TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 326.537 | Formula: C19H34O2S
H donors: 1 H acceptors: 2 LogP: 7.61 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCCCC1(C)SC(=C(C1=O)CCCC)O
InChi: 1S/C19H34O2S/c1-4-6-8-9-10-11-12-13-15-19(3)17(20)16(14-7-5-2)18(21)22-19/h21H,4-15H2,1-3H3
InChiKey: HUAVQZUTUIIAHA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0071	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.2791	0.3293	0.3293
Echinococcus multilocularis	fmrfamide receptor	0.0071	0.0064	0.0193
Echinococcus multilocularis	protein patched	0.0042	0.0029	0.0087
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.2791	0.3293	0.3293
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.1321	0.1547	0.1547
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0064	0.0193
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0023	0.0023
Schistosoma mansoni	cpg binding protein	0.0057	0.0047	0.0085
Onchocerca volvulus		0.0071	0.0064	0.0122
Echinococcus multilocularis	nAChR subunit	0.147	0.1725	0.5238
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0278	0.0278
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.147	0.1725	0.1725
Brugia malayi	CXXC zinc finger family protein	0.0057	0.0047	0.0047
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.1321	0.1547	0.4699
Onchocerca volvulus		0.0071	0.0064	0.0122
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0023	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0172	0.0184	0.0183
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.008	0.0074	0.0224
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.1321	0.1547	0.1547
Echinococcus granulosus	7tm_1 domain containing protein	0.0071	0.0064	0.0193
Onchocerca volvulus		0.0071	0.0064	0.0122
Echinococcus granulosus	thymidine kinase	0.0284	0.0317	0.0961
Schistosoma mansoni	opsin-like receptor	0.0071	0.0064	0.0118
Loa Loa (eye worm)	GABA receptor subunit	0.147	0.1725	0.1725
Loa Loa (eye worm)	hypothetical protein	0.1321	0.1547	0.1547
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0042	0.0029	0.0825
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.2791	0.3293	0.3293
Brugia malayi	hypothetical protein	0.1321	0.1547	0.1547
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0138	0.0143	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0023	0.0023
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.0147	0.4386
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0023	0.0843
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0029	0.084
Trichomonas vaginalis	esterase, putative	0.0037	0.0023	0.6637
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0071	0.0064	0.0118
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0023	0.0843
Echinococcus multilocularis	g protein coupled receptor	0.0071	0.0064	0.0193
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0602	0.0695	0.0694
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0298	0.0334	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0071	0.0064	0.0118
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.2791	0.3293	0.3292
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.0064	0.0193
Echinococcus granulosus	biogenic amine 5HT receptor	0.0071	0.0064	0.0193
Schistosoma mansoni	hypothetical protein	0.0071	0.0064	0.0118
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0071	0.0064	0.0118
Echinococcus granulosus	hypothetical protein	0.0071	0.0064	0.0193
Brugia malayi	latrophilin 2 splice variant baaae	0.0172	0.0184	0.0184
Brugia malayi	Melatonin receptor type 1A	0.0071	0.0064	0.0064
Echinococcus granulosus	microtubule associated protein 2	0.0682	0.0789	0.2395
Schistosoma mansoni	nAChR subunit	0.2791	0.3293	0.6197
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0029	0.0087
Schistosoma mansoni	adenoreceptor	0.0071	0.0064	0.0118
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0071	0.0064	0.0118
Loa Loa (eye worm)	hypothetical protein	0.008	0.0074	0.0074
Schistosoma mansoni	nAChR subunit	0.2791	0.3293	0.6197
Echinococcus granulosus	neuropeptides capa receptor	0.0071	0.0064	0.0193
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.1321	0.1547	0.4699
Schistosoma mansoni	hypothetical protein	0.0682	0.0789	0.1483
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0071	0.0064	0.0064
Brugia malayi	Cation transporter family protein	0.2791	0.3293	0.3293
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0071	0.0064	0.0193
Echinococcus multilocularis	thymidine kinase	0.0284	0.0317	0.0961
Brugia malayi	Serotonin receptor	0.0071	0.0064	0.0064
Brugia malayi	beta-lactamase family protein	0.0037	0.0023	0.0023
Echinococcus multilocularis	expressed conserved protein	0.0091	0.0087	0.0265
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.008	0.0074	0.0074
Loa Loa (eye worm)	acetyltransferase	0.0141	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus granulosus	glycine receptor subunit beta	0.2791	0.3293	1
Brugia malayi	CHE-14 protein	0.0042	0.0029	0.0029
Echinococcus granulosus	geminin	0.0682	0.0789	0.2396
