Detailed view for LOAG_01876

Basic information

TDR Targets ID: 945698
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.7078 | Length (AA): 1160 | MW (Da): 131443 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00008   EGF-like domain
PF02210   Laminin G domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
56 432 2wjs (A) 2269 2708 16.00 0 0.74 0.3108 1.16
129 900 3qcw (A) 301 1146 23.00 0 1 0.617817 1.46
434 472 5kxh (B) 89 126 32.00 0.17 0.99 0.502921 -0.82
439 468 5mwb (A) 425 453 48.00 0.39 1 0.619162 -0.55
682 1059 3asi (A) 868 1261 17.00 0 1 0.409662 0.6
850 886 5fma (A) 144 179 49.00 0.24 1 0.546197 0.14
1040 1097 1b3i (A) 14 72 36.00 0.68 0.28 0.2503 0.96

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128166)

Species Accession Gene Product
Brugia malayi Bm1_36505   Thrombospondin N-terminal -like domain containing protein
Caenorhabditis elegans CELE_F20B10.1   Protein NLR-1
Drosophila melanogaster Dmel_CG6827   Neurexin IV
Echinococcus granulosus EgrG_000215800   neurexin 4
Echinococcus multilocularis EmuJ_000215800   neurexin 4
Homo sapiens ENSG00000154529   contactin associated protein-like 3B
Homo sapiens 102725146   contactin-associated protein-like 3B-like
Homo sapiens ENSG00000155052   contactin associated protein-like 5
Homo sapiens ENSG00000106714   contactin associated protein-like 3
Homo sapiens ENSG00000108797   contactin associated protein 1
Homo sapiens ENSG00000174469   contactin associated protein-like 2
Homo sapiens ENSG00000152910   contactin associated protein-like 4
Loa Loa (eye worm) LOAG_01876   hypothetical protein
Mus musculus ENSMUSG00000039419   contactin associated protein-like 2
Mus musculus ENSMUSG00000031772   contactin associated protein-like 4
Mus musculus 241175   contactin associated protein-like 5B
Mus musculus ENSMUSG00000033063   contactin associated protein-like 3
Mus musculus ENSMUSG00000070695   contactin associated protein-like 5A
Mus musculus ENSMUSG00000017167   contactin associated protein-like 1
Mus musculus ENSMUSG00000038048   contactin associated protein-like 5C
Schistosoma japonicum Sjp_0011630   ko:K00914 phosphatidylinositol 3-kinase [EC2.7.1.137], putative
Schistosoma mansoni Smp_159570   septate junction protein
Schmidtea mediterranea mk4.000142.14  
Schmidtea mediterranea mk4.011348.01  
Schmidtea mediterranea mk4.000142.15   Neurexin-4

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0072 0.2653 0.2653
0.0441 0.3092 0.3092
0.0721 0.3198 0.23
0.0544 0.3467 0.3625
0.0185 0.3031 0.3031
