Detailed information for compound 336571

Basic information

Technical information
  • TDR Targets ID: 336571
  • Name: 3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3 ,4-c]pyridin-7-ol
  • MW: 261.704 | Formula: C14H12ClNO2
  • H donors: 1 H acceptors: 2 LogP: 2.44 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C1OCc2c1cnc(c2O)C
  • InChi: 1S/C14H12ClNO2/c1-8-13(17)12-7-18-14(11(12)6-16-8)9-2-4-10(15)5-3-9/h2-6,14,17H,7H2,1H3
  • InChiKey: CVKNDPRBJVBDSS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • cycletanide
  • 3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[4,3-d]pyridin-7-ol
  • 87520-10-3
  • 89943-82-8
  • (+-)-BN-1270
  • Cicletanina [Spanish]
  • Cicletanine
  • Cicletanine [USAN:BAN:INN]
  • Cicletaninum [Latin]
  • Furo(3,4-c)pyridin-7-ol, 3-(4-chlorophenyl)-1,3-dihydro-6-methyl-, (+-)-
  • Win 90,000
  • Win-90000
  • Cicletanine (USAN)
  • D03487
  • BN-1270
  • BN-50417
  • BN-50418
  • Justar
  • Tenstaten
  • (+-)-3-(p-Chlorophenyl)-1,3-dihydro-6-methylfuro(3,4-c)pyridin-7-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.0045 0.0085
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0042 0.001 0.001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0057 0.0048 0.0048
Schistosoma mansoni cell adhesion molecule 0.0057 0.0048 0.0048
Schistosoma mansoni serine/threonine protein kinase 0.2184 0.5309 0.5309
Brugia malayi endoprotease bli-4 precursor 0.0126 0.0218 0.0218
Echinococcus multilocularis neuroendocrine convertase 2 0.0126 0.0218 0.041
Echinococcus granulosus neuroendocrine convertase 2 0.0126 0.0218 0.041
Echinococcus granulosus neuroglian 0.0057 0.0048 0.009
Schistosoma mansoni site-1 peptidase (S08 family) 0.0126 0.0218 0.0218
Trichomonas vaginalis AGC family protein kinase 0.0592 0.1371 1
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0126 0.0218 0.041
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0418 0.0941 0.6268
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0418 0.0941 0.6268
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.083 0.1959 0.3689
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0056 0.0045 0.0085
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0126 0.0218 0.0218
Trichomonas vaginalis AGC family protein kinase 0.0592 0.1371 1
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0126 0.0218 0.0218
Plasmodium falciparum serine/threonine protein kinase, putative 0.0592 0.1371 1
Schistosoma mansoni serine/threonine protein kinase 0.0592 0.1371 0.1371
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0045 0.0085
Brugia malayi serine/threonine-protein kinase 6 0.0592 0.1371 0.1371
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0126 0.0218 0.0218
Echinococcus granulosus c src tyrosine kinase 0.0056 0.0045 0.0085
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.408 1 1
Echinococcus multilocularis roundabout 2 0.0057 0.0048 0.009
Schistosoma mansoni titin 0.005 0.0029 0.0029
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0592 0.1371 0.2582
Mycobacterium leprae Possible secreted protease 0.0126 0.0218 0.5
Echinococcus multilocularis roundabout 2 0.0057 0.0048 0.009
Brugia malayi hypothetical protein 0.0082 0.0109 0.0109
Onchocerca volvulus 0.0126 0.0218 0.1009
Schistosoma mansoni growth factor receptor-bound protein 0.0039 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0001 0.0001
Echinococcus granulosus tm gpcr rhodopsin 0.0516 0.1182 0.2226
Echinococcus granulosus contactin 0.0057 0.0048 0.009
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0126 0.0218 0.5
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0126 0.0218 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0057 0.0048 0.0048
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0056 0.0045 0.0085
Trichomonas vaginalis AGC family protein kinase 0.0592 0.1371 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0068 0.0074 0.0139
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0057 0.0048 0.009
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0056 0.0045 0.0085
Echinococcus multilocularis neuroglian 0.0057 0.0048 0.009
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.1528 0.3685 0.6941
Loa Loa (eye worm) subtilase 0.408 1 1
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.2184 0.5309 0.5309
Echinococcus granulosus titin 0.005 0.0029 0.0055
Echinococcus multilocularis 0.0126 0.0218 0.041
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0056 0.0045 0.0085
Entamoeba histolytica protein kinase, putative 0.083 0.1959 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0057 0.0048 0.0048
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0057 0.0048 0.009
