Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 4 | Starlite/ChEMBL | References |
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 4 | 303 aa | 312 aa | 29.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.2121 | 0.1886 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.2121 | 0.1886 |
Giardia lamblia | Kinase, CMGC CDK | 0.0053 | 0.0305 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0179 | 0.2121 | 0.3642 |
Giardia lamblia | Kinase, CMGC CDK | 0.0053 | 0.0305 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0053 | 0.0305 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.489 | 0.4737 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0053 | 0.0305 | 0.0017 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0305 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0436 | 0.5823 | 0.5699 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0726 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0726 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0053 | 0.0305 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0179 | 0.2121 | 0.1886 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0436 | 0.5823 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0179 | 0.2121 | 0.1886 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0436 | 0.5823 | 0.5692 |
Plasmodium vivax | protein kinase Crk2 | 0.0053 | 0.0305 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0053 | 0.0305 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0.0305 | 0.0525 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0305 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0179 | 0.2121 | 0.329 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0436 | 0.5823 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0.0305 | 0.0525 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.2121 | 0.1886 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0053 | 0.0305 | 0.0017 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0179 | 0.2121 | 0.1886 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0179 | 0.2121 | 0.1873 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0436 | 0.5823 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0053 | 0.0305 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0726 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0179 | 0.2121 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0179 | 0.2121 | 0.3642 |
Plasmodium falciparum | protein kinase 5 | 0.0053 | 0.0305 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0305 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0179 | 0.2121 | 0.329 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0436 | 0.5823 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.36 uM | inhibitory concentration for anti-proliferative activity against A549 and H29 human tumor cell lines was determined | ChEMBL. | 15261277 |
IC50 (functional) | = 1.36 uM | inhibitory concentration for anti-proliferative activity against A549 and H29 human tumor cell lines was determined | ChEMBL. | 15261277 |
Ki (binding) | = 0.05 uM | Inhibition of Cyclin dependent kinase 2 | ChEMBL. | 15261277 |
Ki (binding) | = 0.05 uM | Inhibition of Cyclin dependent kinase 2 | ChEMBL. | 15261277 |
Ki (binding) | = 0.26 uM | Ihibition of Cyclin dependent kinase 4 | ChEMBL. | 15261277 |
Ki (binding) | = 0.26 uM | Ihibition of Cyclin dependent kinase 4 | ChEMBL. | 15261277 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15261277 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.