TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 532.421 | Formula: C28H23Cl2N5O2
H donors: 1 H acceptors: 3 LogP: 6.06 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc2c(cc1C#Cc1cccc(n1)CN(C)C)ncc(c2Nc1cc(OC)c(cc1Cl)Cl)C#N
InChi: 1S/C28H23Cl2N5O2/c1-35(2)16-20-7-5-6-19(33-20)9-8-17-10-24-21(11-26(17)36-3)28(18(14-31)15-32-24)34-25-13-27(37-4)23(30)12-22(25)29/h5-7,10-13,15H,16H2,1-4H3,(H,32,34)
InChiKey: OXTDXIFHYWJIOG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0344	0.3283	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.029	0.029
Brugia malayi	cathepsin L precursor	0.0087	0.0757	0.0757
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0087	0.0757	0.0512
Brugia malayi	Papain family cysteine protease containing protein	0.0087	0.0757	0.0757
Loa Loa (eye worm)	hypothetical protein	0.1028	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0045	0.0346	0.0346
Brugia malayi	protein-tyrosine kinase	0.0041	0.0302	0.0302
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0344	0.3283	0.3283
Entamoeba histolytica	cysteine protease, putative	0.0192	0.1781	0.5035
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0924	0.0683
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1028	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0192	0.1781	0.1781
Brugia malayi	Cathepsin L-like precursor	0.0344	0.3283	0.3283
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1028	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0045	0.0346	0.0346
Entamoeba histolytica	cysteine protease, putative	0.0087	0.0757	0.165
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1028	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0192	0.1781	0.1108
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0344	0.3283	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0192	0.1781	0.1781
Plasmodium vivax	vivapain-2	0.0344	0.3283	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0344	0.3283	0.8838
Entamoeba histolytica	cysteine protease, putative	0.0192	0.1781	0.5035
Onchocerca volvulus		0.0344	0.3283	1
Brugia malayi	Cathepsin L-like precursor	0.024	0.2259	0.2259
Brugia malayi	SRC-1	0.0045	0.0346	0.0346
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0344	0.3283	0.8189
Echinococcus multilocularis	cysteine protease	0.0344	0.3283	0.3283
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1028	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0087	0.0757	0.0757
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0344	0.3283	0.8838
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0344	0.3283	0.3106
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.0346	0.0346
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0087	0.0757	0.0757
Echinococcus granulosus	cathepsin L	0.0192	0.1781	0.1781
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0344	0.3283	0.8838
Brugia malayi	Cathepsin L-like precursor	0.0104	0.0924	0.0924
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0087	0.0757	0.165
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0344	0.3283	0.8838
Echinococcus granulosus	tyrosine protein kinase HCK	0.0036	0.0258	0.0258
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0344	0.3283	0.8838
Onchocerca volvulus	Cathepsin F homolog	0.0344	0.3283	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0344	0.3283	0.8189
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.0346	0.0346
Entamoeba histolytica	cysteine proteinase, putative	0.0344	0.3283	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0192	0.1781	0.5035
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0757	0.0512
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0378	0.3616	1
Entamoeba histolytica	cysteine protease, putative	0.0087	0.0757	0.165
Onchocerca volvulus		0.0344	0.3283	1
Entamoeba histolytica	cysteine proteinase, putative	0.024	0.2259	0.6615
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0192	0.1781	0.1108
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0344	0.3283	0.8189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.024	0.2259	0.5255
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0041	0.0302	0.0302
Entamoeba histolytica	cysteine protease, putative	0.0087	0.0757	0.165
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0344	0.3283	0.8189
Brugia malayi	Papain family cysteine protease containing protein	0.0192	0.1781	0.1781
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0045	0.0346	0.0346
Schistosoma mansoni	tyrosine kinase	0.0045	0.0346	0.0346
Schistosoma mansoni	cathepsin F (C01 family)	0.024	0.2259	0.2259
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0344	0.3283	0.8189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0192	0.1781	0.3583
Giardia lamblia	Cathepsin B precursor	0.0378	0.3616	1
Loa Loa (eye worm)	hypothetical protein	0.024	0.2259	0.2054
Entamoeba histolytica	cysteine proteinase, putative	0.0192	0.1781	0.5035
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0041	0.0302	0.0302
Brugia malayi	Papain family cysteine protease containing protein	0.0087	0.0757	0.0757
Brugia malayi	fibroinase precursor	0.0087	0.0757	0.0757
Loa Loa (eye worm)	hypothetical protein	0.024	0.2259	0.2054
Echinococcus granulosus	tyrosine kinase	0.0041	0.0302	0.0302
Trypanosoma cruzi	cruzipain precursor, putative	0.0344	0.3283	0.2733
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0045	0.0346	0.0346
Entamoeba histolytica	cysteine protease, putative	0.0087	0.0757	0.165
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0087	0.0757	0.0512
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0344	0.3283	0.8838
Trypanosoma cruzi	cysteine peptidase, putative	0.0344	0.3283	0.2733
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.0346	0.0346