Schistosoma mansoni	importin beta-1	0.0056	0.0046	0.0085
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0023	0.0069
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0064	0.0118
Echinococcus granulosus	7TM GPCR rhodopsin	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.0094	0.0094
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.1321	0.1547	0.1547
Brugia malayi	hypothetical protein	0.0071	0.0064	0.0064
Loa Loa (eye worm)	cytochrome P450 family protein	0.0048	0.0036	0.0036
Brugia malayi	hypothetical protein	0.1321	0.1547	0.1547
Schistosoma mansoni	nAChR subunit	0.2791	0.3293	0.6197
Schistosoma mansoni	hypothetical protein	0.004	0.0027	0.0048
Echinococcus granulosus	sex peptide receptor	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.147	0.1725	0.1725
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus multilocularis	transfer RNA-Ile	0.0284	0.0317	0.0961
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.2791	0.3293	0.3293
Brugia malayi	Cation transporter family protein	0.2791	0.3293	0.3293
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.0064	0.0193
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.1321	0.1547	0.1547
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0023	0.0069
Loa Loa (eye worm)	hypothetical protein	0.2791	0.3293	0.3292
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.4492	0.5312	1
Echinococcus multilocularis	sex peptide receptor	0.0071	0.0064	0.0193
Echinococcus multilocularis	somatostatin receptor	0.0071	0.0064	0.0193
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0029	0.084
Entamoeba histolytica	Ran family GTPase	0.0042	0.0029	0.0159
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0111	0.0111	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.2791	0.3293	0.3293
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0042	0.0029	0.0825
Brugia malayi	hypothetical protein	0.0071	0.0064	0.0064
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0046	0.0034	0.0976
Echinococcus multilocularis	geminin	0.0682	0.0789	0.2396
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0071	0.0064	0.0064
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0023	0.0023
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0023	0.6637
Onchocerca volvulus		0.0071	0.0064	0.0122
Echinococcus granulosus	g protein coupled receptor	0.0071	0.0064	0.0193
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.2791	0.3293	0.6197
Schistosoma mansoni	hypothetical protein	0.0172	0.0184	0.0343
Echinococcus granulosus	thymidine kinase	0.0284	0.0317	0.0961
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0023	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0071	0.0064	0.0193
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0071	0.0064	0.0118
Mycobacterium ulcerans	hypothetical protein	0.0157	0.0166	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.2791	0.3293	1
Echinococcus granulosus	g protein coupled receptor	0.0071	0.0064	0.0193
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0064	0.0193
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0071	0.0064	0.0193
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0064	0.0118
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.1321	0.1547	0.1547
Echinococcus granulosus	g-protein coupled receptor	0.0071	0.0064	0.0193
Echinococcus multilocularis	cpg binding protein	0.006	0.005	0.0152
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0023	0.0843
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.2791	0.3293	1
Loa Loa (eye worm)	hypothetical protein	0.287	0.3386	0.3386
Echinococcus multilocularis	neuropeptide Y receptor	0.0071	0.0064	0.0193
Brugia malayi	hypothetical protein	0.0071	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus multilocularis	nAChR subunit	0.2791	0.3293	1
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.2791	0.3293	0.3293
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0137	0.0142	0.0431
Onchocerca volvulus		0.0071	0.0064	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0023	0.0023
Echinococcus multilocularis	glycine receptor subunit beta	0.2791	0.3293	1
Loa Loa (eye worm)	hypothetical protein	0.7121	0.8432	0.8432
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0157	0.0166	0.6447
Loa Loa (eye worm)	hypothetical protein	0.2791	0.3293	0.3292
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.2791	0.3293	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0071	0.0064	0.0064
Entamoeba histolytica	hypothetical protein	0.0046	0.0034	0.0188
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0071	0.0064	0.0193
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.0064	0.0193
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0029	0.084
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0029	0.084
Echinococcus multilocularis	neuropeptides capa receptor	0.0071	0.0064	0.0193
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0138	0.0143	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Schistosoma mansoni	amine GPCR	0.0071	0.0064	0.0118
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0023	0.6637
