulating hormone receptor 0.002 0.0011 0.0024
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0011 0.0009
Schistosoma mansoni opsin-like receptor 0.002 0.0011 0.0009
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0025 0.0023
Schistosoma mansoni neuropeptide receptor 0.002 0.0011 0.0009
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.001 0.0404
Echinococcus granulosus neuropeptide receptor A26 0.002 0.0011 0.0009
Echinococcus granulosus g protein coupled receptor 0.002 0.0011 0.0009
Schistosoma mansoni hypothetical protein 0.002 0.0011 0.0009
Giardia lamblia Hypothetical protein 0.0036 0.0122 0.0677
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0011 0.0009
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0036 0.0122 0.1361
Schistosoma mansoni hypothetical protein 0.0037 0.0129 0.0127
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0011 0.0009
Schistosoma mansoni hypothetical protein 0.0045 0.0178 0.0175
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.002 0.0011 0.0009
Loa Loa (eye worm) cyclin domain-containing protein 0.0036 0.0122 0.033
Schistosoma mansoni neuropeptide receptor 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Loa Loa (eye worm) CYL-1 protein 0.0036 0.0122 0.033
Schistosoma mansoni opsin-like receptor 0.002 0.0011 0.0009
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0209 0.1271 0.1269
Echinococcus granulosus somatostatin receptor 0.002 0.0011 0.0009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0011 0.0009
Trichomonas vaginalis cyclin A, putative 0.0036 0.0122 0.0718
Onchocerca volvulus 0.002 0.0011 0.0052
Brugia malayi G-protein coupled receptor 0.002 0.0011 0.0031
Echinococcus granulosus sex peptide receptor 0.002 0.0011 0.0009
Entamoeba histolytica cyclin family protein 0.0151 0.0884 0.5277
Brugia malayi neuropeptide F receptor 0.002 0.0011 0.0031
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0025 0.0023
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0182 0.018
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.002 0.0011 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0346 0.2057
Schistosoma mansoni hypothetical protein 0.0045 0.0178 0.0175
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0182 0.1077
Trypanosoma brucei cdc2-related kinase 1 0.0045 0.0182 0.1038
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.002 0.0011 0.0009
Trichomonas vaginalis cyclin B, putative 0.027 0.1673 1
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0434 0.0432
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Schistosoma mansoni hypothetical protein 0.0186 0.1118 0.1116
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Onchocerca volvulus 0.002 0.0011 0.0052
Schistosoma mansoni amine GPCR 0.002 0.0011 0.0009
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0189 0.0186
Loa Loa (eye worm) cyclin domain-containing protein 0.0566 0.3641 1
Brugia malayi Serotonin receptor 0.002 0.0011 0.0031
Echinococcus multilocularis cyclin G2 0.0036 0.0122 0.012
Echinococcus multilocularis biogenic amine (5HT) receptor 0.002 0.0011 0.0009
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0246 0.146
Brugia malayi putative neuropeptide receptor 0.002 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.033
Trypanosoma brucei cyclin 3 0.0036 0.0122 0.0677
Echinococcus multilocularis microtubule associated protein 2 0.1522 1 1
Schistosoma mansoni cyclin G2 0.0036 0.0122 0.012
Brugia malayi cell division control protein 2 homolog 0.0045 0.0182 0.0501
Schistosoma mansoni biogenic amine receptor 0.002 0.0011 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0346 0.2022
Echinococcus multilocularis neuropeptide receptor 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Echinococcus granulosus cyclin G2 0.0036 0.0122 0.012
Schistosoma mansoni cyclin d 0.0036 0.0122 0.012
Onchocerca volvulus 0.002 0.0011 0.0052
Echinococcus multilocularis orexin receptor type 2 0.002 0.0011 0.0009
Giardia lamblia G2/mitotic-specific cyclin B 0.027 0.1673 1
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0182 0.018
Echinococcus granulosus geminin 0.0186 0.1118 0.1116
Echinococcus granulosus G1:S specific cyclin D1 0.0036 0.0122 0.012
Echinococcus granulosus dro:myosuppressin receptor 0.002 0.0011 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0011 0.0009
Trichomonas vaginalis cyclin B3, putative 0.0036 0.0122 0.0718
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Entamoeba histolytica hypothetical protein 0.0036 0.0122 0.0718
Onchocerca volvulus 0.002 0.0011 0.0052
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0036 0.0122 0.6666
Schistosoma mansoni alpha-1 adrenergic receptor 0.002 0.0011 0.0009
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0177 0.0174
