TDR Targets

Basic information

Technical information

TDR Targets ID: 339273
Name: 2-[[2-(1H-benzimidazol-2-ylmethoxy)phenyl]met hylamino]-1-(4-bromothiophen-2-yl)ethanol
MW: 458.371 | Formula: C21H20BrN3O2S
H donors: 3 H acceptors: 2 LogP: 3.61 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: Brc1csc(c1)C(CNCc1ccccc1OCc1nc2c([nH]1)cccc2)O
InChi: 1S/C21H20BrN3O2S/c22-15-9-20(28-13-15)18(26)11-23-10-14-5-1-4-8-19(14)27-12-21-24-16-6-2-3-7-17(16)25-21/h1-9,13,18,23,26H,10-12H2,(H,24,25)
InChiKey: IPWNCKFFJZRKSJ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-[[2-(1H-benzimidazol-2-ylmethoxy)phenyl]methylamino]-1-(4-bromo-2-thienyl)ethanol
2-[[2-(1H-benzimidazol-2-ylmethoxy)benzyl]amino]-1-(4-bromo-2-thienyl)ethanol

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	Phenylalanyl-tRNA synthetase alpha chain	Starlite/ChEMBL	References
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	Phenylalanyl-tRNA synthetase alpha chain	Starlite/ChEMBL	References
Staphylococcus aureus	Phenylalanyl-tRNA synthetase alpha chain	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	phenylalanyl tRNA synthetase alpha chain B	Get druggable targets OG5_127036	All targets in OG5_127036
Chlamydia trachomatis	phenylalanine--tRNA ligase subunit alpha	Get druggable targets OG5_127036	All targets in OG5_127036
Toxoplasma gondii	phenylalanyl-tRNA synthetase alpha chain A, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Leishmania donovani	phenylalanyl-tRNA synthetase alpha chain, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Schistosoma mansoni	phenylalanyl-tRNA synthetase subunit alpha	Get druggable targets OG5_127036	All targets in OG5_127036
Cryptosporidium parvum	putative phenylalanyl-tRNA synthetase	Get druggable targets OG5_127036	All targets in OG5_127036
Mycobacterium tuberculosis	Probable phenylalanyl-tRNA synthetase, alpha chain PheS	Get druggable targets OG5_127036	All targets in OG5_127036
Trypanosoma congolense	phenylalanyl-tRNA synthetase alpha chain, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Plasmodium vivax	phenylalanine--tRNA ligase alpha subunit, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Wolbachia endosymbiont of Brugia malayi	phenylalanyl-tRNA synthetase subunit alpha	Get druggable targets OG5_127036	All targets in OG5_127036
Plasmodium berghei	phenylalanine--tRNA ligase alpha subunit, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Schistosoma japonicum	ko:K01889 phenylalanyl-tRNA synthetase alpha chain [EC6.1.1.20A], putative	Get druggable targets OG5_127036	All targets in OG5_127036
Trypanosoma brucei gambiense	phenylalanyl-tRNA synthetase alpha chain, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Giardia lamblia	Phenylalanyl-tRNA synthetase alpha chain	Get druggable targets OG5_127036	All targets in OG5_127036
Theileria parva	phenylalanyl-tRNA synthetase alpha chain, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Brugia malayi	phenylalanyl (f) trna synthetase protein 1	Get druggable targets OG5_127036	All targets in OG5_127036
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127036	All targets in OG5_127036
Leishmania braziliensis	phenylalanyl-tRNA synthetase alpha chain, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Entamoeba histolytica	phenylalanyl-tRNA synthetase alpha subunit, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Leishmania mexicana	phenylalanyl-tRNA synthetase alpha chain, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Plasmodium falciparum	phenylalanine--tRNA ligase alpha subunit	Get druggable targets OG5_127036	All targets in OG5_127036
Leishmania major	phenylalanyl-tRNA synthetase alpha chain, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Echinococcus granulosus	phenylalanyl tRNA synthetase alpha chain B	Get druggable targets OG5_127036	All targets in OG5_127036
Trichomonas vaginalis	phenylalanyl-tRNA synthetase alpha chain, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Candida albicans	phenylalanyl-tRNA synthetase	Get druggable targets OG5_127036	All targets in OG5_127036
Treponema pallidum	phenylalanyl-tRNA synthetase subunit alpha	Get druggable targets OG5_127036	All targets in OG5_127036