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.2791	0.3293	0.3293
Echinococcus multilocularis	neuropeptide s receptor	0.0071	0.0064	0.0193
Schistosoma mansoni	amine GPCR	0.0071	0.0064	0.0118
Loa Loa (eye worm)	hypothetical protein	0.1321	0.1547	0.1547
Echinococcus multilocularis	snurportin 1	0.0602	0.0695	0.2109
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0071	0.0064	0.0193
Brugia malayi	beta-lactamase family protein	0.0037	0.0023	0.0023
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0042	0.0029	0.0029
Onchocerca volvulus		0.0071	0.0064	0.0122
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0071	0.0064	0.0064
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.2791	0.3293	0.3293
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.2791	0.3293	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0023	0.0023
Schistosoma mansoni	hypothetical protein	0.008	0.0074	0.0137
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.0064	0.0193
Brugia malayi	hypothetical protein	0.0148	0.0156	0.0156
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.1321	0.1547	0.1547
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0023	0.0041
Echinococcus granulosus	importin subunit beta 1	0.0056	0.0046	0.014
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.0029	0.8433
Schistosoma mansoni	neurotransmitter gated ion channel	0.147	0.1725	0.3245
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0023	0.6637
Onchocerca volvulus		0.0148	0.0156	0.0395
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0042	0.0029	0.0087
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.1321	0.1547	0.1547
Brugia malayi	Dopamine receptor	0.0071	0.0064	0.0064
Brugia malayi	Serotonin receptor	0.0071	0.0064	0.0064
Plasmodium vivax	tryptophan-rich antigen (Pv-fam-a)	0.388	0.4585	1
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0023	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.1321	0.1547	0.1547
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0042	0.0029	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0064	0.0118
Onchocerca volvulus		0.0057	0.0047	0.007
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0071	0.0064	0.0064
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0025	0.5155
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0138	0.0143	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0071	0.0064	0.0118
Echinococcus multilocularis	orexin receptor type 2	0.0071	0.0064	0.0193
Onchocerca volvulus		0.0071	0.0064	0.0122
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.0147	0.4386
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.2791	0.3293	0.6197
Echinococcus multilocularis	g protein coupled receptor	0.0071	0.0064	0.0193
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0009	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0064	0.0118
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.1321	0.1547	0.1547
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0023	0.0843
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0071	0.0064	0.0193
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.1321	0.1547	0.1547
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.2791	0.3293	0.3293
Brugia malayi	G protein-coupled receptor	0.0071	0.0064	0.0064
Echinococcus granulosus	glycine receptor subunit alpha 1	0.2791	0.3293	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0046	0.0034	1
Schistosoma mansoni	nAChR subunit	0.1321	0.1547	0.2911
Echinococcus granulosus	neuropeptides capa receptor	0.0071	0.0064	0.0193
Schistosoma mansoni	histamine h1 receptor	0.0071	0.0064	0.0118
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.2791	0.3293	1
Echinococcus multilocularis	neuropeptide receptor	0.0071	0.0064	0.0193
Echinococcus granulosus	GPCR family 2	0.008	0.0074	0.0224
Onchocerca volvulus		0.1321	0.1547	0.4533
Brugia malayi	AKH receptor	0.0071	0.0064	0.0064
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.0029	0.2501
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0071	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.2791	0.3293	0.3292
Onchocerca volvulus		0.2791	0.3293	0.9722
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0001	0.0003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.1321	0.1547	0.1547
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.008	0.0074	0.0224
Onchocerca volvulus		0.0071	0.0064	0.0122
Brugia malayi	follicle stimulating hormone receptor	0.0071	0.0064	0.0064
Schistosoma mansoni	opsin-like receptor	0.0071	0.0064	0.0118
Schistosoma mansoni	hypothetical protein	0.008	0.0074	0.0137
Echinococcus multilocularis	allatostatin A receptor	0.0071	0.0064	0.0193
Leishmania major	hypothetical protein, conserved	0.0037	0.0023	0.0648
Brugia malayi	ORL1-like opioid receptor	0.0071	0.0064	0.0064
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.0064	0.0193
Schistosoma mansoni	amine GPCR	0.0071	0.0064	0.0118
Schistosoma mansoni	acetylcholine receptor-related	0.1321	0.1547	0.2911
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0234	0.0257	1