Brugia malayi Dopamine receptor protein 2 0.002 0.0011 0.0031
Brugia malayi Cathepsin L-like precursor 0.0018 0.0003 0.0007
Echinococcus granulosus Niemann Pick C1 protein 0.0155 0.0908 0.0906
Schistosoma mansoni amine GPCR 0.002 0.0011 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0122 0.0718
Trichomonas vaginalis cyclin D, putative 0.0036 0.0122 0.0718
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0045 0.0182 0.1077
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0011 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0011 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0011 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0346 0.2022
Loa Loa (eye worm) TYRA-2 protein 0.002 0.0011 0.0024
Toxoplasma gondii hypothetical protein 0.0036 0.0122 0.1561
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0011 0.0009
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.0348 0.2033
Brugia malayi prolyl oligopeptidase family protein 0.0209 0.1271 0.3492
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0891 0.5804 0.5802
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Brugia malayi Cyclin, N-terminal domain containing protein 0.0036 0.0122 0.0336
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.0348 0.4497
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0011 0.0009
Brugia malayi Cathepsin L-like precursor 0.0018 0.0003 0.0007
Brugia malayi hypothetical protein 0.002 0.0011 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0346 0.2022
Loa Loa (eye worm) hypothetical protein 0.0119 0.0669 0.1833
Echinococcus granulosus neuropeptide s receptor 0.002 0.0011 0.0009
Leishmania major mitotic cyclin, putative 0.0036 0.0122 0.0718
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.0599 0.0597
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0566 0.3641 0.3639
Toxoplasma gondii exonuclease III APE 0.0019 0.001 0.0095
Giardia lamblia PHD finger protein 15 0.0032 0.0093 0.0501
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.001 0.5
Brugia malayi Cathepsin L-like precursor 0.0018 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0011 0.0009
Echinococcus multilocularis g protein coupled receptor 0.002 0.0011 0.0009
Trichomonas vaginalis cyclin B, putative 0.027 0.1673 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0011 0.0009
Brugia malayi hypothetical protein 0.0054 0.0238 0.0653
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0066 0.3513
Schistosoma mansoni myosin xvIII 0.002 0.0011 0.0009
Echinococcus granulosus thyrotropin releasing hormone receptor 0.002 0.0011 0.0009
Onchocerca volvulus 0.0022 0.0025 0.0137
Schistosoma mansoni hypothetical protein 0.002 0.0011 0.0009
Trichomonas vaginalis cyclins, putative 0.027 0.1673 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Echinococcus multilocularis protein patched 0.0046 0.0189 0.0186
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0025 0.0063
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Trypanosoma brucei mitotic cyclin 6 0.027 0.1673 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Brugia malayi G-protein coupled receptor 0.002 0.0011 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0011 0.0009
Echinococcus granulosus peptide allatostatin:somatostatin 0.002 0.0011 0.0009
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0093 0.118
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0025 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Brugia malayi hypothetical protein 0.0022 0.0025 0.007
Trichomonas vaginalis cyclin D, putative 0.0151 0.0884 0.5277
Echinococcus multilocularis g-protein coupled receptor 0.002 0.0011 0.0009
Brugia malayi larval opioid receptor 0.002 0.0011 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0182 0.018
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Echinococcus granulosus alpha 1A adrenergic receptor 0.002 0.0011 0.0009
Echinococcus multilocularis neuropeptide receptor 0.002 0.0011 0.0009
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0036 0.0122 0.012
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0093 0.0249
Mycobacterium ulcerans aldehyde dehydrogenase 0.0134 0.0771 1
Toxoplasma gondii aldehyde dehydrogenase 0.0134 0.0771 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0182 0.018
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.033
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0209 0.1271 0.1269
Echinococcus granulosus allatostatin A receptor 0.002 0.0011 0.0009
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.002 0.0011 0.0024
Trichomonas vaginalis cyclin B, putative 0.027 0.1673 1
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0011 0.0009
Schistosoma mansoni lipoxygenase 0.0131 0.0748 0.0746