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.1528 0.3685 0.6941
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0069 0.0077 0.0077
Echinococcus granulosus NCK adaptor protein 0.0039 0.0001 0.0003
Echinococcus granulosus neuroglian 0.0074 0.009 0.0169
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0126 0.0218 0.0218
Leishmania major protein kinase, putative 0.0592 0.1371 1
Echinococcus granulosus c-Jun N-terminal kinases 0.2184 0.5309 1
Schistosoma mansoni serine/threonine protein kinase 0.043 0.097 0.097
Schistosoma mansoni cell adhesion molecule 0.0101 0.0157 0.0157
Brugia malayi Stress-activated protein kinase jnk-1 0.2184 0.5309 0.5309
Loa Loa (eye worm) hypothetical protein 0.0094 0.0138 0.0138
Loa Loa (eye worm) AUR protein kinase 0.0592 0.1371 0.1371
Trypanosoma cruzi aurora B kinase, putative 0.0592 0.1371 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0516 0.1182 0.2226
Echinococcus granulosus membrane bound transcription factor site 1 0.0126 0.0218 0.041
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0056 0.0045 0.0085
Brugia malayi serine/threonine protein kinase 6 0.0592 0.1371 0.1371
Onchocerca volvulus 0.005 0.0029 0.0134
Echinococcus multilocularis roundabout 2 0.0116 0.0194 0.0366
Echinococcus granulosus furin 0.0126 0.0218 0.041
Schistosoma mansoni site-1 peptidase (S08 family) 0.0126 0.0218 0.0218
Brugia malayi Immunoglobulin I-set domain containing protein 0.0057 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0094 0.0138 0.0138
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.0045 0.0085
Loa Loa (eye worm) AUR protein kinase 0.0592 0.1371 0.1371
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.083 0.1959 0.3689
Schistosoma mansoni tyrosine kinase 0.0052 0.0035 0.0035
Echinococcus granulosus roundabout 2 0.0057 0.0048 0.009
Echinococcus granulosus aurora kinase A 0.0592 0.1371 0.2582
Brugia malayi Immunoglobulin I-set domain containing protein 0.0974 0.2315 0.2315
Brugia malayi Immunoglobulin I-set domain containing protein 0.0082 0.0109 0.0109
Echinococcus multilocularis growth factor receptor bound protein 2 0.0039 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0126 0.0218 0.0218
Loa Loa (eye worm) SRC-1 0.0056 0.0045 0.0045
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0056 0.0045 0.0085
Toxoplasma gondii aurora kinase 0.0592 0.1371 1
Schistosoma mansoni adapter molecule crk 0.0039 0.0001 0.0001
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.005 0.0029 0.0029
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0057 0.0048 0.009
Schistosoma mansoni nephrin 0.0057 0.0048 0.0048
Schistosoma mansoni ephrin receptor 0.004 0.0006 0.0006
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0039 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0059 0.0052 0.0052
Echinococcus multilocularis membrane bound transcription factor site 1 0.0126 0.0218 0.041
Loa Loa (eye worm) CAMK protein kinase 0.005 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0082 0.0109 0.0109
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0592 0.1371 0.2582
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0001 0.0001
Onchocerca volvulus 0.0877 0.2077 0.9625
Schistosoma mansoni cell adhesion molecule 0.0057 0.0048 0.0048
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.001 0.001
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0057 0.0048 0.009
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0974 0.2315 0.2315
Loa Loa (eye worm) hypothetical protein 0.0059 0.0052 0.0052
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0056 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0057 0.0048 0.0048
Echinococcus granulosus Immunoglobulin 0.0059 0.0052 0.0099
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0001 0.0001
Schistosoma mansoni growth factor receptor-bound protein 0.0039 0.0001 0.0001
Echinococcus granulosus roundabout 2 0.0116 0.0194 0.0366
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0126 0.0218 0.5
Echinococcus multilocularis Furin 1 0.0126 0.0218 0.041
Schistosoma mansoni protein kinase 0.0592 0.1371 0.1371
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0045 0.0085
Echinococcus granulosus tyrosine protein kinase Src42A 0.0056 0.0045 0.0085
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0056 0.0045 0.0085
Schistosoma mansoni neuroglian 0.0057 0.0048 0.0048
Echinococcus multilocularis c src tyrosine kinase 0.0056 0.0045 0.0085
Echinococcus multilocularis aurora kinase A 0.0592 0.1371 0.2582
Schistosoma mansoni vesicular amine transporter 0.0059 0.0052 0.0052
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.004 0.0006 0.0011