Leishmania infantum	phenylalanyl-tRNA synthetase alpha chain, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Mycobacterium leprae	Probable phenylalanyl-tRNA synthetase, alpha chain PheS	Get druggable targets OG5_127036	All targets in OG5_127036
Babesia bovis	phenylalanyl-tRNA synthetase family protein	Get druggable targets OG5_127036	All targets in OG5_127036
Cryptosporidium hominis	phenylalanyl-trna synthetase-like protein	Get druggable targets OG5_127036	All targets in OG5_127036
Neospora caninum	hypothetical protein	Get druggable targets OG5_127036	All targets in OG5_127036
Plasmodium yoelii	phenylalanyl-tRNA synthetase, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Plasmodium knowlesi	phenylalanine--tRNA ligase alpha subunit, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Trypanosoma brucei	phenylalanyl-tRNA synthetase alpha chain, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Candida albicans	phenylalanyl-tRNA synthetase	Get druggable targets OG5_127036	All targets in OG5_127036
Trypanosoma cruzi	phenylalanyl-tRNA synthetase alpha chain, putative	Get druggable targets OG5_127036	All targets in OG5_127036
Mycobacterium ulcerans	phenylalanyl-tRNA synthetase subunit alpha	Get druggable targets OG5_127036	All targets in OG5_127036

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium berghei	phenylalanine--tRNA ligase, putative	Phenylalanyl-tRNA synthetase alpha chain	329 aa	356 aa	23.6 %
Echinococcus multilocularis	phenylalanyl tRNA synthetase	Phenylalanyl-tRNA synthetase alpha chain	329 aa	308 aa	26.3 %
Candida albicans	phenylalanine--tRNA ligase	Phenylalanyl-tRNA synthetase alpha chain	352 aa	314 aa	27.1 %
Candida albicans	phenylalanine--tRNA ligase	Phenylalanyl-tRNA synthetase alpha chain	352 aa	314 aa	27.1 %
Theileria parva	phenylalanyl-tRNA synthetase, putative	Phenylalanyl-tRNA synthetase alpha chain	329 aa	385 aa	23.6 %
Babesia bovis	phenylalanine-tRNA ligase, putative	Phenylalanyl-tRNA synthetase alpha chain	329 aa	337 aa	25.2 %
Echinococcus granulosus	phenylalanyl tRNA synthetase	Phenylalanyl-tRNA synthetase alpha chain	329 aa	308 aa	25.6 %
Onchocerca volvulus	Presenilins-associated rhomboid-like protein, mitochondrial homolog	Phenylalanyl-tRNA synthetase alpha chain	329 aa	270 aa	30.4 %
Plasmodium yoelii	Ferredoxin-fold anticodon binding domain, putative	Phenylalanyl-tRNA synthetase alpha chain	329 aa	369 aa	23.3 %
Plasmodium falciparum	phenylalanine--tRNA ligase	Phenylalanyl-tRNA synthetase alpha chain	329 aa	340 aa	24.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0209	0.1548	0.7735
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0045	0.0237	0.1182
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0085	0.0556	0.1171
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0124	0.0871	0.4353
Schistosoma mansoni	serine/threonine protein kinase	0.0103	0.0706	0.3526
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0187	0.1378	0.6887
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.004	0.0198	0.0991
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0422
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0422
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0085	0.0556	0.1171
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	0.0157	0.1132	0.5655
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0556	0.1183
Echinococcus granulosus	ankyrin repeat protein	0.0157	0.1132	0.5655
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.004	0.0198	0.0991
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0085	0.0556	0.1171
Loa Loa (eye worm)	DR-78	0.004	0.0198	0.0422
Schistosoma mansoni	phenylalanyl-tRNA synthetase mitochondrial	0.0077	0.0494	0.2467
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0085	0.0556	0.2778
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0556	0.1183
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0085	0.0556	0.1171
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0085	0.0556	0.2778
Echinococcus granulosus	ecdysone induced protein 78C	0.0085	0.0556	0.2778
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0237	0.0504
Toxoplasma gondii	phenylalanyl-tRNA synthetase alpha chain A, putative	0.0265	0.2001	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0085	0.0556	0.2778
Schistosoma mansoni	zinc finger protein	0.004	0.0198	0.0991
