Detailed information for compound 331500

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 375.661 | Formula: C13H9Cl3N4OS
  • H donors: 1 H acceptors: 2 LogP: 3.72 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1nn(c2c1c(=O)[nH]c(n2)C)c1c(Cl)cc(cc1Cl)Cl
  • InChi: 1S/C13H9Cl3N4OS/c1-5-17-11-9(12(21)18-5)13(22-2)19-20(11)10-7(15)3-6(14)4-8(10)16/h3-4H,1-2H3,(H,17,18,21)
  • InChiKey: BTSZMJKDZCBEGX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin B1 References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens cyclin D1 Starlite/ChEMBL References
Homo sapiens cyclin E2 Starlite/ChEMBL References
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens cyclin B2 Starlite/ChEMBL References
Homo sapiens cyclin E1 References
Homo sapiens cyclin-dependent kinase 4 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_133273 All targets in OG5_133273
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_133273 All targets in OG5_133273
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 4 303 aa 312 aa 29.8 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0232 0.3234 1
Trypanosoma cruzi CYC2-like cyclin, putative 0.0189 0.2458 0.6999
Loa Loa (eye worm) IMP dehydrogenase 1 0.0246 0.3497 0.3502
Trichomonas vaginalis cyclin B, putative 0.0189 0.2458 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0151 0.0151
Trypanosoma cruzi cyclin, putative 0.0189 0.2458 0.6999
Trichomonas vaginalis cyclin B3, putative 0.0129 0.1382 0.5559
Plasmodium falciparum cyclin 0.0129 0.1382 0.421
Onchocerca volvulus 0.0189 0.2458 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0246 0.3497 1
Echinococcus multilocularis cyclins 0.0129 0.1382 0.1351
Trichomonas vaginalis cyclins, putative 0.0189 0.2458 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0129 0.1397 0.0954
Entamoeba histolytica cyclin, putative 0.0129 0.1382 0.5559
Echinococcus granulosus cyclins 0.0129 0.1382 0.1351
Entamoeba histolytica cyclin family protein 0.0129 0.1382 0.5559
Echinococcus multilocularis cyclin B 0.0189 0.2458 0.2431
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0054 0.0036 0.0036
Trypanosoma brucei GMP reductase 0.0246 0.3497 1
Echinococcus multilocularis cyclin b3 0.0129 0.1382 0.1351
Brugia malayi GMP reductase 0.0102 0.0913 0.0881
Echinococcus multilocularis cyclins 0.0129 0.1382 0.1351
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0235 0.3298 0.3303
Brugia malayi Cyclin, N-terminal domain containing protein 0.0316 0.4747 0.4735
Loa Loa (eye worm) hypothetical protein 0.0189 0.2458 0.2462
Trypanosoma cruzi GMP reductase 0.0246 0.3497 1
Leishmania major inosine-5-monophosphate dehydrogenase 0.0246 0.3497 1
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0246 0.3497 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0189 0.2458 0.2435
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0263 0.3793 0.3771
Echinococcus granulosus TGF-beta receptor type-1 0.0609 1 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0246 0.3497 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0316 0.4747 0.4754
Echinococcus multilocularis cyclin B3 1 0.0129 0.1382 0.1351
Echinococcus multilocularis TGF beta receptor type 1 0.0609 1 1
Trichomonas vaginalis cyclin D, putative 0.0129 0.1382 0.5559
Trypanosoma cruzi cyclin 6, putative 0.0189 0.2458 0.6999
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0608 0.9985 1
Schistosoma mansoni protein kinase 0.0609 1 1
Echinococcus granulosus cyclins 0.0129 0.1382 0.1351
Echinococcus multilocularis activin receptor type 0.0277 0.4041 0.402
Brugia malayi bone morphogenetic protein type 1 receptor 0.0608 0.9985 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0102 0.0913 0.0881
Toxoplasma gondii IMP dehydrogenas 0.0246 0.3497 1
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0276 0.402 0.3999
Toxoplasma gondii hypothetical protein 0.0098 0.0826 0.2282
Schistosoma mansoni cyclin B 0.0189 0.2458 0.2431
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0246 0.3497 1
Echinococcus granulosus cyclin B3 1 0.0129 0.1382 0.1351
Loa Loa (eye worm) hypothetical protein 0.0189 0.2458 0.2462
Brugia malayi Protein kinase domain containing protein 0.0235 0.3298 0.3279
Trichomonas vaginalis cyclins, putative 0.0189 0.2458 1
Trichomonas vaginalis cyclin B, putative 0.0189 0.2458 1
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0246 0.3497 0.3474
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0232 0.3234 1
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0246 0.3497 1
Trichomonas vaginalis cyclin D, putative 0.0129 0.1382 0.5559
Schistosoma mansoni protein kinase 0.0275 0.4005 0.3984
Giardia lamblia Hypothetical protein 0.0129 0.1382 0.5559
Trypanosoma cruzi cyclin, putative 0.0189 0.2458 0.6999
Leishmania major guanosine monophosphate reductase 0.0246 0.3497 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0263 0.3793 0.3776
Entamoeba histolytica cyclin, putative 0.0189 0.2458 1
Trypanosoma cruzi GMP reductase 0.0246 0.3497 1
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0189 0.2458 0.6999
Echinococcus granulosus activin receptor type 0.0277 0.4041 0.402
Trichomonas vaginalis cyclins, putative 0.0091 0.0708 0.2774
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0246 0.3497 0.5
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0235 0.3298 0.3303
Schistosoma mansoni cyclin B3 0.0263 0.3793 0.3771
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.1382 0.5559
Trichomonas vaginalis cyclin B, putative 0.0189 0.2458 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0246 0.3497 1
Leishmania major cyclin 0.0189 0.2458 0.6999
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0102 0.0913 0.0881
Trichomonas vaginalis cyclins, putative 0.0189 0.2458 1
Giardia lamblia G2/mitotic-specific cyclin B 0.0189 0.2458 1
Echinococcus granulosus cyclin B 0.0189 0.2458 0.2431
Brugia malayi hypothetical protein 0.0233 0.3262 0.3243
Giardia lamblia Cyclin A 0.0129 0.1382 0.5559
Echinococcus granulosus cyclins 0.0129 0.1382 0.1351
Echinococcus granulosus cyclins 0.0129 0.1382 0.1351
Trichomonas vaginalis cyclin A, putative 0.0189 0.2458 1
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0246 0.3497 0.3474
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0246 0.3497 0.3479
Trichomonas vaginalis cyclin B, putative 0.0189 0.2458 1
Schistosoma mansoni cyclins 0.0129 0.1382 0.1351
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0246 0.3497 0.3474
Echinococcus multilocularis cyclins 0.0129 0.1382 0.1351
Trichomonas vaginalis cyclin B, putative 0.0129 0.1382 0.5559
Loa Loa (eye worm) cyclin domain-containing protein 0.0263 0.3793 0.3799
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0246 0.3497 1
Echinococcus granulosus cyclins 0.0129 0.1382 0.1351
Echinococcus multilocularis cyclins 0.0129 0.1382 0.1351
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0232 0.3234 0.8869
Entamoeba histolytica cyclin family protein 0.0129 0.1382 0.5559
Echinococcus granulosus cyclin b3 0.0129 0.1382 0.1351
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0054 0.0036 0.0036
Loa Loa (eye worm) GMP reductase 0.0102 0.0913 0.0914
Echinococcus multilocularis cyclins 0.0129 0.1382 0.1351
Brugia malayi Cyclin, N-terminal domain containing protein 0.0189 0.2458 0.2435
Trypanosoma brucei mitotic cyclin 6 0.0189 0.2458 0.6999
Echinococcus multilocularis cyclins 0.0129 0.1382 0.1351
Echinococcus multilocularis cyclins 0.0129 0.1382 0.1351
Trichomonas vaginalis cyclins, putative 0.0129 0.1382 0.5559
Trichomonas vaginalis cyclins, putative 0.0189 0.2458 1
Loa Loa (eye worm) hypothetical protein 0.0233 0.3262 0.3267
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0263 0.3793 0.3771
Brugia malayi protein C17H12.11 0.0233 0.3262 0.3243
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0054 0.0036 0.0036

