Detailed information for compound 345278

Basic information

Technical information
  • TDR Targets ID: 345278
  • Name: 2-decyl-5-hydroxy-2-methyl-4-propylthiophen-3 -one
  • MW: 312.51 | Formula: C18H32O2S
  • H donors: 1 H acceptors: 2 LogP: 7.06 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCC1(C)SC(=C(C1=O)CCC)O
  • InChi: 1S/C18H32O2S/c1-4-6-7-8-9-10-11-12-14-18(3)16(19)15(13-5-2)17(20)21-18/h20H,4-14H2,1-3H3
  • InChiKey: NZYOXPYKIYUHBP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-decyl-5-hydroxy-2-methyl-4-propyl-thiophen-3-one
  • 2-decyl-5-hydroxy-2-methyl-4-propyl-3-thiophenone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0023 0.0843
Loa Loa (eye worm) hypothetical protein 0.1321 0.1547 0.1547
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.1321 0.1547 0.1547
Echinococcus multilocularis fmrfamide receptor 0.0071 0.0064 0.0193
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.287 0.3386 0.6373
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.0064 0.0193
Echinococcus multilocularis serotonin receptor 0.0071 0.0064 0.0193
Echinococcus multilocularis neuropeptides capa receptor 0.0071 0.0064 0.0193
Mycobacterium ulcerans beta-lactamase 0.0037 0.0023 0.1307
Onchocerca volvulus 0.1321 0.1547 0.4533
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.2791 0.3293 0.3293
Echinococcus granulosus alpha 1A adrenergic receptor 0.0071 0.0064 0.0193
Echinococcus granulosus allatostatin A receptor 0.0071 0.0064 0.0193
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.1321 0.1547 0.4699
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Onchocerca volvulus 0.0071 0.0064 0.0122
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0023 0.6637
Onchocerca volvulus 0.0071 0.0064 0.0122
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.0257 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.2791 0.3293 0.3292
Echinococcus multilocularis glycine receptor subunit alpha 1 0.157733 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0071 0.0064 0.0193
Echinococcus multilocularis orexin receptor type 2 0.0071 0.0064 0.0193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0064 0.0118
Loa Loa (eye worm) hypothetical protein 0.1321 0.1547 0.1547
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.287 0.3386 0.6373
Brugia malayi hypothetical protein 0.1321 0.1547 0.1547
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0071 0.0064 0.0118
Echinococcus granulosus thymidine kinase 0.0284 0.0317 0.0961
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0029 0.0825
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0009 0.0226
Schistosoma mansoni hypothetical protein 0.0172 0.0184 0.0343
Schistosoma mansoni hypothetical protein 0.0805 0.0935 0.1758
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0064 0.0118
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.2791 0.3293 0.3293
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0071 0.0064 0.0064
Onchocerca volvulus 0.1321 0.1547 0.4533
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Entamoeba histolytica Ran family GTPase 0.0042 0.0029 0.0159
Brugia malayi follicle stimulating hormone receptor 0.0071 0.0064 0.0064
Echinococcus granulosus hypothetical protein 0.0071 0.0064 0.0193
Schistosoma mansoni neuropeptide receptor 0.0071 0.0064 0.0118
Echinococcus granulosus serotonin receptor 0.0071 0.0064 0.0193
Echinococcus multilocularis thymidine kinase 0.0284 0.0317 0.0961
Schistosoma mansoni neuropeptide receptor 0.0071 0.0064 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0143 0.0267
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0023 0.6637
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.2791 0.3293 0.3292
Trichomonas vaginalis esterase, putative 0.0037 0.0023 0.6637
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.2791 0.3293 1
Schistosoma mansoni neuropeptide F-like receptor 0.0071 0.0064 0.0118
Echinococcus granulosus biogenic amine 5HT receptor 0.0071 0.0064 0.0193
Onchocerca volvulus 0.157733 0 0.5
Echinococcus multilocularis fmrfamide receptor 0.0071 0.0064 0.0193
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0071 0.0064 0.0193
Loa Loa (eye worm) G-protein coupled receptor 0.0071 0.0064 0.0064
Brugia malayi CHE-14 protein 0.0042 0.0029 0.0029
Schistosoma mansoni alpha-1 adrenergic receptor 0.0071 0.0064 0.0118
Brugia malayi Cation transporter family protein 0.2791 0.3293 0.3293
Schistosoma mansoni hypothetical protein 0.008 0.0074 0.0137
Mycobacterium tuberculosis Conserved protein 0.0037 0.0023 0.0843
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0071 0.0064 0.0064
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0023 0.0648
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.1321 0.1547 0.1547
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.2791 0.3293 0.3293
Onchocerca volvulus 0.157733 0 0.5
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0147 0.4386
Schistosoma mansoni opsin-like receptor 0.0071 0.0064 0.0118
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0029 0.084
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.1321 0.1547 0.4699
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0284 0.0317 0.0961
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0147 0.0445
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0023 0.0023
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.157733 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0064 0.0118
