Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0972 | 0.3689 | 0.5059 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.109 | 0.4237 | 0.5811 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0252 | 0.0368 | 0.0652 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.0368 | 0.1813 |
Schistosoma mansoni | alpha-glucosidase | 0.0914 | 0.342 | 0.6056 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0172 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.0368 | 0.1813 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.0368 | 0.1813 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.109 | 0.4237 | 0.7503 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0367 | 0.0898 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0972 | 0.3689 | 0.6533 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0252 | 0.0368 | 0.0652 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0972 | 0.3689 | 0.6533 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.1396 | 0.5648 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0367 | 0.0898 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0972 | 0.3689 | 0.5059 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.0368 | 0.1813 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0972 | 0.3689 | 0.5059 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.109 | 0.4237 | 0.5811 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.109 | 0.4237 | 0.7503 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.1752 | 0.7292 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.109 | 0.4237 | 0.7503 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.1752 | 0.7292 | 1 |
Schistosoma mansoni | alpha-l-fucosidase | 0.1396 | 0.5648 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.0368 | 0.1813 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0367 | 0.0898 | 0.0898 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.1752 | 0.7292 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0172 | 0 | 0.5 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0612 | 0.2031 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0367 | 0.0898 | 0.159 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0612 | 0.2031 | 1 |
Trypanosoma brucei | adenosine transporter, putative | 0.2339 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.0009 | 0.0044 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.0368 | 0.1813 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.109 | 0.4237 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.0898 | 0.159 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.0009 | 0.0044 |
Schistosoma mansoni | alpha-glucosidase | 0.0914 | 0.342 | 0.6056 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.007 | 0.0124 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.1396 | 0.5648 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 12.3 uM | Compound was tested for inhibition of Adenosine transporter P2 type by using [2-3H]-adenosine as radioligand in T. equiperdum | ChEMBL. | 10890161 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.