Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | conserved hypothetical protein | 0.0076 | 0.0152 | 0.0138 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 0.0487 | 0.0487 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0312 | 0.1553 | 0.1595 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0075 | 0.0148 | 0.9635 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0148 | 0.0152 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0052 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0258 | 0.1233 | 0.1267 |
Brugia malayi | CHE-14 protein | 0.0134 | 0.0496 | 0.051 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0115 | 0.0382 | 0.1481 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0187 | 0.0192 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0127 | 0.0457 | 0.1776 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0075 | 0.0148 | 0.9635 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0076 | 0.0152 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0749 | 0.0769 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0075 | 0.0148 | 0.9635 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0082 | 0.0187 | 0.0192 |
Echinococcus multilocularis | GPCR, family 2 | 0.0082 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0152 | 0.0156 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 0.0152 | 1 |
Onchocerca volvulus | 0.0075 | 0.0148 | 0.9698 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0075 | 0.0148 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0187 | 0.0181 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0075 | 0.0148 | 0.9719 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0312 | 0.1553 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0076 | 0.0152 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0115 | 0.0382 | 0.1481 |
Schistosoma mansoni | hypothetical protein | 0.0347 | 0.1756 | 0.1795 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.0468 | 0.047 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0076 | 0.0152 | 0.0156 |
Onchocerca volvulus | 0.0076 | 0.0152 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0035 | 0.0036 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0076 | 0.0152 | 0.0156 |
Mycobacterium ulcerans | beta-lactamase | 0.0076 | 0.0152 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0347 | 0.1756 | 0.1795 |
Brugia malayi | TAR-binding protein | 0.0132 | 0.0487 | 0.0501 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0075 | 0.0148 | 0.0573 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0076 | 0.0152 | 0.0156 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0075 | 0.0148 | 0.9635 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0675 | 0.0693 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0076 | 0.0152 | 0.0152 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0317 | 0.1581 | 0.1615 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0076 | 0.0152 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1553 | 0.1595 |
Brugia malayi | Ubiquitin ligase sia-1 | 0.1693 | 0.9736 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0076 | 0.0152 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0148 | 0.0152 |
Brugia malayi | beta-lactamase family protein | 0.0076 | 0.0152 | 0.0156 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.0487 | 0.049 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.1215 | 0.1248 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0152 | 0.0156 |
Plasmodium vivax | hypothetical protein, conserved | 0.0076 | 0.0152 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0076 | 0.0152 | 0.059 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0134 | 0.0496 | 0.051 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0056 | 0.0035 | 0.5 |
Echinococcus granulosus | e3 ubiquitin protein ligase siah1 | 0.1693 | 0.9736 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0312 | 0.1553 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0035 | 0.0036 |
Brugia malayi | beta-lactamase | 0.0076 | 0.0152 | 0.0156 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 0.0487 | 0.0501 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0115 | 0.0382 | 0.1481 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.0468 | 0.047 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0053 | 0.0017 | 0.0065 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0134 | 0.0496 | 0.051 |
Mycobacterium ulcerans | lipase LipD | 0.0076 | 0.0152 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0075 | 0.0148 | 0.9719 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.0487 | 0.049 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0082 | 0.0187 | 0.0192 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0187 | 0.0181 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0056 | 0.0035 | 0.2307 |
Echinococcus multilocularis | expressed conserved protein | 0.0293 | 0.144 | 0.144 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0446 | 0.2347 | 0.2347 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0127 | 0.0457 | 0.1776 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.071 | 0.3909 | 0.3909 |
Echinococcus granulosus | microtubule associated protein 2 | 0.071 | 0.3909 | 0.4015 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0075 | 0.0148 | 0.9635 |
Schistosoma mansoni | ubiquitin ligase sina (ec 6.3.2.-) (seven in absentia homolog)(smsina) | 0.1693 | 0.9736 | 1 |
Echinococcus multilocularis | geminin | 0.0347 | 0.1756 | 0.1756 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0187 | 0.0181 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0312 | 0.1553 | 0.1553 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.0487 | 0.049 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0082 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0148 | 0.0152 |
