TDR Targets

Basic information

Technical information

TDR Targets ID: 336608
Name: N-(2,4-dimethoxyphenyl)-7H-purin-6-amine
MW: 271.275 | Formula: C13H13N5O2
H donors: 2 H acceptors: 3 LogP: 1.64 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(OC)ccc1Nc1[nH]cnc2c1ncn2
InChi: 1S/C13H13N5O2/c1-19-8-3-4-9(10(5-8)20-2)18-13-11-12(15-6-14-11)16-7-17-13/h3-7H,1-2H3,(H2,14,15,16,17,18)
InChiKey: KGHLNAKHHVNRSH-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

(2,4-dimethoxyphenyl)-(7H-purin-6-yl)amine
ZINC00213764
Oprea1_031279

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0041	0.5218	0.5218
Loa Loa (eye worm)	CAMK protein kinase	0.0039	0.4389	0.4389
Entamoeba histolytica	protein kinase domain containing protein	0.0056	1	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.4389	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0056	1	1
Echinococcus multilocularis	titin	0.0039	0.4389	0.0263
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0041	0.5218	0.1703
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Entamoeba histolytica	protein kinase, putative	0.0056	1	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0041	0.5218	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Echinococcus granulosus	roundabout 2	0.005	0.8229	0.6926
Leishmania major	protein kinase, putative	0.0056	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Loa Loa (eye worm)	AUR protein kinase	0.0056	1	1
Echinococcus multilocularis	neuroglian	0.0047	0.7247	0.5223
Brugia malayi	Prion-like-	0.0041	0.5218	0.5218
Echinococcus granulosus	roundabout 2	0.0041	0.5218	0.1703
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0056	1	0.5
Brugia malayi	serine/threonine kinase 12	0.0056	1	1
Echinococcus granulosus	neuroglian	0.0041	0.5218	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Schistosoma mansoni	protein kinase	0.0056	1	1
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0041	0.5218	0.2159
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0038	0.4237	0.4237
Entamoeba histolytica	protein kinase, putative	0.0056	1	0.5
Brugia malayi	Animal haem peroxidase family protein	0.0038	0.4237	0.4237
Brugia malayi	Wrapper/rega-1/klingon homolog protein 1	0.0038	0.4237	0.4237
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Echinococcus multilocularis	tyrosine protein kinase otk	0.0041	0.5218	0.1703
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0052	0.8782	0.7886
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0039	0.4389	0.4389
Onchocerca volvulus		0.0039	0.4389	0.0333
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Echinococcus multilocularis	aurora kinase A	0.0056	1	1
Schistosoma mansoni	titin	0.0041	0.5218	0.1703
Brugia malayi	Leucine Rich Repeat family protein	0.0038	0.4237	0.4237
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0042	0.537	0.537
Schistosoma mansoni	roundabout	0.0041	0.5218	0.1703
Schistosoma mansoni	tyrosine kinase	0.0055	0.9763	0.9589
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0038	0.4237	0.4237
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Schistosoma mansoni	septate junction protein	0.0041	0.5218	0.1703
Echinococcus granulosus	peroxidasin	0.0041	0.5218	0.1703
Loa Loa (eye worm)	AUR protein kinase	0.0056	1	1
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0056	1	0.5
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0041	0.5218	0.1703
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0041	0.5218	0.5218
Loa Loa (eye worm)	projectin	0.0038	0.4237	0.4237
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0056	1	0.5
Brugia malayi	protein unc-22	0.0039	0.4389	0.4389
Loa Loa (eye worm)	hypothetical protein	0.005	0.8229	0.8229
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0041	0.5218	0.5218
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5218	0.5218
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Loa Loa (eye worm)	hypothetical protein	0.005	0.8229	0.8229
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.4389	0.4389
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Toxoplasma gondii	aurora kinase	0.0056	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0041	0.5218	0.1703
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0041	0.5218	0.5218
Echinococcus granulosus	contactin	0.0041	0.5218	0.1703
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0038	0.4237	0.4237
Brugia malayi	serine/threonine-protein kinase 6	0.0056	1	1
Echinococcus multilocularis	hemicentin 1	0.0041	0.5218	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Loa Loa (eye worm)	disorganized muscle protein 1	0.0038	0.4237	0.4237
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0041	0.5218	0.5218
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Trypanosoma cruzi	aurora B kinase, putative	0.0056	1	0.5
Echinococcus granulosus	twitchin	0.0048	0.7399	0.5486
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5218	0.5218
Echinococcus granulosus	aurora kinase A	0.0056	1	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5218	0.5218
Echinococcus granulosus	titin	0.0039	0.4389	0.0263