Schistosoma mansoni myosin xvIII 0.0071 0.0064 0.0118
Onchocerca volvulus 0.157733 0 0.5
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.157733 0 0.5
Onchocerca volvulus 0.0071 0.0064 0.0122
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.1321 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.2791 0.3293 0.3292
Schistosoma mansoni ran 0.0042 0.0029 0.0052
Echinococcus multilocularis geminin 0.0682 0.0789 0.2396
Loa Loa (eye worm) hypothetical protein 0.147 0.1725 0.1725
Echinococcus multilocularis dnaJ subfamily B 0.0805 0.0935 0.284
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0029 0.084
Brugia malayi CXXC zinc finger family protein 0.0057 0.0047 0.0047
Leishmania major hypothetical protein, conserved 0.0037 0.0023 0.0648
Brugia malayi hypothetical protein 0.0071 0.0064 0.0064
Echinococcus granulosus G protein coupled receptor 139 0.0071 0.0064 0.0193
Onchocerca volvulus 0.0071 0.0064 0.0122
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.2791 0.3293 1
Schistosoma mansoni neurotransmitter gated ion channel 0.1321 0.1547 0.2911
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0071 0.0064 0.0193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0064 0.0193
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0064 0.0193
Schistosoma mansoni biogenic amine receptor 0.0071 0.0064 0.0118
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Echinococcus granulosus neuropeptides capa receptor 0.0071 0.0064 0.0193
Loa Loa (eye worm) hypothetical protein 0.147 0.1725 0.1725
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0029 1
Echinococcus granulosus g protein coupled receptor 0.0071 0.0064 0.0193
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.2791 0.3293 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.4492 0.5312 0.5312
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0064 0.0193
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0144 0.0435
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0094 0.0539
Loa Loa (eye worm) hypothetical protein 0.2791 0.3293 0.3292
Loa Loa (eye worm) hypothetical protein 0.2791 0.3293 0.3292
Schistosoma mansoni polycystin 1-related 0.04 0.0454 0.0852
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0071 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.004 0.0027 0.0048
Loa Loa (eye worm) hypothetical protein 0.0097 0.0094 0.0094
Brugia malayi hypothetical protein 0.1321 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.7121 0.8432 0.8432
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.2791 0.3293 0.3293
Echinococcus granulosus glycine receptor subunit alpha 1 0.2791 0.3293 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0071 0.0064 0.0064
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.2791 0.3293 0.3293
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0071 0.0064 0.0118
Schistosoma mansoni amine GPCR 0.0071 0.0064 0.0118
Echinococcus granulosus cpg binding protein 0.006 0.005 0.0152
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0064 0.0193
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0046 0.1357
Echinococcus granulosus microtubule associated protein 2 0.0682 0.0789 0.2395
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0029 0.006
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0071 0.0064 0.0193
Echinococcus multilocularis glycine receptor subunit beta 0.2791 0.3293 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.157733 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0071 0.0064 0.0193
Echinococcus granulosus 7tm_1 domain containing protein 0.0071 0.0064 0.0193
Onchocerca volvulus 0.147 0.1725 0.506
Echinococcus granulosus glycine receptor subunit beta 0.2791 0.3293 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0009 0.1666
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0009
Schistosoma mansoni biogenic amine (5HT) receptor 0.0071 0.0064 0.0118
Echinococcus multilocularis protein dispatched 1 0.0047 0.0036 0.0108
Echinococcus multilocularis glycine receptor subunit alpha 1 0.157733 0 0.5
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0029 0.2501
Echinococcus multilocularis g-protein coupled receptor 0.0071 0.0064 0.0193
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.2791 0.3293 0.6197
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0001 0.5
Schistosoma mansoni nAChR subunit 0.2791 0.3293 0.6197
Loa Loa (eye worm) hypothetical protein 0.1321 0.1547 0.1547
Brugia malayi neuropeptide F receptor 0.0071 0.0064 0.0064
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.0064 0.0193
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0025 0.848
Onchocerca volvulus 0.157733 0 0.5
Onchocerca volvulus 0.2791 0.3293 0.9722
Loa Loa (eye worm) hypothetical protein 0.507319 0.742089 0.742089
Leishmania major hypothetical protein, conserved 0.0025 0.0009 0.0226
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0071 0.0064 0.0118
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.0334 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.2791 0.3293 0.3293
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.0064 0.0118
Schistosoma mansoni biogenic amine receptor 0.0071 0.0064 0.0118
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0071 0.0064 0.0193
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.0064 0.0118
Echinococcus multilocularis GPCR, family 2 0.008 0.0074 0.0224
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.1321 0.1547 0.4699
