Detailed information for compound 333839

Basic information

Technical information
  • TDR Targets ID: 333839
  • Name: 4-[(5-amino-1-benzoyl-1,2,4-triazol-3-yl)amin o]benzenesulfonamide
  • MW: 358.375 | Formula: C15H14N6O3S
  • H donors: 3 H acceptors: 5 LogP: 2.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(nn1C(=O)c1ccccc1)Nc1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C15H14N6O3S/c16-14-19-15(18-11-6-8-12(9-7-11)25(17,23)24)20-21(14)13(22)10-4-2-1-3-5-10/h1-9H,(H2,17,23,24)(H3,16,18,19,20)
  • InChiKey: PTFAHECOMVRYLS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[[5-azanyl-1-(phenylcarbonyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide
  • 4-[[5-amino-1-(benzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide
  • 4-[[5-amino-1-(oxo-phenylmethyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide
  • 4-[(5-amino-1-phenylcarbonyl-1,2,4-triazol-3-yl)amino]benzenesulfonamide
  • 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3a

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens cyclin B2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0116 0.0231 0.1217
Echinococcus granulosus tissue type plasminogen activator 0.0369 0.1899 0.1824
Echinococcus multilocularis serine threonine protein kinase 0.0206 0.0825 0.074
Onchocerca volvulus 0.0096 0.0096 0.0508
Toxoplasma gondii hypothetical protein 0.0096 0.0096 0.0118
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0092 0.0209
Giardia lamblia G2/mitotic-specific cyclin B 0.0116 0.0231 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.027 0.1243 0.6445
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0092 0.0209
Trichomonas vaginalis cyclin B, putative 0.0116 0.0231 1
Onchocerca volvulus 0.0096 0.0096 0.0508
Brugia malayi C1-like domain containing protein 0.0199 0.0774 0.0766
Echinococcus multilocularis serine:threonine protein kinase N2 0.022 0.0918 0.0834
Loa Loa (eye worm) hypothetical protein 0.0096 0.0096 0.0059
Toxoplasma gondii PAN domain-containing protein 0.0096 0.0096 0.0118
Brugia malayi GnHR receptor homolog 0.1448 0.9004 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0096 0.0059
Onchocerca volvulus 0.0201 0.0789 0.4153
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0092 0.0209
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0092 0.0209
Schistosoma mansoni integrin beta subunit 0.018 0.0652 0.3242
Loa Loa (eye worm) hypothetical protein 0.0095 0.0092 0.0052
Echinococcus multilocularis protein kinase c iota type 0.0232 0.0993 0.0909
Echinococcus granulosus serine:threonine protein kinase N2 0.0146 0.0429 0.0341
Loa Loa (eye worm) hypothetical protein 0.027 0.1243 0.161
Onchocerca volvulus 0.0095 0.0092 0.0483
Toxoplasma gondii PAN domain-containing protein 0.0649 0.3738 1
Onchocerca volvulus 0.0095 0.0092 0.0483
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0092 0.0209
Loa Loa (eye worm) hypothetical protein 0.0116 0.0231 0.0241
Echinococcus granulosus Protein kinase C brain isozyme 0.0276 0.1282 0.1202
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0092 0.0209
Loa Loa (eye worm) hypothetical protein 0.0363 0.1857 0.244
Schistosoma mansoni cyclin B3 0.0195 0.0752 0.3789
Brugia malayi PAN domain containing protein 0.0096 0.0096 0.0005
Schistosoma mansoni cyclin B 0.0116 0.0231 0.0964
Brugia malayi PAN domain containing protein 0.0096 0.0096 0.0005
Toxoplasma gondii microneme protein MIC17C 0.0096 0.0096 0.0118
Loa Loa (eye worm) integrin beta-2 0.0305 0.1479 0.1928
Onchocerca volvulus 0.0127 0.0304 0.1599
Trichomonas vaginalis cyclins, putative 0.0116 0.0231 1
Onchocerca volvulus 0.0096 0.0096 0.0508
Onchocerca volvulus 0.0363 0.1857 0.9776
Loa Loa (eye worm) trypsin family protein 0.0095 0.0092 0.0052
Leishmania major hypothetical protein, conserved 0.0369 0.1899 1
Echinococcus multilocularis RNA directed DNA polymerase 0.0123 0.028 0.019
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0092 0.0209
Echinococcus multilocularis protein kinase c epsilon type 0.0296 0.1418 0.1338
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0296 0.1418 0.1846
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0129 0.0318 0.0358
Brugia malayi Kringle domain containing protein 0.0369 0.1899 0.2028
Schistosoma mansoni protein kinase C mu 0.0199 0.0774 0.3907
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0123 0.028 0.019
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0092 0.0209
Loa Loa (eye worm) hypothetical protein 0.0095 0.0092 0.0052
Trypanosoma cruzi CYC2-like cyclin, putative 0.0116 0.0231 0.0964