Brugia malayi	G-protein coupled receptor	0.0071	0.0064	0.0064
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0071	0.0064	0.0193
Brugia malayi	Latrophilin receptor protein 2	0.008	0.0074	0.0074
Schistosoma mansoni	thymidine kinase	0.0284	0.0317	0.0594
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0071	0.0064	0.0193
Echinococcus granulosus	cpg binding protein	0.006	0.005	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus multilocularis	neuropeptide Y receptor	0.0071	0.0064	0.0193
Schistosoma mansoni	hypothetical protein	0.004	0.0027	0.0048
Onchocerca volvulus		0.0071	0.0064	0.0122
Echinococcus granulosus	somatostatin receptor	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.2791	0.3293	0.3292
Onchocerca volvulus		0.0071	0.0064	0.0122
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0071	0.0064	0.0122
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.0094	0.0286
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0071	0.0064	0.0118
Schistosoma mansoni	biogenic amine receptor	0.0071	0.0064	0.0118
Echinococcus granulosus	serotonin receptor	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.2791	0.3293	0.3292
Schistosoma mansoni	hypothetical protein	0.008	0.0074	0.0137
Schistosoma mansoni	ran	0.0042	0.0029	0.0052
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0064	0.0193
Echinococcus granulosus	biogenic amine 5HT receptor	0.0071	0.0064	0.0193
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.2791	0.3293	0.3292
Loa Loa (eye worm)	ACC-1 protein	0.2791	0.3293	0.3292
Schistosoma mansoni	neurotransmitter gated ion channel	0.1321	0.1547	0.2911
Schistosoma mansoni	amine GPCR	0.0071	0.0064	0.0118
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.2791	0.3293	0.3292
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.2791	0.3293	1
Schistosoma mansoni	hypothetical protein	0.004	0.0027	0.0048
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.2791	0.3293	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0138	0.0144	0.0435
Loa Loa (eye worm)	hypothetical protein	0.147	0.1725	0.1725
Loa Loa (eye worm)	hypothetical protein	0.1321	0.1547	0.1547
Loa Loa (eye worm)	hypothetical protein	0.1321	0.1547	0.1547
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0071	0.0064	0.0118
Echinococcus multilocularis	G protein coupled receptor 139	0.0071	0.0064	0.0193
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0064	0.0118
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.2791	0.3293	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0252	0.0278	0.0278
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.2791	0.3293	0.3292
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0023	0.0023
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.1321	0.1547	0.4699
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0064	0.0118
Leishmania major	GTP-binding protein, putative	0.0042	0.0029	0.0825
Onchocerca volvulus		0.0071	0.0064	0.0122
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0023	0.0843
Echinococcus granulosus	dnaJ subfamily B	0.0805	0.0935	0.284
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Schistosoma mansoni	neuropeptide f receptor 76f	0.0071	0.0064	0.0118
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0071	0.0064	0.0118
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0071	0.0064	0.0193
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0001	0.0001
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0071	0.0064	0.0118
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0009	0.0226
Brugia malayi	excitatory GABA receptor EXP-1A	0.2791	0.3293	0.3293
Brugia malayi	hypothetical protein	0.0071	0.0064	0.0064
Brugia malayi	hypothetical protein	0.0025	0.0009	0.0009
Loa Loa (eye worm)	latrophilin receptor protein 2	0.008	0.0074	0.0074
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0156	0.0156
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0071	0.0064	0.0064
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0023	0.1307
Loa Loa (eye worm)	neuropeptide F receptor	0.0071	0.0064	0.0064
Echinococcus granulosus	allatostatin A receptor	0.0071	0.0064	0.0193
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.1321	0.1547	0.1547
Brugia malayi	hypothetical protein	0.1321	0.1547	0.1547
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.2791	0.3293	1
Brugia malayi	neuropeptide F receptor	0.0071	0.0064	0.0064
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0023	0.1307
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0064	0.0193
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0025	0.0135
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0071	0.0064	0.0118
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.147	0.1725	0.1725
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0071	0.0064	0.0193
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0071	0.0064	0.0193
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0029	0.8448
Echinococcus multilocularis	microtubule associated protein 2	0.0682	0.0789	0.2395