Brugia malayi	Cathepsin L-like precursor	0.0344	0.3283	0.3283
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0378	0.3616	0.3616
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0757	0.0512
Brugia malayi	cathepsin F-like cysteine proteinase	0.0104	0.0924	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0924	0.0683
Echinococcus granulosus	cathepsin l1	0.024	0.2259	0.2259
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0344	0.3283	0.8838
Echinococcus multilocularis	cathepsin L	0.0087	0.0757	0.0757
Brugia malayi	Papain family cysteine protease containing protein	0.0192	0.1781	0.1781
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0087	0.0757	0.0757
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0344	0.3283	0.3283
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0087	0.0757	0.0757
Onchocerca volvulus		0.0344	0.3283	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0087	0.0757	0.0757
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0344	0.3283	0.8189
Brugia malayi	Papain family cysteine protease containing protein	0.0087	0.0757	0.0757
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0344	0.3283	0.3283
Loa Loa (eye worm)	TK protein kinase	0.0041	0.0302	0.0046
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0344	0.3283	0.8838
Echinococcus multilocularis	cathepsin L cysteine protease	0.0344	0.3283	0.3283
Trypanosoma cruzi	cysteine peptidase, putative	0.0344	0.3283	0.2733
Entamoeba histolytica	cysteine protease, putative	0.0192	0.1781	0.5035
Entamoeba histolytica	cysteine proteinase 2	0.0192	0.1781	0.5035
Echinococcus multilocularis	cathepsin b	0.1028	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0344	0.3283	0.8838
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0344	0.3283	0.8838
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0045	0.0346	0.0346
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0087	0.0757	0.0757
Entamoeba histolytica	cysteine protease, putative	0.0192	0.1781	0.5035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0192	0.1781	0.3583
Onchocerca volvulus	Cathepsin L homolog	0.0344	0.3283	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0378	0.3616	1
Brugia malayi	Cathepsin L-like precursor	0.0344	0.3283	0.3283
Trypanosoma cruzi	cysteine protease, putative	0.0192	0.1781	0.1108
Brugia malayi	Cathepsin L-like precursor	0.024	0.2259	0.2259
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0344	0.3283	0.8838
Entamoeba histolytica	cysteine protease, putative	0.0192	0.1781	0.5035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0344	0.3283	0.8838
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0344	0.3283	0.8838
Brugia malayi	Cathepsin L-like cysteine proteinase	0.024	0.2259	0.2259
Echinococcus granulosus	cysteine protease	0.0192	0.1781	0.1781
Loa Loa (eye worm)	fibroinase	0.0344	0.3283	0.3106
Toxoplasma gondii	cathepsin B	0.0378	0.3616	1
Plasmodium vivax	unspecified product	0.0104	0.0924	0.066
Echinococcus granulosus	cathepsin L cysteine protease	0.0192	0.1781	0.1781
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.024	0.2259	0.5255
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0378	0.3616	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.024	0.2259	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0757	0.0512
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0344	0.3283	0.8838
Plasmodium vivax	vivapain-3	0.0192	0.1781	0.4054
Echinococcus multilocularis	cysteine protease	0.0344	0.3283	0.3283
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0344	0.3283	0.8838
Entamoeba histolytica	cysteine proteinase, putative	0.0344	0.3283	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0192	0.1781	0.1108
Echinococcus multilocularis	cathepsin b	0.1028	1	1
Entamoeba histolytica	cysteine protease, putative	0.0192	0.1781	0.5035
Echinococcus granulosus	cathepsin b	0.1028	1	1
Entamoeba histolytica	cysteine protease, putative	0.0192	0.1781	0.5035
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0087	0.0757	0.0757
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1028	1	1
Onchocerca volvulus		0.0344	0.3283	1
Echinococcus granulosus	cathepsin b	0.1028	1	1
Entamoeba histolytica	hypothetical protein	0.0087	0.0757	0.165
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0344	0.3283	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0192	0.1781	0.1108
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0344	0.3283	0.8189
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0045	0.0346	0.0346
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0045	0.0346	0.0346
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0087	0.0757	0.0757
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0757	0.0512
Entamoeba histolytica	cysteine protease, putative	0.0192	0.1781	0.5035
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0045	0.0346	0.0346
Loa Loa (eye worm)	cathepsin B	0.0378	0.3616	0.3447
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0041	0.0302	0.0302
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0104	0.0924	0.0924
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0087	0.0757	0.0757
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0344	0.3283	0.8838
Trypanosoma cruzi	cysteine peptidase, putative	0.0104	0.0924	0.018
Plasmodium vivax	vivapain-2	0.0344	0.3283	1
Entamoeba histolytica	cysteine protease, putative	0.0192	0.1781	0.5035
Brugia malayi	Cathepsin L-like precursor	0.0344	0.3283	0.3283
Loa Loa (eye worm)	SRC-1	0.0045	0.0346	0.0091
Schistosoma mansoni	cathepsin F (C01 family)	0.0344	0.3283	0.3283
Onchocerca volvulus		0.024	0.2259	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0344	0.3283	0.8189