0.0117 0.288 0.288
0.0344 0.2544 0.2445
0.0712 0.3765 0.3765
0.0388 0.2709 0.2709
0.0311 0.353 0.5002
0.0468 0.282 0.308
0.0307 0.3053 0.301
0.0123 0.2861 0.2805
0.0392 0.373 0.3703
0.0329 0.3041 0.3041
0.0061 0.2699 0.2699
0.0134 0.262 0.3061
0.0301 0.2899 0.2763
0.0248 0.2934 0.2934
0.0589 0.6349 0.6321
0.0485 0.3148 0.3148
0.0513 0.5993 0.4071
0.0141 0.2963 0.2963
0.0071 0.2586 0.2613
0.0188 0.3327 0.3327
0.0441 0.3092 0.3092
0.0285 0.2904 0.2904
0.0185 0.2761 0.2761
0.0292 0.3166 0.315
0.0329 0.2719 0.2719
0.015 0.3062 0.3062
0.0133 0.3189 0.3189
0.0152 0.2957 0.2957
0.0348 0.7554 0.7525
0.0255 0.2641 0.2641
0.0513 0.5763 0.3783
0.0153 0.3024 0.3024
0.0242 0.2715 0.2713
0.0099 0.2953 0.2573
0.026 0.3526 0.3526
0.0318 0.4022 0.4022
0.0278 0.2611 0.2611
0.0375 0.3622 0.3622
0.0589 0.6349 0.6321
0.0536 0.2587 0.2936
0.0374 0.2988 0.3799
0.0203 0.3381 0.3381
0.0236 0.2789 0.2789
0.0243 0.317 0.3168
0.0198 0.3166 0.3166
0.0121 0.273 0.2781
0.0038 0.276 0.276
0.0517 0.3095 0.3227
0.0259 0.2748 0.3094
0.0153 0.2972 0.2972
0.0414 0.3159 0.3159
0.0162 0.3121 0.3121
0.0451 0.3204 0.3204
0.026 0.2969 0.296
0.0115 0.2784 0.2784
0.026 0.2563 0.3413
0.0404 0.3672 0.3672
0.0249 0.3002 0.2815
0.0087 0.2598 0.2997
0.0164 0.3228 0.3188
0.0258 0.3008 0.3008
0.0103 0.2798 0.2798
0.0207 0.27 0.27
0.0177 0.271 0.271
0.0295 0.3689 0.3689
0.0068 0.2517 0.2517
0.0536 0.2587 0.2936
0.0035127 0.25491 0.25491
0.0142 0.3406 0.3401
0.0475 0.2612 0.2612
0.0164 0.2956 0.2933
0.0254 0.2941 0.2941
0.0115 0.2863 0.2863
0.0491 0.3189 0.3188
0.0601 0.3078 0.3078
0.0366 0.3423 0.3405
0.0666 0.319 0.319
0.0258 0.3206 0.3195
0.043 0.2658 0.3991
0.0426 0.3358 0.3358
0.0525 0.641 0.641
0.021 0.2844 0.2844
0.0239 0.2779 0.2779
0.0441 0.318 0.318
0.0167 0.2843 0.2513
0.0109 0.2786 0.2786
0.0317 0.3449 0.3771
0.0117 0.288 0.288
0.001 0.2746 0
0.0517 0.3095 0.3227
0.0274 0.2517 0.2517
0.0427 0.3069 0.3013
0.008 0.2901 0.2901
0.0135 0.3069 0.3069
0.0099 0.2953 0.2573
0.0142 0.3406 0.3401
0.0352 0.3527 0.3588
0.0227 0.2896 0.3122
0.0389 0.3143 0.3143
0.02 0.3069 0.3069
0.0255 0.2641 0.2641
0.0248 0.2934 0.2934
0.0281 0.3176 0.3176
0.0438 0.3199 0.3187
0.0348 0.3704 0.3704
0.0428 0.2766 0.3179
0.0468 0.282 0.308
0.0123 0.2861 0.2805
0.0405 0.3615 0.3608
0.0625 0.2584 0.2584
0.0307 0.3634 0.3634
0.0224 0.2526 0.2526
0.0146 0.3116 0.3116
0.0427 0.3069 0.3013
0.0095 0.285 0.285
0.0243 0.3092 0.3092
0.0458 0.3099 0.3099
0.0648 0.286 0.2586
0.0061 0.2699 0.2699
0.0236 0.3164 0.3141
0.0522 0.3081 0.3064
0.0535 0.3067 0.3067