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0029 0.0086
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0029 0.8433
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0074 0.0074
Schistosoma mansoni biogenic amine (5HT) receptor 0.0071 0.0064 0.0118
Loa Loa (eye worm) hypothetical protein 0.2791 0.3293 0.3292
Loa Loa (eye worm) hypothetical protein 0.1321 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.1321 0.1547 0.1547
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0029 0.8433
Brugia malayi hypothetical protein 0.0025 0.0009 0.0009
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0001 0.0001
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0144 0.0435
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.2791 0.3293 0.3292
Mycobacterium ulcerans lipase LipD 0.0037 0.0023 0.1307
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0064 0.0193
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0789 0.0916 0.2782
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0143 0.0267
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0023 0.0023
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0071 0.0064 0.0118
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0029 0.0087
Loa Loa (eye worm) hypothetical protein 0.1549 0.1818 0.1818
Loa Loa (eye worm) hypothetical protein 0.147 0.1725 0.1725
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0143 0.0433
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.2791 0.3293 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0071 0.0064 0.0193
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.2791 0.3293 0.3293
Brugia malayi hypothetical protein 0.0071 0.0064 0.0064
Echinococcus granulosus nAChR subunit 0.157733 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Schistosoma mansoni neuropeptide F-like receptor 0.0071 0.0064 0.0118
Brugia malayi beta-lactamase 0.0037 0.0023 0.0023
Echinococcus multilocularis G-protein coupled receptor, putative 0.0071 0.0064 0.0193
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.2791 0.3293 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0142 0.0431
Brugia malayi latrophilin 2 splice variant baaae 0.0172 0.0184 0.0184
Echinococcus granulosus glycine receptor subunit beta 0.157733 0 0.5
Schistosoma mansoni importin beta-1 0.0056 0.0046 0.0085
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0064 0.0193
Schistosoma mansoni nAChR subunit 0.2791 0.3293 0.6197
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0071 0.0064 0.0193
Schistosoma mansoni nAChR subunit 0.2791 0.3293 0.6197
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0023 0.0843
Echinococcus granulosus neuropeptide FF receptor 2 0.0071 0.0064 0.0193
Echinococcus multilocularis nAChR subunit 0.147 0.1725 0.5238
Onchocerca volvulus 0.0148 0.0156 0.0395
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0023 0.0843
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Onchocerca volvulus 0.0071 0.0064 0.0122
Loa Loa (eye worm) hypothetical protein 0.1321 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.147 0.1725 0.1725
Brugia malayi Melatonin receptor type 1A 0.0071 0.0064 0.0064
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0147 0.4386
Brugia malayi GnHR receptor homolog 0.0071 0.0064 0.0064
Echinococcus granulosus neuropeptide s receptor 0.0071 0.0064 0.0193
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0029 0.0087
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.2791 0.3293 0.3293
Brugia malayi hypothetical protein 0.0071 0.0064 0.0064
Onchocerca volvulus 0.287 0.3386 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0029 0.084
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0166 0.6447
Mycobacterium tuberculosis Conserved protein 0.0037 0.0023 0.0843
Brugia malayi hypothetical protein 0.1321 0.1547 0.1547
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0071 0.0064 0.0064
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0029 0.2507
Onchocerca volvulus 0.157733 0 0.5
Toxoplasma gondii hypothetical protein 0.0048 0.0037 0.3223
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0029 0.2501
Loa Loa (eye worm) hypothetical protein 0.1321 0.1547 0.1547
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.2791 0.3293 0.6197
Echinococcus multilocularis importin subunit beta 1 0.0056 0.0046 0.014
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0094 0.0286
Loa Loa (eye worm) GABA receptor subunit 0.147 0.1725 0.1725
Toxoplasma gondii ABC1 family protein 0.0037 0.0023 0.1968
Schistosoma mansoni biogenic amine receptor 0.0071 0.0064 0.0118
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0071 0.0064 0.0118
Echinococcus multilocularis nAChR subunit 0.157733 0 0.5
Schistosoma mansoni opsin-like receptor 0.0071 0.0064 0.0118
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.4492 0.5312 0.5312
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0029 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0064 0.0118
Echinococcus multilocularis somatostatin receptor 0.0071 0.0064 0.0193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0064 0.0118
Brugia malayi hypothetical protein 0.0071 0.0064 0.0064
Leishmania major importin beta-1 subunit, putative 0.0046 0.0034 0.0976
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Echinococcus multilocularis g protein coupled receptor 0.0071 0.0064 0.0193
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0602 0.0695 0.1305
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0071 0.0064 0.0193