Echinococcus multilocularis	thymidine kinase	0.0284	0.0317	0.0961
Echinococcus multilocularis	neuropeptide receptor A26	0.0071	0.0064	0.0193
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.4492	0.5312	0.5312
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0138	0.0143	0.0143
Schistosoma mansoni	cpg binding protein	0.006	0.005	0.0092
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0009	0.0687
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.2791	0.3293	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0071	0.0064	0.0193
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0042	0.0029	0.2507
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0138	0.0143	0.0267
Schistosoma mansoni	neuropeptide F-like receptor	0.0071	0.0064	0.0118
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.1321	0.1547	0.1547
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0071	0.0064	0.0193
Echinococcus granulosus	Thymidine kinase 2 mitochondrial	0.0284	0.0317	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.008	0.0074	0.0224
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0023	0.0648
Echinococcus granulosus	dro:myosuppressin receptor	0.0071	0.0064	0.0193
Echinococcus granulosus	nAChR subunit	0.2791	0.3293	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0071	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.147	0.1725	0.1725
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.008	0.0074	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Schistosoma mansoni	biogenic amine receptor	0.0071	0.0064	0.0118
Schistosoma mansoni	neurotransmitter gated ion channel	0.1321	0.1547	0.2911
Schistosoma mansoni	neuropeptide receptor	0.0071	0.0064	0.0118
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.012	0.0122	0.0227
Loa Loa (eye worm)	ACC-1 protein	0.2791	0.3293	0.3292
Echinococcus granulosus	neuropeptide FF receptor 2	0.0071	0.0064	0.0193
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0298	0.0334	1
Schistosoma mansoni	neuropeptide receptor	0.0071	0.0064	0.0118
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0071	0.0064	0.0118
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0042	0.0029	0.006
Loa Loa (eye worm)	hypothetical protein	0.8441	1	1
Schistosoma mansoni	patched 1	0.0042	0.0029	0.0052
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0023	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0071	0.0064	0.0193
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.2791	0.3293	1
Loa Loa (eye worm)	hypothetical protein	0.2791	0.3293	0.3292
Echinococcus granulosus	expressed conserved protein	0.0091	0.0087	0.0265
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0141	0.0147	0.4386
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0298	0.0334	1
Onchocerca volvulus		0.0071	0.0064	0.0122
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0071	0.0064	0.0193
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.147	0.1725	0.3245
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.0029	0.006
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.147	0.1725	0.1725
Echinococcus granulosus	glycine receptor subunit beta	0.2791	0.3293	1
Loa Loa (eye worm)	hypothetical protein	0.1321	0.1547	0.1547
Schistosoma mansoni	myosin xvIII	0.0071	0.0064	0.0118
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.2791	0.3293	0.3292
Loa Loa (eye worm)	hypothetical protein	0.394	0.4656	0.4656
Brugia malayi	Cation transporter family protein	0.287	0.3386	0.3386
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.2791	0.3293	1
Brugia malayi	Dopamine receptor protein 1	0.0071	0.0064	0.0064
Echinococcus multilocularis	dnaJ subfamily B	0.0805	0.0935	0.284
Onchocerca volvulus		0.2791	0.3293	0.9722
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0023	0.0041
Loa Loa (eye worm)	LGC-31 protein	0.2791	0.3293	0.3292
Loa Loa (eye worm)	hypothetical protein	0.2791	0.3293	0.3292
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.2791	0.3293	1
Schistosoma mansoni	hypothetical protein	0.008	0.0074	0.0137
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0141	0.0147	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Brugia malayi	hypothetical protein	0.1321	0.1547	0.1547
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus granulosus	tm gpcr rhodopsin	0.0071	0.0064	0.0193
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.1321	0.1547	0.4699
Echinococcus multilocularis	GPCR, family 2	0.008	0.0074	0.0224
Entamoeba histolytica	hypothetical protein	0.147	0.1725	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.004	0.004
Echinococcus granulosus	snurportin 1	0.0602	0.0695	0.2109
Echinococcus granulosus	nAChR subunit	0.147	0.1725	0.5238
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.1549	0.1818	0.1818
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0071	0.0064	0.0193
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0023	0.6637
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0071	0.0064	0.0122
Echinococcus multilocularis	g-protein coupled receptor	0.0071	0.0064	0.0193
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0064	0.0193
