Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0779 | 0.0779 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0095 | 0.3162 | 0.3162 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0039 | 0.033 | 0.033 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0094 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0699 | 0.0762 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0576 | 0.0576 |
Trypanosoma brucei | GMP reductase | 0.0095 | 0.3162 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0699 | 0.0699 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0576 | 0.0487 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0095 | 0.3162 | 0.3162 |
Loa Loa (eye worm) | fli-1 protein | 0.0212 | 0.9179 | 0.9179 |
Schistosoma mansoni | gabp alpha | 0.007 | 0.1894 | 0.2064 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0095 | 0.3162 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0576 | 0.0628 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.007 | 0.1894 | 0.1894 |
Leishmania major | guanosine monophosphate reductase | 0.0095 | 0.3162 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0094 | 0.5 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.3162 | 0.3445 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0228 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0164 | 0.6689 | 0.6657 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.3162 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0228 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0039 | 0.033 | 0.033 |
Brugia malayi | Fli-1 protein | 0.0212 | 0.9179 | 0.9179 |
Echinococcus multilocularis | geminin | 0.0164 | 0.6689 | 0.6657 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 1 | 1 |
Schistosoma mansoni | ets-related | 0.0212 | 0.9179 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.6689 | 0.7287 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.3162 | 0.5 |
Loa Loa (eye worm) | GMP reductase | 0.0039 | 0.033 | 0.033 |
Brugia malayi | Ets-domain containing protein | 0.007 | 0.1894 | 0.1894 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.3162 | 0.5 |
Onchocerca volvulus | 0.0047 | 0.0699 | 1 | |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.3162 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0576 | 0.0487 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0576 | 0.0628 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0779 | 0.0779 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.3162 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0095 | 0.3162 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0094 | 0.0094 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0095 | 0.3162 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.3162 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.6689 | 0.7287 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0089 | 0.2875 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0094 | 0.0102 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.3162 | 0.3098 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.007 | 0.1894 | 0.1818 |
Echinococcus granulosus | GA binding protein alpha chain | 0.007 | 0.1894 | 0.1818 |
Brugia malayi | Ets-domain containing protein | 0.007 | 0.1894 | 0.1894 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0576 | 0.0487 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0094 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0779 | 0.0779 |
Brugia malayi | GMP reductase | 0.0039 | 0.033 | 0.033 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0699 | 0.0762 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0576 | 0.0487 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0095 | 0.3162 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0094 | 0.0102 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0576 | 0.0628 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0089 | 0.2875 | 0.8869 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0095 | 0.3162 | 0.5 |
Toxoplasma gondii | IMP dehydrogenas | 0.0095 | 0.3162 | 0.5 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0089 | 0.2875 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0779 | 0.0779 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0094 | 0.5 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.3162 | 0.3098 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1375 | 0.1375 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0576 | 0.0576 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.005 | 0.0861 | 0.0954 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 38 uL/min.mg | Intrinsic clearance in human liver microsomes | ChEMBL. | 16202581 |
IC50 (binding) | = 79 nM | Inhibitory activity against IMPDH II | ChEMBL. | 16202581 |
IC50 (binding) | = 79 nM | Inhibitory activity against IMPDH II | ChEMBL. | 16202581 |
IC50 (functional) | = 1.9 uM | Antiproliferative activity in PMBC | ChEMBL. | 16202581 |
IC50 (functional) | = 1.9 uM | Antiproliferative activity in PMBC | ChEMBL. | 16202581 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 16202581 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.