Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Smad4 | 0.0019 | 0.0003 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0248 | 0.0248 |
Schistosoma mansoni | smad | 0.0019 | 0.0003 | 0.0006 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 0.4985 | 0.4985 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0019 | 0.0003 | 0.0006 |
Echinococcus granulosus | smad | 0.0019 | 0.0003 | 0.0006 |
Echinococcus granulosus | Smad4 | 0.0019 | 0.0003 | 0.0006 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0036 | 0.0248 | 0.0248 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0036 | 0.0248 | 0.042 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0248 | 0.042 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0036 | 0.0248 | 0.042 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0019 | 0.0003 | 0.0006 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0019 | 0.0003 | 0.0006 |
Brugia malayi | MH1 domain containing protein | 0.0019 | 0.0003 | 0.0003 |
Brugia malayi | Smad1 | 0.0019 | 0.0003 | 0.0003 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0115 | 0.1339 | 0.1339 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0019 | 0.0003 | 0.0003 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0274 | 0.3566 | 0.3566 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0248 | 0.042 |
Echinococcus multilocularis | GPCR, family 2 | 0.0036 | 0.0248 | 0.042 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0036 | 0.0248 | 0.042 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0442 | 0.5901 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0274 | 0.3566 | 0.3566 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0019 | 0.0003 | 0.0006 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0115 | 0.1339 | 0.1339 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0442 | 0.5901 | 0.5901 |
Brugia malayi | MH2 domain containing protein | 0.0019 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0036 | 0.0248 | 0.0248 |
Schistosoma mansoni | smad1 5 8 and | 0.0019 | 0.0003 | 0.0006 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0442 | 0.5901 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0019 | 0.0003 | 0.0006 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0736 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0736 | 1 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0019 | 0.0003 | 0.0006 |
Brugia malayi | MH2 domain containing protein | 0.0274 | 0.3566 | 0.3566 |
Brugia malayi | MH2 domain containing protein | 0.0019 | 0.0003 | 0.0003 |
Echinococcus granulosus | GPCR family 2 | 0.0036 | 0.0248 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.1339 | 0.1339 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0115 | 0.1339 | 0.1339 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0442 | 0.5901 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0036 | 0.0248 | 0.0248 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0036 | 0.0248 | 0.042 |
Brugia malayi | MH1 domain containing protein | 0.0019 | 0.0003 | 0.0003 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0736 | 1 | 1 |
Schistosoma mansoni | Smad4 | 0.0019 | 0.0003 | 0.0006 |
Echinococcus multilocularis | smad | 0.0019 | 0.0003 | 0.0006 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0248 | 0.042 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0078 | 0.0834 | 0.0834 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0442 | 0.5901 | 0.5901 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0834 | 0.0834 |
Loa Loa (eye worm) | Smad1 | 0.0019 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0834 | 0.1413 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0019 | 0.0003 | 0.0003 |
Schistosoma mansoni | smad1 5 8 and | 0.0019 | 0.0003 | 0.0006 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0442 | 0.5901 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0248 | 0.042 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | inhibitory concentration of the compound against PGE-2 production in LPS-stimulated RAW264.7 cells | ChEMBL. | 15501064 |
IC50 (functional) | > 50 uM | inhibitory concentration of the compound against PGE-2 production in LPS-stimulated RAW264.7 cells | ChEMBL. | 15501064 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.