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0023 0.0648
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.157733 0 0.5
Brugia malayi G-protein coupled receptor 0.0071 0.0064 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0064 0.0118
Loa Loa (eye worm) hypothetical protein 0.1321 0.1547 0.1547
Onchocerca volvulus 0.2791 0.3293 0.9722
Loa Loa (eye worm) hypothetical protein 0.2791 0.3293 0.3292
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0029 0.006
Echinococcus granulosus nAChR subunit 0.147 0.1725 0.5238
Schistosoma mansoni patched 1 0.0042 0.0029 0.0052
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.147 0.1725 0.1725
Echinococcus multilocularis cpg binding protein 0.006 0.005 0.0152
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0071 0.0064 0.0118
Loa Loa (eye worm) hypothetical protein 0.008 0.0074 0.0074
Onchocerca volvulus 0.0071 0.0064 0.0122
Brugia malayi Dopamine receptor 0.0071 0.0064 0.0064
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0071 0.0064 0.0122
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0009 0.0687
Schistosoma mansoni growth hormone secretagogue receptor 0.0071 0.0064 0.0118
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0023 0.0047
Onchocerca volvulus 0.0071 0.0064 0.0122
Loa Loa (eye worm) beta-lactamase 0.0037 0.0023 0.0023
Echinococcus multilocularis glycine receptor subunit alpha 1 0.2791 0.3293 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0023
Brugia malayi ORL1-like opioid receptor 0.0071 0.0064 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0252 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0071 0.0064 0.0064
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.1321 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0023
Brugia malayi hypothetical protein 0.0071 0.0064 0.0064
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0029 0.0087
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0071 0.0064 0.0193
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.147 0.1725 0.3245
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.147 0.1725 0.1725
Echinococcus multilocularis neuropeptide s receptor 0.0071 0.0064 0.0193
Schistosoma mansoni nAChR subunit 0.2791 0.3293 0.6197
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0034 1
Leishmania major GTP-binding protein, putative 0.0042 0.0029 0.0825
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0071 0.0064 0.0064
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0046 0.1357
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Schistosoma mansoni nAChR subunit 0.1321 0.1547 0.2911
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.157733 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0071 0.0064 0.0193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0143 0.0433
Loa Loa (eye worm) hypothetical protein 0.1321 0.1547 0.1547
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0143 0.0143
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0071 0.0064 0.0193
Echinococcus multilocularis protein patched 0.0042 0.0029 0.0087
Brugia malayi hypothetical protein 0.0071 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Brugia malayi RNA, U transporter 1 0.016 0.017 0.017
Schistosoma mansoni neuropeptide receptor 0.0071 0.0064 0.0118
Echinococcus granulosus dro:myosuppressin receptor 0.0071 0.0064 0.0193
Echinococcus multilocularis neuropeptide receptor 0.0071 0.0064 0.0193
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0252 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.147 0.1725 0.1725
Loa Loa (eye worm) hypothetical protein 0.1321 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0071 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Brugia malayi hypothetical protein 0.1321 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Echinococcus multilocularis allatostatin A receptor 0.0071 0.0064 0.0193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0064 0.0193
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0001 0.0003
Entamoeba histolytica hypothetical protein 0.0046 0.0034 0.0188
Echinococcus multilocularis glycine receptor subunit alpha 1 0.2791 0.3293 1
Schistosoma mansoni opsin-like receptor 0.0071 0.0064 0.0118
Brugia malayi G protein-coupled receptor 0.0071 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.008 0.0074 0.0137
Echinococcus multilocularis transfer RNA-Ile 0.0284 0.0317 0.0961
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0074 0.0224
Onchocerca volvulus 0.0071 0.0064 0.0122
Echinococcus multilocularis dro:myosuppressin receptor 0.0071 0.0064 0.0193
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Echinococcus granulosus 7TM GPCR rhodopsin 0.0071 0.0064 0.0193
Echinococcus granulosus glycine receptor subunit alpha 1 0.2791 0.3293 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.0184 0.0183
Echinococcus granulosus importin subunit beta 1 0.0056 0.0046 0.014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.0122 0.0227
Echinococcus granulosus biogenic amine 5HT receptor 0.0071 0.0064 0.0193
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0023 0.0843
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0071 0.0064 0.0193
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.157733 0 0.5
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.2791 0.3293 0.3292
Echinococcus granulosus nAChR subunit 0.2791 0.3293 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0023 0.6637