Brugia malayi Cyclin, N-terminal domain containing protein 0.0036 0.0122 0.0336
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0134 0.0771 0.0768
Echinococcus multilocularis dro:myosuppressin receptor 0.002 0.0011 0.0009
Echinococcus multilocularis cyclin G2 0.0036 0.0122 0.012
Onchocerca volvulus 0.0036 0.0122 0.0718
Echinococcus granulosus cyclin t1 0.0036 0.0122 0.012
Echinococcus multilocularis cyclins 0.0151 0.0884 0.0882
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0045 0.0182 0.0495
Giardia lamblia Cyclin B-like protein 0.0036 0.0122 0.0677
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0011 0.0009
Echinococcus multilocularis cyclin t1 0.0036 0.0122 0.012
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.002 0.0011 0.0031
Schistosoma mansoni hypothetical protein 0.0032 0.0093 0.0091
Brugia malayi Cyclin, N-terminal domain containing protein 0.0036 0.0122 0.0336
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Schistosoma mansoni polycystin 1-related 0.0022 0.0025 0.0023
Trichomonas vaginalis cyclin B, putative 0.0151 0.0884 0.5277
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0036 0.0122 0.1361
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0131 0.0748 0.0746
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0036 0.0122 0.033
Schistosoma mansoni neuropeptide receptor 0.002 0.0011 0.0009
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.002 0.0011 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0122 0.0718
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0134 0.0771 0.4598
Echinococcus multilocularis cyclins 0.0151 0.0884 0.0882
Onchocerca volvulus Alhambra homolog 0.0032 0.0093 0.0543
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.0348 0.2033
Echinococcus multilocularis cyclin dependent kinase 5 0.0045 0.0182 0.018
Echinococcus granulosus g-protein coupled receptor 0.002 0.0011 0.0009
Brugia malayi Cyclin, N-terminal domain containing protein 0.0036 0.0122 0.0336
Entamoeba histolytica cyclin C, putative 0.0036 0.0122 0.0718
Brugia malayi sulfakinin receptor protein 0.002 0.0011 0.0031
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0046 0.0189 0.0512
Brugia malayi gonadotropin-releasing hormone receptor 2 0.002 0.0011 0.0031
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0011 0.0009
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.027 0.1673 1
Schistosoma mansoni neuropeptide receptor 0.002 0.0011 0.0009
Echinococcus multilocularis sex peptide receptor 0.002 0.0011 0.0009
Echinococcus multilocularis cyclins 0.0151 0.0884 0.0882
Echinococcus multilocularis peregrin 0.0032 0.0093 0.0091
Brugia malayi Cyclin, N-terminal domain containing protein 0.0036 0.0122 0.0336
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0011 0.0009
Echinococcus multilocularis G protein coupled receptor 139 0.002 0.0011 0.0009
Schistosoma mansoni Cyclin fold protein 0.0036 0.0122 0.012
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0122 0.6666
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0036 0.0122 0.1561
Echinococcus granulosus cyclins 0.0151 0.0884 0.0882
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0066 0.0823
Brugia malayi cyclin fold protein 1 variant b 0.0036 0.0122 0.0336
Onchocerca volvulus 0.027 0.1673 1
Leishmania major cyclin 9, putative 0.0036 0.0122 0.0718
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0182 0.1077
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Brugia malayi CHE-14 protein 0.0046 0.0189 0.0519
Echinococcus granulosus cyclin b3 0.0151 0.0884 0.0882
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.0599 0.3572
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0063
Trichomonas vaginalis cyclins, putative 0.027 0.1673 1
Onchocerca volvulus 0.0166 0.0984 0.5875
Trichomonas vaginalis cyclin B, putative 0.0036 0.0122 0.0718
Toxoplasma gondii hypothetical protein 0.0115 0.0642 0.8323
Toxoplasma gondii cyclin 4, putative 0.0036 0.0122 0.1561
Onchocerca volvulus 0.002 0.0011 0.0052
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0138 0.0135
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.002 0.0011 0.0024
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0036 0.0122 0.012
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0036 0.0122 0.0677
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0182 0.0495
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0138 0.0372
Schistosoma mansoni loxhd1 0.0022 0.0025 0.0023
Echinococcus multilocularis cyclin y 0.0036 0.0122 0.012
Schistosoma mansoni cyclin B 0.027 0.1673 0.1671
Echinococcus multilocularis Cyclin L1 0.0036 0.0122 0.012
Schistosoma mansoni aldehyde dehydrogenase 0.0134 0.0771 0.0768
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0045 0.0182 0.018