Schistosoma mansoni | microtubule-associated protein tau | 0.071 | 0.3909 | 0.4009 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0152 | 0.0156 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0485 | 0.2576 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.0749 | 0.0759 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.0487 | 0.049 |
Echinococcus granulosus | GPCR family 2 | 0.0082 | 0.0187 | 0.0192 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 0.0487 | 0.0501 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0115 | 0.0382 | 0.1481 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 0.0487 | 0.0501 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0152 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0152 | 0.0156 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0115 | 0.0382 | 0.1481 |
Onchocerca volvulus | 0.0076 | 0.0152 | 1 | |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0076 | 0.0152 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0035 | 0.0036 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0115 | 0.0382 | 0.1481 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0082 | 0.0187 | 0.0192 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0076 | 0.0152 | 0.0145 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.0487 | 0.049 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 0.0487 | 0.0501 |
Mycobacterium tuberculosis | Conserved protein | 0.0076 | 0.0152 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0035 | 0.0036 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0075 | 0.0148 | 0.9635 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.0468 | 0.047 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0076 | 0.0152 | 0.059 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0187 | 0.0181 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0255 | 0.1215 | 0.1248 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0075 | 0.0148 | 0.9719 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0056 | 0.0035 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0496 | 0.051 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0076 | 0.0152 | 1 |
Echinococcus granulosus | geminin | 0.0347 | 0.1756 | 0.1804 |
Loa Loa (eye worm) | hypothetical protein | 0.1693 | 0.9736 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0076 | 0.0152 | 0.0145 |
Mycobacterium ulcerans | hypothetical protein | 0.0076 | 0.0152 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0258 | 0.1233 | 0.1267 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0127 | 0.0457 | 0.1776 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0076 | 0.0152 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0076 | 0.0152 | 0.059 |
Brugia malayi | hypothetical protein | 0.0255 | 0.1215 | 0.1248 |
Echinococcus multilocularis | protein dispatched 1 | 0.0153 | 0.0608 | 0.0608 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 0.0487 | 0.0501 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0056 | 0.0035 | 0.0136 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0446 | 0.2347 | 0.241 |
Toxoplasma gondii | ABC1 family protein | 0.0076 | 0.0152 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0075 | 0.0148 | 0.0573 |
Schistosoma mansoni | patched 1 | 0.0134 | 0.0496 | 0.0499 |
Brugia malayi | AMP-binding enzyme family protein | 0.0075 | 0.0148 | 0.0152 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0082 | 0.0187 | 0.0187 |
Echinococcus granulosus | expressed conserved protein | 0.0293 | 0.144 | 0.1479 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0082 | 0.0187 | 0.0192 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0177 | 0.0749 | 0.0769 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.0468 | 0.047 |
Mycobacterium tuberculosis | Conserved protein | 0.0076 | 0.0152 | 0.059 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0076 | 0.0152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.1233 | 0.1267 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0115 | 0.0382 | 0.7552 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0134 | 0.0496 | 0.0496 |
Mycobacterium ulcerans | hypothetical protein | 0.0075 | 0.0148 | 0.9635 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0127 | 0.0457 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0082 | 0.0187 | 0.0192 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0152 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0035 | 0.0036 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0053 | 0.0017 | 0.0065 |
Brugia malayi | RNA binding protein | 0.0132 | 0.0487 | 0.0501 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0255 | 0.1215 | 0.1215 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0053 | 0.0017 | 0.0065 |
Brugia malayi | AMP-binding enzyme family protein | 0.0075 | 0.0148 | 0.0152 |
Echinococcus multilocularis | protein patched | 0.0134 | 0.0496 | 0.0496 |
Onchocerca volvulus | 0.0076 | 0.0152 | 1 | |
Echinococcus multilocularis | e3 ubiquitin protein ligase siah1 | 0.1693 | 0.9736 | 0.9736 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0134 | 0.0496 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0076 | 0.0152 | 0.0156 |
Loa Loa (eye worm) | beta-lactamase | 0.0076 | 0.0152 | 0.0156 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0134 | 0.0496 | 0.051 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0258 | 0.1233 | 0.1267 |
Mycobacterium leprae | Probable lipase LipE | 0.0076 | 0.0152 | 0.0138 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 0.0152 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0075 | 0.0148 | 0.9635 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0053 | 0.0017 | 0.0065 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0076 | 0.0152 | 0.059 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1 ug ml-1 | In vitro minimum inhibitory concentration against Plasmodium falciparum NF-54 strain development during 40 hours incubation | ChEMBL. | 15925306 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.