0.0274 0.2643 0.3625
0.0418 0.3123 0.3117
0.0062 0.3531 0.3519
0.0157 0.3041 0.3041
0.0522 0.3081 0.3064
0.0259 0.2734 0.308
0.0357 0.272 0.3183
0.0089 0.2899 0.2738
0.0211 0.2942 0.2787
0.0387 0.3184 0.3172
0.0172 0.3272 0.3272
0.0057 0.2918 0.2918
0.0411 0.3295 0.3295
0.0463 0.3122 0.3122
0.0157 0.2891 0.2891
0.0098 0.3264 0.3264
0.0055 0.2631 0.2631
0.0165 0.3133 0.3132
0.0369 0.4233 0.782
0.0387 0.3184 0.3172
0.0174 0.3761 0.3696
0.0096 0.2614 0.2614
0.018 0.2733 0.3131
0.043 0.2658 0.3991
0.0366 0.3159 0
0.0451 0.3204 0.3204
0.0443 0.2936 0.2936
0.0141 0.2963 0.2963
0.0183 0.3306 0.3306
0.0544 0.3467 0.3625
0.03 0.3129 0.3129
0.0255 0.3014 0.2961
0.0589 0.6349 0.6321
0.0311 0.353 0.5002
0.0468 0.282 0.308
0.0381 0.3678 0.3678
0.016 0.2777 0.3712
0.0412 0.3476 0.3109
0.0138 0.2801 0.2641
0.0292 0.2888 0.3126
0.0165 0.3287 0.3287
0.0224 0.2788 0.2788
0.0226 0.3796 0.342
0.0311 0.2882 0.1729
0.0259 0.361 0.3577
0.0399 0.347 0.3469
0.025 0.296 0.296
0.0055 0.2631 0.2631
0.0286 0.29 0.29
0.0218 0.3166 0.3155
0.0302 0.2951 0.3099
0.0295 0.3205 0.3205
0.0101 0.2986 0.2986
0.0116 0.2929 0.2929
0.02 0.2558 0.2969
0.0616 0.3351 0.3342
0.0516 0.6767 0.6767
0.0525 0.641 0.641
0.0549733 0.310216 0.310216
0.0414 0.3159 0.3159
0.0524 0.3648 0.3721
0.0223 0.2869 0.2869
0.0113 0.3212 0.3212
0.0115 0.2723 0.2723
0.0198 0.2747 0.2645
0.0189 0.3075 0.3071
0.0427 0.3069 0.3013
0.0153 0.2985 0.2985
0.0325 0.3629 0.3629
0.0059 0.357 0.357
0.0248 0.3027 0.314
0.0115 0.2711 0.2711
0.0573 0.2651 0.2544
0.0243 0.3092 0.3092
0.0267 0.2959 0
0.0295 0.3689 0.3689
0.0036 0.2571 0.2467
0.0124 0.3533 0.3495
0.008 0.2901 0.2901
0.0258 0.2728 0.2728
0.0098 0.2684 0.2684
0.0295 0.3689 0.3689
0.0062 0.3531 0.3519
0.0585 0.275 0.2516
0.0170248 0.320891 0.231358
0.0148 0.2663 0.2663
0.0184 0.2697 0.259
0.0183 0.3184 0.3184
0.0421 0.317 0.317
0.043 0.2658 0.3991
0.0114 0.3011 0.2979
0.0097 0.2834 0.2255
0.0093 0.2577 0.2577
0.0506 0.3131 0.3131
0.0394 0.2742 0.3388
0.0246 0.2518 0.2518
0.0214 0.3074 0.3074
0.0315 0.2905 0.2905
0.0096 0.2834 0.2829
0.0201 0.3767 0.3723
0.0258 0.2748 0.2748
0.0338 0.312 0.312
0.0418 0.3175 0.3175
0.013 0.2761 0.3003
0.0612 0.2794 0.3746
0.0362 0.3703 0.3689
0.0259 0.2992 0.3114
0.0533 0.6501 0.3653
0.043 0.2658 0.3991
0.044 0.2648 0.2648
0.0279 0.3 0.3
0.0239 0.2779 0.2779
0.0201 0.3767 0.371
0.0198 0.2799 0.2799
0.0666 0.319 0.319
0.0246 0.2628 0.2628
0.0115 0.3331 0.3258
0.0112 0.2767 0.2767
0.0606 0.2955 0.2955
0.0232 0.2789 0.2836
0.0491 0.3189 0.3188
0.004 0.2552 0.2488
0.0241 0.2883 0.2883