Loa Loa (eye worm) hypothetical protein 0.0095 0.0092 0.0052
Onchocerca volvulus 0.0196 0.076 0.4004
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0092 0.0209
Toxoplasma gondii PAN domain-containing protein 0.0096 0.0096 0.0118
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.0096 0.0059
Brugia malayi PAN domain containing protein 0.0096 0.0096 0.0005
Echinococcus multilocularis tissue type plasminogen activator 0.0369 0.1899 0.1824
Schistosoma mansoni hypothetical protein 0.0369 0.1899 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0116 0.0231 0.0156
Loa Loa (eye worm) cyclin domain-containing protein 0.0195 0.0752 0.0946
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0095 0.0092 0.0209
Trichomonas vaginalis cyclin B, putative 0.0116 0.0231 1
Trypanosoma cruzi cyclin, putative 0.0116 0.0231 0.0964
Trypanosoma cruzi hypothetical protein, conserved 0.0369 0.1899 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0369 0.1899 0.5
Loa Loa (eye worm) hypothetical protein 0.0201 0.0789 0.0995
Brugia malayi protein kinase C II. 0.0296 0.1418 0.1488
Toxoplasma gondii microneme protein MIC17B 0.0096 0.0096 0.0118
Echinococcus granulosus protein kinase c epsilon type 0.0296 0.1418 0.1338
Echinococcus multilocularis cathepsin b 0.027 0.1243 0.1162
Mycobacterium ulcerans hypothetical protein 0.0095 0.0092 0.5
Brugia malayi Integrin beta pat-3 precursor 0.0305 0.1479 0.1556
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0092 0.0209
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0096 0.0096 0.0118
Onchocerca volvulus 0.0096 0.0096 0.0508
Loa Loa (eye worm) TK/ROR protein kinase 0.0369 0.1899 0.2497
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0092 0.0209
Onchocerca volvulus 0.0096 0.0096 0.0508
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.027 0.1243 0.6445
Brugia malayi PAN domain containing protein 0.0096 0.0096 0.0005
Toxoplasma gondii PAN domain-containing protein 0.0096 0.0096 0.0118
Loa Loa (eye worm) hypothetical protein 0.0363 0.1857 0.244
Loa Loa (eye worm) hypothetical protein 0.0127 0.0304 0.0339
Echinococcus granulosus protein kinase C gamma type 0.0206 0.0825 0.074
Brugia malayi Tachykinin-like peptides receptor 99D 0.1212 0.7445 0.8251
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0195 0.0752 0.0667
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0363 0.1857 0.977
Brugia malayi PAN domain containing protein 0.0096 0.0096 0.0005
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.027 0.1243 0.6445
Schistosoma mansoni hypothetical protein 0.0095 0.0092 0.0209
Brugia malayi protein kinase C3,putative 0.0158 0.0504 0.0463
Brugia malayi PAN domain containing protein 0.0096 0.0096 0.0005
Onchocerca volvulus 0.0095 0.0092 0.0483
Brugia malayi cathepsin B-like cysteine proteinase 0.027 0.1243 0.1292
Brugia malayi PAN domain containing protein 0.0096 0.0096 0.0005
Trichomonas vaginalis cyclin A, putative 0.0116 0.0231 1
Echinococcus granulosus cathepsin b 0.027 0.1243 0.1162
Echinococcus multilocularis cyclin B 0.0116 0.0231 0.0141
Toxoplasma gondii microneme protein MIC4 0.0096 0.0096 0.0118
Toxoplasma gondii subtilisin SUB12 0.0096 0.0096 0.0118
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.16 1 1
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0199 0.0774 0.0976
Echinococcus granulosus cathepsin b 0.027 0.1243 0.1162
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.027 0.1243 0.6445
Onchocerca volvulus 0.0288 0.1364 0.718
Echinococcus granulosus integrin beta 2 0.0226 0.0957 0.0873
Loa Loa (eye worm) hypothetical protein 0.0193 0.0737 0.0925
Toxoplasma gondii microneme protein, putative 0.0096 0.0096 0.0118
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.0096 0.0059
Brugia malayi Protein kinase domain containing protein 0.0369 0.1899 0.2028
Loa Loa (eye worm) hypothetical protein 0.0096 0.0096 0.0059
Schistosoma mansoni hypothetical protein 0.0095 0.0092 0.0209
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0092 0.0209
Loa Loa (eye worm) hypothetical protein 0.0288 0.1364 0.1773
Echinococcus multilocularis cathepsin b 0.027 0.1243 0.1162
Trypanosoma brucei mitotic cyclin 6 0.0116 0.0231 1
Trichomonas vaginalis cyclins, putative 0.0116 0.0231 1
Loa Loa (eye worm) hypothetical protein 0.0288 0.1364 0.1773
Loa Loa (eye worm) hypothetical protein 0.0123 0.028 0.0307
Brugia malayi PAN domain containing protein 0.0096 0.0096 0.0005
Loa Loa (eye worm) hypothetical protein 0.0116 0.0231 0.0241
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.0096 0.0059
