TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 296.708 | Formula: C16H9ClN2O2
H donors: 2 H acceptors: 4 LogP: 3.79 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cc(Cl)c2c(c1)c(O)c(c(n2)O)c1ccccc1
InChi: 1S/C16H9ClN2O2/c17-12-7-9(8-18)6-11-14(12)19-16(21)13(15(11)20)10-4-2-1-3-5-10/h1-7H,(H2,19,20,21)
InChiKey: ZNYXWKZWGPVWJR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fatty acid synthase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase Pks9	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	Short-chain dehydrogenase/reductase SDR, related	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsB	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium parvum	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	KR domain domain-containing protein, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Onchocerca volvulus		Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks3	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Onchocerca volvulus	Fatty acid synthase homolog	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	Soraphen polyketide synthase A, related	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks12	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks4	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsE	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium parvum	type I fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Probable polyketide synthase Pks1	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	acyl carrier protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks2	Get druggable targets OG5_126633	All targets in OG5_126633

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0029	0.2428	0.1398
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0024	0.1765	0.172
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0032	0.2752	0.481
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0029	0.2428	0.1398
Entamoeba histolytica	hypothetical protein	0.002	0.1198	0.5
Loa Loa (eye worm)	fatty acid synthase	0.003	0.2463	0.2112
Loa Loa (eye worm)	hypothetical protein	0.002	0.1198	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0029	0.2428	0.1398
Echinococcus granulosus	glycine receptor subunit beta	0.0029	0.2428	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0029	0.2428	1
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0029	0.2428	0.1398
Loa Loa (eye worm)	GABA receptor subunit	0.002	0.1198	0.0788
Echinococcus multilocularis	glycine receptor subunit beta	0.0029	0.2428	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.1198	0.0788
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0028	0.2262	0.1902
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.0012	0.0232	0.0527
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0057	0.5944	0.5392
Onchocerca volvulus	Putative nachr subunit	0.0029	0.2428	0.1398
Mycobacterium ulcerans	thioesterase	0.0025	0.1875	0.2064
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.2514	0.4065
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0029	0.2428	1
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.003	0.2514	0.5702
Loa Loa (eye worm)	hypothetical protein	0.002	0.1198	0.0788
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0028	0.2262	0.5131
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Echinococcus granulosus	nAChR subunit	0.0029	0.2428	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0029	0.2428	0.1398
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0029	0.2428	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0029	0.2428	0.1398
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.2262	0.1209
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0029	0.2428	0.1398
Echinococcus multilocularis	nAChR subunit	0.0029	0.2428	1
Schistosoma mansoni	nAChR subunit	0.0029	0.2428	0.1398
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0029	0.2428	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0029	0.2428	1
Onchocerca volvulus		0.0029	0.2428	0.1398
Mycobacterium leprae	Polyketide synthase Pks13	0.0045	0.4409	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Loa Loa (eye worm)	ACC-1 protein	0.0029	0.2428	0.2076
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0029	0.2428	0.1398
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0029	0.2428	0.1398
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0029	0.2428	0.2076
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0029	0.2428	1
Mycobacterium ulcerans	polyketide synthase	0.003	0.2514	0.4065
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0089	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.5119	0.4891
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0029	0.2428	1
Schistosoma mansoni	nAChR subunit	0.0029	0.2428	0.1398
Schistosoma mansoni	nAChR subunit	0.0029	0.2428	0.1398
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0017	0.0861	0.1953
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0029	0.2428	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0025	0.1816	0.4119
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.003	0.2514	0.5702
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0029	0.2428	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0089	1	1
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.2514	0.4065
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0029	0.2428	0.1398
Brugia malayi	excitatory GABA receptor EXP-1A	0.0029	0.2428	0.1398
Loa Loa (eye worm)	hypothetical protein	0.002	0.1198	0.0788
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0029	0.2428	0.2076
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.003	0.2514	0.4065