Loa Loa (eye worm) LGC-31 protein 0.2791 0.3293 0.3292
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.2791 0.3293 1
Brugia malayi Cytochrome P450 family protein 0.0048 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.2791 0.3293 0.3292
Echinococcus multilocularis snurportin 1 0.0602 0.0695 0.2109
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.157733 0 0.5
Echinococcus granulosus glycine receptor subunit beta 0.157733 0 0.5
Echinococcus granulosus thymidine kinase 0.0284 0.0317 0.0961
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0074 0.0074
Echinococcus granulosus dnaJ subfamily B 0.0805 0.0935 0.284
Loa Loa (eye worm) hypothetical protein 0.2791 0.3293 0.3292
Brugia malayi Latrophilin receptor protein 2 0.008 0.0074 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0064 0.0118
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.1321 0.1547 0.1547
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.157733 0 0.5
Toxoplasma gondii HEAT repeat-containing protein 0.0056 0.0046 0.4124
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0001 0.0001
Schistosoma mansoni amine GPCR 0.0071 0.0064 0.0118
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.2791 0.3293 0.3293
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.2791 0.3293 1
Onchocerca volvulus 0.0071 0.0064 0.0122
Echinococcus multilocularis glycine receptor subunit beta 0.157733 0 0.5
Brugia malayi excitatory GABA receptor EXP-1A 0.2791 0.3293 0.3293
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0023
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.2791 0.3293 1
Loa Loa (eye worm) hypothetical protein 0.4492 0.5312 0.5312
Loa Loa (eye worm) hypothetical protein 0.287 0.3386 0.3386
Schistosoma mansoni hypothetical protein 0.0071 0.0064 0.0118
Schistosoma mansoni neurotransmitter gated ion channel 0.1321 0.1547 0.2911
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.2791 0.3293 0.6197
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0034 1
Loa Loa (eye worm) hypothetical protein 0.2791 0.3293 0.3292
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.2791 0.3293 0.3292
Schistosoma mansoni nAChR subunit 0.2791 0.3293 0.6197
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.1321 0.1547 0.1547
Mycobacterium ulcerans hypothetical protein 0.0157 0.0166 1
Loa Loa (eye worm) hypothetical protein 0.147 0.1725 0.1725
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0064 0.0193
Echinococcus multilocularis neuropeptide FF receptor 2 0.0071 0.0064 0.0193
Echinococcus granulosus neuropeptide receptor 0.0071 0.0064 0.0193
Onchocerca volvulus 0.147 0.1725 0.506
Loa Loa (eye worm) hypothetical protein 0.0252 0.0278 0.0278
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.157733 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.1321 0.1547 0.4699
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0143 0.0267
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.4548 0.5378 1
Schistosoma mansoni microtubule-associated protein tau 0.0682 0.0789 0.1483
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0023 0.0648
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0023 0.0843
Loa Loa (eye worm) hypothetical protein 0.2791 0.3293 0.3292
Brugia malayi Tachykinin-like peptides receptor 99D 0.0071 0.0064 0.0064
Echinococcus granulosus geminin 0.0682 0.0789 0.2396
Brugia malayi Importin beta-1 subunit 0.0056 0.0046 0.0046
Echinococcus granulosus fmrfamide receptor 0.0071 0.0064 0.0193
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.157733 0 0.5
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0009 0.0226
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0071 0.0064 0.0118
Loa Loa (eye worm) hypothetical protein 0.1321 0.1547 0.1547
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0111 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0252 0.0278 0.0278
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0029 0.0087
Onchocerca volvulus 0.287 0.3386 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0064 0.0193
Brugia malayi hypothetical protein 0.0148 0.0156 0.0156
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0094 0.0094
Brugia malayi Serotonin/octopamine receptor family protein 7 0.250263 0.196419 0.264684
Brugia malayi hypothetical protein 0.0071 0.0064 0.0064
Echinococcus multilocularis glycine receptor subunit alpha 1 0.157733 0 0.5
Onchocerca volvulus 0.0071 0.0064 0.0122
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.0334 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.2791 0.3293 0.3292
Echinococcus granulosus orexin receptor type 2 0.0071 0.0064 0.0193
Mycobacterium ulcerans hypothetical protein 0.0037 0.0023 0.1307
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.0064 0.0193
Loa Loa (eye worm) hypothetical protein 0.1321 0.1547 0.1547
Onchocerca volvulus 0.0071 0.0064 0.0122
Loa Loa (eye worm) hypothetical protein 0.8441 1 1
Plasmodium vivax importin-beta 2, putative 0.0056 0.0046 0.0098
Schistosoma mansoni cpg binding protein 0.006 0.005 0.0092
Schistosoma mansoni hypothetical protein 0.004 0.0027 0.0048
Echinococcus multilocularis neuropeptide Y receptor 0.0071 0.0064 0.0193
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.2791 0.3293 0.3293
Onchocerca volvulus 0.0071 0.0064 0.0122
Brugia malayi beta-lactamase family protein 0.0037 0.0023 0.0023
Brugia malayi hypothetical protein 0.0071 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0042 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0029 0.0825
