Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Chorion peroxidase homolog | 0.0858 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0858 | 1 | 1 |
Echinococcus multilocularis | neural cadherin | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0277 | 0.1797 | 0.1797 |
Schistosoma mansoni | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Brugia malayi | Animal haem peroxidase family protein | 0.0858 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0277 | 0.1797 | 0.1797 |
Schistosoma mansoni | septate junction protein | 0.0277 | 0.1797 | 0.1797 |
Echinococcus multilocularis | notch | 0.0277 | 0.1797 | 0.1797 |
Echinococcus granulosus | delta-like protein 1 | 0.0277 | 0.1797 | 0.1797 |
Schistosoma mansoni | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0277 | 0.1797 | 0.1797 |
Schistosoma mansoni | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 1 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0277 | 0.1797 | 0.1797 |
Onchocerca volvulus | 0.0858 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0277 | 0.1797 | 0.1797 |
Schistosoma mansoni | slit | 0.0277 | 0.1797 | 0.1797 |
Brugia malayi | Animal haem peroxidase family protein | 0.0858 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0858 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Echinococcus granulosus | peroxidasin | 0.0858 | 1 | 1 |
Echinococcus multilocularis | fibropellin Ia | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 1 | 1 |
Echinococcus multilocularis | protein jagged 2 | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0858 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Schistosoma mansoni | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 1 | 1 |
Echinococcus granulosus | protein jagged 2 | 0.0277 | 0.1797 | 0.1797 |
Echinococcus granulosus | neural cadherin | 0.0277 | 0.1797 | 0.1797 |
Onchocerca volvulus | Peroxidase homolog | 0.0858 | 1 | 1 |
Schistosoma mansoni | notch | 0.0277 | 0.1797 | 0.1797 |
Echinococcus granulosus | protein jagged 1 | 0.0277 | 0.1797 | 0.1797 |
Onchocerca volvulus | 0.0858 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Echinococcus multilocularis | protein jagged 1 | 0.0277 | 0.1797 | 0.1797 |
Schistosoma mansoni | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0277 | 0.1797 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Schistosoma mansoni | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | Notch2 | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0858 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 1 | 1 |
Onchocerca volvulus | 0.0858 | 1 | 1 | |
Onchocerca volvulus | Peroxidase homolog | 0.0858 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0858 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0277 | 0.1797 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 1 | 1 |
Schistosoma mansoni | notch | 0.0277 | 0.1797 | 0.1797 |
Brugia malayi | Animal haem peroxidase family protein | 0.0858 | 1 | 1 |
Schistosoma mansoni | notch | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | notch protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Schistosoma mansoni | cell polarity protein | 0.0277 | 0.1797 | 0.1797 |
Brugia malayi | Blistered cuticle protein 3 | 0.0858 | 1 | 1 |
Echinococcus granulosus | fibropellin Ia | 0.0277 | 0.1797 | 0.1797 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 1 | 1 |
Schistosoma mansoni | notch | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0858 | 1 | 1 |
Schistosoma mansoni | notch | 0.0277 | 0.1797 | 0.1797 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0277 | 0.1797 | 0.1797 |
Echinococcus granulosus | protein jagged 2 | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0858 | 1 | 1 |
Schistosoma mansoni | notch | 0.0277 | 0.1797 | 0.1797 |
Brugia malayi | Peroxidasin | 0.0858 | 1 | 1 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0858 | 1 | 1 |
Echinococcus granulosus | protein jagged 1 | 0.0277 | 0.1797 | 0.1797 |
Echinococcus granulosus | notch | 0.0277 | 0.1797 | 0.1797 |
Schistosoma mansoni | peroxidasin | 0.0858 | 1 | 1 |
Echinococcus multilocularis | slit 2 protein | 0.0277 | 0.1797 | 0.1797 |
Schistosoma mansoni | peroxidasin | 0.0858 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0858 | 1 | 1 |
Echinococcus granulosus | slit 2 protein | 0.0277 | 0.1797 | 0.1797 |
Brugia malayi | Animal haem peroxidase family protein | 0.0858 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0858 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 23 % | Inhibition of [3H]paroxetine binding to rat cortical 5-HT reuptake at 100 nM | ChEMBL. | 16332439 |
Inhibition (binding) | = 23 % | Inhibition of [3H]paroxetine binding to rat cortical 5-HT reuptake at 100 nM | ChEMBL. | 16332439 |
Ki (binding) | = 30.21 nM | Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in CHO cells | ChEMBL. | 16332439 |
Ki (binding) | = 30.21 nM | Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in CHO cells | ChEMBL. | 16332439 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.