TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 346.353 | Formula: C18H19FN2O4
H donors: 1 H acceptors: 2 LogP: 1.98 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OCCOc1cc(ccc1OC)N1CCN(C1=O)c1cccc(c1)F
InChi: 1S/C18H19FN2O4/c1-24-16-6-5-15(12-17(16)25-10-9-22)21-8-7-20(18(21)23)14-4-2-3-13(19)11-14/h2-6,11-12,22H,7-10H2,1H3
InChiKey: FUMOASGTOSVGIK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	Starlite/ChEMBL	References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	Starlite/ChEMBL	References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	hypothetical protein	Get druggable targets OG5_144688	All targets in OG5_144688
Brugia malayi	Serotonin receptor	Get druggable targets OG5_135430	All targets in OG5_135430
Echinococcus multilocularis	conserved hypothetical protein	Get druggable targets OG5_144688	All targets in OG5_144688

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	melibiase subfamily protein	0.0121	0.1148	1
Trichomonas vaginalis	ATP synthase, putative	0.0039	0.0223	0.2915
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0024	0.0049	0.0046
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0024	0.0049	0.0031
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0024	0.0049	0.0046
Schistosoma mansoni	thyroid hormone receptor	0.0173	0.1733	1
Echinococcus granulosus	vacuolar ATP synthase subunit b	0.0039	0.0223	0.0209
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0024	0.0049	0.0031
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0024	0.0049	0.0031
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0028	0.0091	0.3226
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0024	0.0049	0.0031
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.0049	0.011
Brugia malayi	nuclear receptor NHR-88	0.0024	0.0049	0.0031
Schistosoma mansoni	survival motor neuron protein	0.0054	0.0386	0.2093
Trypanosoma brucei	ATP synthase F1, alpha subunit	0.0032	0.0141	0.2138
Loa Loa (eye worm)	vacuolar ATP synthase subunit B	0.0039	0.0223	0.0474
Trypanosoma brucei	DNA polymerase kappa, putative	0.0025	0.006	0.0909
Trypanosoma brucei	unspecified product	0.0041	0.0239	0.3619
Trypanosoma brucei	DNA polymerase kappa, putative	0.0037	0.0194	0.2934
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0024	0.0049	0.0019
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0024	0.0049	0.011
Schistosoma mansoni	thyroid hormone receptor	0.0173	0.1733	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0024	0.0049	0.0031
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0049	0.0328	0.4715
Brugia malayi	nuclear hormone receptor	0.0024	0.0049	0.0031
Trypanosoma brucei	DNA polymerase kappa, putative	0.0037	0.0194	0.2934
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0024	0.0049	0.011
Schistosoma mansoni	hypothetical protein	0.0149	0.1462	0.8412
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0121	0.1148	0.6569
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0024	0.0049	0.0019
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0049	0.0328	0.4715
Giardia lamblia	DINP protein human, muc B family	0.0025	0.006	0.157
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0078	0.0661	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0049	0.0328	0.4715
Leishmania major	ATPase alpha subunit	0.0032	0.0141	0.1767
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0024	0.0049	0.011
Treponema pallidum	V-type ATP synthase subunit B	0.0039	0.0223	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0264	0.2759	0.2737
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0121	0.1148	0.1122
Trypanosoma brucei	ATP synthase F1, alpha subunit	0.0032	0.0141	0.2138
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0028	0.0091	0.2056
Brugia malayi	vacuolar ATP synthase subunit B	0.0039	0.0223	0.0315
Trypanosoma brucei	DNA polymerase kappa, putative	0.0049	0.0328	0.4953
Giardia lamblia	Vacuolar ATP synthase subunit B	0.0039	0.0223	1
Brugia malayi	ATP synthase alpha chain, mitochondrial precursor, putative	0.0039	0.022	0.031
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0024	0.0049	0.0031
Wolbachia endosymbiont of Brugia malayi	ATP synthase F0F1 subunit alpha	0.0039	0.022	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0049	0.0328	0.4953
Schistosoma mansoni	hypothetical protein	0.0054	0.0386	0.2093
Brugia malayi	hypothetical protein	0.0264	0.2759	0.4461
Echinococcus granulosus	FTZ F1 alpha	0.0024	0.0049	0.002
Schistosoma mansoni	RAR-like nuclear receptor	0.0024	0.0049	0.011
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0081	0.0692	0.3888
Brugia malayi	Melibiase family protein	0.0081	0.0692	0.1082
Echinococcus granulosus	ATPase H transporting lysosomal accessory	0.0383	0.4098	0.4396
Brugia malayi	photoreceptor-specific nuclear receptor	0.0024	0.0049	0.0031
Trypanosoma brucei	DNA polymerase IV, putative	0.0049	0.0328	0.4953
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0024	0.0049	0.0046
Echinococcus multilocularis	ecdysone induced protein 78C	0.0024	0.0049	0.0019
Echinococcus granulosus	ecdysone induced protein 78C	0.0024	0.0049	0.002
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0049	0.0328	0.4715
