Detailed information for compound 32436

Basic information

Technical information
  • TDR Targets ID: 32436
  • Name: 8-(4-bromophenyl)sulfanyl-1-azabicyclo[2.2.2] octane
  • MW: 298.242 | Formula: C13H16BrNS
  • H donors: 0 H acceptors: 0 LogP: 3.75 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)SC1CN2CCC1CC2
  • InChi: 1S/C13H16BrNS/c14-11-1-3-12(4-2-11)16-13-9-15-7-5-10(13)6-8-15/h1-4,10,13H,5-9H2
  • InChiKey: XZTZASNDFHUJCK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-bromophenyl)sulfanylquinuclidine
  • 3-[(4-bromophenyl)thio]quinuclidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) DR-78 0.0041 0.0181 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0087 0.0871 0.1709
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0087 0.0871 0.1709
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0181 0.0109
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0145 0.0128
Onchocerca volvulus 0.0036 0.011 0.0297
Brugia malayi nuclear hormone receptor family member nhr-6 0.0041 0.0181 0.0329
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0181 0.0365
Loa Loa (eye worm) nuclear receptor NHR-67 0.0041 0.0181 0.0329
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3985 0.7864
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0041 0.0181 0.0165
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0207 0.0176
Loa Loa (eye worm) hypothetical protein 0.0087 0.0871 0.1709
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0255 0.0477
Echinococcus granulosus single minded 2 0.0036 0.011 0.011
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0087 0.0871 0.0856
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0046 0.0255 0.0239
Giardia lamblia Fructose-bisphosphate aldolase 0.0295 0.3985 0.5
Echinococcus granulosus ras gtpase 0.0364 0.5018 0.5018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2712 0.539
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3985 0.7864
Brugia malayi hypothetical protein 0.0165 0.2033 0.4032
Loa Loa (eye worm) hypothetical protein 0.0165 0.2033 0.4032
Loa Loa (eye worm) hypothetical protein 0.0364 0.5018 1
Plasmodium falciparum topoisomerase I 0.0187 0.2372 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0871 0.1709
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0041 0.0181 0.0181
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.087 0.3997
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0145 0.0145
Echinococcus multilocularis ras gtpase 0.0364 0.5018 0.501
Loa Loa (eye worm) glutathione reductase 0.0038 0.0137 0.0241
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0087 0.0871 0.0871
Trichomonas vaginalis GTP-binding protein rit, putative 0.0364 0.5018 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0207 0.043
Brugia malayi Thioredoxin reductase 0.0038 0.0137 0.0241
Loa Loa (eye worm) Ras protein let-60 0.0364 0.5018 1
Echinococcus multilocularis microtubule associated protein 2 0.0696 1 1
Brugia malayi Ras protein let-60 0.0364 0.5018 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.1016 0.4791
Brugia malayi nuclear hormone receptor family member odr-7 0.0041 0.0181 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0087 0.0871 0.1709
Brugia malayi Pre-SET motif family protein 0.021 0.2712 0.539
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0082 0.0124
Loa Loa (eye worm) hypothetical protein 0.0041 0.0181 0.0329
Plasmodium vivax glutathione reductase, putative 0.0038 0.0137 0.0512
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0087 0.0871 0.0871
Echinococcus multilocularis nuclear receptor nhr 48 0.0041 0.0181 0.0165
Echinococcus granulosus dna polymerase kappa 0.0041 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0041 0.0181 0.0329
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3985 0.7864
Leishmania major DNA topoisomerase IB, large subunit 0.014 0.1667 0.383
Brugia malayi DNA topoisomerase I 0.0187 0.2372 0.471
Loa Loa (eye worm) steroid hormone receptor 0.0087 0.0871 0.1709
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0181 0.0365
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.4132 1
Plasmodium vivax topoisomerase I, putative 0.0187 0.2372 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0348 0.0527
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0087 0.0871 0.0856
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1971 1
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0181 0.0383
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.4132 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0181 0.0109
Loa Loa (eye worm) hypothetical protein 0.0046 0.0255 0.0477
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0087 0.0871 0.0856
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.1016 0.4791
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.1016 0.4791
Schistosoma mansoni DNA topoisomerase type I 0.014 0.1667 0.1653
Loa Loa (eye worm) hypothetical protein 0.0041 0.0181 0.0329
Entamoeba histolytica Ras family GTPase 0.0364 0.5018 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0041 0.0181 0.0165
Onchocerca volvulus 0.0087 0.0871 0.2731
Loa Loa (eye worm) hypothetical protein 0.0041 0.0181 0.0329
Trichomonas vaginalis set domain proteins, putative 0.0239 0.3147 0.6132
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0087 0.0871 0.2731
Brugia malayi ecdysteroid receptor 0.0087 0.0871 0.1709
Schistosoma mansoni RAR-like nuclear receptor 0.0087 0.0871 0.0856
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.1724 0.8655
Echinococcus granulosus thyroid hormone receptor alpha 0.0041 0.0181 0.0181
Entamoeba histolytica Ras family GTPase 0.0364 0.5018 1
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0181 0.0329
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0181 0.0365
Trichomonas vaginalis ras-dva small GTPase, putative 0.0364 0.5018 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0181 0.0329
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1727 0.3978