Brugia malayi putative neuropeptide receptor NPR1 0.002 0.0011 0.0031
Brugia malayi jmjC domain containing protein 0.0039 0.0138 0.0379
Giardia lamblia Cyclin A 0.0151 0.0884 0.5256
Echinococcus granulosus cyclin G2 0.0036 0.0122 0.012
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0093 0.0091
Schistosoma mansoni hypothetical protein 0.002 0.0011 0.0009
Trichomonas vaginalis cyclins, putative 0.027 0.1673 1
Trichomonas vaginalis cyclin A, putative 0.027 0.1673 1
Schistosoma mansoni neuropeptide f receptor 76f 0.002 0.0011 0.0009
Leishmania major cathepsin L-like protease 0.007 0.0346 0.2057
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.002 0.0011 0.0009
Echinococcus multilocularis cyclin y 0.0036 0.0122 0.012
Echinococcus multilocularis fmrfamide receptor 0.002 0.0011 0.0009
Echinococcus granulosus 7TM GPCR rhodopsin 0.002 0.0011 0.0009
Echinococcus multilocularis tachykinin peptides receptor 99D 0.002 0.0011 0.0009
Echinococcus granulosus cyclin k 0.0036 0.0122 0.012
Echinococcus multilocularis cyclins 0.0151 0.0884 0.0882
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0011 0.0009
Brugia malayi hypothetical protein 0.002 0.0011 0.0031
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0025 0.0023
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0244 0.0671
Echinococcus granulosus G protein coupled receptor 139 0.002 0.0011 0.0009
Entamoeba histolytica cyclin, domain containing protein 0.0036 0.0122 0.0718
Onchocerca volvulus 0.002 0.0011 0.0052
Onchocerca volvulus 0.002 0.0011 0.0052
Schistosoma mansoni cyclin G 0.0036 0.0122 0.012
Brugia malayi Cyclin, N-terminal domain containing protein 0.027 0.1673 0.4596
Echinococcus granulosus cyclin dependent kinase 1 0.0045 0.0182 0.018
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0011 0.0009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0138 0.0135
Brugia malayi prolyl oligopeptidase family protein 0.007 0.0348 0.0956
Entamoeba histolytica cyclin, putative 0.027 0.1673 1
Echinococcus multilocularis serotonin receptor 0.002 0.0011 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0011 0.0009
Schistosoma mansoni biogenic amine receptor 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0063
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0011 0.0024
Schistosoma mansoni ap endonuclease 0.0019 0.001 0.0007
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.002 0.0011 0.0009
Echinococcus multilocularis cyclins 0.0151 0.0884 0.0882
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.0884 0.5277
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0346 0.2057
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0011 0.0009
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0011 0.0009
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0036 0.0122 0.012
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0011 0.0009
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0036 0.0122 0.012
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.001 0.0007
Loa Loa (eye worm) cyclin domain-containing protein 0.0036 0.0122 0.033
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.001 0.0083
Echinococcus granulosus cyclin A3 4 0.0036 0.0122 0.012
Trypanosoma cruzi cyclin 6, putative 0.027 0.1673 1
Brugia malayi hypothetical protein 0.002 0.0011 0.0031
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.001 0.002
Schistosoma mansoni microtubule-associated protein tau 0.1522 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0011 0.0009
Onchocerca volvulus 0.002 0.0011 0.0052
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0177 0.0174
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0189 0.0186
Trichomonas vaginalis cyclins, putative 0.027 0.1673 1
Echinococcus granulosus g protein coupled receptor 0.002 0.0011 0.0009
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.002 0.0011 0.0009
Onchocerca volvulus 0.002 0.0011 0.0052
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0011 0.0009
Echinococcus multilocularis serotonin receptor 0.002 0.0011 0.0009
Trichomonas vaginalis cyclins, putative 0.0155 0.0912 0.5441
Echinococcus granulosus fmrfamide receptor 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0134 0.0771 1
Echinococcus granulosus Cyclin L1 0.0036 0.0122 0.012
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0066 0.0336
Giardia lamblia Hypothetical protein 0.0151 0.0884 0.5256
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0122 0.0718
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0011 0.0009
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.002 0.0011 0.0052
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.0348 0.0346
Entamoeba histolytica cyclin, domain containing protein 0.0036 0.0122 0.0718