Schistosoma mansoni	nuclear receptor	0.004	0.0198	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0556	0.1183
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0045	0.0237	0.0504
Plasmodium falciparum	phenylalanine--tRNA ligase alpha subunit	0.0265	0.2001	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0422
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0422
Echinococcus granulosus	mitogen activated protein kinase 3	0.0103	0.0706	0.3526
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0422
Brugia malayi	nuclear hormone receptor family member odr-7	0.004	0.0198	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0602	0.4697	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0045	0.0237	0.1182
Echinococcus granulosus	mitogen activated protein kinase	0.0103	0.0706	0.3526
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0085	0.0556	0.2778
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.004	0.0198	0.0991
Trypanosoma cruzi	phenylalanyl-tRNA synthetase alpha chain, putative	0.0265	0.2001	1
Treponema pallidum	phenylalanyl-tRNA synthetase subunit alpha	0.0265	0.2001	0.5
Loa Loa (eye worm)	nuclear receptor NHR-67	0.004	0.0198	0.0422
Echinococcus multilocularis	phenylalanyl tRNA synthetase alpha chain B	0.0265	0.2001	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0045	0.0237	0.1182
Schistosoma mansoni	thyroid hormone receptor	0.0209	0.1548	0.7735
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0085	0.0556	0.2778
Brugia malayi	hypothetical protein	0.0045	0.0237	0.0491
Mycobacterium ulcerans	phenylalanyl-tRNA synthetase subunit alpha	0.1265	1	1
Trypanosoma brucei	phenylalanyl-tRNA synthetase alpha chain, putative	0.0265	0.2001	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0198	0.0991
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0085	0.0556	0.1183
Loa Loa (eye worm)	hypothetical protein	0.0265	0.2001	0.426
Schistosoma mansoni	nuclear hormone receptor	0.0085	0.0556	0.2778
Schistosoma mansoni	coup transcription factor	0.0085	0.0556	0.2778
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0085	0.0556	0.1183
Brugia malayi	nuclear hormone receptor family member nhr-6	0.004	0.0198	0.0409
Echinococcus multilocularis	nuclear receptor nhr 48	0.004	0.0198	0.0991
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0422
Brugia malayi	orphan nuclear receptor NR2E1	0.004	0.0198	0.0409
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0085	0.0556	0.1171
Schistosoma mansoni	nuclear receptor	0.004	0.0198	0.0991
Brugia malayi	tailless protein	0.004	0.0198	0.0409
Entamoeba histolytica	phenylalanyl-tRNA synthetase alpha subunit, putative	0.0265	0.2001	1
Echinococcus granulosus	transient receptor potential cation channel	0.016	0.1157	0.5783
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0422
Echinococcus granulosus	phenylalanyl tRNA synthetase alpha chain B	0.0265	0.2001	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0085	0.0556	0.1171
Brugia malayi	Nuclear hormone receptor-like 1	0.0045	0.0237	0.0491
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0103	0.0706	0.1406
Echinococcus granulosus	Nuclear hormone receptor HR96	0.004	0.0198	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0237	0.0504
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0085	0.0556	0.1183
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0085	0.0556	0.1183
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0124	0.0871	0.4353
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0085	0.0556	0.1171
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0085	0.0556	0.2778
Schistosoma mansoni	thyroid hormone receptor	0.0209	0.1548	0.7735
Brugia malayi	hypothetical protein	0.0038	0.0179	0.0368
Loa Loa (eye worm)	nuclear hormone receptor	0.004	0.0198	0.0422
Brugia malayi	ecdysone receptor	0.004	0.0198	0.0409
Brugia malayi	conserved hypotetical protein	0.004	0.0198	0.0409
Toxoplasma gondii	aldehyde dehydrogenase	0.0123	0.0864	0.2457
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0123	0.0864	0.4318
Echinococcus multilocularis	phenylalanyl tRNA synthetase	0.0077	0.0494	0.2467
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0556	0.1183
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0085	0.0556	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0556	0.1183
