TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 399.914 | Formula: C22H26ClN3O2
H donors: 2 H acceptors: 2 LogP: 3.62 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CNC(=O)c1cccc(c1)C)NCC1CCCN1Cc1ccc(cc1)Cl
InChi: 1S/C22H26ClN3O2/c1-16-4-2-5-18(12-16)22(28)25-14-21(27)24-13-20-6-3-11-26(20)15-17-7-9-19(23)10-8-17/h2,4-5,7-10,12,20H,3,6,11,13-15H2,1H3,(H,24,27)(H,25,28)
InChiKey: UEOGQPZYSMZGAM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chemokine (C-C motif) receptor 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0043	0.0195	0.0183
Brugia malayi	nuclear hormone receptor	0.0043	0.0195	0.0183
Toxoplasma gondii	heat shock protein 75, putative	0.003	0.0089	0.0605
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0043	0.0195	0.0183
Schistosoma mansoni	heat shock protein	0.0045	0.021	0.0336
Schistosoma mansoni	serine/threonine protein kinase	0.0098	0.0632	0.1052
Trypanosoma brucei	heat shock protein, putative	0.0045	0.021	0.0473
Schistosoma mansoni	thyroid hormone receptor	0.0043	0.0195	0.031
Schistosoma mansoni	hypothetical protein	0.0185	0.1336	0.2247
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.019	0.0302
Brugia malayi	hypothetical protein	0.0023	0.0031	0.002
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0043	0.0195	0.0183
Schistosoma mansoni	hypothetical protein	0.0033	0.0112	0.0169
Brugia malayi	latrophilin 2 splice variant baaae	0.0071	0.0417	0.0405
Trypanosoma brucei	heat shock protein, putative	0.0045	0.021	0.0473
Trypanosoma brucei	Heat shock protein 83, putative	0.0045	0.021	0.0473
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0043	0.0195	0.1835
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0076	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0679	0.0668
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0112	0.0169
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0039	0.0158	0.7309
Brugia malayi	RNA, U transporter 1	0.0081	0.0495	0.0484
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0043	0.0195	0.0183
Trypanosoma cruzi	heat shock protein 90, putative	0.0039	0.0158	0.0383
Trypanosoma cruzi	squalene monooxygenase, putative	0.0532	0.4119	1
Trichomonas vaginalis	heat shock protein, putative	0.0042	0.0188	0.8856
Schistosoma mansoni	coup transcription factor	0.0043	0.0195	0.031
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0184	0.1325	0.2227
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0043	0.0195	0.031
Plasmodium falciparum	heat shock protein 90	0.0045	0.021	0.1614
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Schistosoma mansoni	endoplasmin	0.0045	0.021	0.0336
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0031	0.0033
Entamoeba histolytica	hypothetical protein	0.0098	0.0632	1
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0076	0.0109
Trypanosoma brucei	heat shock protein 90, putative	0.0045	0.021	0.0473
Schistosoma mansoni	hypothetical protein	0.015	0.1048	0.1758
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0042	0.0188	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0417	0.0405
Entamoeba histolytica	heat shock protein 90, putative	0.0045	0.021	0.3149
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0043	0.0195	0.0183
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.019	0.0302
Loa Loa (eye worm)	endoplasmin	0.0045	0.021	0.0199
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0043	0.0195	0.031
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Trichomonas vaginalis	heat shock protein, putative	0.0033	0.0111	0.4892
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0045	0.021	1
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Schistosoma mansoni	hypothetical protein	0.0033	0.0112	0.0169
Toxoplasma gondii	heat shock protein 90, putative	0.0045	0.021	0.1614
Trichomonas vaginalis	heat shock protein, putative	0.0045	0.021	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0043	0.0195	0.031
Echinococcus granulosus	endoplasmin	0.0042	0.0188	0.0299
Echinococcus multilocularis	ecdysone induced protein 78C	0.0043	0.0195	0.031
Toxoplasma gondii	heat shock protein HSP90	0.0045	0.021	0.1614
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0043	0.0195	0.0183
Trichomonas vaginalis	endoplasmin, putative	0.0033	0.0111	0.4892
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0076	0.0499
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0042	0.0188	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0195	0.0183
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0098	0.0632	0.1535
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0104	0.0679	0.0668
Plasmodium falciparum	heat shock protein 90, putative	0.0171	0.1218	1
Schistosoma mansoni	microtubule-associated protein tau	0.0755	0.5906	1
Brugia malayi	MH2 domain containing protein	0.0111	0.0739	0.0728
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0043	0.0195	0.031
Plasmodium falciparum	endoplasmin, putative	0.0033	0.0111	0.0789
Schistosoma mansoni	heat shock protein	0.0045	0.021	0.0336