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0182 0.1077
Brugia malayi Cyclin C 0.0036 0.0122 0.0336
Schistosoma mansoni cyclin k 0.0036 0.0122 0.012
Onchocerca volvulus 0.0022 0.0025 0.0137
Loa Loa (eye worm) cyclin domain-containing protein 0.0036 0.0122 0.033
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Brugia malayi Dopamine receptor 0.002 0.0011 0.0031
Brugia malayi follicle stimulating hormone receptor 0.002 0.0011 0.0031
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.001 0.0027
Schistosoma mansoni growth hormone secretagogue receptor 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.027 0.1673 0.4592
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0093 0.5038
Leishmania major mitotic cyclin, putative 0.0036 0.0122 0.0718
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.002 0.0011 0.0009
Schistosoma mansoni amine GPCR 0.002 0.0011 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0011 0.0009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0138 0.0135
Loa Loa (eye worm) cyclin C 0.0036 0.0122 0.033
Schistosoma mansoni biogenic amine receptor 0.002 0.0011 0.0009
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.001 0.0044
Echinococcus multilocularis allatostatin A receptor 0.002 0.0011 0.0009
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0182 0.1077
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0182 0.0495
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0045 0.0182 0.2342
Brugia malayi Protein kinase domain containing protein 0.0045 0.0182 0.0501
Echinococcus multilocularis RUN 0.0022 0.0025 0.0023
Schistosoma mansoni amine GPCR 0.002 0.0011 0.0009
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0025 0.0259
Echinococcus granulosus cyclins 0.0151 0.0884 0.0882
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0011 0.0024
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0244 0.0665
Entamoeba histolytica cyclin, putative 0.0151 0.0884 0.5277
Brugia malayi Cathepsin L-like precursor 0.0018 0.0003 0.0007
Trichomonas vaginalis cyclins, putative 0.0036 0.0122 0.0718
Loa Loa (eye worm) hypothetical protein 0.0057 0.0258 0.0703
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0306 0.1815
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Trichomonas vaginalis cyclin D, putative 0.0151 0.0884 0.5277
Echinococcus granulosus g protein coupled receptor 0.002 0.0011 0.0009
Echinococcus multilocularis protein dispatched 1 0.0053 0.0232 0.023
Onchocerca volvulus 0.002 0.0011 0.0052
Echinococcus multilocularis G-protein coupled receptor, putative 0.002 0.0011 0.0009
Echinococcus multilocularis neuropeptide receptor A26 0.002 0.0011 0.0009
Echinococcus multilocularis cyclin k 0.0036 0.0122 0.012
Schistosoma mansoni hypothetical protein 0.0186 0.1118 0.1116
Brugia malayi RE15519p 0.002 0.0011 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0346 0.2022
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0011 0.0009
Brugia malayi hypothetical protein 0.002 0.0011 0.0031
Echinococcus granulosus tachykinin peptides receptor 99D 0.002 0.0011 0.0009
Trypanosoma brucei cdc2-related kinase 3 0.0045 0.0182 0.1038
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.002 0.0011 0.0009
Schistosoma mansoni hypothetical protein 0.0036 0.0122 0.012
Echinococcus granulosus RUN 0.0022 0.0025 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0182 0.1077
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0346 0.2022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0346 0.2022
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.002 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0045 0.0179 0.0486
Echinococcus granulosus cyclins 0.0151 0.0884 0.0882
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Echinococcus multilocularis cyclin B 0.027 0.1673 0.1671
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0182 0.1077
Loa Loa (eye worm) hypothetical protein 0.027 0.1673 0.4592
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0182 0.1077
Echinococcus multilocularis G1:S specific cyclin D1 0.0036 0.0122 0.012
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0011 0.0009
Brugia malayi hypothetical protein 0.002 0.0011 0.0031
Echinococcus granulosus neuropeptide receptor 0.002 0.0011 0.0009
Schistosoma mansoni hypothetical protein 0.002 0.0011 0.0009
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0011 0.0009
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0066 0.0717
Brugia malayi AKH receptor 0.002 0.0011 0.0031
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0209 0.1271 0.7595
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0189 0.0186
Echinococcus granulosus cyclins 0.0151 0.0884 0.0882
