Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.019 | 0.646 | 0.6413 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3769 | 1 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.3769 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0232 | 0.0103 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.019 | 0.646 | 1 |
Onchocerca volvulus | Netrin receptor homolog | 0.0193 | 0.6562 | 1 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.019 | 0.646 | 0.646 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0361 | 0.0234 |
Echinococcus multilocularis | tumor necrosis factor receptor superfamily | 0.029 | 1 | 1 |
Schistosoma mansoni | nephrin | 0.0014 | 0.0232 | 0.0232 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0194 | 0.659 | 1 |
Schistosoma mansoni | tumor necrosis factor receptor related | 0.029 | 1 | 1 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0194 | 0.659 | 0.6545 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0183 | 0.6194 | 0.9579 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.3769 | 0.5 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.026 | 0.0131 |
Echinococcus multilocularis | TNFR CD27 30 40 95 cysteine rich region | 0.029 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3769 | 1 |
Onchocerca volvulus | 0.0167 | 0.563 | 0.6665 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3769 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3769 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.646 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.646 | 1 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0011 | 0.013 | 0.013 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0011 | 0.013 | 0.013 |
Echinococcus granulosus | tumor necrosis factor receptor superfamily | 0.029 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3769 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.3769 | 0.5749 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.019 | 0.646 | 0.6413 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.019 | 0.646 | 0.646 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0361 | 0.0365 |
Echinococcus granulosus | Ankyrin | 0.019 | 0.646 | 0.6413 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.3769 | 0.5 |
Schistosoma mansoni | kinase | 0.0058 | 0.1784 | 0.1784 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3769 | 1 |
Schistosoma mansoni | netrin receptor unc5 | 0.0194 | 0.659 | 0.659 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.3769 | 0.5 |
Brugia malayi | Uncoordinated protein 44 | 0.019 | 0.646 | 0.9799 |
Echinococcus granulosus | twitchin | 0.0014 | 0.0245 | 0.0116 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.3769 | 0.3687 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.646 | 0.646 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.3769 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.3769 | 0.3769 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0361 | 0.0365 |
Brugia malayi | Protein kinase domain containing protein | 0.019 | 0.6473 | 0.982 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.3769 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.3769 | 0.5633 |
Schistosoma mansoni | vesicular amine transporter | 0.0011 | 0.013 | 0.013 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0361 | 0.0234 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0232 | 0.0103 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.3769 | 0.5 |
Echinococcus granulosus | death domain containing protein | 0.019 | 0.646 | 0.6413 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0171 | 0.5768 | 0.7158 |
Brugia malayi | Death domain containing protein | 0.019 | 0.646 | 0.9799 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.026 | 0.026 |
Echinococcus multilocularis | Ankyrin | 0.019 | 0.646 | 0.6413 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.026 | 0.0205 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.3769 | 0.3687 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0194 | 0.659 | 0.6545 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0183 | 0.6194 | 0.9387 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 uM | Inhibitory activity against KDR | ChEMBL. | 16216502 |
IC50 (binding) | = 2 uM | Inhibitory activity against KDR | ChEMBL. | 16216502 |
IC50 (binding) | = 17 uM | Inhibitory activity against Plk1 | ChEMBL. | 16216502 |
IC50 (binding) | = 17 uM | Inhibitory activity against Plk1 | ChEMBL. | 16216502 |
IC50 (binding) | > 20 uM | Inhibitory activity against Pak4 | ChEMBL. | 16216502 |
IC50 (binding) | > 20 uM | Inhibitory activity against CK2 | ChEMBL. | 16216502 |
IC50 (binding) | > 20 uM | Inhibitory activity against Akt1 | ChEMBL. | 16216502 |
IC50 (binding) | > 20 uM | Inhibitory activity against CDK2/Cyclin A | ChEMBL. | 16216502 |
IC50 (binding) | > 20 uM | Inhibitory activity against p38alpha | ChEMBL. | 16216502 |
IC50 (binding) | > 20 uM | Inhibitory activity against MK2 | ChEMBL. | 16216502 |
IC50 (binding) | > 20 uM | Inhibitory activity against COT | ChEMBL. | 16216502 |
IC50 (binding) | > 20 uM | Inhibitory activity against Pak4 | ChEMBL. | 16216502 |
IC50 (binding) | > 20 uM | Inhibitory activity against CK2 | ChEMBL. | 16216502 |
IC50 (binding) | > 20 uM | Inhibitory activity against Akt1 | ChEMBL. | 16216502 |
IC50 (binding) | > 20 uM | Inhibitory activity against CDK2/Cyclin A | ChEMBL. | 16216502 |
IC50 (binding) | > 20 uM | Inhibitory activity against p38alpha | ChEMBL. | 16216502 |
IC50 (binding) | > 20 uM | Inhibitory activity against MK2 | ChEMBL. | 16216502 |
IC50 (binding) | > 20 uM | Inhibitory activity against COT | ChEMBL. | 16216502 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.