Onchocerca volvulus 0.0369 0.1899 1
Trypanosoma cruzi cyclin, putative 0.0116 0.0231 0.0964
Onchocerca volvulus 0.0095 0.0092 0.0483
Entamoeba histolytica PH domain containing protein kinase, putative 0.015 0.0457 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0092 0.0209
Trypanosoma cruzi cyclin 6, putative 0.0116 0.0231 0.0964
Toxoplasma gondii hypothetical protein 0.0096 0.0096 0.0118
Loa Loa (eye worm) hypothetical protein 0.0127 0.0304 0.0339
Loa Loa (eye worm) hypothetical protein 0.0095 0.0092 0.0052
Loa Loa (eye worm) hypothetical protein 0.0364 0.1866 0.2452
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0132 0.0337 0.0384
Trichomonas vaginalis cyclin B, putative 0.0116 0.0231 1
Schistosoma mansoni serine/threonine protein kinase 0.0276 0.1282 0.6658
Onchocerca volvulus 0.0096 0.0096 0.0508
Toxoplasma gondii kringle domain-containing protein 0.0369 0.1899 0.5009
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0116 0.0231 0.0964
Loa Loa (eye worm) hypothetical protein 0.0357 0.182 0.2391
Onchocerca volvulus 0.0095 0.0092 0.0483
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0195 0.0752 0.0667
Loa Loa (eye worm) hypothetical protein 0.0096 0.0096 0.0059
Loa Loa (eye worm) hypothetical protein 0.0196 0.076 0.0957
Trichomonas vaginalis cyclin B, putative 0.0116 0.0231 1
Schistosoma mansoni serine/threonine protein kinase 0.0276 0.1282 0.6658
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0363 0.1857 0.977
Loa Loa (eye worm) hypothetical protein 0.0096 0.0096 0.0059
Loa Loa (eye worm) hypothetical protein 0.1212 0.7445 1
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.0096 0.0059
Onchocerca volvulus 0.0096 0.0096 0.0508
Echinococcus granulosus protein kinase c iota type 0.0232 0.0993 0.0909
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0092 0.0209
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0164 0.0546 0.0667
Loa Loa (eye worm) hypothetical protein 0.0369 0.1899 0.2497
Echinococcus granulosus RNA directed DNA polymerase 0.0123 0.028 0.019
Loa Loa (eye worm) hypothetical protein 0.0096 0.0096 0.0059
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0276 0.1282 0.1202
Loa Loa (eye worm) hypothetical protein 0.0096 0.0096 0.0059
Onchocerca volvulus 0.0096 0.0096 0.0508
Echinococcus granulosus neuropeptide FF receptor 2 0.1212 0.7445 0.7422
Onchocerca volvulus 0.0096 0.0096 0.0508
Schistosoma mansoni atypical protein kinase C 0.0238 0.1034 0.5316
Plasmodium falciparum cysteine repeat modular protein 1 0.0369 0.1899 0.5
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.0096 0.0059
Brugia malayi PAN domain containing protein 0.0096 0.0096 0.0005
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0092 0.0209
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.027 0.1243 0.6445
Onchocerca volvulus 0.0096 0.0096 0.0508
Brugia malayi Trypsin family protein 0.0363 0.1857 0.198
Onchocerca volvulus 0.0096 0.0096 0.0508
Leishmania major cyclin 0.0116 0.0231 0.0964
Echinococcus granulosus cyclin B 0.0116 0.0231 0.0141
Loa Loa (eye worm) hypothetical protein 0.0095 0.0092 0.0052
Onchocerca volvulus 0.0268 0.1232 0.6487
Toxoplasma gondii PAN/Apple domain-containing protein 0.0096 0.0096 0.0118
Brugia malayi Cyclin, N-terminal domain containing protein 0.0195 0.0752 0.0741
Toxoplasma gondii PAN domain-containing protein 0.0649 0.3738 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.1212 0.7445 0.7422
Brugia malayi PAN domain containing protein 0.0096 0.0096 0.0005
Toxoplasma gondii PAN domain-containing protein 0.0096 0.0096 0.0118
Brugia malayi Protein kinase c protein 2 0.0201 0.0794 0.0788
Loa Loa (eye worm) hypothetical protein 0.0288 0.1364 0.1773
Schistosoma mansoni serine/threonine protein kinase 0.0296 0.1418 0.7392
Trichomonas vaginalis cyclins, putative 0.0116 0.0231 1
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0199 0.0774 0.0766
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0092 0.0209
Toxoplasma gondii microneme protein MIC17A 0.0096 0.0096 0.0118
Trichomonas vaginalis cyclins, putative 0.0116 0.0231 1
Echinococcus multilocularis integrin beta 2 0.0226 0.0957 0.0873
Brugia malayi Cyclin, N-terminal domain containing protein 0.0116 0.0231 0.0156

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.045 uM Inhibition of Cyclin B-cyclin-dependent kinase 1 ChEMBL. 15974571
IC50 (binding) = 0.045 uM Inhibition of Cyclin B-cyclin-dependent kinase 1 ChEMBL. 15974571

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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