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.2791 0.3293 1
Onchocerca volvulus 0.0071 0.0064 0.0122
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.2791 0.3293 0.3293
Echinococcus multilocularis glycine receptor subunit beta 0.2791 0.3293 1
Loa Loa (eye worm) hypothetical protein 0.250263 0.196419 0.196419
Onchocerca volvulus Putative nachr subunit 0.157733 0 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0071 0.0064 0.0193
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0025 0.0135
Schistosoma mansoni hypothetical protein 0.0682 0.0789 0.1483
Echinococcus granulosus neuropeptide Y receptor 0.0071 0.0064 0.0193
Brugia malayi G-protein coupled receptor 0.0071 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.2791 0.3293 0.3292
Loa Loa (eye worm) hypothetical protein 0.0056 0.0046 0.0046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.2791 0.3293 0.3293
Loa Loa (eye worm) neuropeptide F receptor 0.0071 0.0064 0.0064
Echinococcus multilocularis neuropeptide receptor A26 0.0071 0.0064 0.0193
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0034 0.0976
Onchocerca volvulus 0.0071 0.0064 0.0122
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0023 0.0843
Brugia malayi putative neuropeptide receptor NPR1 0.0071 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Echinococcus multilocularis expressed conserved protein 0.0091 0.0087 0.0265
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0096 0.0178
Onchocerca volvulus 0.0071 0.0064 0.0122
Schistosoma mansoni amine GPCR 0.0071 0.0064 0.0118
Onchocerca volvulus 0.0057 0.0047 0.007
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0023 0.6637
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0064 0.0118
Schistosoma mansoni cpg binding protein 0.006 0.005 0.0092
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0029 0.8448
Loa Loa (eye worm) hypothetical protein 0.1321 0.1547 0.1547
Schistosoma mansoni hypothetical protein 0.0682 0.0789 0.1483
Echinococcus granulosus sex peptide receptor 0.0071 0.0064 0.0193
Loa Loa (eye worm) melatonin receptor type 1A 0.0071 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.008 0.0074 0.0137
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.157733 0 0.5
Schistosoma mansoni cpg binding protein 0.0057 0.0047 0.0085
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.2791 0.3293 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0029 0.084
Echinococcus granulosus GPCR family 2 0.008 0.0074 0.0224
Echinococcus multilocularis neuropeptide receptor 0.0071 0.0064 0.0193
Loa Loa (eye worm) G-protein coupled receptor 0.0071 0.0064 0.0064
Echinococcus multilocularis sex peptide receptor 0.0071 0.0064 0.0193
Onchocerca volvulus 0.287 0.3386 1
Loa Loa (eye worm) hypothetical protein 0.250263 0.196419 0.196419
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0143 0.0143
Echinococcus granulosus peptide allatostatin:somatostatin 0.0071 0.0064 0.0193
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0064 0.0193
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.388 0.4585 1
Schistosoma mansoni hypothetical protein 0.0071 0.0064 0.0118
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0147 0.0147
Echinococcus multilocularis glycine receptor subunit alpha 1 0.2791 0.3293 1
Brugia malayi sulfakinin receptor protein 0.0071 0.0064 0.0064
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0023 0.0069
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0023 0.0041
Brugia malayi putative neuropeptide receptor 0.0071 0.0064 0.0064
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0009 0.0016
Schistosoma mansoni amine GPCR 0.0071 0.0064 0.0118
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0074 0.0224
Loa Loa (eye worm) acetylcholine receptor protein 0.1321 0.1547 0.1547
Echinococcus multilocularis microtubule associated protein 2 0.0682 0.0789 0.2395
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.0334 1
Loa Loa (eye worm) hypothetical protein 0.394 0.4656 0.4656
Loa Loa (eye worm) acetyltransferase 0.0141 0.0147 0.0147
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0094 0.0286
Schistosoma mansoni nAChR subunit 0.2791 0.3293 0.6197
Schistosoma mansoni hypothetical protein 0.004 0.0027 0.0048
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0071 0.0064 0.0118
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0071 0.0064 0.0193
Echinococcus granulosus glycine receptor subunit beta 0.2791 0.3293 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0023 0.0843
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0064 0.0193
Loa Loa (eye worm) hypothetical protein 0.7502 0.8885 0.8885
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0602 0.0695 0.0694
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.157733 0 0.5
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0029 0.0825
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Schistosoma mansoni amine GPCR 0.0071 0.0064 0.0118
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.1321 0.1547 0.1547
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.0064 0.0193
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.147 0.1725 0.3245
Onchocerca volvulus 0.1321 0.1547 0.4533
Echinococcus multilocularis serotonin receptor 0.0071 0.0064 0.0193
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Onchocerca volvulus 0.2791 0.3293 0.9722
