TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 312.363 | Formula: C18H20N2O3
H donors: 1 H acceptors: 1 LogP: 2.25 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2NC(c3ccc(cc3)C)[N+](=C(c2cc1OC)C)[O-]
InChi: 1S/C18H20N2O3/c1-11-5-7-13(8-6-11)18-19-15-10-17(23-4)16(22-3)9-14(15)12(2)20(18)21/h5-10,18-19H,1-4H3
InChiKey: OYGXGTBMPANBEJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	DNA topoisomerase type I	0.021	0.2372	0.2372
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0069	0.0488	0.0488
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.033	0.3985	1
Schistosoma mansoni	thyroid hormone receptor	0.0069	0.0488	0.0488
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0162	0.1727	0.4134
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0161	0.1724	0.8655
Brugia malayi	bHLH-PAS transcription factor	0.0041	0.011	0.0319
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0046	0.0181	0.0109
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0069	0.0488	0.1427
Echinococcus granulosus	thioredoxin glutathione reductase	0.0043	0.0145	0.0145
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.033	0.3985	1
Brugia malayi	Thioredoxin reductase	0.0043	0.0137	0.04
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0488	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0053	0.0144
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0488	0.1347
Echinococcus granulosus	single minded 2	0.0041	0.011	0.011
Mycobacterium ulcerans	DNA polymerase IV	0.0046	0.0181	0.0383
Onchocerca volvulus	Protein ultraspiracle homolog	0.0069	0.0488	0.1549
Trypanosoma brucei	DNA polymerase IV, putative	0.0046	0.0181	0.0365
Schistosoma mansoni	DNA topoisomerase type I	0.0157	0.1667	0.1667
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0069	0.0488	0.1427
Echinococcus multilocularis	FTZ F1 alpha	0.0069	0.0488	0.0488
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0069	0.0488	0.1427
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0069	0.0488	0.1427
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0069	0.0488	0.0488
Mycobacterium ulcerans	hypothetical protein	0.018	0.1971	1
Brugia malayi	nuclear hormone receptor	0.0069	0.0488	0.1427
Loa Loa (eye worm)	hypothetical protein	0.0303	0.3621	1
Echinococcus multilocularis	microtubule associated protein 2	0.078	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0069	0.0488	0.0488
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0098	0.087	0.3997
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0488	0.1347
Onchocerca volvulus		0.0268	0.3147	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0098	0.087	0.3997
Onchocerca volvulus		0.0041	0.011	0.0347
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0069	0.0488	0.1427
Echinococcus granulosus	thyroid hormone receptor alpha	0.0033	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0053	0.0144
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0069	0.0488	0.0488
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0098	0.087	0.3997
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0069	0.0488	0.0488
Brugia malayi	steroid hormone receptor	0.0069	0.0488	0.1427
Echinococcus multilocularis	ras gtpase	0.0288	0.3418	0.3417
Loa Loa (eye worm)	hypoxia-induced factor 1	0.017	0.1842	0.5086
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.033	0.3985	1
Schistosoma mansoni	aryl hydrocarbon receptor	0.0055	0.0301	0.03
Plasmodium vivax	thioredoxin reductase, putative	0.0043	0.0137	0.0512
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0033	0.0001	0.0001
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0069	0.0488	0.1549
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.033	0.3985	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0069	0.0488	0.1427
Brugia malayi	hypoxia-induced factor 1	0.017	0.1842	0.5389
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0069	0.0488	0.1347
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0069	0.0488	0.0488
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0036	0.0053	0.0052
Brugia malayi	DNA topoisomerase I	0.021	0.2372	0.6942
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0069	0.0488	0.0488
Echinococcus granulosus	ecdysone induced protein 78C	0.0069	0.0488	0.0488
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.033	0.3985	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.033	0.3985	1
Trichomonas vaginalis	ral, putative	0.0288	0.3418	0.8509
Toxoplasma gondii	DNA topoisomerase I, putative	0.021	0.2372	0.6537
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0162	0.1727	0.3978
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0069	0.0488	0.0488
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0108	0.1016	0.4791
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0017	0.0016
Schistosoma mansoni	DNA topoisomerase type I	0.0157	0.1667	0.1667
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0069	0.0488	0.1347
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0069	0.0488	0.1427
Schistosoma mansoni	single-minded	0.0055	0.0301	0.03
Echinococcus multilocularis	ecdysone induced protein 78C	0.0069	0.0488	0.0488
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0069	0.0488	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0488	0.1347