Schistosoma mansoni	hypothetical protein	0.0124	0.0871	0.4353
Echinococcus multilocularis	mitogen activated protein kinase	0.0103	0.0706	0.3526
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0085	0.0556	0.1183
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0179	0.0895
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0422
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0085	0.0556	0.2778
Trichomonas vaginalis	CMGC family protein kinase	0.0103	0.0706	0.1406
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0085	0.0556	0.1171
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0085	0.0556	0.2778
Leishmania major	phenylalanyl-tRNA synthetase alpha chain, putative	0.0265	0.2001	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0237	0.0504
Plasmodium vivax	phenylalanine--tRNA ligase alpha subunit, putative	0.0265	0.2001	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0556	0.1183
Loa Loa (eye worm)	steroid hormone receptor	0.0085	0.0556	0.1183
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0045	0.0237	0.1182
Echinococcus multilocularis	ankyrin repeat protein	0.0157	0.1132	0.5655
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0085	0.0556	0.2778
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0422
Brugia malayi	Steroid receptor seven-up type 2	0.0085	0.0556	0.1171
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0085	0.0556	0.1171
Brugia malayi	nuclear hormone receptor	0.004	0.0198	0.0409
Echinococcus granulosus	nuclear receptor nhr 48	0.004	0.0198	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0237	0.0504
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0085	0.0556	0.2778
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0103	0.0706	0.1502
Mycobacterium tuberculosis	Probable phenylalanyl-tRNA synthetase, alpha chain PheS	0.1265	1	1
Schistosoma mansoni	nuclear hormone receptor	0.004	0.0198	0.0991
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0198	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0237	0.0504
Brugia malayi	nuclear receptor RXR	0.004	0.0198	0.0409
Trichomonas vaginalis	CMGC family protein kinase	0.0103	0.0706	0.1406
Brugia malayi	small heat shock protein	0.0602	0.4697	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0556	0.1183
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0179	0.0895
Trichomonas vaginalis	CMGC family protein kinase	0.0103	0.0706	0.1406
Schistosoma mansoni	phenylalanyl-tRNA synthetase subunit alpha	0.0077	0.0494	0.2467
Brugia malayi	hypothetical protein	0.0045	0.0237	0.0491
Onchocerca volvulus	Protein ultraspiracle homolog	0.0085	0.0556	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0085	0.0556	0.2778
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0123	0.0864	0.4318
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0422
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0085	0.0556	0.2778
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0085	0.0556	1
Schistosoma mansoni	phenylalanyl-tRNA synthetase subunit alpha	0.0265	0.2001	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0422
Brugia malayi	ecdysteroid receptor	0.0085	0.0556	0.1171
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0085	0.0556	0.2778
Onchocerca volvulus		0.0085	0.0556	1
Echinococcus granulosus	phenylalanyl tRNA synthetase	0.0077	0.0494	0.2467
Onchocerca volvulus	Bile acid receptor homolog	0.0085	0.0556	1
Brugia malayi	MAP kinase sur-1	0.0103	0.0706	0.149
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.004	0.0198	0.0991
Brugia malayi	nuclear receptor NHR-88	0.004	0.0198	0.0409
Schistosoma mansoni	nuclear hormone receptor	0.004	0.0198	0.0991
Brugia malayi	photoreceptor-specific nuclear receptor	0.0085	0.0556	0.1171
Brugia malayi	Nuclear hormone receptor E75	0.004	0.0198	0.0409
Brugia malayi	nuclear receptor NHR-88	0.0085	0.0556	0.1171
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0085	0.0556	0.2778
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0556	0.1183
Brugia malayi	hypothetical protein	0.004	0.0198	0.0409
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.004	0.0198	0.0409
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0085	0.0556	0.2778
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0422