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0081	0.0692	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0121	0.1148	0.6569
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0028	0.0091	0.3173
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0024	0.0049	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0264	0.2759	0.6709
Schistosoma mansoni	ATP synthase subunit beta vacuolar	0.0039	0.0223	0.1133
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0024	0.0049	0.0046
Brugia malayi	steroid hormone receptor	0.0024	0.0049	0.0031
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0024	0.0049	0.0019
Trypanosoma brucei	DNA polymerase kappa, putative	0.0049	0.0328	0.4953
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0024	0.0049	0.0019
Echinococcus multilocularis	ATPase, H+ transporting, lysosomal accessory	0.0383	0.4098	0.408
Echinococcus granulosus	survival motor neuron protein 1	0.0264	0.2759	0.2949
Schistosoma mansoni	coup transcription factor	0.0024	0.0049	0.011
Leishmania major	vacuolar ATP synthase subunit b, putative	0.0039	0.0223	0.3056
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0049	0.0046
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.003	0.0451
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0054	0.0386	0.0583
Chlamydia trachomatis	V-type ATP synthase subunit B	0.0039	0.0223	1
Onchocerca volvulus		0.0054	0.0386	0.401
Echinococcus multilocularis	transcription factor Dp 1	0.0045	0.0289	0.026
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0149	0.1462	0.1548
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0024	0.0049	0.002
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0049	0.0046
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0078	0.0661	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0194	0.0404
Echinococcus multilocularis	dna polymerase kappa	0.0049	0.0328	0.0299
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0024	0.0049	0.002
Mycobacterium ulcerans	DNA polymerase IV	0.0049	0.0328	1
Plasmodium falciparum	V-type proton ATPase subunit B	0.0039	0.0223	1
Brugia malayi	hypothetical protein	0.0383	0.4098	0.6649
Mycobacterium ulcerans	F0F1 ATP synthase subunit alpha	0.0039	0.022	0.6373
Mycobacterium tuberculosis	Probable ATP synthase alpha chain AtpA	0.0039	0.022	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0049	0.0328	0.4953
Trypanosoma cruzi	Vacuolar proton pump subunit B, putative	0.0039	0.0223	0.3056
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0024	0.0049	0.011
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0099	0.089	0.0863
Brugia malayi	ecdysteroid receptor	0.0024	0.0049	0.0031
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0028	0.0091	0.3226
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0028	0.0091	0.3173
Trypanosoma brucei	Vacuolar proton pump subunit B, putative	0.0039	0.0223	0.3369
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0692	0.1628
Echinococcus multilocularis	vacuolar ATP synthase subunit b	0.0039	0.0223	0.0194
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0099	0.089	0.1407
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0049	0.0328	0.4497
Leishmania major	phosphopantetheinyl transferase-like protein	0.0028	0.0091	0.097
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0049	0.0046
Echinococcus granulosus	L aminoadipate semialdehyde	0.0099	0.089	0.093
Mycobacterium leprae	PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA	0.0039	0.022	1
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0078	0.0661	0.3708
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0024	0.0049	0.0046
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0078	0.0661	0.0633
Trypanosoma brucei	DNA polymerase IV, putative	0.0049	0.0328	0.4953
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0024	0.0049	0.011
Mycobacterium leprae	PROBABLE ATP SYNTHASE BETA CHAIN ATPD	0.0039	0.022	1
Toxoplasma gondii	vacuolar ATP synthase subunit b, putative	0.0039	0.0223	0.1725
Echinococcus granulosus	transcription factor Dp 1	0.0045	0.0289	0.028
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0078	0.0661	1
Mycobacterium ulcerans	DNA polymerase IV	0.0049	0.0328	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0239	0.3619
Mycobacterium tuberculosis	Probable ATP synthase beta chain AtpD	0.0039	0.022	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0025	0.006	0.1596
Plasmodium vivax	ATP synthase alpha chain, putative	0.0039	0.022	0.9833
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0024	0.0049	0.0019
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0024	0.0049	0.0046
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0024	0.0049	0.002
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0049	0.0046
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0024	0.0049	0.0019
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0028	0.0091	0.3173
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0121	0.1148	0.6569
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0049	0.0046
Echinococcus granulosus	dna polymerase kappa	0.0049	0.0328	0.0322
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0024	0.0049	0.0031
Leishmania major	DNA polymerase kappa, putative	0.0025	0.006	0.048
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0028	0.0091	0.0547