Loa Loa (eye worm)	hypothetical protein	0.002	0.1198	0.0788
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0029	0.2428	0.2076
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0029	0.2428	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0024	0.1765	0.172
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0029	0.2428	1
Schistosoma mansoni	nAChR subunit	0.0029	0.2428	0.1398
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0029	0.2428	1
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0032	0.2752	0.481
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0022	0.1435	0.3255
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0029	0.2428	1
Mycobacterium ulcerans	thioesterase TesA	0.0025	0.1875	0.2064
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0032	0.2752	0.6242
Onchocerca volvulus		0.0029	0.2428	0.1398
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0045	0.4409	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.877	0.8712
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0829	0.0403
Onchocerca volvulus		0.0029	0.2428	0.1398
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0029	0.2397	0.5436
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0029	0.2428	0.1398
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0029	0.2428	0.2076
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0032	0.2752	0.6242
Loa Loa (eye worm)	hypothetical protein	0.0089	1	1
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0032	0.2752	0.481
Toxoplasma gondii	type I fatty acid synthase, putative	0.0032	0.2752	1
Onchocerca volvulus		0.0052	0.5351	0.4718
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0029	0.2428	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0029	0.2428	0.1398
Loa Loa (eye worm)	LGC-31 protein	0.0029	0.2428	0.2076
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0029	0.2428	0.1398
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0045	0.4409	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0029	0.2428	0.2076
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0029	0.2428	1
Mycobacterium ulcerans	polyketide synthase Pks13	0.0045	0.4409	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0029	0.2428	0.1398
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.2514	0.4065
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0025	0.1875	0.4254
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0029	0.2428	1
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0029	0.2428	0.2076
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.003	0.2514	0.5702
Toxoplasma gondii	type I fatty acid synthase, putative	0.0021	0.141	0.3708
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0032	0.2752	0.6242
Loa Loa (eye worm)	hypothetical protein	0.002	0.1198	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Loa Loa (eye worm)	hypothetical protein	0.0089	1	1
Schistosoma mansoni	nAChR subunit	0.0029	0.2428	0.1398
Onchocerca volvulus		0.0089	1	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Echinococcus multilocularis	glycine receptor subunit beta	0.0029	0.2428	1
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0029	0.2428	1
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0025	0.1875	0.2064
Brugia malayi	Cation transporter family protein	0.0029	0.2428	0.1398
Loa Loa (eye worm)	hypothetical protein	0.002	0.1198	0.0788
Loa Loa (eye worm)	ACC-1 protein	0.0029	0.2428	0.2076
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0029	0.2428	0.1398
Brugia malayi	Cation transporter family protein	0.0029	0.2428	0.1398
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0032	0.2752	0.481
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.003	0.2514	0.1495
Onchocerca volvulus		0.0089	1	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0029	0.2397	0.5436
Mycobacterium ulcerans	polyketide synthase	0.0032	0.2752	0.481
Onchocerca volvulus		0.0089	1	1
Echinococcus granulosus	glycine receptor subunit beta	0.0029	0.2428	1
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.003	0.2514	0.4065
Loa Loa (eye worm)	hypothetical protein	0.002	0.1198	0.0788
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.002	0.1168	0.2574
Onchocerca volvulus		0.0028	0.2262	0.1209
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0029	0.2428	0.1398
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0029	0.2428	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0029	0.2428	0.1398
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0029	0.2428	0.1398
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0029	0.2428	1
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0029	0.2428	1
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0029	0.2428	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0024	0.1765	0.172
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.003	0.2514	0.4065
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0029	0.2428	1
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0029	0.2428	1
Schistosoma mansoni	nAChR subunit	0.0029	0.2428	0.1398
Schistosoma mansoni	nAChR subunit	0.0029	0.2428	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0029	0.2428	0.2076
Onchocerca volvulus	Fatty acid synthase homolog	0.0054	0.5589	0.4988
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0032	0.2752	0.481

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of rat FAS	ChEMBL.	16784844
IC50 (binding)	0	Inhibition of rat FAS	ChEMBL.	16784844
IC50 (binding)	= 402 nM	Inhibition of human FAS	ChEMBL.	16784844
IC50 (binding)	= 402 nM	Inhibition of human FAS	ChEMBL.	16784844

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL209656

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 368658