Loa Loa (eye worm) hypothetical protein 0.0041 0.0181 0.0329
Schistosoma mansoni nuclear receptor nhr-48 0.0041 0.0181 0.0165
Loa Loa (eye worm) hypothetical protein 0.0087 0.0871 0.1709
Echinococcus multilocularis FTZ F1 alpha 0.0087 0.0871 0.0856
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0087 0.0871 0.1709
Leishmania major DNA topoisomerase type IB small subunit 0.0047 0.0271 0.0334
Toxoplasma gondii DNA topoisomerase I, putative 0.0187 0.2372 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0087 0.0871 0.1709
Brugia malayi Steroid receptor seven-up type 2 0.0087 0.0871 0.1709
Brugia malayi glutathione reductase 0.0038 0.0137 0.0241
Onchocerca volvulus Bile acid receptor homolog 0.0087 0.0871 0.2731
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0041 0.0181 0.0329
Echinococcus granulosus FTZ F1 alpha 0.0087 0.0871 0.0871
Echinococcus granulosus DNA topoisomerase 1 0.0187 0.2372 0.2372
Trichomonas vaginalis ral, putative 0.0364 0.5018 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0087 0.0871 0.1709
Loa Loa (eye worm) hypothetical protein 0.0041 0.0181 0.0329
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0301 0.0285
Schistosoma mansoni thyroid hormone receptor 0.0087 0.0871 0.0856
Loa Loa (eye worm) hypothetical protein 0.0087 0.0871 0.1709
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0137 0.0512
Loa Loa (eye worm) hypothetical protein 0.0087 0.0871 0.1709
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0181 0.0329
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0087 0.0871 0.0856
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0087 0.0871 0.1709
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.0047 0.0271 0.0584
Toxoplasma gondii hypothetical protein 0.0049 0.0302 0.1211
Brugia malayi hypothetical protein 0.0041 0.0181 0.0329
Schistosoma mansoni nuclear receptor 0.0041 0.0181 0.0165
Brugia malayi polk-prov protein 0.0031 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.0041 0.0181 0.0329
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0046 0.0255 0.0239
Brugia malayi PAS domain containing protein 0.0049 0.0301 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0181 0.0365
Loa Loa (eye worm) hypothetical protein 0.0087 0.0871 0.1709
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1727 0.3978
Treponema pallidum fructose-bisphosphate aldolase 0.0295 0.3985 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0087 0.0871 0.1709
Brugia malayi ecdysone receptor 0.0041 0.0181 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0087 0.0871 0.1709
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0087 0.0871 0.1709
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0181 0.0181
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.087 0.3997
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0087 0.0871 0.0871
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0181 0.0365
Brugia malayi nuclear receptor RXR 0.0041 0.0181 0.0329
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0181 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0181 0.0365
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.1727 0.4134
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0255 0.0477
Loa Loa (eye worm) hypothetical protein 0.0046 0.0255 0.0477
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3985 0.7864
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0041 0.0181 0.0165
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0087 0.0871 0.0856
Onchocerca volvulus Protein ultraspiracle homolog 0.0087 0.0871 0.2731
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0041 0.0181 0.0329
Trichomonas vaginalis dexras1, putative 0.0364 0.5018 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0181 0.0329
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.4132 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.4132 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0152 0.1842 0.3649
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0087 0.0871 0.0856
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.014 0.1667 0.383
Loa Loa (eye worm) hypothetical protein 0.0041 0.0181 0.0329
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0087 0.0871 0.1709
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0087 0.0871 0.0871
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.011 0.0093
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0181 0.0165
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0087 0.0871 0.0871
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.1016 0.1705
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0087 0.0871 0.1709
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0181 0.0109
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0181 0.0365
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0207 0.0176
Loa Loa (eye worm) hypothetical protein 0.0046 0.0255 0.0477
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0087 0.0871 0.1709
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0087 0.0871 0.0856
Schistosoma mansoni zinc finger protein 0.0041 0.0181 0.0165
Schistosoma mansoni retinoic acid receptor RXR 0.0087 0.0871 0.0856
Schistosoma mansoni nuclear hormone receptor 0.0087 0.0871 0.0856
Schistosoma mansoni nuclear receptor 0.0041 0.0181 0.0165
Echinococcus multilocularis thyroid hormone receptor alpha 0.0087 0.0871 0.0856
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0255 0.0239
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0181 0.0181
Brugia malayi nuclear hormone receptor 0.0041 0.0181 0.0329
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.087 0.3997
Echinococcus multilocularis DNA topoisomerase 1 0.0187 0.2372 0.236
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0087 0.0871 0.0856
Brugia malayi nuclear receptor NHR-88 0.0041 0.0181 0.0329
Brugia malayi nuclear receptor NHR-88 0.0087 0.0871 0.1709
Echinococcus granulosus nuclear receptor nhr 48 0.0041 0.0181 0.0181