Onchocerca volvulus		0.147	0.1725	0.506
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.287	0.3386	0.6373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus granulosus	tm gpcr rhodopsin	0.0071	0.0064	0.0193
Brugia malayi	GnHR receptor homolog	0.0071	0.0064	0.0064
Onchocerca volvulus		0.287	0.3386	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0056	0.0046	0.4124
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.2791	0.3293	0.3293
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Brugia malayi	putative neuropeptide receptor	0.0071	0.0064	0.0064
Brugia malayi	G protein-coupled receptor F59B2.13	0.0071	0.0064	0.0064
Brugia malayi	Cytochrome P450 family protein	0.0048	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Schistosoma mansoni	hypothetical protein	0.0602	0.0695	0.1305
Loa Loa (eye worm)	G-protein coupled receptor	0.0071	0.0064	0.0064
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0138	0.0143	0.0433
Onchocerca volvulus		0.287	0.3386	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.0096	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus multilocularis	fmrfamide receptor	0.0071	0.0064	0.0193
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0023	0.0047
Loa Loa (eye worm)	hypothetical protein	0.2791	0.3293	0.3292
Echinococcus granulosus	fmrfamide receptor	0.0071	0.0064	0.0193
Brugia malayi	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus multilocularis	serotonin receptor	0.0071	0.0064	0.0193
Echinococcus multilocularis	glycine receptor subunit beta	0.2791	0.3293	1
Loa Loa (eye worm)	hypothetical protein	0.7502	0.8885	0.8885
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0071	0.0064	0.0118
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0009	0.1666
Schistosoma mansoni	neuropeptide F-like receptor	0.0071	0.0064	0.0118
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0023	0.0843
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0023	0.0843
Trypanosoma brucei	importin beta-1 subunit, putative	0.0056	0.0046	0.1357
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.2791	0.3293	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0071	0.0064	0.0118
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.2791	0.3293	0.3292
Schistosoma mansoni	nAChR subunit	0.2791	0.3293	0.6197
Loa Loa (eye worm)	hypothetical protein	0.147	0.1725	0.1725
Schistosoma mansoni	nAChR subunit	0.1321	0.1547	0.2911
Toxoplasma gondii	ABC1 family protein	0.0037	0.0023	0.1968
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0138	0.0143	0.0143
Echinococcus granulosus	g protein coupled receptor	0.0071	0.0064	0.0193
Echinococcus granulosus	neuropeptide Y receptor	0.0071	0.0064	0.0193
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.2791	0.3293	1
Brugia malayi	sulfakinin receptor protein	0.0071	0.0064	0.0064
Echinococcus multilocularis	neuropeptide receptor	0.0071	0.0064	0.0193
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0029	0.0087
Echinococcus granulosus	glycine receptor subunit alpha 1	0.2791	0.3293	1
Schistosoma mansoni	neuropeptide receptor	0.0071	0.0064	0.0118
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0025	0.848
Schistosoma mansoni	hypothetical protein	0.0071	0.0064	0.0118
Loa Loa (eye worm)	G-protein coupled receptor	0.0071	0.0064	0.0064
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Onchocerca volvulus		0.0071	0.0064	0.0122
Schistosoma mansoni	neuropeptide receptor	0.0071	0.0064	0.0118
Brugia malayi	Importin beta-1 subunit	0.0056	0.0046	0.0046
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0042	0.0029	0.0087
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0046	0.0034	1
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0042	0.0029	0.0029
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0029	0.0087
Brugia malayi	RNA, U transporter 1	0.016	0.017	0.017
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0023	0.0648
Trichomonas vaginalis	importin beta-1, putative	0.0046	0.0034	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0138	0.0144	0.0435
Plasmodium falciparum	importin beta, putative	0.0056	0.0046	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0064	0.0193
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0023	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0023	0.1307
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.004	0.1168
Brugia malayi	putative neuropeptide receptor NPR1	0.0071	0.0064	0.0064
Echinococcus multilocularis	neuropeptides capa receptor	0.0071	0.0064	0.0193
Onchocerca volvulus		0.2791	0.3293	0.9722
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0064	0.0118
Echinococcus granulosus	neuropeptide receptor	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.2791	0.3293	0.3292
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0071	0.0064	0.0193
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0023	0.0023
Schistosoma mansoni	microtubule-associated protein tau	0.0682	0.0789	0.1483
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.2791	0.3293	0.3293