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0098	0.0632	0.1535
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0104	0.0679	0.0668
Trypanosoma brucei	squalene monooxygenase, putative	0.0532	0.4119	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0043	0.0195	0.0183
Schistosoma mansoni	hypothetical protein	0.0185	0.1336	0.2247
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0303	0.2277	0.2268
Brugia malayi	Hsp90 protein	0.003	0.0089	0.0077
Trypanosoma cruzi	heat shock protein 85, putative	0.0045	0.021	0.051
Echinococcus granulosus	GPCR family 2	0.0033	0.0112	0.0169
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0043	0.0195	0.031
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0016	0.0007
Entamoeba histolytica	hypothetical protein	0.0023	0.0033	0.0276
Mycobacterium ulcerans	heat shock protein 90	0.0042	0.0188	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0348	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0064
Echinococcus granulosus	microtubule associated protein 2	0.0755	0.5906	1
Echinococcus multilocularis	microtubule associated protein 2	0.0755	0.5906	1
Trypanosoma cruzi	squalene monooxygenase, putative	0.0532	0.4119	1
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.003	0.0089	0.0773
Schistosoma mansoni	ran	0.0021	0.0016	0.0007
Entamoeba histolytica	hypothetical protein	0.0041	0.0176	0.2597
Brugia malayi	hypothetical protein	0.0023	0.0031	0.002
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.019	0.0302
Echinococcus multilocularis	heat shock protein 90	0.0045	0.021	0.0336
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0043	0.019	0.0178
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0031	0.002
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0023	0.0031	0.0033
Schistosoma mansoni	importin beta-1	0.0028	0.0076	0.0109
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0112	0.01
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.003	0.0089	0.0131
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0043	0.0195	0.031
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0043	0.0195	0.031
Schistosoma mansoni	hypothetical protein	0.0033	0.0112	0.0169
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0043	0.0195	0.0183
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0112	0.0169
Onchocerca volvulus		0.0144	0.1008	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0076	0.0499
Echinococcus granulosus	heat shock protein 90	0.0045	0.021	0.0336
Schistosoma mansoni	heat shock protein	0.003	0.0089	0.0131
Trypanosoma brucei	heat shock protein, putative	0.0045	0.021	0.0473
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0043	0.019	0.0178
Entamoeba histolytica	hypothetical protein	0.0041	0.0176	0.2597
Echinococcus granulosus	jun protein	0.0184	0.1325	0.2227
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.0632	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0043	0.0195	0.031
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0348	0.0337
Echinococcus multilocularis	dual specificity	0.0098	0.0632	0.1052
Brugia malayi	RNA binding protein	0.0062	0.0348	0.0337
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0033	0.008
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0176	0.0279
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0043	0.0195	0.031
Echinococcus multilocularis	jun protein	0.0184	0.1325	0.2227
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0098	0.0632	0.1502
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0043	0.0195	0.0183
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0059	0.2201
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0348	0.0571
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0348	0.0337
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0348	0.0571
Brugia malayi	TAR-binding protein	0.0062	0.0348	0.0337
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0043	0.0195	0.0183
Onchocerca volvulus		0.0043	0.0195	0.1835
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0112	0.0169
Leishmania major	squalene monooxygenase-like protein	0.0532	0.4119	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0112	0.0169
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0023	0.0031	0.002
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0076	0.0146
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0104	0.0679	0.0668
Brugia malayi	nuclear receptor RXR	0.0023	0.0031	0.002
Trypanosoma cruzi	heat shock protein 85, putative	0.0045	0.021	0.051
Leishmania major	heat shock protein, putative	0.003	0.0089	0.0177
Trypanosoma cruzi	heat shock protein 85, putative	0.0039	0.0158	0.0383
Brugia malayi	steroid hormone receptor	0.0043	0.0195	0.0183
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.019	0.0302
Loa Loa (eye worm)	transcription factor SMAD2	0.0111	0.0739	0.0728
Echinococcus multilocularis	heat shock protein 90	0.0039	0.0158	0.0248
Trypanosoma brucei	heat shock protein 90, putative	0.0045	0.021	0.0473
Loa Loa (eye worm)	heat shock protein 90	0.0045	0.021	0.0199