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0024	0.0049	0.0031
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0078	0.0661	0.1552
Leishmania major	ATPase alpha subunit	0.0032	0.0141	0.1767
Trypanosoma brucei	DNA polymerase kappa, putative	0.0049	0.0328	0.4953
Plasmodium falciparum	ATP synthase F1, alpha subunit	0.0039	0.022	0.9833
Trichomonas vaginalis	DNA polymerase eta, putative	0.0049	0.0328	0.4497
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0099	0.089	0.5054
Trypanosoma brucei	DNA polymerase kappa, putative	0.0049	0.0328	0.4953
Trypanosoma brucei	DNA polymerase kappa, putative	0.0049	0.0328	0.4953
Treponema pallidum	V-type ATP synthase subunit B	0.0039	0.0223	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0173	0.1733	0.1708
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0081	0.0692	0.3888
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0121	0.1148	0.1209
Echinococcus multilocularis	conserved hypothetical protein	0.0833	0.9187	0.9185
Echinococcus granulosus	hypothetical protein	0.0842	0.9284	1
Loa Loa (eye worm)	steroid hormone receptor	0.0024	0.0049	0.0046
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0024	0.0049	0.002
Onchocerca volvulus	ATP synthase subunit alpha, mitochondrial homolog	0.0039	0.022	0.2031
Echinococcus multilocularis	ATP synthase subunit alpha, mitochondrial	0.0039	0.022	0.019
Trypanosoma brucei	hypothetical protein, conserved	0.0028	0.0091	0.1377
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0024	0.0049	0.0031
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0024	0.0049	0.0031
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0149	0.1462	0.1437
Schistosoma mansoni	ATP synthase alpha subunit mitochondrial	0.0039	0.022	0.1114
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0121	0.1148	0.1122
Brugia malayi	Steroid receptor seven-up type 2	0.0024	0.0049	0.0031
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0024	0.0049	0.0046
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0025	0.006	0.048
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0078	0.0661	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0049	0.0046
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0078	0.0661	0.0682
Trypanosoma cruzi	V-type proton ATPase subunit B, putative	0.0039	0.0223	0.3056
Onchocerca volvulus		0.0099	0.089	1
Entamoeba histolytica	hypothetical protein	0.0028	0.0091	0.097
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0024	0.0049	0.0031
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0024	0.0049	0.002
Loa Loa (eye worm)	hypothetical protein	0.0383	0.4098	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0024	0.0049	0.002
Brugia malayi	Serotonin receptor	0.0564	0.6148	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0121	0.1148	0.6569
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0028	0.0091	0.0547
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0049	0.0046
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0024	0.0049	0.011
Entamoeba histolytica	V-type ATPase, B subunit, putative	0.0039	0.0223	0.3056
Echinococcus multilocularis	FTZ F1 alpha	0.0024	0.0049	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0049	0.0046
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0024	0.0049	0.002
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0024	0.0049	0.0031
Trypanosoma brucei	DNA polymerase kappa, putative	0.0049	0.0328	0.4953
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0028	0.0091	0.2056
Plasmodium vivax	vacuolar ATP synthase subunit b, putative	0.0039	0.0223	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0078	0.0661	1
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0078	0.0661	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0024	0.0049	0.011
Loa Loa (eye worm)	hypothetical protein	0.0099	0.089	0.2115
Schistosoma mansoni	nuclear hormone receptor	0.0024	0.0049	0.011
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0049	0.0031
Echinococcus granulosus	ATP synthase subunit alpha mitochondrial	0.0039	0.022	0.0205
Trichomonas vaginalis	ATP synthase alpha subunit mitochondrial, putative	0.0039	0.0223	0.2915
Trypanosoma brucei	DNA polymerase kappa, putative	0.0049	0.0328	0.4953
Brugia malayi	polk-prov protein	0.0037	0.0194	0.0268

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	> 5	Binding affinity for human 5-hydroxytryptamine 2A receptor expressed in HEK 293 cells using [3H]-ketanserin	ChEMBL.	16168649
Ki (binding)	= 5.9	Binding affinity for human 5-hydroxytryptamine 2C receptor expressed in HEK 293 cells using [3H]-mesulergine	ChEMBL.	16168649
Ki (binding)	= 5.9	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]-5-HT	ChEMBL.	16168649
Log Ki (binding)	< 5	Binding affinity for human 5-hydroxytryptamine 2A receptor expressed in HEK 293 cells using [3H]-ketanserin	ChEMBL.	16168649
Log Ki (binding)	= 5.9	Binding affinity for human 5-hydroxytryptamine 2C receptor expressed in HEK 293 cells using [3H]-mesulergine	ChEMBL.	16168649
Log Ki (binding)	= 5.9	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]-5-HT	ChEMBL.	16168649

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL198192

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 343873