Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0028 | 0.0046 | 0.008 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0028 | 0.0046 | 0.008 |
Echinococcus granulosus | serotonin transporter | 0.0162 | 0.3692 | 0.6449 |
Onchocerca volvulus | 0.0162 | 0.3692 | 0.642 | |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0162 | 0.3692 | 0.642 |
Plasmodium vivax | amine transporter, putative | 0.0028 | 0.0046 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0162 | 0.3692 | 0.642 |
Toxoplasma gondii | hypothetical protein | 0.0028 | 0.0046 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0046 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.4769 | 0.4745 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0028 | 0.0046 | 0.008 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0028 | 0.0046 | 0.008 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0028 | 0.0046 | 0.008 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0395 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0395 | 1 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0237 | 0.5725 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0162 | 0.3692 | 0.6449 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0237 | 0.5725 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0162 | 0.3692 | 0.3663 |
Plasmodium vivax | hypothetical protein, conserved | 0.0028 | 0.0046 | 0.5 |
Plasmodium falciparum | transporter, putative | 0.0028 | 0.0046 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0028 | 0.0046 | 0.008 |
Plasmodium falciparum | amino acid transporter, putative | 0.0028 | 0.0046 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0237 | 0.5725 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0162 | 0.3692 | 0.3663 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0028 | 0.0046 | 0.008 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0028 | 0.0046 | 0.008 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0237 | 0.5725 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.3692 | 0.3663 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.3692 | 0.3663 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0046 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0162 | 0.3692 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0028 | 0.0046 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0237 | 0.5725 | 0.5705 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0028 | 0.0046 | 0.008 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0046 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0162 | 0.3692 | 0.3663 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0028 | 0.0046 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0395 | 1 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0162 | 0.3692 | 0.3663 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0237 | 0.5725 | 0.5705 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0028 | 0.0046 | 0.008 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0028 | 0.0046 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.3692 | 0.3663 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 157 uM | Inhibition of JNK-stimulating phosphatase-1 (JSP-1) | ChEMBL. | 15961311 |
IC50 (binding) | = 157 uM | Inhibition of JNK-stimulating phosphatase-1 (JSP-1) | ChEMBL. | 15961311 |
IC50 (binding) | > 200 uM | In vitro inhibitory concentration against VH1-related (VHR) phosphatase | ChEMBL. | 15961311 |
IC50 (binding) | > 200 uM | In vitro inhibitory concentration against VH1-related (VHR) phosphatase | ChEMBL. | 15961311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.