Leishmania major	DNA topoisomerase IB, large subunit	0.0157	0.1667	0.383
Mycobacterium ulcerans	DNA polymerase IV	0.0046	0.0181	0.0383
Trypanosoma brucei	DNA polymerase IV, putative	0.0046	0.0181	0.0365
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0048	0.0207	0.0176
Trichomonas vaginalis	ras-dva small GTPase, putative	0.0288	0.3418	0.8509
Onchocerca volvulus	Bile acid receptor homolog	0.0069	0.0488	0.1549
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0036	0.0053	0.0052
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0069	0.0488	0.0488
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0036	0.0053	0.0144
Brugia malayi	nuclear receptor NHR-88	0.0069	0.0488	0.1427
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0048	0.0207	0.0176
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0033	0.0001	0.0001
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.0082	0.0124
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0069	0.0488	0.0488
Leishmania major	mitochondrial DNA polymerase beta	0.0341	0.4132	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0017	0.0044
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0069	0.0488	0.0488
Trypanosoma brucei	trypanothione reductase	0.0043	0.0137	0.0258
Brugia malayi	Steroid receptor seven-up type 2	0.0069	0.0488	0.1427
Brugia malayi	nuclear receptor RXR	0.0036	0.0053	0.0153
Trichomonas vaginalis	dexras1, putative	0.0288	0.3418	0.8509
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0069	0.0488	0.0488
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0046	0.0181	0.0109
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0046	0.0181	0.0109
Schistosoma mansoni	retinoic acid receptor RXR	0.0069	0.0488	0.0488
Trypanosoma brucei	DNA topoisomerase IB, large subunit	0.0157	0.1667	0.3989
Giardia lamblia	Fructose-bisphosphate aldolase	0.033	0.3985	0.5
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0341	0.4132	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0053	0.0144
Trichomonas vaginalis	rap1 and, putative	0.0288	0.3418	0.8509
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0053	0.0144
Trichomonas vaginalis	set domain proteins, putative	0.0268	0.3147	0.7798
Loa Loa (eye worm)	hypothetical protein	0.0184	0.2033	0.5615
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0108	0.1016	0.4791
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0053	0.0144
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0069	0.0488	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0488	0.1347
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0303	0.3621	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0036	0.0053	0.0052
Brugia malayi	hypothetical protein	0.0036	0.0053	0.0153
Loa Loa (eye worm)	Ras protein let-60	0.0288	0.3418	0.9439
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0069	0.0488	0.1347
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0069	0.0488	0.1427
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0036	0.0053	0.0053
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0161	0.1724	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0069	0.0488	0.1427
Loa Loa (eye worm)	steroid hormone receptor	0.0069	0.0488	0.1347
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0303	0.3621	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0069	0.0488	0.0488
Brugia malayi	Ras protein let-60	0.0288	0.3418	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0235	0.2712	0.7491
Brugia malayi	glutathione reductase	0.0043	0.0137	0.04
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0048	0.0207	0.0176
Echinococcus granulosus	DNA topoisomerase 1	0.021	0.2372	0.2372
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.033	0.3985	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0069	0.0488	0.1347
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0017	0.0016
Echinococcus multilocularis	DNA topoisomerase 1	0.021	0.2372	0.2372
Echinococcus granulosus	nuclear receptor nhr 48	0.0033	0.0001	0.0001
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0341	0.4132	1
Brugia malayi	Pre-SET motif family protein	0.0034	0.0017	0.0047
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0033	0.0001	0.0001
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0341	0.4132	1
Brugia malayi	hypothetical protein	0.0184	0.2033	0.5948
Schistosoma mansoni	microtubule-associated protein tau	0.078	1	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0017	0.0016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0069	0.0488	0.0488
Brugia malayi	photoreceptor-specific nuclear receptor	0.0069	0.0488	0.1427
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0069	0.0488	0.1427
Brugia malayi	ecdysteroid receptor	0.0069	0.0488	0.1427
Loa Loa (eye worm)	thioredoxin reductase	0.0043	0.0137	0.0378
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.033	0.3985	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0069	0.0488	0.1427
Trypanosoma brucei	unspecified product	0.0039	0.0082	0.0124
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0058	0.0348	0.0527
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0161	0.1724	0.8675
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0069	0.0488	0.0488