0.0274 0.2517 0.2517
0.0468 0.2812 0.308
0.0201 0.3767 0.3723
0.0043 0.3198 0.3198
0.0163 0.3341 0.3341
0.0218 0.3166 0.3155
0.042 0.3054 0.2763
0.0412 0.2524 0.3093
0.0269 0.3081 0.2412
0.0495 0.3224 0.3224
0.0152 0.2957 0.2957
0.044 0.2648 0.2648
0.0253 0.3532 0.3532
0.0145 0.2507 0.2507
0.0482 0.3189 0.3185
0.0525 0.641 0.641
0.0195 0.3148 0.3148
0.0564921 0.310152 0.310152
0.0221 0.2635 0.3671
0.114146 0.305441 0.305441
0.0064 0.3626 0.3393
0.0637 0.2626 0.2626
0.0086 0.2612 0.2376
0.0101 0.2986 0.2986
0.0045 0.2542 0.2542
0.0115 0.2711 0.2711
0.0219 0.3355 0.0979
0.0429 0.3187 0.3186
0.03 0.3129 0.3129
0.0487 0.3215 0.3215
0.0185 0.2761 0.2761
0.0146 0.3116 0.3116
0.02 0.2558 0.2969
0.0254 0.2941 0.2941
0.0142 0.3406 0.3401
0.0399 0.347 0.3469
0.028 0.2815 0.3011
0.0032 0.3069 0.2957
0.0189 0.3071 0.3071
0.0185 0.3031 0.3031
0.0326 0.2784 0.3531
0.02 0.3069 0.3069
0.0098 0.3126 0.3124
0.0398 0.2883 0.2883
0.0135 0.2708 0.2708
0.0295 0.3689 0.3689
0.0158 0.2722 0.2722
0.0206 0.3162 0.3162
0.0525 0.641 0.641
0.0311 0.3596 0.3596
0.0115 0.2543 0.2514
0.0162 0.3121 0.3121
0.0153 0.2722 0.152
0.0233 0.3409 0.3409
0.0217 0.2677 0.2532
0.0246 0.2518 0.2518
0.0238 0.2923 0
0.0168 0.3109 0.31
0.0417 0.3664 0.3659
0.0239 0.3501 0.3501
0.0335 0.3191 0.3191
0.0083 0.2853 0.2898
0.0545 0.2969 0.3182
0.0258 0.3008 0.3008
0.0444 0.3781 0.3773
0.0721 0.3198 0.23
0.0259 0.3073 0.3073
0.0454 0.3211 0.3211
0.0135 0.2885 0.2864
0.0353 0.3096 0.3096
0.0047 0.256 0.256
0.0126 0.251 0.2508
0.0352 0.3625 0.3625
0.0467 0.2591 0.2591
0.0317 0.3449 0.3771
0.0637 0.2626 0.2626
0.0467 0.2591 0.2591
0.0171 0.3505 0.3505
0.0077 0.2526 0.2526
0.0248 0.3027 0.314
0.0209 0.2835 0.2835
0.0181 0.2883 0.2883
0.0255 0.369 0.369
0.0292 0.2888 0.3126
0.0089 0.2518 0.2399
0.0126 0.2915 0.2915
0.033 0.352 0.352
0.0133 0.3189 0.3189
0.0544 0.3467 0.3625
0.0225947 0.316661 0.315286
0.0454 0.3211 0.3211
0.0202 0.3689 0.3687
0.0244 0.329 0.329
0.0485 0.3148 0.3148
0.0348 0.3704 0.3704
0.0274 0.2723 0.3725
0.0258 0.3523 0.3523
0.0883211 0.296142 0.281096
0.0117 0.2916 0.2916
0.0115 0.2784 0.2784
0.0175 0.2715 0.2715
0.0122 0.2639 0.2639
0.0311 0.353 0.5002
0.0351 0.2683 0.2683
0.0092 0.2977 0.2977
0.0143 0.2557 0
0.0511 0.3093 0.3093
0.0113 0.2892 0.2875
0.0038 0.276 0.276
0.0421 0.317 0.317
0.0239 0.2779 0.2779
0.0402 0.2826 0.3604
0.0239 0.3192 0.3192
0.0086 0.2779 0.2779
0.0437 0.3061 0.3061
0.0277 0.3118 0.31
0.0491 0.6698 0.6698
0.0233 0.3409 0.3409
0.0279 0.3 0.3
0.0483 0.3 0.2661
0.0292 0.3166 0.315