Giardia lamblia	Cathepsin B precursor	0.0378	0.3616	1
Entamoeba histolytica	cysteine protease, putative	0.0192	0.1781	0.5035
Entamoeba histolytica	cysteine proteinase, putative	0.0192	0.1781	0.5035
Entamoeba histolytica	cysteine protease, putative	0.0087	0.0757	0.165
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0192	0.1781	0.4054
Loa Loa (eye worm)	ctsf protein	0.0344	0.3283	0.3106
Entamoeba histolytica	cysteine protease, putative	0.0192	0.1781	0.5035
Plasmodium vivax	unspecified product	0.0192	0.1781	0.4054
Brugia malayi	cathepsin L-like cysteine proteinase	0.0087	0.0757	0.0757
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0087	0.0757	0.0757
Onchocerca volvulus		0.0344	0.3283	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0344	0.3283	0.3283
Brugia malayi	Papain family cysteine protease containing protein	0.0344	0.3283	0.3283
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0087	0.0757	0.0757
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0344	0.3283	0.3106
Schistosoma mansoni	cathepsin S (C01 family)	0.0087	0.0757	0.0757
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0344	0.3283	0.8838
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0344	0.3283	0.8838
Echinococcus granulosus	cathepsin l1	0.0344	0.3283	0.3283
Onchocerca volvulus		0.0344	0.3283	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0344	0.3283	1
Entamoeba histolytica	cysteine protease, putative	0.0344	0.3283	1
Brugia malayi	Cathepsin L-like precursor	0.0344	0.3283	0.3283
Trypanosoma cruzi	cruzipain precursor, putative	0.0104	0.0924	0.018
Echinococcus multilocularis	cathepsin L cysteine protease	0.0344	0.3283	0.3283
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0344	0.3283	0.8189
Plasmodium vivax	vivapain-1	0.0192	0.1781	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0757	0.0512
Schistosoma mansoni	cathepsin C	0.0087	0.0757	0.0757
Onchocerca volvulus	Cathepsin L homolog	0.0344	0.3283	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.0302	0.0302
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0045	0.0346	0.0346
Entamoeba histolytica	cysteine protease, putative	0.0192	0.1781	0.5035
Entamoeba histolytica	cysteine protease, putative	0.0192	0.1781	0.5035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0344	0.3283	0.8189
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0036	0.0258	0.0258
Echinococcus granulosus	tyrosine protein kinase Blk	0.0041	0.0302	0.0302
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.029	0.029
Brugia malayi	Cathepsin L-like precursor	0.0344	0.3283	0.3283
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0344	0.3283	0.8838
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0344	0.3283	0.8838
Trypanosoma cruzi	cysteine peptidase, putative	0.0344	0.3283	0.2733
Echinococcus multilocularis	cathepsin L	0.0192	0.1781	0.1781
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0344	0.3283	0.8838
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0087	0.0757	0.0512
Schistosoma mansoni	cathepsin B (C01 family)	0.0087	0.0757	0.0757
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.0346	0.0346
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0192	0.1781	0.1781
Entamoeba histolytica	cysteine proteinase, putative	0.0192	0.1781	0.5035
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0045	0.0346	0.0346
Brugia malayi	cathepsin F-like cysteine proteinase	0.0087	0.0757	0.0757
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0344	0.3283	0.8838
Brugia malayi	cathepsin L-like precursor	0.024	0.2259	0.2259
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0344	0.3283	0.8838
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0757	0.0512
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0087	0.0757	0.165
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.0346	0.0346
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0344	0.3283	0.8189
Loa Loa (eye worm)	hypothetical protein	0.024	0.2259	0.2054
Trypanosoma cruzi	cysteine peptidase, putative	0.0344	0.3283	0.2733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0344	0.3283	0.8838
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0378	0.3616	0.3093
Loa Loa (eye worm)	hypothetical protein	0.0344	0.3283	0.3106
Toxoplasma gondii	cathepsin CPL	0.0344	0.3283	0.8838
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0344	0.3283	0.8838
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0104	0.0924	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0924	0.0683
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0087	0.0757	0.0757
Entamoeba histolytica	cysteine protease, putative	0.0087	0.0757	0.165
Loa Loa (eye worm)	cysteine protease	0.0344	0.3283	0.3106
Schistosoma mansoni	cathepsin s	0.0104	0.0924	0.0924
Giardia lamblia	Cathepsin B precursor	0.0378	0.3616	1
Echinococcus granulosus	cathepsin L	0.0087	0.0757	0.0757
Schistosoma mansoni	cathepsin F (C01 family)	0.0344	0.3283	0.3283
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.0346	0.0346
Entamoeba histolytica	cysteine proteinase, putative	0.0192	0.1781	0.5035
Schistosoma mansoni	tyrosine kinase	0.0045	0.0346	0.0346
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0045	0.0346	0.0346

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.5 nM	Inhibition of human recombinant Src	ChEMBL.	16735116
IC50 (binding)	= 4.5 nM	Inhibition of human recombinant Src	ChEMBL.	16735116
IC50 (functional)	= 120 nM	Inhibition of Src dependent proliferation	ChEMBL.	16735116
IC50 (functional)	= 120 nM	Inhibition of Src dependent proliferation	ChEMBL.	16735116

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL214308

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 369892