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0346 0.2022
Schistosoma mansoni rab6-interacting 0.0022 0.0025 0.0023
Brugia malayi G protein-coupled receptor F59B2.13 0.002 0.0011 0.0031
Brugia malayi Serotonin/octopamine receptor family protein 7 0.002 0.0011 0.0031
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.002 0.0011 0.0009
Brugia malayi Cathepsin L-like precursor 0.0018 0.0003 0.0007
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0011 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0011 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.032 0.0872
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0189 0.1115
Echinococcus granulosus 7tm_1 domain containing protein 0.002 0.0011 0.0009
Echinococcus granulosus peregrin 0.0032 0.0093 0.0091
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0138 0.0135
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0011 0.0009
Echinococcus multilocularis cyclin b3 0.0151 0.0884 0.0882
Trichomonas vaginalis cyclin B, putative 0.0036 0.0122 0.0718
Echinococcus multilocularis Niemann Pick C1 protein 0.0155 0.0908 0.0906
Trichomonas vaginalis cyclin B3, putative 0.0151 0.0884 0.5277
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0122 0.0718
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0134 0.0771 0.0768
Echinococcus multilocularis expressed conserved protein 0.0102 0.0556 0.0553
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.0578 0.0575
Brugia malayi Melatonin receptor type 1A 0.002 0.0011 0.0031
Brugia malayi hypothetical protein 0.002 0.0011 0.0031
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.0578 0.0575
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0011 0.0024
Echinococcus granulosus cyclin y 0.0036 0.0122 0.012
Loa Loa (eye worm) cyclin domain-containing protein 0.0036 0.0122 0.033
Brugia malayi hypothetical protein 0.002 0.0011 0.0031
Echinococcus granulosus neuropeptide FF receptor 2 0.002 0.0011 0.0009
Entamoeba histolytica cyclin family protein 0.0151 0.0884 0.5277
Trichomonas vaginalis cyclin B3, putative 0.0036 0.0122 0.0718
Trichomonas vaginalis cyclins, putative 0.0151 0.0884 0.5277
Schistosoma mansoni hypothetical protein 0.0036 0.0122 0.012
Plasmodium vivax protein kinase Crk2 0.0045 0.0182 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0346 0.2022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0346 0.2022
Trypanosoma cruzi cyclin, putative 0.027 0.1673 1
Leishmania major cyclin 0.027 0.1673 1
Onchocerca volvulus 0.002 0.0011 0.0052
Trypanosoma cruzi CYC2-like cyclin, putative 0.027 0.1673 1
Echinococcus multilocularis cyclins 0.0151 0.0884 0.0882
Trypanosoma cruzi mitotic cyclin, putative 0.0036 0.0122 0.0718
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Brugia malayi hypothetical protein 0.002 0.0011 0.0031
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0011 0.0009
Brugia malayi hypothetical protein 0.0022 0.0025 0.007
Loa Loa (eye worm) melatonin receptor type 1A 0.002 0.0011 0.0024
Echinococcus multilocularis cyclin 0.0036 0.0122 0.012
Brugia malayi Cyclin, N-terminal domain containing protein 0.0036 0.0122 0.0336
Loa Loa (eye worm) hypothetical protein 0.0108 0.0599 0.164
Echinococcus granulosus cyclin B 0.027 0.1673 0.1671
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.001 0.0044
Onchocerca volvulus 0.002 0.0011 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0122 0.0718
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0066 0.0717
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.0348 0.0346
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.001 0.0007
Plasmodium falciparum phd finger protein, putative 0.0032 0.0093 0.1028
Schistosoma mansoni hypothetical protein 0.0022 0.0025 0.0023
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.0348 0.2068
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0189 0.0512
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0011 0.0009
Giardia lamblia Cyclin fold protein 1, putative 0.0036 0.0122 0.0677
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.0348 0.0346
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.002 0.0011 0.0024
Brugia malayi hypothetical protein 0.0166 0.0984 0.2703
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.002 0.0011 0.0009
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0129 0.0355
Brugia malayi Serotonin receptor 0.002 0.0011 0.0031
Brugia malayi neuropeptide F receptor 0.002 0.0011 0.0031
Schistosoma mansoni lipoxygenase 0.0091 0.0487 0.0485
Trypanosoma cruzi cyclin, putative 0.027 0.1673 1
Schistosoma mansoni hypothetical protein 0.0045 0.0178 0.0175
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Echinococcus granulosus cyclin B3 1 0.0151 0.0884 0.0882