0.0351 0.2683 0.2683
0.0079 0.2918 0.2918
0.044 0.2648 0.2648
0.0214 0.3074 0.3074
0.0258 0.3105 0.3719
0.0063 0.2839 0.2779
0.0295 0.2591 0.2591
0.0307 0.3634 0.3634
0.0458 0.3099 0.3099
0.00548004 0.291746 0.287613
0.0115 0.3083 0.3083
0.0536 0.2587 0.2936
0.0441 0.3092 0.3092
0.0459 0.3147 0.3144
0.0196876 0.301589 0.301589
0.0278 0.307 0.3068
0.0127 0.305 0
0.0616 0.3351 0.3342
0.0247 0.3396 0.3307
0.0149 0.3047 0.3096
0.0149 0.3047 0.3096
0.0589 0.3143 0.3139
0.0544 0.3467 0.3625
0.016 0.31 0.31
0.0381 0.3678 0.3678
0.0511 0.4339 0.3986
0.0199 0.3647 0.3647
0.0239 0.3501 0.3501
0.0263 0.3113 0.3077
0.0437 0.3061 0.3061
0.0441 0.3092 0.3092
0.0153 0.2722 0.152
0.042 0.3187 0.3187
0.0441 0.3048 0.3048
0.0299 0.3422 0.369
0.023 0.3189 0.3189
0.0463 0.3122 0.3122
0.0211 0.3162 0.3162
0.0143 0.283 0.1486
0.0254 0.3758 0.3736
0.0051 0.2567 0.2743
0.0102 0.2895 0.2834
0.001 0.2746 0
0.044 0.2648 0.2648
0.0233 0.3409 0.3409
0.0167 0.2924 0.2924
0.0142 0.3406 0.3401
0.0476 0.3544 0.3411
0.0427 0.3069 0.3013
0.0368 0.3229 0.3229
0.0764 0.2955 0.2932
0.0301 0.2899 0.2763
0.0096 0.2901 0.2901
0.0089 0.2735 0.2999
0.0123 0.255 0.255
0.0479 0.2521 0.2519
0.0194 0.3508 0.3404
0.0458 0.3099 0.3099
0.0255 0.2641 0.2641
0.0068 0.2732 0.2732
0.0459 0.3147 0.3144
0.0112 0.2854 0.2854
0.0261 0.2708 0.2554
0.0079 0.295 0.2689
0.0352 0.3625 0.3625
0.0067 0.2742 0.2581
0.0247 0.3396 0.3307
0.0281 0.3176 0.3176
0.0368 0.3229 0.3229
0.0169 0.3047 0.2989
0.0197 0.2999 0.2999
0.0404 0.3672 0.3672
0.0143 0.2557 0
0.0436 0.3134 0.3134
0.0277 0.3082 0.3062
0.0185 0.3031 0.3031
0.0123 0.255 0.255
0.023 0.3189 0.3189
0.0299 0.3422 0.369
0.0441 0.3092 0.3092
0.0159 0.3111 0.311
0.0171 0.3505 0.3505
0.0113 0.3212 0.3212
0.0248 0.3027 0.314
0.0544 0.3467 0.3625
0.0168 0.2873 0.2421
0.0299 0.3769 0.3769
0.0258 0.3105 0.3719
0.0144 0.3315 0.3315
0.0165 0.3133 0.3132
0.0106 0.276 0.276
0.008 0.2988 0.2988
0.0274 0.2723 0.3725
0.0366 0.3423 0.3405
0.0198 0.3166 0.3166
0.016 0.2777 0.3712
0.1034 0.2987 0.2986
0.024 0.303 0.3018
0.0245 0.2653 0.2653
0.0121 0.273 0.2781
0.0399 0.347 0.3469
0.0284 0.2758 0.3507
0.0329 0.3041 0.3041
0.0662 0.3131 0.3108
0.0287 0.2873 0.2873
0.0181 0.2992 0.2992
0.0402 0.2826 0.3604
0.0369 0.4233 0.782
0.0069 0.2751 0.2751
0.0153 0.2722 0.152
0.0284 0.2758 0.3507

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

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Gene identifier LOAG_01876 (Loa Loa (eye worm)), hypothetical protein
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