Brugia malayi	hypothetical protein	0.0071	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.2791	0.3293	0.3292
Onchocerca volvulus		0.0071	0.0064	0.0122
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.2791	0.3293	0.3293
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.147	0.1725	0.3245
Brugia malayi	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.2791	0.3293	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0071	0.0064	0.0064
Echinococcus granulosus	G protein coupled receptor 139	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0023	0.0023
Brugia malayi	G-protein coupled receptor	0.0071	0.0064	0.0064
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0009	0.1666
Loa Loa (eye worm)	hypothetical protein	0.2791	0.3293	0.3292
Echinococcus multilocularis	dro:myosuppressin receptor	0.0071	0.0064	0.0193
Loa Loa (eye worm)	hypothetical protein	0.147	0.1725	0.1725
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Loa Loa (eye worm)	acetylcholine receptor protein	0.1321	0.1547	0.1547
Wolbachia endosymbiont of Brugia malayi	extracellular metallopeptidase	0.4548	0.5378	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0138	0.0143	0.0267
Brugia malayi	neuropeptide F receptor	0.0071	0.0064	0.0064
Echinococcus granulosus	orexin receptor type 2	0.0071	0.0064	0.0193
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.0029	0.2501
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.4492	0.5312	0.5312
Schistosoma mansoni	acetylcholine receptor subunit beta	0.1321	0.1547	0.2911
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0138	0.0143	0.0267
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0023	0.0843
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0252	0.0278	0.0278
Echinococcus granulosus	neuropeptide s receptor	0.0071	0.0064	0.0193
Echinococcus multilocularis	g protein coupled receptor	0.0071	0.0064	0.0193
Brugia malayi	acetyltransferase, GNAT family protein	0.0141	0.0147	0.0147
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0071	0.0064	0.0118
Brugia malayi	hypothetical protein	0.1321	0.1547	0.1547
Brugia malayi	RE15519p	0.0071	0.0064	0.0064
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0064	0.0118
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.2791	0.3293	0.3293
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.2791	0.3293	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0071	0.0064	0.0118
Onchocerca volvulus		0.0071	0.0064	0.0122
Schistosoma mansoni	hypothetical protein	0.004	0.0027	0.0048
Echinococcus granulosus	glycine receptor subunit alpha 1	0.2791	0.3293	1
Echinococcus granulosus	neuropeptide Y receptor	0.0071	0.0064	0.0193
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.0029	0.8433
Brugia malayi	hypothetical protein	0.0071	0.0064	0.0064
Leishmania major	hypothetical protein, conserved	0.0025	0.0009	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Schistosoma mansoni	nAChR subunit	0.2791	0.3293	0.6197
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.2791	0.3293	0.3293
Brugia malayi	beta-lactamase	0.0037	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.1321	0.1547	0.1547
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0009	0.0226
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0036	0.0108
Schistosoma mansoni	opsin-like receptor	0.0071	0.0064	0.0118
Echinococcus granulosus	tm gpcr rhodopsin	0.0071	0.0064	0.0193
Onchocerca volvulus		0.287	0.3386	1
Echinococcus granulosus	neuropeptide receptor A26	0.0071	0.0064	0.0193
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0057	0.0047	0.0046
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0141	0.0147	0.0445
Trichomonas vaginalis	ran, putative	0.0042	0.0029	0.8453
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0042	0.0029	0.6078
Onchocerca volvulus		0.147	0.1725	0.506
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.1321	0.1547	0.1547
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0071	0.0064	0.0193
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0009	0.0016
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0789	0.0916	0.2782
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.2791	0.3293	0.6197
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.147	0.1725	0.1725
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0023	0.1307
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.0064	0.0193
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0023	0.0843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0042	0.0029	0.0825
Leishmania major	mitochondrial DNA polymerase beta	0.0298	0.0334	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.1321	0.1547	0.4699
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Schistosoma mansoni	polycystin 1-related	0.04	0.0454	0.0852
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.0094	0.0539
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.0094	0.0286
Loa Loa (eye worm)	hypothetical protein	0.2791	0.3293	0.3292
Loa Loa (eye worm)	hypothetical protein	0.2791	0.3293	0.3292
Loa Loa (eye worm)	hypothetical protein	0.147	0.1725	0.1725