Brugia malayi Bromodomain containing protein 0.0032 0.0093 0.0256
Trichomonas vaginalis cyclins, putative 0.0036 0.0122 0.0718
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0209 0.1271 0.1269
Plasmodium falciparum protein kinase 5 0.0045 0.0182 0.2041
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0025 0.0023
Echinococcus granulosus orexin receptor type 2 0.002 0.0011 0.0009
Trypanosoma brucei cyclin 9 0.0036 0.0122 0.0677
Schistosoma mansoni ap endonuclease 0.0019 0.001 0.0007
Echinococcus multilocularis somatostatin receptor 0.002 0.0011 0.0009
Leishmania major hypothetical protein, conserved 0.0028 0.0066 0.0378
Loa Loa (eye worm) hypothetical protein 0.0054 0.0238 0.0646
Brugia malayi G protein-coupled receptor 0.002 0.0011 0.0031
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0182 0.1038
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0036 0.0122 0.012
Schistosoma mansoni rab6-interacting 0.0022 0.0025 0.0023
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0131 0.0748 0.0746
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0182 0.1077
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0011 0.0009
Echinococcus multilocularis geminin 0.0186 0.1118 0.1116
Brugia malayi jmjC domain containing protein 0.0105 0.0578 0.1587
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Echinococcus multilocularis g protein coupled receptor 0.002 0.0011 0.0009
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0182 0.1038
Brugia malayi GnHR receptor homolog 0.002 0.0011 0.0031
Echinococcus granulosus serotonin receptor 0.002 0.0011 0.0009
Echinococcus granulosus cyclin dependent kinase 5 0.0045 0.0182 0.018
Onchocerca volvulus 0.002 0.0011 0.0052
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0045 0.0182 0.1077
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0566 0.3641 0.3639
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0025 0.1267
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.0599 0.1646
Mycobacterium ulcerans aldehyde dehydrogenase 0.0134 0.0771 1
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Trypanosoma brucei mitotic cyclin 0.0036 0.0122 0.0677
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.0348 0.2068
Echinococcus granulosus expressed conserved protein 0.0102 0.0556 0.0553
Loa Loa (eye worm) cyclin domain-containing protein 0.0036 0.0122 0.033
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0093 0.0091
Echinococcus granulosus cyclins 0.0151 0.0884 0.0882
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.002 0.0011 0.0009
Brugia malayi Cyclin, N-terminal domain containing protein 0.027 0.1673 0.4596
Onchocerca volvulus Cyclin L homolog 0.0036 0.0122 0.0718
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Schistosoma mansoni cyclins 0.0151 0.0884 0.0882
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0036 0.0122 0.1561
Echinococcus multilocularis g protein coupled receptor 0.002 0.0011 0.0009
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0066 0.0378
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0011 0.0009
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.001 0.0044
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0174
Echinococcus multilocularis fmrfamide receptor 0.002 0.0011 0.0009
Plasmodium falciparum cyclin 0.0151 0.0884 1
Echinococcus multilocularis neuropeptide s receptor 0.002 0.0011 0.0009
Brugia malayi hypothetical protein 0.0036 0.0122 0.0336
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0011 0.0024
Schistosoma mansoni niemann-pick C1 (NPC1) 0.011 0.0611 0.0608
Echinococcus granulosus cyclin y 0.0036 0.0122 0.012
Brugia malayi Dopamine receptor protein 1 0.002 0.0011 0.0031
Echinococcus granulosus cyclins 0.0036 0.0122 0.012
Brugia malayi Cyclin, N-terminal domain containing protein 0.0566 0.3641 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0093 0.0091
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0346 0.2057
Brugia malayi ORL1-like opioid receptor 0.002 0.0011 0.0031
Onchocerca volvulus Cyclin L homolog 0.0036 0.0122 0.0718
Loa Loa (eye worm) hypothetical protein 0.0055 0.0245 0.0667
Leishmania major cathepsin L-like protease 0.007 0.0346 0.2057
Onchocerca volvulus 0.002 0.0011 0.0052
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Schistosoma mansoni cyclin B3 0.0566 0.3641 0.3639
Echinococcus multilocularis alpha 1A adrenergic receptor 0.002 0.0011 0.0009
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0011 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0011 0.0009
Onchocerca volvulus 0.002 0.0011 0.0052
Echinococcus granulosus neuropeptide receptor 0.002 0.0011 0.0009
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0346 0.2057
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0011 0.0009