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.003	0.0089	0.0131
Schistosoma mansoni	hypothetical protein	0.0041	0.0176	0.0279
Onchocerca volvulus	Protein ultraspiracle homolog	0.0043	0.0195	0.1835
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0195	0.0183
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0043	0.0195	0.031
Brugia malayi	Importin beta-1 subunit	0.0028	0.0076	0.0064
Brugia malayi	hypothetical protein	0.0144	0.1008	0.0997
Brugia malayi	ecdysteroid receptor	0.0043	0.0195	0.0183
Echinococcus multilocularis	endoplasmin	0.0042	0.0188	0.0299
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0628	0.0617
Trypanosoma brucei	heat shock protein, putative	0.0045	0.021	0.0473
Trypanosoma cruzi	heat shock protein, putative	0.003	0.0089	0.0216
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0043	0.0195	0.0183
Schistosoma mansoni	hypothetical protein	0.0071	0.0417	0.0687
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0042	0.0188	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0043	0.0195	0.031
Entamoeba histolytica	protein kinase, putative	0.0098	0.0632	1
Entamoeba histolytica	hypothetical protein	0.0041	0.0176	0.2597
Entamoeba histolytica	hypothetical protein	0.0041	0.0176	0.2597
Entamoeba histolytica	heat shock protein 90, putative	0.0045	0.021	0.3149
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0043	0.0195	0.031
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0195	0.0183
Plasmodium falciparum	heat shock protein 90, putative	0.0026	0.0059	0.0355
Trypanosoma cruzi	Heat shock protein 83, putative	0.0045	0.021	0.051
Trypanosoma cruzi	heat shock protein 90, putative	0.0045	0.021	0.051
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0112	0.01
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0043	0.0195	0.031
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0043	0.0195	0.031
Schistosoma mansoni	RAR-like nuclear receptor	0.0043	0.0195	0.031
Trypanosoma brucei	heat shock protein, putative	0.0045	0.021	0.0473
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0043	0.0195	0.031
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0016	0.0004
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.019	0.0302
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Echinococcus granulosus	dual specificity	0.0098	0.0632	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0195	0.0183
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0043	0.0195	0.031
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0112	0.0169
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0076	0.0146
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0043	0.0195	0.0183
Echinococcus multilocularis	snurportin 1	0.0303	0.2277	0.3842
Brugia malayi	nuclear receptor NHR-88	0.0043	0.0195	0.0183
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Entamoeba histolytica	protein kinase, putative	0.0098	0.0632	1
Schistosoma mansoni	nuclear hormone receptor	0.0043	0.0195	0.031
Brugia malayi	Steroid receptor seven-up type 2	0.0043	0.0195	0.0183
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0043	0.0195	0.031
Echinococcus granulosus	geminin	0.0185	0.1336	0.2247
Brugia malayi	Nuclear hormone receptor-like 1	0.0043	0.0195	0.0183
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0023	0.0031	0.0033
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Loa Loa (eye worm)	heat shock protein 75	0.003	0.0089	0.0077
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0348	0.0337
Echinococcus granulosus	snurportin 1	0.0303	0.2277	0.3842
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.019	0.0302
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0043	0.0195	0.031
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Schistosoma mansoni	jun-related protein	0.015	0.1048	0.1758
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Echinococcus multilocularis	geminin	0.0185	0.1336	0.2247
Schistosoma mansoni	ran	0.0021	0.0016	0.0007
Loa Loa (eye worm)	MH2 domain-containing protein	0.0111	0.0739	0.0728
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0016	0.0039
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0348	0.0571
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0031	0.002
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0043	0.0195	0.0183
Trichomonas vaginalis	heat shock protein, putative	0.0042	0.0188	0.8856
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0043	0.0195	0.0183
Trypanosoma brucei	heat shock protein 84, putative	0.003	0.0089	0.0177
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0016	0.0007
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0043	0.0195	0.0183
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Plasmodium vivax	heat shock protein 90, putative	0.003	0.0089	0.0605
Schistosoma mansoni	endoplasmin	0.0045	0.021	0.0336
Echinococcus granulosus	heat shock protein	0.0045	0.021	0.0336
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.019	0.0302
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0348	0.0337