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0069	0.0488	0.1427
Leishmania major	DNA topoisomerase type IB small subunit	0.0053	0.0271	0.0334
Brugia malayi	hypothetical protein	0.0036	0.0053	0.0153
Echinococcus granulosus	ras gtpase	0.0288	0.3418	0.3418
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0069	0.0488	0.0488
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0069	0.0488	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0288	0.3418	0.9439
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0069	0.0488	0.1427
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0069	0.0488	0.0488
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0069	0.0488	0.1347
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Brugia malayi	Nuclear hormone receptor-like 1	0.0036	0.0053	0.0153
Plasmodium vivax	topoisomerase I, putative	0.021	0.2372	1
Trichomonas vaginalis	GTP-binding protein rit, putative	0.0288	0.3418	0.8509
Schistosoma mansoni	coup transcription factor	0.0069	0.0488	0.0488
Mycobacterium tuberculosis	Conserved hypothetical protein	0.018	0.1971	1
Trypanosoma cruzi	DNA topoisomerase type IB small subunit, putative	0.0053	0.0271	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0488	0.1347
Onchocerca volvulus		0.0069	0.0488	0.1549
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0162	0.1727	0.3978
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.033	0.3985	1
Treponema pallidum	fructose-bisphosphate aldolase	0.033	0.3985	0.5
Brugia malayi	Pre-SET motif family protein	0.0235	0.2712	0.7936
Toxoplasma gondii	hypothetical protein	0.0303	0.3621	1
Brugia malayi	PAS domain containing protein	0.0055	0.0301	0.0879
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0069	0.0488	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0488	0.1347
Schistosoma mansoni	nuclear hormone receptor	0.0069	0.0488	0.0488
Echinococcus multilocularis	dna polymerase kappa	0.0046	0.0181	0.018
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0031	0.0085
Mycobacterium tuberculosis	Probable oxidoreductase	0.0108	0.1016	0.4791
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0069	0.0488	0.0488
Brugia malayi	Nuclear hormone receptor-like 1	0.0036	0.0053	0.0153
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0017	0.0016
Toxoplasma gondii	thioredoxin reductase	0.0043	0.0137	0.0335
Loa Loa (eye worm)	glutathione reductase	0.0043	0.0137	0.0378
Schistosoma mansoni	thyroid hormone receptor	0.0069	0.0488	0.0488
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0001	0.0001
Plasmodium falciparum	topoisomerase I	0.021	0.2372	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0017	0.0017
Plasmodium vivax	glutathione reductase, putative	0.0043	0.0137	0.0512
Brugia malayi	polk-prov protein	0.0035	0.0031	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0069	0.0488	0.1427
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0043	0.0145	0.0144
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0048	0.0207	0.043
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.033	0.3985	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.0365
Echinococcus granulosus	FTZ F1 alpha	0.0069	0.0488	0.0488
Echinococcus granulosus	dna polymerase kappa	0.0046	0.0181	0.0181
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0108	0.1016	0.1705
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0017	0.0016
Trypanosoma brucei	DNA topoisomerase type IB small subunit	0.0053	0.0271	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0488	0.1347
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0069	0.0488	0.0488
Toxoplasma gondii	hypothetical protein	0.0055	0.0302	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0303	0.3621	1
Trypanosoma cruzi	DNA topoisomerase IB, large subunit, putative	0.0157	0.1667	0.383
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0046	0.0181	0.0109
Onchocerca volvulus		0.0034	0.0017	0.0051
Echinococcus multilocularis	transfer RNA-Lys	0.0041	0.011	0.0109
Mycobacterium tuberculosis	Probable reductase	0.0098	0.087	0.3997
Mycobacterium tuberculosis	Probable dehydrogenase	0.0098	0.087	0.3997
Trichomonas vaginalis	rheb, putative	0.0288	0.3418	0.8509
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0069	0.0488	0.0488
Loa Loa (eye worm)	DNA topoisomerase I	0.021	0.2372	0.6552
Brugia malayi	Ras-related protein R-Ras2	0.0288	0.3418	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0098	0.087	0.3997

Activities

Activity type	Activity value	Assay description	Source	Reference
CF (functional)	= 45 %	Inotropic activity of compound was evaluated as % increase in cardiac force at a dose of 1.87 (mg/Kg) in anesthetized dog	ChEMBL.	No reference
HR (functional)	= 10 %	Inotropic activity of compound was evaluated as % change in heart rate at a dose of 1.87 (mg/Kg) in anesthetized dog	ChEMBL.	No reference
MABP (functional)	= -6 %	Inotropic activity of compound was evaluated as % change in mean arterial blood pressure at a dose of 1.87 (mg/Kg) in anesthetized dog	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL281984

Bibliographic References

No literature references available for this target.

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Detailed information for compound 36641