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.2791 0.3293 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0071 0.0064 0.0193
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0147 0.0274
Brugia malayi Cation transporter family protein 0.2791 0.3293 0.3293
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0036 0.0036
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0071 0.0064 0.0118
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0071 0.0064 0.0193
Plasmodium falciparum importin beta, putative 0.0056 0.0046 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.008 0.0074 0.0137
Mycobacterium leprae Probable lipase LipE 0.0037 0.0023 0.5
Echinococcus granulosus expressed conserved protein 0.0091 0.0087 0.0265
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.2791 0.3293 0.6197
Loa Loa (eye worm) hypothetical protein 0.2791 0.3293 0.3292
Schistosoma mansoni neuropeptide f receptor 76f 0.0071 0.0064 0.0118
Schistosoma mansoni hypothetical protein 0.004 0.0027 0.0048
Entamoeba histolytica hypothetical protein 0.147 0.1725 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0023 0.0041
Brugia malayi RE15519p 0.0071 0.0064 0.0064
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.0064 0.0118
Brugia malayi beta-lactamase family protein 0.0037 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.351293 0.410883 0.410883
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0071 0.0064 0.0193
Loa Loa (eye worm) hypothetical protein 0.1321 0.1547 0.1547
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0064 0.0193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0064 0.0118
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Brugia malayi Serotonin receptor 0.0071 0.0064 0.0064
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0029 0.0087
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0034 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0071 0.0064 0.0193
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Brugia malayi Dopamine receptor protein 2 0.0071 0.0064 0.0064
Onchocerca volvulus Putative nachr subunit 0.2791 0.3293 0.9722
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0074 0.0224
Onchocerca volvulus 0.0071 0.0064 0.0122
Echinococcus granulosus glycine receptor subunit alpha 1 0.2791 0.3293 1
Brugia malayi Serotonin receptor 0.0071 0.0064 0.0064
Echinococcus granulosus somatostatin receptor 0.0071 0.0064 0.0193
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0029 0.0029
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0009 0.0226
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.2791 0.3293 0.3293
Schistosoma mansoni acetylcholine receptor subunit beta 0.1321 0.1547 0.2911
Loa Loa (eye worm) ACC-1 protein 0.2791 0.3293 0.3292
Echinococcus granulosus neuropeptide receptor A26 0.0071 0.0064 0.0193
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0074 0.0224
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.250263 0.196419 1
Loa Loa (eye worm) hypothetical protein 0.287 0.3386 0.3386
Echinococcus multilocularis g protein coupled receptor 0.0071 0.0064 0.0193
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0023 0.6637
Loa Loa (eye worm) hypothetical protein 0.2791 0.3293 0.3292
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0064 0.0193
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0023 0.1307
Echinococcus granulosus neuropeptide receptor 0.0071 0.0064 0.0193
Echinococcus multilocularis G protein coupled receptor 139 0.0071 0.0064 0.0193
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0029 0.6078
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0023 0.5
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.2791 0.3293 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0071 0.0064 0.0122
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Onchocerca volvulus 0.157733 0 0.5
Echinococcus granulosus glycine receptor subunit alpha 1 0.157733 0 0.5
Schistosoma mansoni adenoreceptor 0.0071 0.0064 0.0118
Echinococcus granulosus snurportin 1 0.0602 0.0695 0.2109
Loa Loa (eye worm) hypothetical protein 0.628816 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.0064 0.0193
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.507319 0.742089 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.004 0.004
Schistosoma mansoni neurotransmitter gated ion channel 0.147 0.1725 0.3245
Loa Loa (eye worm) neuropeptide F receptor 0.0071 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0071 0.0064 0.0193
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0023 0.0843
Brugia malayi G protein-coupled receptor F59B2.13 0.0071 0.0064 0.0064
Schistosoma mansoni histamine h1 receptor 0.0071 0.0064 0.0118
Schistosoma mansoni acetylcholine receptor-related 0.1321 0.1547 0.2911
Onchocerca volvulus 0.0071 0.0064 0.0122
Echinococcus granulosus neuropeptides capa receptor 0.0071 0.0064 0.0193
Schistosoma mansoni neuropeptide receptor 0.0071 0.0064 0.0118
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.147 0.1725 0.1725
Echinococcus granulosus neuropeptide Y receptor 0.0071 0.0064 0.0193
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.004 0.1168
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.2791 0.3293 1
Echinococcus multilocularis glycine receptor subunit beta 0.157733 0 0.5
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.2791 0.3293 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0071 0.0064 0.0118
Echinococcus granulosus glycine receptor subunit alpha 1 0.157733 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.431224 0.580559 0.580559