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0085	0.0556	0.1183
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0143	0.1021	0.5101
Brugia malayi	Nuclear hormone receptor E75	0.004	0.0198	0.0409
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0077	0.0493	0.2465
Echinococcus multilocularis	transient receptor potential cation channel	0.016	0.1158	0.5788
Schistosoma mansoni	aldehyde dehydrogenase	0.0123	0.0864	0.4318
Brugia malayi	Nuclear hormone receptor-like 1	0.0045	0.0237	0.0491
Echinococcus granulosus	Nuclear hormone receptor HR96	0.004	0.0198	0.0991
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0085	0.0556	0.1171
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0123	0.0864	0.1223
Schistosoma mansoni	nuclear receptor nhr-48	0.004	0.0198	0.0991
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.004	0.0198	0.0991
Brugia malayi	phenylalanyl (f) trna synthetase protein 1	0.0265	0.2001	0.4252
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0085	0.0556	0.2778
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0085	0.0556	0.2778
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0179	0.0895
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0085	0.0556	0.1171
Brugia malayi	steroid hormone receptor	0.0085	0.0556	0.1171
Echinococcus granulosus	thyroid hormone receptor alpha	0.004	0.0198	0.0991
Trichomonas vaginalis	phenylalanyl-tRNA synthetase alpha chain, putative	0.0265	0.2001	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0085	0.0556	0.2778
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0085	0.0556	0.2778
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0085	0.0556	0.1183
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0103	0.0706	0.3526
Trichomonas vaginalis	CMGC family protein kinase	0.0103	0.0706	0.1406
Brugia malayi	nuclear receptor NHR-67	0.004	0.0198	0.0409
Echinococcus multilocularis	FTZ F1 alpha	0.0085	0.0556	0.2778
Schistosoma mansoni	retinoic acid receptor RXR	0.0187	0.1378	0.6887
Wolbachia endosymbiont of Brugia malayi	phenylalanyl-tRNA synthetase subunit alpha	0.1265	1	0.5
Schistosoma mansoni	aldehyde dehydrogenase	0.0123	0.0864	0.4318
Echinococcus granulosus	FTZ F1 alpha	0.0085	0.0556	0.2778
Brugia malayi	nuclear receptor RXR	0.0045	0.0237	0.0491
Giardia lamblia	Phenylalanyl-tRNA synthetase alpha chain	0.0265	0.2001	1
Mycobacterium leprae	Probable phenylalanyl-tRNA synthetase, alpha chain PheS	0.0188	0.1387	0.5
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0077	0.0493	0.2465
Schistosoma mansoni	hypothetical protein	0.0038	0.0179	0.0895
Brugia malayi	phenylalanyl-tRNA synthetase, mitochondrial precursor, putative	0.0077	0.0494	0.1039
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0422
Brugia malayi	nuclear hormone receptor	0.0085	0.0556	0.1171
Loa Loa (eye worm)	phenylalanyl-tRNA synthetase	0.0077	0.0494	0.1051
Brugia malayi	hypothetical protein	0.004	0.0198	0.0409
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0085	0.0556	0.1171
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.004	0.0198	0.0422
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0085	0.0556	0.1171
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0085	0.0556	0.2778
Echinococcus multilocularis	ecdysone induced protein 78C	0.0085	0.0556	0.2778
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.004	0.0198	0.0991

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 26 nM	Inhibitory concentration against Staphylococcus aureus Phenylalanyl-tRNA synthetase	ChEMBL.	15837314
IC50 (binding)	= 26 nM	Inhibitory concentration against Staphylococcus aureus Phenylalanyl-tRNA synthetase	ChEMBL.	15837314
IC50 (binding)	= 150 nM	Inhibitory concentration against Haemophilus influenzae Phenylalanyl-tRNA synthetase	ChEMBL.	15837314
IC50 (binding)	= 150 nM	Inhibitory concentration against Haemophilus influenzae Phenylalanyl-tRNA synthetase	ChEMBL.	15837314
IC50 (binding)	= 250 nM	Inhibitory concentration against Streptococcus pneumoniae Phenylalanyl-tRNA synthetase	ChEMBL.	15837314
IC50 (binding)	= 250 nM	Inhibitory concentration against Streptococcus pneumoniae Phenylalanyl-tRNA synthetase	ChEMBL.	15837314

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL372001
PubChem: 23647946

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 339273