Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0999 | 0.907 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0129 | 0.0408 | 0.0408 |
Leishmania major | polyprenyl synthase, putative | 0.1093 | 1 | 1 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0416 | 0.3269 | 0.2983 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.1093 | 1 | 1 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.1093 | 1 | 1 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.1093 | 1 | 1 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0416 | 0.3269 | 0.3303 |
Onchocerca volvulus | 0.0129 | 0.0408 | 0.5 | |
Loa Loa (eye worm) | hexokinase | 0.0129 | 0.0408 | 0.0408 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.1093 | 1 | 1 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.1093 | 1 | 1 |
Plasmodium falciparum | octaprenyl pyrophosphate synthase | 0.0416 | 0.3269 | 0.3303 |
Trypanosoma cruzi | solanesyl-diphosphate synthase | 0.0416 | 0.3269 | 0.2983 |
Onchocerca volvulus | 0.0129 | 0.0408 | 0.5 | |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.0999 | 0.907 | 0.9031 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.1093 | 1 | 1 |
Plasmodium vivax | octaprenyl pyrophosphate synthase, putative | 0.0416 | 0.3269 | 0.3303 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0999 | 0.907 | 0.907 |
Loa Loa (eye worm) | hexokinase type II | 0.0129 | 0.0408 | 0.0408 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.0416 | 0.3269 | 1 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.0416 | 0.3269 | 0.5 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.0999 | 0.907 | 0.5 |
Schistosoma mansoni | trans-prenyltransferase | 0.0416 | 0.3269 | 0.2983 |
Trypanosoma brucei | solanesyl-diphosphate synthase, putative | 0.0416 | 0.3269 | 0.3303 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0416 | 0.3269 | 0.3269 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.0999 | 0.907 | 0.5 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.0999 | 0.907 | 0.9031 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.0999 | 0.907 | 1 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.0999 | 0.907 | 1 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.1093 | 1 | 1 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.0999 | 0.907 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0416 | 0.3269 | 0.5 |
Leishmania major | solanesyl-diphosphate synthase, putative | 0.0416 | 0.3269 | 0.2983 |
Leishmania major | farnesyl pyrophosphate synthase | 0.0999 | 0.907 | 0.9031 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.0999 | 0.907 | 1 |
Schistosoma mansoni | glutathione synthetase | 0.0416 | 0.3269 | 0.2983 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0416 | 0.3269 | 0.5 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0999 | 0.907 | 0.9031 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.0999 | 0.907 | 1 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.0416 | 0.3269 | 1 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.0999 | 0.907 | 1 |
Onchocerca volvulus | 0.0129 | 0.0408 | 0.5 | |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.0416 | 0.3269 | 0.2983 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.0999 | 0.907 | 1 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.0999 | 0.907 | 0.9031 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.0416 | 0.3269 | 0.2983 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.0999 | 0.907 | 0.9031 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0416 | 0.3269 | 0.2983 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0416 | 0.3269 | 0.2983 |
Echinococcus granulosus | prenyl decaprenyl diphosphate synthase | 0.0416 | 0.3269 | 0.2983 |
Entamoeba histolytica | bifunctional short chain isoprenyl diphosphate synthase, putative | 0.0416 | 0.3269 | 1 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.0999 | 0.907 | 0.9031 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.0999 | 0.907 | 0.5 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0416 | 0.3269 | 0.5 |
Echinococcus multilocularis | prenyl (decaprenyl) diphosphate synthase | 0.0416 | 0.3269 | 0.2983 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.56 uM | In vitro cytotoxicity variant MES-SA/Dx5 multidrug resistant cells | ChEMBL. | 16169719 |
IC50 (functional) | = 1.56 uM | In vitro cytotoxicity variant MES-SA/Dx5 multidrug resistant cells | ChEMBL. | 16169719 |
IC50 (functional) | = 1.59 uM | In vitro cytotoxicity against uterine sarcoma MES-SA cells | ChEMBL. | 16169719 |
IC50 (functional) | = 1.59 uM | In vitro cytotoxicity against uterine sarcoma MES-SA cells | ChEMBL. | 16169719 |
IC50 (functional) | = 5.88 uM | In vitro cytotoxicity against murineleukemia cell line L1210 | ChEMBL. | 16169719 |
IC50 (functional) | = 5.88 uM | In vitro cytotoxicity against murineleukemia cell line L1210 | ChEMBL. | 16169719 |
IC50 (functional) | = 6.49 uM | In vitro cytotoxicity against colorectal adenocarcinoma HT-29 cells | ChEMBL. | 16169719 |
IC50 (functional) | = 6.49 uM | In vitro cytotoxicity against colorectal adenocarcinoma HT-29 cells | ChEMBL. | 16169719 |
RF (functional) | = 0.98 | Resistant factor as ability to overcome multidrug resistance of MES-SA/Dx5 cells compared to MES-SA cells | ChEMBL. | 16169719 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 16169719 | |
Homo sapiens | ChEMBL23 | 16169719 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.