Echinococcus multilocularis neuropeptides capa receptor 0.0071 0.0064 0.0193
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.0334 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0023 0.1307
Schistosoma mansoni ran 0.0042 0.0029 0.0052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0064 0.0193
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0064 0.0193
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.508211 0.743984 0.5
Brugia malayi neuropeptide F receptor 0.0071 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.2791 0.3293 0.3292
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0147 0.4386
Echinococcus granulosus g-protein coupled receptor 0.0071 0.0064 0.0193
Echinococcus granulosus g protein coupled receptor 0.0071 0.0064 0.0193
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0071 0.0064 0.0118
Echinococcus granulosus glycine receptor subunit alpha 1 0.157733 0 0.5
Brugia malayi Dopamine receptor protein 1 0.0071 0.0064 0.0064
Brugia malayi larval opioid receptor 0.0071 0.0064 0.0064
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0023 0.0069
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.157733 0 0.5
Schistosoma mansoni nAChR subunit 0.2791 0.3293 0.6197
Schistosoma mansoni nAChR subunit 0.1321 0.1547 0.2911
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0025 0.5155
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0143 0.0433
Trichomonas vaginalis ran, putative 0.0042 0.0029 0.8453
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.2791 0.3293 0.3293
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.147 0.1725 0.1725
Brugia malayi hypothetical protein 0.1321 0.1547 0.1547
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0047 0.0046
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.1321 0.1547 0.1547
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.0064 0.0193
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0023
Schistosoma mansoni thymidine kinase 0.0284 0.0317 0.0594
Echinococcus multilocularis thymidine kinase 0.0284 0.0317 0.0961
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.2791 0.3293 1
Loa Loa (eye worm) hypothetical protein 0.2791 0.3293 0.3292
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.157733 0 0.5
Brugia malayi hypothetical protein 0.0071 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.1321 0.1547 0.1547
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0071 0.0064 0.0193
Loa Loa (eye worm) hypothetical protein 0.0148 0.0156 0.0156
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.157733 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.147 0.1725 0.1725
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.2791 0.3293 0.3293
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0009 0.1666
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.1321 0.1547 0.4699
Brugia malayi hypothetical protein 0.0071 0.0064 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0143 0.0433
Brugia malayi AKH receptor 0.0071 0.0064 0.0064
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.4492 0.5312 1
Loa Loa (eye worm) TYRA-2 protein 0.0071 0.0064 0.0064
Loa Loa (eye worm) ACC-1 protein 0.2791 0.3293 0.3292
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.2791 0.3293 0.3292
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0071 0.0064 0.0064
Brugia malayi Cation transporter family protein 0.287 0.3386 0.3386
Echinococcus multilocularis nAChR subunit 0.2791 0.3293 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 uM In vitro inhibitory concentration against erythrocytic stages of chloroquine and pyrimethamine resistant K1 strain of Plasmodium falciparum ChEMBL. 16161997
IC50 (functional) = 10 uM In vitro inhibitory concentration against erythrocytic stages of chloroquine and pyrimethamine resistant K1 strain of Plasmodium falciparum ChEMBL. 16161997
IC50 (functional) = 21 uM Inhibitory concentration against Trypanosoma brucei rhodesiense STIB 900 upon incubation at 37 degrees C in 5% CO2 for 72 hours ChEMBL. 16161997
IC50 (functional) = 21 uM Inhibitory concentration against Trypanosoma brucei rhodesiense STIB 900 upon incubation at 37 degrees C in 5% CO2 for 72 hours ChEMBL. 16161997
IC50 (functional) = 56 uM Inhibitory concentration against Trypanosoma cruzi [Tulahuen strain C2C4] in rat skeletal myoblasts upon incubation at 37 degrees C for 4 days in 5% CO2 ChEMBL. 16161997
IC50 (functional) = 56 uM Inhibitory concentration against Trypanosoma cruzi [Tulahuen strain C2C4] in rat skeletal myoblasts upon incubation at 37 degrees C for 4 days in 5% CO2 ChEMBL. 16161997
Inhibition (binding) = 55 % Percent inhibition of Plasmodium falciparum Beta-Ketoacyl-acyl carrier protein synthase III activity (MBP-pfKASIII) expressed in E. coli cells using [1-14C]-acetyl-CoA as radioligand upon incubation at 37 degrees C for 15 minutes with compound dissloved in 2% DMSO at 10 uM ChEMBL. 16161997
Inhibition (binding) = 55 % Percent inhibition of Plasmodium falciparum Beta-Ketoacyl-acyl carrier protein synthase III activity (MBP-pfKASIII) expressed in E. coli cells using [1-14C]-acetyl-CoA as radioligand upon incubation at 37 degrees C for 15 minutes with compound dissloved in 2% DMSO at 10 uM ChEMBL. 16161997

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 16161997

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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