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0348	0.0571
Trypanosoma cruzi	heat shock protein 85, putative	0.0045	0.021	0.051
Brugia malayi	photoreceptor-specific nuclear receptor	0.0043	0.0195	0.0183
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0033	0.0878
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0023	0.0031	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0031	0.002
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0176	0.0279
Echinococcus multilocularis	heat shock protein	0.0045	0.021	0.0336
Brugia malayi	Endoplasmin precursor	0.0045	0.021	0.0199
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0043	0.0195	0.0183
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0043	0.0195	0.0183
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0042	0.0188	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0031	0.002
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0043	0.0195	0.0183
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0043	0.0195	0.031
Treponema pallidum	heat shock protein 90	0.0042	0.0188	0.5
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0033	0.0042
Plasmodium vivax	heat shock protein, putative	0.0171	0.1218	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0043	0.0195	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0195	0.0183
Echinococcus multilocularis	FTZ F1 alpha	0.0043	0.0195	0.031
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0628	0.0617
Brugia malayi	hypothetical protein	0.0041	0.0176	0.0164
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0184	0.1325	0.2227
Schistosoma mansoni	hypothetical protein	0.0303	0.2277	0.3842
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0112	0.01
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0043	0.0195	0.031
Onchocerca volvulus	Bile acid receptor homolog	0.0043	0.0195	0.1835
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0043	0.0195	0.031
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0098	0.0632	0.1502
Brugia malayi	bZIP transcription factor family protein	0.0184	0.1325	0.1314
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0033	0.0878
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1284	0.1274
Plasmodium falciparum	importin beta, putative	0.0028	0.0076	0.0499
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0176	0.0279
Loa Loa (eye worm)	hypothetical protein	0.1266	1	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0195	0.0183
Entamoeba histolytica	90 kDa heat shock protein, putative	0.003	0.0089	0.118
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0098	0.0632	0.0621
Toxoplasma gondii	Hsp90 domain-containing protein	0.0171	0.1218	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0348	0.0571
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0033	0.0878
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0039	0.0158	0.0248
Giardia lamblia	Grp94/Hsp90	0.0042	0.0188	0.8856
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0348	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0031	0.002
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0043	0.0195	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0031	0.002
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0195	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0195	0.0183
Echinococcus granulosus	FTZ F1 alpha	0.0043	0.0195	0.031
Brugia malayi	heat shock protein 90	0.0045	0.021	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0031	0.002
Loa Loa (eye worm)	steroid hormone receptor	0.0043	0.0195	0.0183
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0043	0.0195	0.031
Echinococcus granulosus	heat shock protein 90	0.0039	0.0158	0.0248
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0043	0.0195	0.031
Plasmodium vivax	endoplasmin, putative	0.0045	0.021	0.1614
Schistosoma mansoni	hypothetical protein	0.0033	0.0112	0.0169
Trypanosoma brucei	heat shock protein, putative	0.0045	0.021	0.0473
Trypanosoma brucei	heat shock protein, putative	0.0045	0.021	0.0473
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0112	0.01
Schistosoma mansoni	thyroid hormone receptor	0.0043	0.0195	0.031
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0016	0.0039
Trypanosoma brucei	heat shock protein, putative	0.0045	0.021	0.0473
Brugia malayi	Protein kinase domain containing protein	0.0098	0.0632	0.0621
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0016	0.0004
Plasmodium vivax	heat shock protein 86, putative	0.0045	0.021	0.1614
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473
Trichomonas vaginalis	heat shock protein, putative	0.0039	0.0158	0.7309
Leishmania major	heat shock protein 83-1	0.0045	0.021	0.0473

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 14 uM	Concentration required to inhibit [125I]-MCP-1 binding to Chemokine receptor 2B	ChEMBL.	15454236
IC50 (binding)	= 14 uM	Concentration required to inhibit [125I]-MCP-1 binding to Chemokine receptor 2B	ChEMBL.	15454236

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 325298