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0059 0.0052 0.0052
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0056 0.0045 0.0085
Schistosoma mansoni nck2/grb4 0.0039 0.0001 0.0001
Echinococcus granulosus insulin growth factor 1 receptor beta 0.004 0.0006 0.0011
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0042 0.001 0.0019
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0045 0.0085
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0126 0.0218 0.041
Brugia malayi neuroendocrine convertase 1 precursor 0.0126 0.0218 0.0218
Loa Loa (eye worm) IRE protein kinase 0.083 0.1959 0.1959
Brugia malayi Fibronectin type III domain containing protein 0.0082 0.0109 0.0109
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0592 0.1371 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0057 0.0048 0.009
Loa Loa (eye worm) hypothetical protein 0.0078 0.01 0.01
Echinococcus multilocularis Immunoglobulin 0.0059 0.0052 0.0099
Trichomonas vaginalis AGC family protein kinase 0.0592 0.1371 1
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0126 0.0218 0.5
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0029 0.0029
Echinococcus granulosus growth factor receptor bound protein 2 0.0039 0.0001 0.0003
Schistosoma mansoni furin-1 (S08 family) 0.0126 0.0218 0.0218
Schistosoma mansoni nephrin 0.0097 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0082 0.0109 0.0109
Onchocerca volvulus Tyrosine kinase homolog 0.091 0.2158 1
Echinococcus granulosus titin 0.005 0.0029 0.0055
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0126 0.0218 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0056 0.0045 0.0085
Loa Loa (eye worm) endoprotease bli-4 0.0126 0.0218 0.0218
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0039 0.0001 0.0001
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0059 0.0052 0.0052
Loa Loa (eye worm) AUR protein kinase 0.0592 0.1371 0.1371
Brugia malayi protein unc-22 0.005 0.0029 0.0029
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0126 0.0218 0.5
Echinococcus granulosus defective proboscis extension response 0.0059 0.0052 0.0099
Brugia malayi Ribonuclease 2-5A family protein 0.083 0.1959 0.1959
Echinococcus granulosus roundabout 2 0.0057 0.0048 0.009
Echinococcus multilocularis titin 0.005 0.0029 0.0055
Echinococcus granulosus tyrosine protein kinase Src64B 0.0056 0.0045 0.0085
Trypanosoma brucei aurora B kinase 0.0592 0.1371 1
Echinococcus granulosus twitchin 0.0086 0.0119 0.0224
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0126 0.0218 0.5
Echinococcus multilocularis tyrosine protein kinase Abl 0.0056 0.0045 0.0085
Loa Loa (eye worm) hypothetical protein 0.0059 0.0052 0.0052
Brugia malayi Sex muscle abnormal protein 5 0.0039 0.0001 0.0001
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0126 0.0218 0.0218
Brugia malayi SRC-1 0.0056 0.0045 0.0045
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0057 0.0048 0.0048
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0056 0.0045 0.0085
Brugia malayi celfurPC protein 0.0126 0.0218 0.0218
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0039 0.0001 0.0001
Brugia malayi serine/threonine kinase 12 0.0592 0.1371 0.1371
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0059 0.0052 0.0099
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0126 0.0218 0.5
Loa Loa (eye worm) hypothetical protein 0.0082 0.0109 0.0109
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.0045 0.0085
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0042 0.001 0.0019
Loa Loa (eye worm) proprotein convertase 2 0.0126 0.0218 0.0218
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Entamoeba histolytica protein kinase, putative 0.083 0.1959 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0078 0.01 0.0189
Echinococcus multilocularis neuroglian 0.0074 0.009 0.0169
Echinococcus multilocularis c Jun NH2 terminal kinase 0.2184 0.5309 1
Brugia malayi proprotein convertase 2 0.0126 0.0218 0.0218
Echinococcus granulosus Furin 1 0.0126 0.0218 0.041
Echinococcus multilocularis NCK adaptor protein 0.0039 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0126 0.0218 0.0218
Brugia malayi Tyrosine-protein kinase abl-1 0.0056 0.0045 0.0045
Giardia lamblia Aurora kinase 0.0592 0.1371 0.5
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0126 0.0218 0.5
Schistosoma mansoni tyrosine kinase 0.0056 0.0045 0.0045
Echinococcus multilocularis Immunoglobulin 0.0059 0.0052 0.0099

Activities

Activity type Activity value Assay description Source Reference
Log PNalk = -1.76 Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system ChEMBL. 15857133

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.