Schistosoma mansoni adenoreceptor 0.002 0.0011 0.0009
Plasmodium vivax cyclin 4, putative 0.0036 0.0122 0.6666
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0244 0.0671
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.001 0.0044
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.0599 0.0597
Echinococcus multilocularis neuropeptide FF receptor 2 0.002 0.0011 0.0009
Schistosoma mansoni aldehyde dehydrogenase 0.0134 0.0771 0.0768
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Schistosoma mansoni hypothetical protein 0.0045 0.0178 0.0175
Loa Loa (eye worm) prolyl oligopeptidase 0.0209 0.1271 0.3488
Onchocerca volvulus 0.002 0.0011 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0346 0.2022
Trypanosoma cruzi cyclin 9, putative 0.0036 0.0122 0.0718
Echinococcus granulosus cyclin dependent kinase 0.0045 0.0182 0.018
Schistosoma mansoni cyclin l 0.0036 0.0122 0.012
Brugia malayi Doublecortin family protein 0.0022 0.0025 0.007
Trichomonas vaginalis cyclin B, putative 0.027 0.1673 1
Giardia lamblia Hypothetical protein 0.0036 0.0122 0.0677
Echinococcus multilocularis cyclin dependent kinase 0.0045 0.0182 0.018
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0134 0.0771 1
Echinococcus multilocularis cyclin B3 1 0.0151 0.0884 0.0882
Brugia malayi hypothetical protein 0.002 0.0011 0.0031
Leishmania major cathepsin L-like protease 0.007 0.0346 0.2057
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0003 0.0007
Schistosoma mansoni amine GPCR 0.002 0.0011 0.0009
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0093 0.118
Brugia malayi hypothetical protein 0.0028 0.0066 0.0181
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.001 0.0044
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Brugia malayi Cyclin, N-terminal domain containing protein 0.0036 0.0122 0.0336
Schistosoma mansoni g1/s-specific cyclin C 0.0036 0.0122 0.012
Brugia malayi PHD-finger family protein 0.0032 0.0093 0.0256
Loa Loa (eye worm) hypothetical protein 0.0037 0.0129 0.0348
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0182 0.1077
Echinococcus multilocularis cyclin A3 4 0.0036 0.0122 0.012
Toxoplasma gondii cyclin dependent kinase binding protein 0.0036 0.0122 0.1561
Plasmodium vivax cyclin homologue, putative 0.0036 0.0122 0.6666
Trypanosoma cruzi mitotic cyclin, putative 0.0036 0.0122 0.0718
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0011 0.0009
Loa Loa (eye worm) cyclin domain-containing protein 0.0036 0.0122 0.033
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0024
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0011 0.0009
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0066 0.0378
Loa Loa (eye worm) hypothetical protein 0.0166 0.0984 0.2698
Onchocerca volvulus Neuropeptide F receptor homolog 0.002 0.0011 0.0052
Brugia malayi hypothetical protein 0.002 0.0011 0.0031
Brugia malayi Cathepsin L-like precursor 0.0018 0.0003 0.0007
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.002 0.0011 0.0024
Onchocerca volvulus Protein CNPPD1 homolog 0.0036 0.0122 0.0718
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.001 0.5
Onchocerca volvulus 0.002 0.0011 0.0052
Schistosoma mansoni opsin-like receptor 0.002 0.0011 0.0009
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0011 0.0009
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0011 0.0009
Plasmodium falciparum cyclin 1 0.0036 0.0122 0.1361
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0055 0.0244 0.0665
Schistosoma mansoni histamine h1 receptor 0.002 0.0011 0.0009
Echinococcus granulosus cyclin 0.0036 0.0122 0.012
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0093 0.0249
Schistosoma mansoni patched 1 0.0046 0.0189 0.0186
Brugia malayi hypothetical protein 0.0036 0.0122 0.0336
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0011 0.0009
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.0348 0.2068
Brugia malayi Tachykinin-like peptides receptor 99D 0.002 0.0011 0.0031
Echinococcus granulosus hypothetical protein 0.002 0.0011 0.0009
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.002 0.0011 0.0031
Echinococcus multilocularis cyclins 0.0151 0.0884 0.0882

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3611 nM Inhibitory concentration against Dipeptidyl peptidase IV ChEMBL. 15324903
IC50 (binding) = 3611 nM Inhibitory concentration against Dipeptidyl peptidase IV ChEMBL. 15324903
IC50 (binding) = 24570 nM Inhibitory concentration against quiescent cell proline dipeptidase ChEMBL. 15324903
IC50 (binding) = 24570 nM Inhibitory concentration against quiescent cell proline dipeptidase ChEMBL. 15324903

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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