Echinococcus multilocularis	serotonin receptor	0.0071	0.0064	0.0193
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0252	0.0278	0.0278
Loa Loa (eye worm)	TYRA-2 protein	0.0071	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.147	0.1725	0.1725
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0071	0.0064	0.0064
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0071	0.0064	0.0064
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.2791	0.3293	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.1321	0.1547	0.1547
Brugia malayi	larval opioid receptor	0.0071	0.0064	0.0064
Schistosoma mansoni	hypothetical protein	0.0682	0.0789	0.1483
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.287	0.3386	0.6373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0071	0.0064	0.0193
Schistosoma mansoni	nAChR subunit	0.2791	0.3293	0.6197
Loa Loa (eye worm)	hypothetical protein	0.2791	0.3293	0.3292
Onchocerca volvulus		0.0071	0.0064	0.0122
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.2791	0.3293	0.3293
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.2791	0.3293	0.6197
Loa Loa (eye worm)	hypothetical protein	0.1321	0.1547	0.1547
Loa Loa (eye worm)	neuropeptide F receptor	0.0071	0.0064	0.0064
Echinococcus multilocularis	importin subunit beta 1	0.0056	0.0046	0.014
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0064	0.0064
Schistosoma mansoni	hypothetical protein	0.0071	0.0064	0.0118
Toxoplasma gondii	hypothetical protein	0.0048	0.0037	0.3223
Trypanosoma brucei	importin beta-1 subunit, putative	0.0056	0.0046	0.1357
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.0064	0.0118
Schistosoma mansoni	hypothetical protein	0.0805	0.0935	0.1758
Brugia malayi	Dopamine receptor protein 2	0.0071	0.0064	0.0064
Leishmania major	importin beta-1 subunit, putative	0.0046	0.0034	0.0976
Loa Loa (eye worm)	hypothetical protein	0.1321	0.1547	0.1547
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0029	0.0086
Schistosoma mansoni	nAChR subunit	0.2791	0.3293	0.6197
Onchocerca volvulus		0.1321	0.1547	0.4533
Loa Loa (eye worm)	hypothetical protein	0.2791	0.3293	0.3292
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0046	0.0046
Schistosoma mansoni	ran	0.0042	0.0029	0.0052
Schistosoma mansoni	cpg binding protein	0.006	0.005	0.0092
Onchocerca volvulus		0.1321	0.1547	0.4533
Loa Loa (eye worm)	hypothetical protein	0.287	0.3386	0.3386
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0094	0.0094
Schistosoma mansoni	hypothetical protein	0.0071	0.0064	0.0118
Schistosoma mansoni	biogenic amine receptor	0.0071	0.0064	0.0118
Mycobacterium ulcerans	lipase LipD	0.0037	0.0023	0.1307
Schistosoma mansoni	amine GPCR	0.0071	0.0064	0.0118
Onchocerca volvulus	Putative nachr subunit	0.2791	0.3293	0.9722
Brugia malayi	hypothetical protein	0.0071	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.4492	0.5312	0.5312
Onchocerca volvulus		0.0071	0.0064	0.0122
Echinococcus granulosus	neuropeptide receptor	0.0071	0.0064	0.0193
Plasmodium vivax	importin-beta 2, putative	0.0056	0.0046	0.0098

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 8 uM	Inhibitory concentration against Trypanosoma brucei rhodesiense STIB 900 upon incubation at 37 degrees C in 5% CO2 for 72 hours	ChEMBL.	16161997
IC50 (functional)	= 8 uM	Inhibitory concentration against Trypanosoma brucei rhodesiense STIB 900 upon incubation at 37 degrees C in 5% CO2 for 72 hours	ChEMBL.	16161997
IC50 (functional)	= 71 uM	In vitro inhibitory concentration against erythrocytic stages of chloroquine and pyrimethamine resistant K1 strain of Plasmodium falciparum	ChEMBL.	16161997
IC50 (functional)	= 71 uM	In vitro inhibitory concentration against erythrocytic stages of chloroquine and pyrimethamine resistant K1 strain of Plasmodium falciparum	ChEMBL.	16161997
IC50 (functional)	= 77 uM	Inhibitory concentration against Trypanosoma cruzi [Tulahuen strain C2C4] in rat skeletal myoblasts upon incubation at 37 degrees C for 4 days in 5% CO2	ChEMBL.	16161997
IC50 (functional)	= 77 uM	Inhibitory concentration against Trypanosoma cruzi [Tulahuen strain C2C4] in rat skeletal myoblasts upon incubation at 37 degrees C for 4 days in 5% CO2	ChEMBL.	16161997
Inhibition (binding)	= 60 %	Percent inhibition of Plasmodium falciparum Beta-Ketoacyl-acyl carrier protein synthase III activity (MBP-pfKASIII) expressed in E. coli cells using [1-14C]-acetyl-CoA as radioligand upon incubation at 37 degrees C for 15 minutes with compound dissloved in 2% DMSO at 10 uM	ChEMBL.	16161997
Inhibition (binding)	= 60 %	Percent inhibition of Plasmodium falciparum Beta-Ketoacyl-acyl carrier protein synthase III activity (MBP-pfKASIII) expressed in E. coli cells using [1-14C]-acetyl-CoA as radioligand upon incubation at 37 degrees C for 15 minutes with compound dissloved in 2% DMSO at 10 uM	ChEMBL.	16161997

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma brucei gambiense		16161997

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL197941

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 344483