Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.009 | 0 | 0.5 |
Schistosoma mansoni | protein kinase | 0.009 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0024 | 0.0024 |
Trichomonas vaginalis | STE family protein kinase | 0.009 | 0 | 0.5 |
Onchocerca volvulus | 2.0476 | 1 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0201 | 0.0055 | 0.0055 |
Trypanosoma brucei | phospholipase A1, putative | 2.0476 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0201 | 0.0055 | 0.0055 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.009 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0201 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0201 | 0.0055 | 0.0055 |
Trichomonas vaginalis | STE family protein kinase | 0.009 | 0 | 0.5 |
Trypanosoma cruzi | phospholipase A1, putative | 2.0476 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.009 | 0 | 0.5 |
Onchocerca volvulus | 2.0476 | 1 | 0.5 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0201 | 0.0055 | 0.0055 |
Trypanosoma brucei | cytochrome P450, putative | 0.0201 | 0.0055 | 0.0055 |
Leishmania major | cytochrome p450-like protein | 0.0201 | 0.0055 | 0.0055 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0201 | 0.0055 | 0.5 |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.939 | 0.4562 | 0.4562 |
Trypanosoma cruzi | phospholipase A2-like protein, putative | 0.939 | 0.4562 | 0.4562 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0201 | 0.0055 | 0.0055 |
Giardia lamblia | Kinase, STE STE20 | 0.009 | 0 | 0.5 |
Trypanosoma cruzi | phospholipase A1, putative | 2.0476 | 1 | 1 |
Loa Loa (eye worm) | platelet-activating factor acetylhydrolase | 2.0476 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0201 | 0.0055 | 0.0055 |
Onchocerca volvulus | 2.0476 | 1 | 0.5 | |
Leishmania major | phospholipase A1, putative | 2.0476 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 22 nM | Inhibition of basal ERK phosphorylation in Malme-3M cells | ChEMBL. | 16420026 |
Activity (functional) | = 22 nM | Inhibition of basal ERK phosphorylation in Malme-3M cells | ChEMBL. | 16420026 |
Activity (functional) | = 115 nM | Inhibition of cellular viability of Malme-3M cells | ChEMBL. | 16420026 |
Activity (functional) | = 115 nM | Inhibition of cellular viability of Malme-3M cells | ChEMBL. | 16420026 |
IC50 (binding) | = 9.3 nM | Inhibitory activity aginst MEK1 | ChEMBL. | 16420026 |
IC50 (binding) | = 9.3 nM | Inhibitory activity aginst MEK1 | ChEMBL. | 16420026 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.