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.36 uM Inhibition of Cyclin-dependent kinase 2-cyclin E ChEMBL. 15537345
IC50 (binding) = 0.36 uM Inhibition of Cyclin-dependent kinase 2-cyclin E ChEMBL. 15537345
IC50 (binding) = 2.1 uM Inhibition of Cyclin-dependent kinase 4-cyclin D1 ChEMBL. 15537345
IC50 (binding) = 2.1 uM Inhibition of Cyclin-dependent kinase 4/cyclin D1 ChEMBL. 15537345
IC50 (binding) = 2.1 uM Inhibition of Cyclin-dependent kinase 4-cyclin D1 ChEMBL. 15537345
IC50 (binding) = 2.1 uM Inhibition of Cyclin-dependent kinase 4/cyclin D1 ChEMBL. 15537345
IC50 (functional) = 2.5 uM Concentration required for growth inhibition of human colon carcinoma cell line HCT-116 ChEMBL. 15537345
IC50 (functional) = 2.5 uM Concentration required for growth inhibition of human colon carcinoma cell line HCT-116 ChEMBL. 15537345
IC50 (binding) = 6.2 uM Inhibition of Cyclin-dependent kinase 1-cyclin B ChEMBL. 15537345
IC50 (binding) = 6.2 uM Inhibition of Cyclin-dependent kinase 1-cyclin B ChEMBL. 15537345
IC50 (functional) = 9.2 uM Concentration required for growth inhibition of human fibroblast cell line Ag 1523 ChEMBL. 15537345
IC50 (functional) = 9.2 uM Concentration required for growth inhibition of human fibroblast cell line Ag 1523 ChEMBL. 15537345
IC50 (binding) = 420 uM Inhibition of Protein Kinase C activity ChEMBL. 15537345
IC50 (binding) = 420 uM Inhibition of Protein Kinase C activity ChEMBL. 15537345
IC50 (binding) > 500 uM Inhibition of Protein Kinase A activity ChEMBL. 15537345
IC50 (binding) > 500 uM Inhibition of c-Abl tyrosine kinase activity ChEMBL. 15537345
IC50 (binding) > 500 uM Inhibition of c-Abl tyrosine kinase activity ChEMBL. 15537345

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15537345

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.