Schistosoma mansoni	nephrin	0.0041	0.5218	0.1703
Trichomonas vaginalis	AGC family protein kinase	0.0056	1	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Echinococcus multilocularis	lachesin	0.0041	0.5218	0.1703
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0041	0.5218	0.1703
Brugia malayi	Prion-like-	0.0038	0.4237	0.4237
Loa Loa (eye worm)	one IG domain family member	0.0038	0.4237	0.4237
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.4389	0.0263
Giardia lamblia	Aurora kinase	0.0056	1	0.5
Echinococcus multilocularis	twitchin	0.0039	0.4389	0.0263
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Brugia malayi	Disorganized muscle protein 1	0.0038	0.4237	0.4237
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0041	0.5218	0.5218
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0041	0.5218	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Echinococcus granulosus	titin	0.0039	0.4389	0.0263
Brugia malayi	kettin	0.0038	0.4237	0.4237
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0038	0.4237	0.4237
Echinococcus multilocularis	peroxidasin	0.0041	0.5218	0.1703
Loa Loa (eye worm)	AUR protein kinase	0.0056	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0041	0.5218	0.5218
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0056	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Echinococcus multilocularis	roundabout 2	0.0041	0.5218	0.1703
Echinococcus multilocularis	roundabout 2	0.005	0.8229	0.6926
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5218	0.5218
Schistosoma mansoni	neuroglian	0.0041	0.5218	0.1703
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5218	0.5218
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0041	0.5218	0.5218
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5218	0.5218
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5218	0.5218
Loa Loa (eye worm)	TK protein kinase	0.0052	0.8782	0.8782
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0056	1	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0041	0.5218	0.5218
Trichomonas vaginalis	AGC family protein kinase	0.0056	1	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Echinococcus granulosus	hemicentin 1	0.0041	0.5218	0.1703
Schistosoma mansoni	cell adhesion molecule	0.0041	0.5218	0.1703
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0038	0.4237	0.4237
Entamoeba histolytica	protein kinase , putative	0.0056	1	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0041	0.5218	0.5218
Schistosoma mansoni	nephrin	0.0047	0.7247	0.5223
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0041	0.5218	0.5218
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0052	0.8782	0.7886
Trichomonas vaginalis	AGC family protein kinase	0.0056	1	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0038	0.4237	0.4237
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0041	0.5218	0.1703
Echinococcus granulosus	neuroglian	0.0047	0.7247	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5218	0.5218
Schistosoma mansoni	cell adhesion molecule	0.0041	0.5218	0.1703
Echinococcus multilocularis	hemicentin 1	0.0041	0.5218	0.1703
Loa Loa (eye worm)	animal heme peroxidase	0.0038	0.4237	0.4237
Brugia malayi	Prion-like-	0.0038	0.4237	0.4237
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0041	0.5218	0.5218
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0038	0.4237	0.4237
Schistosoma mansoni	titin	0.0039	0.4389	0.0263
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0041	0.5218	0.1703
Echinococcus multilocularis	neuroglian	0.0041	0.5218	0.1703
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0038	0.4237	0.4237
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Trypanosoma brucei	aurora B kinase	0.0056	1	0.5
Schistosoma mansoni	septate junction protein	0.0041	0.5218	0.1703
Echinococcus granulosus	lachesin	0.0041	0.5218	0.1703
Brugia malayi	Prion-like-	0.0038	0.4237	0.4237
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.4237	0.4237
Brugia malayi	Peroxidasin	0.0041	0.5218	0.5218
Schistosoma mansoni	cell adhesion molecule	0.0041	0.5218	0.1703
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0056	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Onchocerca volvulus	Tyrosine kinase homolog	0.0052	0.8782	1
Echinococcus granulosus	tyrosine protein kinase otk	0.0041	0.5218	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0038	0.4237	0.4237
Loa Loa (eye worm)	hypothetical protein	0.0038	0.4237	0.4237
Echinococcus multilocularis	roundabout 2	0.0041	0.5218	0.1703
Trichomonas vaginalis	AGC family protein kinase	0.0056	1	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0052	0.8782	0.8782
Schistosoma mansoni	serine/threonine protein kinase	0.0056	1	1
Echinococcus granulosus	roundabout 2	0.0041	0.5218	0.1703
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0052	0.8782	0.8782

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	0 uM	Inhibition of EPH receptor B2 using ELISA; ND = Not determined	ChEMBL.	15857128

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 756648

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 336608