Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin II receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase | 0.0769 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0769 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.012 | 0.1223 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0769 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0769 | 1 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.012 | 0.1223 | 0.006 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.1274 | 0.1274 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0769 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0769 | 1 | 0.5 |
Onchocerca volvulus | 0.012 | 0.1223 | 1 | |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.012 | 0.1223 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0769 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0769 | 1 | 0.5 |
Onchocerca volvulus | 0.0116 | 0.117 | 0.866 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0769 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0769 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0769 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0769 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1223 | 0.006 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0769 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0116 | 0.117 | 0.117 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0769 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0769 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0769 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0769 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0769 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.012 | 0.1223 | 0.006 |
Schistosoma mansoni | hypothetical protein | 0.012 | 0.1223 | 0.1223 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0769 | 1 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.012 | 0.1223 | 0.006 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0769 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.9 uM | Inhibitory concentration of the compound that gave 50 percent displacement of specific binding of [3H]-AII (2 nM) to Angiotensin II receptor | ChEMBL. | 2329553 |
IC50 (binding) | = 5.9 uM | Inhibitory concentration of the compound that gave 50 percent displacement of specific binding of [3H]-AII (2 nM) to Angiotensin II receptor | ChEMBL. | 2329553 |
pKa | = 4.5 | Dissociation constant (pKa) | ChEMBL. | 2329553 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.