Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0242 | 0.1136 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.0619 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0516 | 0.0739 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0242 | 0.1136 |
Trichomonas vaginalis | set domain proteins, putative | 0.0253 | 0.802 | 0.7971 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0516 | 0.0955 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0039 | 0.0874 | 0.1264 |
Brugia malayi | secreted modular calcium-binding protein 1 | 0.0128 | 0.385 | 0.5461 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0039 | 0.0874 | 0.164 |
Loa Loa (eye worm) | thyroglobulin type-1 repeat family protein | 0.0128 | 0.385 | 0.5506 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0242 | 0.1136 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0032 | 0.0619 | 0.0755 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0242 | 0.1136 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0222 | 0.6992 | 1 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0516 | 0.0955 |
Onchocerca volvulus | 0.0128 | 0.385 | 0.4442 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0499 | 0.0713 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0619 | 0.0755 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.007 | 0.1912 | 0.3341 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0516 | 0.0955 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0874 | 0.0648 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0032 | 0.0619 | 0.1152 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0242 | 0.0251 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0242 | 0.0251 |
Brugia malayi | Thyroglobulin type-1 repeat family protein | 0.0128 | 0.385 | 0.5461 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.0242 | 0.043 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.058 | 0.1077 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0039 | 0.0874 | 0.164 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0069 | 0.0098 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0312 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.382 | 0.5463 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0242 | 0.043 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.007 | 0.1912 | 0.1711 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0039 | 0.0874 | 0.0648 |
Schistosoma mansoni | lamin | 0.0029 | 0.0516 | 0.0548 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0039 | 0.0874 | 0.164 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.1912 | 0.3627 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.385 | 0.5506 |
Brugia malayi | Thyroglobulin type-1 repeat family protein | 0.0128 | 0.385 | 0.5461 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0152 | 0.4656 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0619 | 0.0755 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.0242 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0874 | 0.125 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0312 | 1 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.007 | 0.1912 | 1 |
Onchocerca volvulus | 0.0128 | 0.385 | 0.4442 | |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.0874 | 0.4491 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0242 | 0.1136 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.1912 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0152 | 0.4656 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0242 | 0.1136 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0242 | 0.1136 |
Onchocerca volvulus | 0.0253 | 0.802 | 1 | |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0039 | 0.0874 | 0.0648 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0039 | 0.0874 | 0.1264 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.0874 | 0.3785 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0039 | 0.0874 | 0.0648 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.007 | 0.1912 | 0.2735 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0516 | 0.0646 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0242 | 0.1136 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0516 | 0.0955 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0312 | 1 | 1 |
Onchocerca volvulus | 0.0128 | 0.385 | 0.4442 | |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.0619 | 0.0795 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0242 | 0.043 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0242 | 0.1136 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0039 | 0.0874 | 0.0648 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0619 | 0.0755 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.1912 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0018 | 0.0025 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0041 | 0.0918 | 0.1724 |
Schistosoma mansoni | insulin-like growth factor binding protein-related | 0.017 | 0.5241 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0242 | 0.1136 |
Brugia malayi | Thyroglobulin type-1 repeat family protein | 0.0128 | 0.385 | 0.5461 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0242 | 0.1136 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0312 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0516 | 0.0739 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0039 | 0.0874 | 0.1163 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0312 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.385 | 0.5506 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0619 | 0.1152 |
Echinococcus multilocularis | insulin growth factor binding | 0.017 | 0.5241 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0242 | 0.1136 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0516 | 0.0955 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0032 | 0.0619 | 0.1152 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0516 | 0.0548 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0152 | 0.4656 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.1912 | 0.3627 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.0619 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.1401 | 0.2319 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0039 | 0.0874 | 0.164 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0039 | 0.0874 | 0.164 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.385 | 0.5506 |
Schistosoma mansoni | lamin | 0.0029 | 0.0516 | 0.0548 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0312 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.385 | 0.5506 |
Onchocerca volvulus | 0.0128 | 0.385 | 0.4442 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0516 | 0.0739 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.1912 | 1 |
Onchocerca volvulus | 0.0032 | 0.0619 | 0.0137 | |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.0242 | 0.043 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.382 | 0.5418 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.007 | 0.1912 | 0.2662 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0312 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0516 | 0.0646 |
Echinococcus granulosus | lamin | 0.0029 | 0.0516 | 0.0955 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0242 | 0.1136 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.382 | 0.5463 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0039 | 0.0874 | 0.3785 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 0.0242 | 0.1136 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.0242 | 0.1136 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0041 | 0.0918 | 0.1724 |
Brugia malayi | Pre-SET motif family protein | 0.0222 | 0.6992 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0312 | 1 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.0242 | 0.043 |
Echinococcus granulosus | insulin growth factor binding | 0.017 | 0.5241 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.0242 | 0.043 |
Loa Loa (eye worm) | thyroglobulin type-1 repeat family protein | 0.0128 | 0.385 | 0.5506 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0312 | 1 | 0.5 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.0874 | 0.3785 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0312 | 1 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0039 | 0.0874 | 0.164 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0312 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0619 | 0.0886 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0242 | 0.0346 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | In vitro dissociation constant of compound required for inhibition of Escherichia coli translation was determined | ChEMBL. | 15454207 |
IC50 (functional) | > 100 uM | In vitro dissociation constant of compound required for inhibition of Escherichia coli translation was determined | ChEMBL. | 15454207 |
Inhibition (functional) | < 75 % | Antibacterial activity of the compound against Escherichia coli was determined at 100 uM | ChEMBL. | 15454207 |
Inhibition (functional) | < 75 % | Antibacterial activity of the compound against Staphylococcus aureus was determined at 100 uM | ChEMBL. | 15454207 |
Inhibition (functional) | < 75 % | Antibacterial activity of the compound against Escherichia coli was determined at 100 uM | ChEMBL. | 15454207 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.