Brugia malayi nuclear hormone receptor 0.0087 0.0871 0.1709
Echinococcus granulosus ecdysone induced protein 78C 0.0087 0.0871 0.0871
Brugia malayi bHLH-PAS transcription factor 0.0036 0.011 0.0186
Brugia malayi hypothetical protein 0.0046 0.0255 0.0477
Schistosoma mansoni microtubule-associated protein tau 0.0696 1 1
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0181 0.0165
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3985 0.7864
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0087 0.0871 0.1709
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3985 0.7864
Mycobacterium ulcerans hypothetical protein 0.0161 0.1971 1
Schistosoma mansoni thyroid hormone receptor 0.0087 0.0871 0.0856
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0181 0.0365
Brugia malayi photoreceptor-specific nuclear receptor 0.0087 0.0871 0.1709
Mycobacterium tuberculosis Probable reductase 0.0087 0.087 0.3997
Loa Loa (eye worm) hypothetical protein 0.0046 0.0255 0.0477
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0181 0.0165
Loa Loa (eye worm) hypothetical protein 0.0046 0.0255 0.0477
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0087 0.0871 0.0871
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0181 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0181 0.0365
Brugia malayi conserved hypotetical protein 0.0041 0.0181 0.0329
Brugia malayi hypoxia-induced factor 1 0.0152 0.1842 0.3649
Brugia malayi tailless protein 0.0041 0.0181 0.0329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0087 0.0871 0.1709
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0181 0.0365
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0087 0.0871 0.0871
Schistosoma mansoni single-minded 0.0049 0.0301 0.0285
Brugia malayi hypothetical protein 0.0046 0.0255 0.0477
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0087 0.0871 0.0856
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0181 0.0526
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0087 0.0871 0.0856
Brugia malayi Nuclear hormone receptor-like 1 0.0087 0.0871 0.1709
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0181 0.0365
Toxoplasma gondii thioredoxin reductase 0.0038 0.0137 0.0512
Schistosoma mansoni steroid hormone receptor ad4bp 0.0087 0.0871 0.0856
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0087 0.0871 0.1709
Onchocerca volvulus 0.0041 0.0181 0.0526
Brugia malayi nuclear receptor RXR 0.0046 0.0255 0.0477
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.1724 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0087 0.0871 0.0856
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0087 0.0871 0.0856
Onchocerca volvulus 0.0041 0.0181 0.0526
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3985 0.7864
Brugia malayi orphan nuclear receptor NR2E1 0.0041 0.0181 0.0329
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.1724 0.8675
Loa Loa (eye worm) hypothetical protein 0.0041 0.0181 0.0329
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0137 0.0241
Loa Loa (eye worm) hypothetical protein 0.0087 0.0871 0.1709
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0181 0.0383
Brugia malayi nuclear receptor NHR-67 0.0041 0.0181 0.0329
Trichomonas vaginalis rap1 and, putative 0.0364 0.5018 1
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.014 0.1667 0.3989
Trypanosoma brucei unspecified product 0.0034 0.0082 0.0124
Brugia malayi steroid hormone receptor 0.0087 0.0871 0.1709
Onchocerca volvulus 0.0239 0.3147 1
Schistosoma mansoni coup transcription factor 0.0087 0.0871 0.0856
Brugia malayi Ras-related protein R-Ras2 0.0364 0.5018 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3985 0.7864
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0087 0.0871 0.1709
Trypanosoma brucei trypanothione reductase 0.0038 0.0137 0.0258
Loa Loa (eye worm) hypothetical protein 0.0041 0.0181 0.0329
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0181 0.0165
Brugia malayi hypothetical protein 0.0041 0.0181 0.0329
Schistosoma mansoni DNA topoisomerase type I 0.014 0.1667 0.1653
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0087 0.0871 0.1709
Loa Loa (eye worm) hypothetical protein 0.0041 0.0181 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0087 0.0871 0.1709
Echinococcus multilocularis ecdysone induced protein 78C 0.0087 0.0871 0.0856
Schistosoma mansoni DNA topoisomerase type I 0.0187 0.2372 0.236
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0046 0.0255 0.0255
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative 0.0047 0.0271 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0087 0.0871 0.1709
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0041 0.0181 0.0165
Trichomonas vaginalis rheb, putative 0.0364 0.5018 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.087 0.3997
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0017 0.0017
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0181 0.0165
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0046 0.0255 0.0477
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0181 0.0526
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.087 0.3997
Entamoeba histolytica ras-1, putative 0.0364 0.5018 1
Loa Loa (eye worm) nuclear hormone receptor 0.0041 0.0181 0.0329
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0207 0.0176
Loa Loa (eye worm) DNA topoisomerase I 0.0187 0.2372 0.471
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0087 0.0871 0.1709

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 47 % The in vivo assay of compound for inhibition of cholesterol biosynthesis was measured on Oxidosqualene-lanosterol cyclase of rat at 20 mg/kg ChEMBL. 10197973
Inhibition (functional) = 47 % The in vivo assay of compound for inhibition of cholesterol biosynthesis was measured on Oxidosqualene-lanosterol cyclase of rat at 20 mg/kg ChEMBL. 10197973

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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